208 results about "Hemostatic function" patented technology

The invention relates to a method and to a device for examining the properties of the global, in particular the primary, hemostasis functions in whole blood or platelet-rich plasma, comprising a storage chamber (15) for the blood to be examined, a reaction device (39) having at least one flow path (5, 16) via which the blood to be examined is transported for carrying out certain reactions, a conveyor device (1) which conveys a volumetric flow for the transport of the blood through the reaction device (39), thereby generating a conveyor pressure, a pressure gauge (8, 9) which in a blood-free pressure gauge chamber (3) measures changes in the conveyor pressure which appear depending on the reactions of the blood to be examined which have taken place in the reaction device (39), a blood collection chamber (10) for collecting the blood transported through the reaction device (39), the conveyor pressure in a pressure-sealed working chamber (12) being generated by a piston-cylinder system (1), a working surface (33) of the piston (4) forming a boundary of the working chamber (12), and the working chamber (12) being formed by the blood collection chamber (10) and the blood-free pressure gauge chamber (3). According to the method of the invention, the volumetric flow is preferably adjusted, depending on the measured pressure of the volumetric flow, in such a way that the shear rate or the shear force, whose action in the reaction opening causes blood components, in particular thrombocytes, to deposit, follows a predetermined characteristic curve and in particular is held constant.

A method and a device are provided for examining the properties of the global, in particular the primary, hemostasis functions in whole blood or platelet-rich plasma. A volumetric blood flow is preferably adjusted, depending on the measured pressure of the volumetric flow, so that the shear rate or the shear force, whose action in the reaction opening causes blood components, in particular thrombocytes, to deposit, follows a predetermined characteristic curve and in particular is held constant.

A method is disclosed for predicting the presence of haemostatic dysfunction. At least one time-dependent measurement on an unknown sample is performed and a respective property of the sample is measured over time so as to derive a time-dependent measurement profile. One or more predictor variables, including initial slope, are defined which sufficiently define the data of the time-dependent measurement profile. A model is then derived that represents the relationship between the abnormality and the set of predictor variables. Subsequently, the model is utilized to predict haemostatic dysfunction, such as septicemia or disseminated intravascular coagulation (DIC).

The invention relates to a preparation method of an anti-adhesion fibrous membrane with a hemostatic function. Two or three organic polymer solutions are mixed, composite fiber materials in a multi-nozzle electrostatic spinning mode are prepared, and the anti-adhesion fibrous membrane is prepared by treating the composite fiber materials in a crosslinking mode. According to the composite fiber materials prepared by the preparation method, two or three organic polymer solutions are mixed and then processed in a multi-nozzle electrostatic spinning mode by using the electrostatic spinning technology, due to the fact that organic polymer materials is adjusted, the mechanical strength of the organic polymer materials is improved, and meanwhile through crossing treatment, an anti-adhesion material which forms gels on the surface after contacting with blood is prepared, a physical hemostasis effect is achieved, and meanwhile the anti-adhesion fibrous effect is achieved. The preparation method of the anti-adhesion fibrous membrane preparation method with the hemostatic function is simple in technic, easy to operate and low in cost, enables the functions of hemostasis and postoperative adhesion prevention to be achieved, and has wide application prospect in surgical field.

A self-assembling peptide constituted by D-amino acid is named as d-RAD16 and has an amino acid sequence represented by SEQ ID NO.1 in a sequence list. Test shows that hydrogel formed by the self-assembling peptide can be used for preparing a moisture keeping and water locking agent, and has the function of stopping bleeding rapidly for wound, so that the hydrogel can be used for preparing a hemostatic drug suiting clinical application by adding a pharmaceutically acceptable carrier or excipient. Nanofiber scaffold formed by the self-assembling peptide supports the growth of various cells and can be used as the substrate material for 3D cell culture. The substrate material for 3D cell culture can simulate the in-vivo environment to support the 3D growth of cells in the substrate, thereby providing a cell 3D culture drug screening mode capable of simulating the in-vivo environment and improving the success rate for the development of new drugs.

