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Application of active parts of gallnut in preparing anti-ulcerative colitis medicine

A kind of technology of effective parts, gallium, applied in the field of preparation of medicines for the treatment of anti-ulcerative colitis

Active Publication Date: 2012-03-14
XINJIANG CICONHABO UYGUR MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there has not been any report on the use of the effective part of gallic acid as a drug for preparing anti-ulcerative colitis

Method used

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  • Application of active parts of gallnut in preparing anti-ulcerative colitis medicine
  • Application of active parts of gallnut in preparing anti-ulcerative colitis medicine
  • Application of active parts of gallnut in preparing anti-ulcerative colitis medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] a. Take the dried gallic medicinal material and crush it, pass it through a No. 2 sieve, weigh 100g of the medicinal material powder, add water to extract 3 times, add 5 times the amount of water each time, and extract for 20 minutes;

[0016] b. Concentrate the extract under reduced pressure to 500ml, extract the concentrated solution with ether until the ether layer is clarified, and discard the ether layer;

[0017] c. Extract the part of the water layer with ethyl acetate, recover the ethyl acetate, and dry it in vacuum at a temperature of 45° C. to obtain 30% effective parts of galls;

[0018] d. Use a gel chromatography column (model: Sephadex LH-20) to separate the chemical components of the effective part of gallia obtained in step c, and carry out gradient elution with water and 20%-100% methanol to obtain 40%-70 % methanol eluent extract Ⅰ and 70%-100% methanol eluent extract Ⅱ, and then the extract Ⅰ and Ⅱ were separated with a model: MCI-GEL CHP-20P gel chro...

Embodiment 2

[0021] a. Take the dried gallic medicinal material and pulverize it, pass through a No. 2 sieve, weigh 100g of the medicinal material powder, add water to extract 3 times, add 10 times the amount of water each time, and extract for 50 minutes;

[0022] b. Concentrate the extract under reduced pressure to 800ml, extract the concentrated solution with ether until the ether layer is clarified, and discard the ether layer;

[0023] c. Extract the part of the water layer with ethyl acetate, recover the ethyl acetate, and dry it in vacuum at a temperature of 65° C. to obtain 45% of the effective part of the galls;

[0024] d. Use a gel chromatography column (model: Sephadex LH-20) to separate the chemical components of the effective part of gallia obtained in step c, and carry out gradient elution with water and 20%-100% methanol to obtain 40%-70 % methanol eluent extract Ⅰ and 70%-100% methanol eluent extract Ⅱ, and then the extract Ⅰ and Ⅱ were separated with a model: MCI-GEL CHP-...

Embodiment 3

[0027] a. Take the dried gallic medicinal material and crush it, pass it through a No. 2 sieve, weigh 100g of medicinal material powder, add water to extract 3 times, add 15 times the amount of water each time, and extract for 120min;

[0028] b. Concentrate the extract under reduced pressure to 1500ml, extract the concentrated solution with ether until the ether layer is clarified, and discard the ether layer;

[0029] c. Extract the water layer with ethyl acetate, recover the ethyl acetate, and vacuum dry at a temperature of 90°C to obtain 60% of the effective parts of the galls;

[0030]d. Use a gel chromatography column (model: Sephadex LH-20) to separate the chemical components of the effective part of gallia obtained in step c, and carry out gradient elution with water and 20%-100% methanol to obtain 40%-70 % methanol eluent extract Ⅰ and 70%-100% methanol eluent extract Ⅱ, and then the extract Ⅰ and Ⅱ were separated with a model: MCI-GEL CHP-20P gel chromatography colum...

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Abstract

The invention relates to an application of active parts of gallnut in preparing an anti-ulcerative colitis medicine, wherein the active parts of the gallnut are obtained by water extraction and then organic solvent extraction and mainly comprise a tannin type; and then the active parts are subject to extraction separation through a gel chromatography to obtain a monomeric compound, gallic acid, m-digallic acid, methyl gallate, 1,2,3,6-4-O-galloyl group-Beta-D-glucose and 1,2,3,4,6-5-O-galloyl group-Beta-D-glucose. Clinical outcomes show that the active parts of the gallnut have obvious therapeutic action on ulcerative colitis with the total effective rate up to 91.7%, the short-term cure rate up to 66.7%, effective rate of 25% and inefficiency of 8.3%. Pharmacologic research shows that the active parts of the gallnut can obviously increase SOD content and lower MPO content of an ulcer tissue, and has obvious therapeutic action on rat ulcerative colitis, obvious anti-inflammatory and analgesic action and bacteriostatic action on the common pathogenic bacteria related to ulcerative colitis.

Description

technical field [0001] The invention relates to the medicinal application of the effective parts of gallicia, in particular to the preparation of medicinals for treating ulcerative colitis. Background technique [0002] Gallalls are the larvae of Cynips gallae-tinctorice Oliv, an insect of the Fagaceae family, which parasitize on the twigs of the Fagaceae plant Quercus infectoria Oliv., and produce galls. Gallatin is dry and cold in nature, bitter and astringent in taste, and has the functions of strengthening astringency, astringent, dampness, hemostasis, and anti-inflammatory. It is a commonly used medicinal material in Uighur medicine. The theory of Uyghur medicine believes that it can directly act on the intestinal wall to reduce the absorption and pinching force of the intestinal wall caused by colitis, astringe the intestines, reduce inflammation and diarrhea, open up intestinal resistance, and promote ulcer healing. Clinically used in the treatment of ulcerative coli...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/64A61P1/04
Inventor 斯拉甫·艾白李治建
Owner XINJIANG CICONHABO UYGUR MEDICINE
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