55 results about "Dencichine" patented technology

The invention relates to toothpaste containing dencichine, which is characterized in that the toothpaste is prepared by adding arasaponin and dencichine into a toothpaste matrix, wherein the weight percent of the arasaponin is 0.2-1.2% and the weight percent of the dencichine is 0.01-1.0%. The toothpaste according to the invention can kill pyococcus, candida albicans, staphylococcus aureus, anaerobic bacteria and other pathogens which can cause gingivitis, periodontitis, canker sores, halitosis, ngival hamorrhage, caries and other symptoms in the oral cavity and eliminate the peculiar smell in the oral cavity. The effective rate for the gingivitis and the ngival hamorrhage achieves 94.6%; and the effective rate for the canker sores achieves 89%, and the efficacy is significant. The toothpaste has no toxicity or side effects, is safe to use and can prevent drug resistance. The toothpaste has significant efficacy for the gingivitis, the ngival hamorrhage, the canker sores and the like. The hemostatic effect of the toothpaste is well promoted. Sanchi extract and the dencichine are simultaneously used in the toothpaste, thereby enabling the effects of relieving pain and preventing thegingivitis, the ngival hamorrhage and the pain of the toothpaste to be more significant.

The invention discloses collagen-based composite hemostasis powder and a preparation method thereof. The method is characterized by comprising the following steps: modifying type I collagen by using dencichine, preparing the modified type I collagen into a solution with the concentration of 1-2 percent by using polylysine-modified chitosan; preparing medical gelatin into a 1-3% solution; preparing the modified chitosan into a 1-3% solution; blending the three solutions according to a mass ratio of 0.5-1:2-8:8-2; stirring at the temperature of 4-10 DEG C for 8-10 hours, and performing freeze drying to prepare composite sponge; sequentially impregnating the composite sponge in a modifier and a blood coagulation factor in an ultrasonic cleaner, fully washing, performing freeze drying, and grinding by a grinder to prepare the collagen-based composite hemostasis powder. The powder has the effects of rapidly and effectively stopping bleeding, resisting bacteria, diminishing inflammation, relieving pain, promoting wound healing and repairing, has high adhesion property, hydrophilicity, biological degradability and biocompatibility and is low in price and suitable for wound hemostasis or repair.

The invention discloses a preparation method and application of D-dencichine. The preparation method comprises the following steps: carrying out Fmoc protection on the amino group of D-asparagine so as to obtain a first intermediate; subjecting the first intermediate to Hoffman degradation reaction so as to obtain a second intermediate; subjecting the second intermediate to removal of Fmoc protection under the action of organic base so as to obtain a third intermediate; and subjecting the third intermediate and monomethyl oxalate to condensation reaction under a highly basic condition so as to obtain D-dencichine. D-dencichine is prepared by using the high-efficiency safe preparation method; the preparation method is simple and has high yield; the compound D-dencichine prepared by using the method has good treatment effect on thrombocytopenia and the effect is better than the effect of a clinical medicine interleukin-11, so D-dencichine can be used as a candidate medicine for treating thrombocytopenia.

The invention discloses a device for extracting dencichine from radix notoginseng and an extraction method thereof. The device comprises a cleaning and drying device, wherein one end of the cleaning and drying device is connected with a pulverizing device; one end of the pulverizing device is connected with an extracting device; one side of the extracting device is connected with a centrifuge; oneend of the centrifuge is connected with a concentrating device; the lower end of the concentrating device is connected with a stirring device; one side of the stirring device is connected with a suction filtration device; one end of the suction filtration device is connected with an ethanol recovery device; and one side of the ethanol recovery device is connected with an eluting device. By adopting the structure and the extraction method thereof, radix notoginseng can be pulverized into powder, uniform heating of an extracting solution can be realized, the extracting solution and filter residues can be quickly separated, and the solution can be quickly and uniformly mixed, thereby effectively improving the extracting efficiency and improving the extraction efficiency of dencichine.

