1544results about How to "Inhibition of activation" patented technology

A surgical stapler which includes or onto which a tool assembly can be mounted for deforming a plurality of surgical fasteners through and fastening tissue includes a housing having a fixed handle and a clamping handle mountable to the housing. The clamping handle is selectively movable relative to the fixed handle from a first position in spaced relation relative to the fixed handle to a second position closer to the fixed handle to actuate the clamping of tissue. An adapter yoke is included which translates within the housing upon actuation of the clamping handle. The adapter yoke mechanically cooperates with a lead screw to actuate the tool assembly to clamp tissue. A drive assembly is also included for rotating a shaft which mechanically engages the lead screw. Upon selective activation of the drive assembly, the shaft rotates the lead screw to advance a roll nut and force a firing piston into the tool assembly to deform the surgical fasteners through and fasten the tissue.

A desired effect is produced by therapeutically activating tissue at a first site within a patient's body and a corresponding undesired side effect is reduced by blocking activation of tissue or conduction of action potentials at a second site within the patient's body by applying high frequency stimulation and / or direct current pulses at or near the second site. Time-varying DC pulses may be used before or after a high frequency blocking signal. The high frequency stimulation may begin before and continue during the therapeutic activation. The high frequency stimulation may begin with a relatively low amplitude, and the amplitude may be gradually increased. The desired effect may be promotion of micturition or defecation and the undesired side effect may be sphincter contraction. The desired effect may be defibrillation of the patient's atria or defibrillation of the patient's ventricles, and the undesired side effect may be pain.

Expandable sealing means for endoluminal devices have been developed for controlled activation. The devices have the benefits of a low profile mechanism (for both self-expanding and balloon-expanding prostheses), contained, not open, release of the material, active conformation to the “leak sites” such that leakage areas are filled without disrupting the physical and functional integrity of the prosthesis, and on-demand, controlled activation, that may not be pressure activated.

An electrosurgical instrument including a housing assembly having a first disposable treatment portion selectively attached thereto. The disposable treatment portion is adapted to connect to an electrosurgical generator that supplies energy to the electrosurgical instrument. A control circuit is included and disposed in electrical communication between the electrosurgical generator and the first disposable treatment portion. The control circuit is selectively actuatable to enable the flow of electrosurgical energy from the electrosurgical generator to the first disposable treatment portion. An indicator, coupled to the housing assembly or the first disposable treatment portion, is configured to indicate a parameter related to the use of the electrosurgical instrument. The control circuit is configured to prevent activation of the electrosurgical instrument when the parameter of the indicator indicates the useful life of the disposable treatment portion has expired.

A hearing aid insertable into an ear canal includes a microphone which translates acoustic energy into electrical signals, signal processing circuitry which processes the electrical signals provided by the microphone, a receiver which converts the processed electrical signals into acoustic energy, and a power source connectable to the signal processing circuitry.

An apparatus and method are disclosed for treating overweight and obese patients by applying a restrictive Artificial Gastric Valve (AGV) on part of the stomach. The apparatus includes a mechanism to control the opening of the AGV automatically on demand, dynamically and progressively. The controlled opening of the AGV inside the stomach controls and regulates the flow of food.

Provided are retroviral vector genomes and vector systems comprising the genomes. In particular, a retroviral vector genome comprising two or more NOIs, operably linked by one or more Internal Ribosome Entry Site(s); a lentiviral vector genome comprising two or more NOIs suitable for treating a neurodegenerative disorder; and a lentiviral vector genome which encodes tyrosine hydroxylase, GTP-cyclohydrolase I and, optionally, Aromatic Amino Acid Dopa Decarboxylase are provided.

A light emitting toothbrush is provided that includes three light emitting diodes, each having a different primary color. A battery is provided as a power source, and a control circuit is used to control the diodes. The control circuit is configured to sequentially or simultaneously power some or all of the diodes, and it can be configured to vary the power to each diode, thereby providing an almost infinite spectrum of colors of light. A switch is actuated when the brush head contacts an operator's teeth, thereby activating the diodes. A package is provided that allows a potential purchaser to apply a force to the brush head and activate the lights while the toothbrush is still in the package. The control circuit can be configured to control the diodes to provide signals to the operator and / or provide aesthetically pleasing light.