The invention discloses a medicinal sustained-release and hemostatic composition and a preparation method thereof, which belong to the technical field of novel hemostatic materials. The medicinal sustained-release and hemostatic composition comprises the composition of a medicament-loaded chitosan microsphere, chitosan and hyaluronic acid, wherein the medicament-loaded chitosan microsphere comprises medicinal grade chitosan and medicinal grade tranexamic acid. The novel hemostatic composition is prepared by using chitosan and the hyaluronic acid as a main hemostatic matrix, combining chitosan medicament sustained-release microsphere composite medicament, namely tranexamic acid, utilizing the special property of the chitosan with a hemostatic function and a medicament sustained-release function, and adopting the composition of the hyaluronic acid with good hemostatic function and high biocompatibility and the chitosan as the main matrix. The novel hemostatic composition has the advantages of stopping bleeding rapidly and releasing medicament / factors continuously and stably in a certain time, along with great economic and social benefits.

The invention relates to a high-effect Chinese traditional drug-chitose hemostatic material, since chitose has better hemostatic function, wherein its preparation comprises that: adding 8-17 deals of hemostatic with 75-98% deacetylated degree into acetate solution to prepare chitose acetate solution; filtering out the foreign materials via filter paper; putting filter solution into dialysis bag; immerging it into phosphate buffer solution to dialyze; changing buffer solution each 6-12h; taking out chitose solution, adding 28-50 deals medical biological findings and glycerin, mixing for 30min, adding 35-60 deals hemostatic traditional drug powder, to be mixed uniformly; pouring into glass container; laying for 30min; drying and freezing in vacuum freezing drier, to obtain the composite hemostatic material.

The invention discloses a drug-delivery absorbable hemostatic sponge, which belongs to the technical field of novel hemostatic materials and comprises drug-loaded chitosan microsphere and collagen protein, wherein the drug-loaded chitosan microsphere comprises medicinal grade chitosan and medicinal grade tranexamic acid. The weight ratios of the medicinal grade chitosan to the medicinal grade tranexamic acid are (0.01-100):1 respectively. The invention also discloses a method for preparing the drug-delivery absorbable hemostatic sponge. By selecting collagen with good hemostatic function and biocompatibility as the main hemostatic substrate, compounding the drug-delivery chitosan microsphere and the medicinal grade tranexamic acid, and making use of the special properties of the chitosan including hemostatic function and drug-delivery function, a novel hemostatic sponge with rapid hemostasis and lasting and steady drug delivery in a period of time can be prepared, and has considerable economic and social benefits.

The invention discloses chitosan hemostatic gauze. The chitosan hemostatic gauze is characterized by being prepared from the following raw materials in parts by weight: 3-5 parts of pelargonium hortorum, 3-5 parts of dahurian angelica root, 1-2 parts of panax notoginseng, 1-2 parts of cape jasmine, 4-6 parts of chitosan, 8-12 parts of gelatin, 0.1-0.2 part of squalane, 0.1-0.2 part of polysorbate-80, 2-4 parts of sodium alginate, 2-4 parts of sodium carboxymethylcellulose, 1-2 parts of hydroxyethyl starch, 1-2 parts of auxiliary materials and 200-250 parts of water. According to the chitosan hemostatic gauze disclosed by the invention, soluble hemostatic gauze is prepared from natural high molecular materials such as chitosan and the like in a coordination mode, the soluble hemostatic gauze has good hemostatic functions and good antibacterial effects, is easy to be absorbed by a human body, is good in biocompatibility, and cannot cause toxic or side effect; by extracting and compounding natural plant effective components, the hemostatic gauze can be used for diminishing inflammation and relieving pain, and converging and removing scars; and moreover, the chitosan hemostatic gauze has slow release effects, can be used for effectively prolonging the action time, and ensures that better use effects can be achieved.

The invention relates to a mixed preparation method of hyacinth bletilla effective components and a gel, and particularly relates to a method for preparing a hemostatic gel through polymerization of a hyacinth bletilla extract and hyaluronic acid and application of the hemostatic gel. Hyacinth bletilla and hyaluronic acid are used as raw materials, so that the hydrogel has high elasticity and certain mechanical strength and facilitates release of the hyaluronic acid, thereby ensuring that the hydrogel can be used as an injection hydrogel. By regulating the amount of the hyacinth bletilla and the concentration of the sulfhydrylated hyaluronic acid, hydrogels with different mechanical parameters can be obtained, thereby obtaining the hydrogel having a hemostatic function. The hyaluronic acid is an in vivo inherent component, can promote growth of cells and is fine in biocompatibility. The hyaluronic acid in the hydrogel obtained by the invention is easier to dissociate.