The invention discloses a panax notoginseng loaded hemostatic tissue repair membrane. The panax notoginseng loaded hemostatic tissue repair membrane comprises a hemostatic layer and a tissue membrane repair layer, wherein the hemostatic layer is prepared by mixing panax notoginseng and / or dencichine with natural high polymer materials; the tissue membrane repair layer is prepared by performing electrostatic spinning on panax notoginseng and / or dencichine and an electrostatic spinning material for tissue repair; and in the tissue membrane repair layer, the panax notoginseng and / or dencichine accounts for 5-30 percent of the mass of the tissue membrane repair layer. The tissue repair membrane disclosed by the invention has a good hemostatic function, is conveniently operated by a doctor, realizes hemostasis, does not influence the original repair effect of the tissue repair membrane and is particularly suitable for repairing tissues of easily bleeding parts.

The invention discloses dencichine-containing medicinal toothpaste, which comprises, by weight percentage, the following constituents: 15%-75% of humectant, 0.5%-2% of binding agent, 0.5%-3% of sweetener, 1.5%-3% of foaming agent, 0.8%-2% of odorant, 15%-60% of abradant and 0.05%-1% of dencichine; and the rest of deionized water, wherein the medicinal constituent is the dencichine. The perpetration method of the dencichine-containing medicinal toothpaste comprises the following steps of: firstly, adding the dencichine into the toothpaste as the main constituent for stopping bleeding, then, determining the effective ratio of the dencichine being independently added or added with other constituents into the toothpaste. Except for the function of cleaning teeth, the dencichine-containing medicinal toothpaste can obviously improve the function of stopping bleeding and effectively reduce dental problems such as gingival bleeding.

The invention discloses an improved synthesis method for dencichine, and belongs to the fields of medicine and chemical engineering. Dencichine is a white solid, and can be used for hemostasis by shortening blood coagulation time and thrombinogen time, thereby being important medicine; while, natural dencichine is low in extraction rate, and low in profit margin. The improved synthesis method is an efficient way to obtain dencichine according to a chemosynthesis method, and is low in cost, suitable for industrial production, and low in reaction cost, thereby providing an important reference for industrialization.

The invention provides a dencichine extraction method, which takes industrial pseudo-ginseng waste residue as a raw material to extract dencichine. During an extraction process, a thin layer detection method is employed for verifying the product containing the dencichine, subsequent processes such as purifying and crystallization are carried out continuously, after purifying, thin-layer detection is carried out, the eluates having only one spot and having a same Rf value with a dencichine reference substance are merged, and crystallization is carried out. The invention also provides a pseudo-ginseng amino acid extraction method, which takes industrial pseudo-ginseng waste residue as the raw material. The process of the method is substantially same with the above dencichine extraction method, the difference is characterized in that while crystallization is carried out, the merged eluate and the dencichine reference substance have the same spot and other spots. The invention further provides an application of the obtained dencichine, the dencichine can be used for the product having haemostasis function such as toothpaste and adhesive bandage. According to the invention, the industrial pseudo-ginseng waste residue is fully used, waste is changed into valuables, resource re-utilization is realized, and the resource waste is effectively reduced.

The invention relates to a method for preparing a solid dispersion medicine for treating hemorrhagic disease. The solid dispersion medicine for treating the hemorrhagic disease is prepared according to the parts by weight as follows: 1-5 parts of dencichine, 0.4-2 parts of a cosolvent, 0.5-2.5 parts of a dispersion carrier and 0.1-0.5 part of a cryoprotectant. The invention also discloses a method for preparing the solid dispersion medicine and a method for preparing the solid dispersion medicine into various pharmaceutically acceptable dosage forms by adding pharmaceutic adjuvants, such as injection, oral solid preparation and preparations for external use. The solid dispersion medicine has obvious functions of preventing and treating hemorrhage. The medicine is prepared by a dispersion system and better disperses both in vivo and in vitro, which is beneficial to the absorption of human body, thus improving the haemostatic effect.

The invention discloses a formaldehyde removing agent. The formaldehyde removing agent comprises the following components in parts by weight: 1-5 parts of glycine, 0.8-3 parts of chitosan quaternary ammonium salt, 0.5-1 part of dencichine, 0.5-1 part of maca root extractive, 1-5 parts of glycerin, 0.5-1 part of triethyl citrate water solution, and 100-150 parts of de-ionized water. The formaldehyde removing agent can effectively remove formaldehyde in furniture boards, is convenient to use and low in cost, can avoid formaldehyde recurrence after use, cannot generate secondary environment pollution in the product use process, and is long in acting time, more thorough in treatment and high in formaldehyde removing rate.