The present invention relates to retroviral vector genomes and to vector systems comprising such genomes. In particular the present invention relates to a retroviral vector genome comprising two or more NOIs operably linked by one or more Internal Ribosome Entry Site(s); a lentiviral vector genome comprising two or more NOIs suitable for treating a neurodegenerative disorder; and a lentiviral vector genome which encodes tyrosine hydroxylase, GTP-cyclohydrolase I and optionally Aromatic Amino Acid Dopa Decarboxylase.

Expandable sealing means for endoluminal devices have been developed for controlled activation. The devices have the benefits of a low profile mechanism (for both self-expanding and balloon-expanding prostheses), contained, not open, release of the material, active conformation to the “leak sites” such that leakage areas are filled without disrupting the physical and functional integrity of the prosthesis, and on-demand, controlled activation, that may not be pressure activated.

Expandable sealing means for endoluminal devices have been developed for controlled activation. The devices have the benefits of a low profile mechanism (for both self-expanding and balloon-expanding prostheses), contained, not open, release of the material, active conformation to the “leak sites” such that leakage areas are filled without disrupting the physical and functional integrity of the prosthesis, and on-demand, controlled activation, that may not be pressure activated.

A computing device includes a touch screen display with at least one force sensor, each of which provides a signal in response to contact with the touch screen display. Using force signals from the at least one force sensor that result from contact with the touch screen, the operation of the computing device may be controlled, e.g. to select one of a plurality of overlaying interface elements, to prevent the unintended activation of suspect commands that require secondary confirmation, and to mimic the force requirements of real-world objects in augmented reality applications.

A foot operable controller for a surgical instrument having a main foot pedal assembly providing either proportional or linear control signals when moved laterally and in a vertical direction. Friction between an operator's foot and the foot pedal is minimized by a foot pad having a rotating heel plate. A neutral zone between left and right control positions of the foot pedal enables the operator to move his foot freely without changing control settings. Vertical displacement of the foot pedal is indicated by a plurality of mechanical detents during both upward and downward travel. Changing detent resistance alerts the operator to the vertical position of the foot pedal, indicating that further vertical displacement will change an instrument control signal corresponding to the new foot pedal position, thus providing sensory feedback to the operator indicating a change in the functional mode when the foot pedal is moved.

A semiconductor apparatus includes a semiconductor substrate of a first conductivity type, a base region of a second conductivity type formed on a principal surface of the semiconductor substrate, a trench formed in a periphery of the base region, and an endless source region of the first conductivity type formed on a surface of the base region along the trench. In this semiconductor apparatus, the principal planes on side surfaces of the trench are composed of planes [100] and [110]. The interior angle of intersection of adjacent side surfaces of the trench is 135°. A minimum distance between the base region and the plane [110] facing each other through the source region is shorter than a minimum distance between the base region and the plane [100] facing each other through the source region.

Methods, systems and devices are described for operating an electronic system to emulate a touch sensitive interface using a touchpad and a display screen which does not overlap the touchpad. The method includes determining positional information and force information for an input object in a sensing region of the touchpad; positioning an input object representation on the display screen based on the positional information; selecting a user selectable item on the display screen based on the force information satisfying a first force threshold; and activating the selected item based on the force information satisfying at least one of the first force threshold and a second force threshold.

Methods and systems for improving nerve stimulation are disclosed and are termed enhanced transcutaneous electrical stimulation (eTENS). One embodiment can be used for enhancing the excitation properties of neural tissue. In one embodiment, systems and methods are provided to enable the selective modulation of specific (targeted) neural substrate, while minimizing the activation of adjacent (non-targeted) nervous tissue, or differentially providing different modulation signals to tissue targeted by different implants. In one embodiment, the system consists of an implant that is used to modify the extracellular potential (i.e. activating function) generated by an independent electrical stimulus generator. Certain aspects of this technology can be applied to any part of the central and peripheral nervous systems. Particular embodiments of this technology provide for therapy related to urological disorders.