The present invention discloses a pure natural medical dressing. The pure natural medical dressing is composed of a covering layer, a moisture-absorbing layer and a stanching layer which are orderly combined together. The covering layer is made from a non-woven fabric with certain air permeability, one side of which is provided with adhesive. The moisture-absorbing layer is made from a vegetable sponge; the natural vegetable sponge is processed into honeycomb thin fibers, which are then compacted into the shape of a sponge; and after sterilization, natural honey is sprayed into the vegetable sponge by high pressure. The stanching layer is made from algal protein fibers with a hemostatic function. The pure natural medical dressing, which adopts the pure natural materials with pharmaceutical functions, has the functions of antibiosis, pain relief, antiphlogosis, stanching and accelerating the healing of wound, and moreover, the pure natural medical dressing also has good natural degradability and is environment-friendly.

The invention discloses a production method of water-soluble hemostatic gauze. The production method comprises the following steps: carrying out sterilizing process on natural full-cotton gauze after preprocessing, sitallization processing, cross linking reaction, washing and drying, wherein the preprocessing is realized by modifying the natural full-cotton gauze by using ethanol or acetone; the sitallization processing is carried out for 1-2h by adopting a sodium hydroxide solution under the condition that the temperature is 20-30 DEG C and the rotational speed of a reaction vessel is 15-20 r / min; and the cross linking reaction is carried out for 1-2h at the temperature of 25-30 DEG C by adopting an ethanol chloroactic acid solution. The water-soluble hemostatic gauze has favorable functions of physical hemostasis, chemical hemostasis and physiological hemostasis, can rapidly realize hemostasis and diminish inflammation without medicaments, also prevent operation conglutination and be finally decomposed in the body to form monosaccharide absorbed by a human body.

The invention belongs to the field of medical equipment, particularly relates to the field of medical biopolymer materials and provides sustained antibacterial hemostatic powder and a preparation method of the sustained antibacterial hemostatic powder. The sustained antibacterial hemostatic powder is prepared from nanometer silver, sodium carboxymethyl cellulose and alginate, and by weight, 1-3 parts of the nanometer silver, 10-20 parts of the sodium carboxymethyl cellulose and 5-10 parts of the alginate are included. According to the sustained antibacterial hemostatic powder, the nanometer silver, the sodium carboxymethyl cellulose and the alginate are used as the raw materials, and the sustained antibacterial hemostatic powder is obtained through a spray drying method; and the hemostatic powder not only has the hemostatic function, but also has the excellent antibacterial function, as degradation of the sodium carboxymethyl cellulose and the alginate after the hemostatic powder is in contact with the blood or diffusate, the contained nanometer silver is released slowly, and thus the sustained antibacterial purpose is achieved.

The invention aims to provide amphipathic self-assembly ultra-short peptide. The amino acid sequence general formula of the peptide is I3-X-Q-G-K(1-2). According to the amphipathic self-assembly ultra-short peptide, the content of amino acid is small, synthesis cost is low, and synthesis conditions can be controlled easily; high-strength in-situ hydrogel can be formed at the moment the ultra-short peptide makes contact with blood, so that a fast hemostatic function is achieved; meanwhile, the series short peptide is low in toxicity, good in biocompatibility and capable of not causing a non-specific immunity reaction of lymphocyte, thereby being an ideal nano hemostatic material. By the application of the amphipathic self-assembly ultra-short peptide, the variety of existing nano medicine materials can be enriched, and it is of great significance to the life and health of people.