The invention relates to a high-efficiency synthesis method of a hemostasis compound D-dencichine, comprising the following steps: firstly enabling D-serine to react with di-tert-butyl dicarbonate ester to generate Boc-D-serine, then generating Gabriel reaction with hydroxy of methylsulfonyl chloride activated Boc-D--serine to obtain N-alpha-Boc-D-alpha, beta-diaminopro, finally condensing with oxalate mono-methyl ester sylvite then performing hydrolytic acidification to obtain a dencichine crude product, and purifying to obtain a dencichine competitive product, with the product content reaching more than 99.8%. Compared with existing D-dencichine synthesis methods, the reaction condition is more mild, the operation is simple and convenient, the material cost is relatively low, and the hemostasis compound D-dencichine is environment-friendly, is suitable for industrial production, and solves the problem of resource for later development of clinical trial of D-dencichine.

The major functional components in radix notoginseng stems and leaves comprise total saponins of the radix notoginseng stems and leaves, total flavones of the radix notoginseng and dencichine. The annual stock of the radix notoginseng stems and leaves can reach 8000-10000 tons, but in the prior art, only about 5% of the stock is used for the radix notoginseng stems and leaves, the rest is discarded, waste is caused. The reason is that most of the components of the radix notoginseng stems and leaves are extracted from single component, no technology for extracting three components simultaneously is seen at present, and thus the extraction efficiency is low. The invention provides an extraction process of radix notoginseng stems and leaves components for the problem, three components can beextracted simultaneously, the yield and content of each component are higher than the prior art, and the utilization of the radix notoginseng stems and leaves can be promoted.

The invention relates to application of a dencichine medicament, in particular to the application of a small dose of dencichine in preparation of a medicament for treating chronic neurologic diseases. A cytological method is used by researchers of the experiment, so that the condition that a small dose of dencichine can achieve a protection effect on neurogenic cell damages caused by a chronic anoxic effect is proved and a protection effect of a small dose of dencichine on the chronic neurologic diseases is prompted by a cellular morphology observation method, a cellular staining method and other methods by establishing a cellular chronic anoxic model and the like.

The invention relates to toothpaste containing dencichine, which is characterized in that the toothpaste is prepared by adding arasaponin and dencichine into a toothpaste matrix, wherein the weight percent of the arasaponin is 0.2-1.2% and the weight percent of the dencichine is 0.01-1.0%. The toothpaste according to the invention can kill pyococcus, candida albicans, staphylococcus aureus, anaerobic bacteria and other pathogens which can cause gingivitis, periodontitis, canker sores, halitosis, ngival hamorrhage, caries and other symptoms in the oral cavity and eliminate the peculiar smell in the oral cavity. The effective rate for the gingivitis and the ngival hamorrhage achieves 94.6%; and the effective rate for the canker sores achieves 89%, and the efficacy is significant. The toothpaste has no toxicity or side effects, is safe to use and can prevent drug resistance. The toothpaste has significant efficacy for the gingivitis, the ngival hamorrhage, the canker sores and the like. The hemostatic effect of the toothpaste is well promoted. Sanchi extract and the dencichine are simultaneously used in the toothpaste, thereby enabling the effects of relieving pain and preventing the gingivitis, the ngival hamorrhage and the pain of the toothpaste to be more significant.

The invention relates to a meat analogue condiment, in particular to a coconut-flavor meat analogue condiment and a preparation method thereof. The coconut-flavor meat analogue condiment comprises raw materials in percentage by weight as follows: 40%-60% of coconut powder, 20%-40% of meat analogue meal, 5%-10% of corn starch, 4%-8% of rapeseed oil, 2%-5% of edible salt, 1%-2% of an aromatic material, 1%-2% of monosodium glutamate, 0.8%-1.5% of Panax notoginseng powder, 0.8%-1.5% of white granulated sugar, 0.5%-1.2% of cinnamon, 0.5%-1.2% of powdered soy, 0.5%-1.1% of an enzyme preparation and 0.5%-0.9% of a yeast extract. The Panax notoginseng powder contained in the condiment contains rich effective constituents including notoginsenoside, Panax notoginseng polysaccharides, dencichine and flavone and has the functions of hemostasis, circulation promotion, stasis removal, subsidence of swelling, analgesic therapy, nourishing, strengthening, anti-fatigue, anti-hypoxia, anti-aging, lipid reduction, blood sugar reduction, organism immune function enhancement and the like; the cinnamon contained in the condiment contains volatile oil and has fragrant aroma, so that a dish can be aromatic and tasty, and the appetite can be improved greatly.