Compositions and methods for the treatment of asthma with oligonucleotides which specifically hybridize with nucleic acids encoding B7 proteins.

A device is proposed which is used to detachably connect a wiper blade (12) to clean windows, particularly of motor vehicles, to a driven wiper arm (10) featuring a wiper blade holder (50 or 150), whereby the wiper blade (12) that can be placed on the window (20) with a long-stretched-out, rubber elastic wiper strip (18) features a band-like, long-stretched-out elastic supporting element (16) that is curved in the longitudinal direction over its band surfaces (15, 17) on whose lower, concave band surface (17) the wiper strip (18) is arranged parallel to the longitudinal axis. On the outer convex band surface (15) of the supporting element (16) sits a connecting element (26), which features two parallel wall surfaces (36) that are aligned in a vertical plane on the band surface and extend in the longitudinal direction of the wiper blade and that a pivot pin (42) projects from each wall surface, whereby the longitudinal axes of the two pivot pins are aligned with one another. An especially simple embodiment of the articulated connection with an integrated connecting device is achieved if an adapter (66 or 166) that can move in a pendulum fashion is positioned on the two pivot pins of the connecting element (26), and said adapter features means to connect to the wiper blade holder (50 or 150) of the wiper arm (10).

The present invention relates to selective inhibitors of phosphoinositide (PI) 3-kinase β, use of the selective inhibitors in anti-thrombotic therapy, and a method for screening compounds useful for the new anti-thrombotic therapy by detecting selective inhibitory activity of PI 3-kinase β of the compound. The invention also relates to novel compounds that are inhibitors of PI 3-kinase.

An object locator device is disclosed for use in conjunction with both a GPS satellite system and a two-way communication satellite. The object locating system includes a mobile unit physically connected to the object to be located. The mobile unit includes a satellite communication transceiver capable of receiving and transmitting encoded signals. A decoder is associated with the satellite communication transceiver for decoding a unique signal associated with that mobile unit and for generating an activation signal upon receipt of the unique signal. The mobile unit further includes a GPS receiver which is activated in response to the receipt of the unique signal so that the GPS receiver generates a position signal representative of the position of the mobile unit. The output signal from the GPS receiver is connected as an input signal to the satellite communication transceiver such that the satellite communication transceiver transmits the.position signal to a base station on the communication satellite. The base station physically separated from the remote unit is operable to both transmit the unique signal to the communication satellite in order to activate the mobile unit as well as for receiving the position signal from the communication satellite following activation. The base station creates a display representative of the location of the mobile unit. Preferably, this display signal is transmitted via a telephone line and modem to a computer which generates the display on a computer monitor. Energy conservation algorithms including periodic activation of the satellite communication transceiver as well as activation of the satellite communication transceiver only when the position of the mobile unit has changed more than a threshold amount between periodic signals is disclosed.

A package is provided for a medical device that a spring-driven button-actuated safety shield. The package includes a tray with a bottom wall and sidewall enclosure that extends upwardly from the bottom wall a distance greater than the height or thickness of the medical device. A flange extends outwardly from edges of the sidewall enclosure opposite the bottom wall. At least two gripping towers are formed unitarily with the bottom wall and project upwardly a distance greater than the thickness or height of the medical implement. Gripping towers are spaced from one another and are configured to grippingly engage the medical implement on opposite respective sides of the actuating button for preventing inadvertent actuation of the safety shield while the medical implement is in the tray. A cover extends removably across the flange and is supported by the gripping towers.

The invention provides a natural killer cell, NK-92, modified to express an Fc receptor on the surface of the cell, such as CD16 (FcγRIII-A), or other Fcγ or Fc receptors. The modified NK-92 cell can be further modified to concurrently express an associated accessory signaling protein, such as FcεRI-γ, TCR-ζ, or to concurrently express interleukin-2 (IL-2) or other cytokines. Additional methods are disclosed for various assays, assessments, and therapeutic treatments with the modified NK-92 cells.

