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Preparation method of anti-adhesion fibrous membrane with hemostatic function

An anti-adhesion, fibrous membrane technology, applied in medical science, textiles and papermaking, non-woven fabrics, etc., to achieve wide application prospects, postoperative adhesion after hemostasis, and prevention of postoperative adhesions.

Inactive Publication Date: 2013-02-13
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

Most of the products currently on the market only have a simple anti-adhesion function, but scientific research has found that bleeding during surgery is the root cause of adhesion, so the market urgently needs a product that can stop bleeding and prevent adhesion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Prepare the anti-adhesion fibrous membrane with hemostatic function as follows:

[0019] (1) Prepare organic polymer mixed solution: dissolve polylactic acid-glycolic acid copolymer (PLGA), polylactic acid-glycolic acid copolymer (PELA) and hyaluronic acid (HA) in a mass ratio of 85:10:5 in In a mixed solution of acetone and dimethylformamide (DMF) at a volume ratio of 1:1, a mixed solution of organic polymers with a concentration of 50% (W / V) was prepared, and stirred at room temperature for 12 hours.

[0020] (2) Preparation of composite fiber material: Inject the prepared organic polymer mixed solution into ten 10ml syringes respectively, add No. 5 stainless steel pillows with a diameter of 2mm, the voltage is 20KV, the solution flow rate is 5ml / h, and the receiving distance Multi-nozzle electrospinning was carried out under the condition of 20 cm to obtain a composite fiber material; the composite fiber material was vacuum-dried at room temperature for 24 hours to r...

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PUM

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Abstract

The invention relates to a preparation method of an anti-adhesion fibrous membrane with a hemostatic function. Two or three organic polymer solutions are mixed, composite fiber materials in a multi-nozzle electrostatic spinning mode are prepared, and the anti-adhesion fibrous membrane is prepared by treating the composite fiber materials in a crosslinking mode. According to the composite fiber materials prepared by the preparation method, two or three organic polymer solutions are mixed and then processed in a multi-nozzle electrostatic spinning mode by using the electrostatic spinning technology, due to the fact that organic polymer materials is adjusted, the mechanical strength of the organic polymer materials is improved, and meanwhile through crossing treatment, an anti-adhesion material which forms gels on the surface after contacting with blood is prepared, a physical hemostasis effect is achieved, and meanwhile the anti-adhesion fibrous effect is achieved. The preparation method of the anti-adhesion fibrous membrane preparation method with the hemostatic function is simple in technic, easy to operate and low in cost, enables the functions of hemostasis and postoperative adhesion prevention to be achieved, and has wide application prospect in surgical field.

Description

Technical field: [0001] The invention relates to a preparation method of an anti-adhesion fibrous film, in particular to a preparation method of an anti-adhesion fibrous film with a hemostatic function. Background technique: [0002] Most abdominal operations will have different degrees of abdominal adhesions. Studies have reported that the incidence of adhesions after traditional laparotomy is as high as 60-90%, and about 5% of them have adhesive ileus, which not only increases the pain of patients, but also brings great harm to surgical clinicians. Workers put forward a severe challenge, postoperative adhesions have become the main cause of adhesive intestinal obstruction. Therefore, preventing and reducing the occurrence of postoperative adhesions has always been highly valued by clinical surgeons. Most of the products currently on the market only have a simple anti-adhesion function, but scientific research has found that bleeding during surgery is the root cause of adh...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/04A61L31/14D04H1/4382D04H1/728
Inventor 韩志超许杉杉
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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