The invention discloses a nosal hemostat, consisting of a breather pipe and hemostatic sponge. The hemostatic sponge is wrapped outside the breather pipe to form a cylindrical entirety. The front end of the outer surface of the breather pipe wrapped by the hemostatic sponge is thin and the rear end thereof is thick so as to lead the front end of the whole nosal hemostat to be thin and the rear end thereof to be thick; the breather pipe is made of medical macromolecular material, can be pressed to be dented; when in use, the breather pipe and the hemostatic sponge are plugged into the nosal cavity after being dented; after the breather pipe and the hemostatic sponge naturally restore, natural force when the hemostatic sponge and the macromolecular breather pipe restore is utilized to press and staunch hemorrhagic spots in the nosal cavity; and with the hemostatic function of the hemostatic sponge, the hemostatic effect is better. As being thin at the front end and thick at the rear end, the whole nosal hemostat is suitable for physiological structure of the nosal cavity and is convenient to be put into the nosal cavity; and as the macromolecular breather pipe is arranged, the smoothness of breathing of the nosal cavity can be kept when in hemostasia, normal breathing is not interfered and uncomfortableness of patients is reduced.

Method and systems for of evaluating a mechanical property of a material by applying force to the material sufficient to physically displace a portion of the material, measuring displacement of the material, adaptively adjusting the force when the displacement measured is not within a predetermined range of displacement values, wherein the force is increased or decreased depending upon whether the measured displacement is below or above the predetermined range, respectively, and computing a mechanical property value resultant from the displacement of the material

The invention belongs to the field of biomedical material preparation, and relates to a preparation method of a polyelectrolyte sponge wound dressing based on carboxymethyl chitosan. According to the preparation method, a proper amount of carboxymethyl chitosan and biocompatible anionic polyelectrolyte / amphoteric polyelectrolyte are dissolved in deionized water, and then the solution is injected into a mould. By reducing the pH value of the water solution of the polyelectrolyte mixture, the amino group of carboxymethyl chitosan molecules is protonated, thus the carboxymethyl chitosan will interact with anionic polyelectrolyte / amphoteric polyelectrolyte through Coulomb force to form compounds, and gelation happens gradually. The compound gel is freeze-dried to obtain a sponge like wound dressing. The obtained polyelectrolyte sponge wound dressing has an excellent hemostatic function, water-absorbing performance and moisturizing property, can effectively control the exudates generated by the wounds, provides water for the dry wounds, accelerates the healing speed of wounds, and can be easily removed from the wounds. At the same time, the preparation technology is simple and can be applied to industry easily.

The present invention provides a preparation method of an external-use ophicalcitum compound emergency hemostat. The present invention grinds the natural ophicalcitum into a certain particle diameter, carries out the calcium chloride modification treatment through different temperature treatments, and obtains the ophicalcitum compound material with high hematopoietic function by mixing with other auxiliary compound materials. The present invention can be used for hemostasis on different medical occasions, can be combined with other medical materials and medical apparatuses, can be made into adhesive bandage, transfusion bandage, self-adhesive dressing, tablet and capsule core material, operation packet, first-aid packet, etc., and can also be made as the oral medicine and be used with other external-use medicines so as to get better curing effect. The present invention has the advantages of simple and feasible operation, abundant materials, low price and easy access, convenient application, good hematopoietic effect and less discharged heat.

The invention relates to a potent composite hemostatic material mainly used for emergency aid and a preparation method and application of the material. The composite hemostatic material has the advantages of strong hemostatic function, safety, effectiveness, higher practicability, rich raw material sources, cheap raw materials, simple and convenient preparation technology, simplicity and convenience in quality control, convenience in use, remarkable curative effect and small toxic or side effects, is used for stopping bleeding after a surgical wound, particularly for hemorrhoea, overcomes the shortcomings of a conventional commonly-used hemostatic product, is more suitable for mass production and commercial application in industries like medicine and medical instruments, is particularly suitable for field first aid in battle field and disaster relief as well as normal pre-hospital first aid, and has a good application prospect and remarkable social and economic benefits.

The invention discloses a preparation method and application of a polyvinyl alcohol hemostatic porous material with high liquid absorption and high expansion performance and an active hemostatic function. The hemostatic sponge prepared by the invention can be used for hemostasis of penetrating wounds and irregular incompressible wounds in an emergency site; the prepared polyvinyl alcohol hemostatic sponge does not adopt a traditional aldehyde group crosslinking mode; a large amount of concentrated acid catalyst is not added; therefore, tedious cleaning steps of post-treatment are avoided; theprepared sponge has high liquid absorption capacity and expansion performance, so that after the sponge is in contact with blood, a large amount of water in the blood can be absorbed to concentrate blood coagulation components, and the sponge can be quickly expanded in the liquid absorption process to achieve the effect of hemostasis by compression; meanwhile, due to the addition of an active hemostatic preparation, the blood coagulation effect of the sponge can be better improved, and the sponge has good biocompatibility, high liquid absorption capacity and expansibility, excellent hemostaticeffect and the like, and has a wide clinical application prospect.