Apparatus, system and method for providiing tactical information. One aspect is a system and method for displaying vectors (preferably in real time) for very fast moving (VFM) elements, such as projectiles (e.g., bullets or shells), missiles, and other transient events that arise in a battlefield or civil police action. The system optically and / or acoustically collects information about the ordinance and displays vectors of otherwise unseen ordinance. One aspect is a device for collecting intelligence on and confusing enemy troops, as well as small munition deployment.

Injection device for manual penetration and injection comprising a distal housing part (10); a proximal housing part (12) with a multi-chamber container (20); a plunger rod (40); a push button (70); an activation member (30); a drive force means(100) and a locking member (50), wherein the device further comprises a guide rod (60) arranged to generate an audible and tactile indication of the start of an injection.

Devices and methods to heat and cool human beings, including inducing and maintaining hypothermia in human patients. Methods include inducing hypothermia to treat ischemic events, including heart attack and stroke, to limit damage caused by the ischemic event. Methods can include: using the lungs for heat exchange; using cooled gases for ventilation; using helium in the ventilation gas mixture, using medications to control reflex heat production; and injecting a perfluorocarbon mist into the gas stream to increase the cooling rate. The high thermal conductivity and diffusivity of helium results in greater inspired gas temperature equalization toward body temperature. Due to the latent heat of vaporization, addition of even small quantity of phase-change perfluorocarbon dramatically increases the heat carrying capacity of the respiratory gases. Hypothermia may be terminated by discontinuing the medications and warming the patient using a warmed helium-oxygen mixture.

Peptides that are designed to inhibit the biological activity of the IL-1R type 1 receptor and inhibit IL-1R / IL-1RacP related cell signaling and biological activity are disclosed. Compositions comprising IL-1R antagonists of the present invention are useful in the treatment of IL-1 related diseases or conditions such as arthritis, rheumatoid arthritis, osteoarthritis, and inflammatory bowel disease as well as other chronic or acute inflammatory diseases. This invention also discloses an isolated compound having an IL-1R antagonist activity, said compound being selected from the group consisting of: a peptide comprising the amino acid sequence RYTPELX, wherein R, Y, T, P, E, L, refer to their corresponding amino acids, and X is selected from no amino acid and alanine (A); and a derivative of (a) wherein the derivative incorporates one, two or three amino acid modification selected from an amino acid addition, deletion or substitution in the RYTPEL portion of the peptide, and wherein said derivative maintains its antagonist IL-1R activity.

The invention relates to a method of treating diverse human disorders that may arise, in part, out of sleep hypoxia and oxygen deprivation occurring in the context of sleep apnea / hypopnea disturbances. The disorders that may be treated by the invention comprise gastroesophageal reflux disease (GERD), asthma-associated gastroesophageal reflux (GER), GER-associated asthma, asthma, cardiomyopathy, cardioarrhythmia, congestive heart failure, sudden infant death syndrome, and diverse neurologic conditions. The mode of treatment uses somatostatin receptor ligands (SstRLs), particularly somatostatin-receptor agonists. The invention concerns the method of treatment utilizing, and compositions comprising SstRLs and somatostatin receptor agonists, including agonists of the somatostatin receptor types 2 and 5, particularly, the type 2A receptor (SsR-2A), including octreotide and lanreotide.

A method and controller for controlling the operation of a zoned climate control system including a primary heat source, a secondary heat source, a cooling unit, and a humidifier unit. The controller is configured to receive both heating demand signals and cooling demand signals from a plurality of zone thermostats positioned throughout the residence. Upon receiving a heating demand signal, the controller operates the primary heat source to provide heat to the zone issuing the heating demand signal. The controller determines whether the primary heat source satisfies the heating demand signal within a maximum heating period. If the heating demand is not satisfied within this period, the controller activates the secondary heat source to supplement the heat being supplied by the primary heat source.