The invention discloses a
sodium alginate chiral cross-linked membrane and applications thereof. The preparation method of the
sodium alginate chiral cross-linked membrane comprises the following steps: weighing a certain amount of
sodium alginate, dissolving the
sodium alginate into a water solution of
acetic acid, carrying out a supersonic treatment to remove the aggregated particle molecules, allowing the
system to stand still so as to remove the bubbles; pouring the membrane-forming solution on a clean and smooth glass board at a
room temperature, scrapping off the membrane from the glass board with a membrane-scrapping knife,
drying for 4 days; putting the dry membrane into an
acetone cross-linking agent containing
glutaraldehyde and
hydrochloric acid to carry out cross-linking reactions; and washing the cross-linked membrane with a large amount of
acetone and
ultrapure water until the membrane turns neutral so as to obtain the needed chiral cross-linked membrane. The cross-linked membrane is loaded into a normal
dialysis device, and then separates D,L-p-hydroxyphenylglycine
raceme aqueous solution under the driving of concentration difference, and the
enantiomer purity of p-hydroxyphenylglycine in the permeate reaches 60% or more. The raw materials of the membrane are cheap, the purity of the obtained mono-
enantiomer is high, and the preparation method of the membrane has the advantages of large
throughput, environment-friendliness, low cost, and easiness in
continuous operation and massive industrial production.