The invention relates to a pharmaceutical composition for treating metrorrhagia and metrostaxis, a pharmaceutical preparation and application and a preparation method of the pharmaceutical preparation. The pharmaceutical composition and the pharmaceutical preparation contain single components of radix notoginseng, rhizoma paridis and herba cirsii, preferably contain notoginsenoside r1, dencichine, polyphyllin ii, polyphyllin I and linarin. The preparation method comprises the following steps: adding auxiliary materials to the selected medicinal material extracts, and preparing the pharmaceutical preparation by adopting the conventional preparation technology. The pharmaceutical composition and the pharmaceutical preparation prepared thereby acquire an unexpected treatment effect when being applied to treat various gynecological diseases such as metrorrhagia and metrostaxis, morbid leucorrhoea, functional uterine bleeding, blood heat and blood stasis and the like, and the technical difficulty that the toxicity is high while the metrorrhagia and metrostaxis disease is treated can be solved.

The invention discloses collagen-based composite hemostasis powder and a preparation method thereof. The method is characterized by comprising the following steps: modifying type I collagen by using dencichine, preparing the modified type I collagen into a solution with the concentration of 1-2 percent by using polylysine-modified chitosan; preparing medical gelatin into a 1-3% solution; preparing the modified chitosan into a 1-3% solution; blending the three solutions according to a mass ratio of 0.5-1:2-8:8-2; stirring at the temperature of 4-10 DEG C for 8-10 hours, and performing freeze drying to prepare composite sponge; sequentially impregnating the composite sponge in a modifier and a blood coagulation factor in an ultrasonic cleaner, fully washing, performing freeze drying, and grinding by a grinder to prepare the collagen-based composite hemostasis powder. The powder has the effects of rapidly and effectively stopping bleeding, resisting bacteria, diminishing inflammation, relieving pain, promoting wound healing and repairing, has high adhesion property, hydrophilicity, biological degradability and biocompatibility and is low in price and suitable for wound hemostasis or repair.

The invention discloses a method for improving the content of dencichine in pseudo-ginseng. A sodium selenite solution is sprayed after the flowering of the pseudo-ginseng, then the sodium selenite solution is sprayed to leaves once every two weeks, the continuous spraying is performed for 3 to 4 times. Experiments prove that the content of the dencichine in leaves and roots after spraying the sodium selenite solution to the leaves of the pseudo-ginseng is 1.4 to 2.1 times and 1.2 to 1.7 times of that without spraying the sodium selenite solution, and the activity of an antioxidant enzyme system is enhanced in the pseudo-ginseng. The method of the invention is simple, efficient and convenient to implement and is suitable for being popularized and applied in industrial production and agricultural production.

The invention discloses a preparation method and application of a molecularly imprinted polymer for extracting dencichine. The molecularly imprinted polymer of the dencichine is taken as a column chromatography filler and loaded in a column; then, a pseudo-ginseng root extract is applied to the column, and then a mixed solution of n-hexane / ethanol in a volume ratio of 10:1 is adopted for drip washing, and finally, the chromatographic column is eluted by use of alcohol and the effluent is the dencichine, wherein the alcohol refers to ethanol, isopropyl alcohol, n-propyl alcohol or n-butyl alcohol. The molecular imprinting technology is applied to extracting the dencichine in the pseudo-ginseng for the first time; compared with the traditional extraction method, the high-purity dencichine can be prepared quickly by virtue of the oriented enrichment effect of the molecular imprinting-solid-phase extraction column, and a raw material source is provided for the clinical pharmacological research of the dencichine.

The invention belongs to a process or method for purifying active ingredients in the field of medicines, and particularly relates to a pretreatment method for extracting dencichine from plants. The pretreatment method does not involve an organic solvent, so that the obtained product has no toxic or side effect and is safe to use. And on the other hand, dencichine is used as a hemostatic component, so that the hemostatic effect of toothpaste, band-aid or hemostatic bandage can be better promoted. For example, the mass ratio of the crude dencichine extract in the toothpaste is 0.01%-4.0%.