The invention discloses absorbable bone wax with a hemostasis function. The absorbable bone wax is prepared from the following raw materials: solid and water, wherein the solid is prepared from crosslinking hyaluronic acid, calcium phosphate and soluble starch; the weight of water is 20-100% of the weight of the solid; the weight ratio of the solid is that the ratio of the crosslinking hyaluronicacid, the calcium phosphate and the soluble starch is (20-70):(20-50):(0-10). According to the bone wax disclosed by the invention, the defects that traditional bone wax has poor biocompatibility, isnondegradable and affects bone healing can be eliminated. While a good hemostasis effect of the traditional bone wax is kept, the bone wax disclosed by the invention can be naturally degraded in the body without causing late period relevant complications due to residues.

The invention discloses a pectin hemostatic gauze which is characterized by being prepared from the following raw materials in parts by weight: 8-12 parts of pectin, 4-6 parts of gelatin, 1-2 parts of poloxamer 188, 3-5 parts of sodium alga acid, 1-2 parts of wheat germ oil, 1-2 parts of soybean oil, 0.1-0.2 part of polysorbate-80, 0.05-0.1 part of propylgallate, 1-2 parts of lactose, 1-2 parts of xylitol, 2-4 parts of sodium carboxymethylcellulose, 1-2 parts of auxiliary materials and 200-250 parts of water. A soluble hemostatic gauze is prepared by taking natural pectin as a main ingredient, has a good hemostatic function and can achieve the effects of resisting bacteria, diminishing inflammation and protecting the wound; and meanwhile, the pectin hemostatic gauze is rich in raw materials, simple in preparation process, low in cost, safe, environment-friendly and high in biocompatibility, is easily absorbed by a human body and does not have any toxic or side effect.

The invention discloses a composite polysaccharide hemostatic composition and a preparation method and application thereof. The composite polysaccharide hemostatic composition is prepared from the following components in percentage by mass: 20% to 99% of absorbable composite starch, 0.1% to 60% of forming agent, and 0.001% to 20% of plasticizer. The composite polysaccharide hemostatic composition has the advantages that the water in blood can be quickly adsorbed by the molecular structure, the blood platelet, erythrocyte and binding protein (thrombin and fibrinogen) are concentrated, the normal blood coagulation speed in the dewatering process is accelerated, and the hemostatic function is quickly realized; the gel and adhesive substrate can be formed to provide mechanical barriers for the subsequent hemostatic operation, and the probability of bleeding again is reduced by the super-hydrophilic property and adhesion property; the degrading speed is higher, and the use safety of a patient is improved.

The invention relates to a preparation method of multifunctional hemostatic antibacterial and anti-Inflammatory toothpaste, a product and application thereof. The preparation process of the multifunctional hemostatic antibacterial and anti-inflammatory toothpaste is characterized by comprising the following steps of: firstly preparing surface-modified mesoporous silicon dioxide, then grafting chitosan molecules on the surface of the mesoporous silicon dioxide to obtain an inorganic / organic hybrid nano material, adopting the inorganic / organic hybrid nano material to adsorb natural plant extract, adopting a product obtained as an abrasive to prepare the antibacterial toothpaste. The preparation method, the product and the application have the advantages that the mesoporous silicon dioxide isadopted as a medium to realize the fast-hemostasis effect; the chitosan molecules are modified on the surface of the mesoporous silicon dioxide to realize the antibacterial effect; the natural plantextract is adsorbed in mesoporous channels to realize the anti-inflammatory effect. The multifunctional toothpaste prepared by utilizing the multifunctional abrasive integrates the hemostatic function, the antibacterial function and the anti-inflammatory function; the preparation method disclosed by the invention is simple in process and strong in operability and can further meet production and application.

The invention discloses a syringe needle with a hemostatic function and a preparation method thereof. The syringe needle comprises a syringe needle main body, and chitosan nanospheres and / or drug-loading chitosan nanospheres for promoting a hemostatic function and coating the outer surface of the syringe needle main body. The polymer material such as polydopamine uniformly bonds the chitosan nanospheres to the surface of the syringe needle under action of a certain adhesion force. The syringe needle is used for in-situ solid-gel phase transfer after clinical tissue puncturing and needle withdrawal so that the perforation tissue is sealed and thus the purpose of rapid bleeding is realized.

The invention discloses a hemostatic material which includes a first hemostatic functional layer, a second hemostatic functional layer and a third hemostatic functional layer that are sequentially stacked, wherein the second hemostatic functional layer is respectively fixedly connected with the first hemostatic functional layer and the third hemostatic functional layer; the first hemostatic functional layer includes a first hemostatic component; the second hemostatic functional layer includes a second hemostatic component being an inorganic material with the water absorption characteristic; the third hemostatic functional layer includes a third hemostatic component being an organic material with the water absorption characteristic. The hemostatic material provided by the invention can be used for hemostasis for various bleeding conditions through the arranged three hemostatic functional layers, is wide in application range, efficient and quick in hemostasis treatment, particularly suitable for hemostasis treatment to hemorrhoea caused by main artery and vena cava rupture, and has the effect of quick hemostasis treatment in site.

The invention discloses a panax notoginseng loaded hemostatic tissue repair membrane. The panax notoginseng loaded hemostatic tissue repair membrane comprises a hemostatic layer and a tissue membrane repair layer, wherein the hemostatic layer is prepared by mixing panax notoginseng and / or dencichine with natural high polymer materials; the tissue membrane repair layer is prepared by performing electrostatic spinning on panax notoginseng and / or dencichine and an electrostatic spinning material for tissue repair; and in the tissue membrane repair layer, the panax notoginseng and / or dencichine accounts for 5-30 percent of the mass of the tissue membrane repair layer. The tissue repair membrane disclosed by the invention has a good hemostatic function, is conveniently operated by a doctor, realizes hemostasis, does not influence the original repair effect of the tissue repair membrane and is particularly suitable for repairing tissues of easily bleeding parts.

The invention provides an insoluble polysaccharide compound with a hemostatic function. The compound includes insoluble polysaccharide and a blood component. The blood component is whole blood or plasma, and the insoluble polysaccharide is macromolecular polysaccharide insoluble in whole blood or plasma. According to the invention, by mixing the blood component with the insoluble polysaccharide, the blood component undergoes clotting reaction evenly and dispersedly on the surface of the insoluble polysaccharide, so that clotting factors generated in the clotting process can be adsorbed by the insoluble polysaccharide surface, and high clotting activity can be maintained, thereby obtaining a composite hemostatic material with an excellent clotting effect. The preparation method of the insoluble polysaccharide compound provided by the invention is simple, and is convenient and safe to use, thus being widely applicable to trauma and surgical hemostasis. The insoluble polysaccharide compound can be combined with other medical materials and medical instruments so as to be prepared into band aids, infusion bands, self-adhesive dressings, tablets and capsule core materials, operation packages and first-aid packets, etc. At the same time, the adsorption performance and other characteristics of the insoluble polysaccharide compound are utilized to adsorb antibiotics, painkillers and the like thereinto, thus achieving better curative effect.

The invention discloses antibacterial hydrogel, which is prepared from the following components: methacrylated chitosan and antibacterial microspheres, and the antibacterial microspheres are sodium alginate microspheres loaded with nano-silver, wherein a mass ratio of the methacrylated chitosan to the antibacterial microspheres is 10: (0.1-2). According to the preparation method, the nano-silver is loaded into the sodium alginate microspheres, so that the slow release of the nano-silver is realized. Meanwhile, the sodium alginate microspheres loaded with the nano-silver are added into the methacrylated chitosan hydrogel to form microsphere-containing antibacterial hydrogel, so that the antibacterial property of the material is greatly improved, the cytotoxicity of the nano-silver is reduced, and the release period of the nano-silver is as long as 10 days or longer. The antibacterial hydrogel disclosed by the invention is safe, non-toxic and good in antibacterial property, shows appropriate swelling and degradation behaviors, has excellent biocompatibility and mechanical properties, is biodegradable and bioabsorbable, and also has injectability and a hemostatic function.