The invention discloses a method and a device for preparing preparing panaxadiol saponins, panaxatriol saponins, and dencichine, and belongs to the technical field of dencichine extraction. The technical problem that no suitable industrial production device and method for preparing panaxadiol saponins and panaxatriol saponins exists in the prior art is solved. The device comprises a crushing device, a stirring kettle I, an ultrasonic extraction device, a filtering device, a stirring kettle II, a liquid separator, a reaction kettle I, a reaction kettle II, a reduced pressure concentrator I, a dryer I, a reduced pressure concentrator II, a vacuum crystallizer, a dryer II, an elution device, a reduced pressure concentrator III, an impurity removal device and a glucan gel column. According tothe method, a large amount of manpower and material resources are saved, and panaxadiol saponins, panaxatriol saponins, and dencichine contained in pseudo-ginseng are obtained at a time through a specific technology, so that the defects in the prior art are overcome, a large amount of resources are saved, the social benefits and economic benefits are clearer, and the economic benefits of comprehensive utilization of pseudo-ginseng are more remarkable.

The invention relates to an inorganic antibacterial material synthesized by taking natural plants as raw materials and a method. Soybean powder, dencichine, a rubber emulsion, chlorophyll, perylenequinone and ethylene glycol are used as raw materials, and inorganic antibacterial materials with different morphologies are prepared by adopting a solvothermal synthesis method. Compared with other technologies, the method has the advantages that eco-friendly and non-toxic biological materials with different morphologies, such as soybean meal, dencichine, rubber latex, chlorophyll and perylenequinone, are used as raw materials, the morphology of the inorganic material is controlled within a certain range, and the characteristics of the inorganic material are used for inhibiting bacillus subtilis.

The invention discloses an electric cable sheath material having a flame retardant function, wherein the raw materials comprise, by weight, 20-33 parts of raw rubber, 10-18 parts of graphene, 3-6 parts of magnesium hydroxide, 24-38 parts of carbon tetrafluoride, 0.5-5 parts of aluminum nitride, 8-12 parts of zinc borate, 12-21 parts of fly ash, 8-18 parts of mica, 4-12 parts of starch, 7-15 parts of plant fiber, 1-2 parts of an antioxidant, 0.4-1 part of a cross-linking agent, 0.8-2.5 parts of a coupling agent, and 2-11 parts of dencichine. The invention further discloses a preparation method of the electric cable sheath material. According to the present invention, the advantages of various components are combined, such that the prepared electric cable sheath material has advantages of good processing performance, good mechanical property, and the prepared material has advantages of good rigidity, high flexibility, good tear resistance, good high-temperature aging resistance, good low-temperature aging resistance, good flame retardant performance and good chemical corrosion resistance, can meet the specific use environment conditions, and has good market application prospects.

The invention provides a ginkgo flavone and lactone composition, a dripping pill thereof, and an application of the dripping pill. The effective drug effect components of the composition comprise ginkgo flavone and lactone and dencichine, the composition is prepared through mixing ginkgo flavone and lactone with dencichine according to a ratio of 1:0.1-1:0.2. The ginkgo flavone and lactone composition and the dripping pill thereof can effectively improve the hemorrhage problem induced by long-term use of ginkgo flavone and lactone.

The invention relates to the field of biological pharmaceuticals, in particular to a purpose of Dencichine to preparation of medicines for treating inflammatory intestinal diseases.

The invention discloses a traditional Chinese medicine nano-composite for stopping bleeding and resisting inflammation and a preparation method thereof. The traditional Chinese medicine nano-composite is prepared by compounding carboxymethyl chitosan, bletilla striata polysaccharide and dencichine. Firstly, the carboxymethyl chitosan is prepared through an enzymolysis reaction, then, the carboxymethyl chitosan, the bletilla striata polysaccharide and the dencichine are mixed for acidification treatment, neutralizing, washing, drying and sterilizing are carried out, and thus the traditional Chinese medicine nano-composite is obtained. The material has hemostasis and adhesion effects, instant gel can be formed, the material can be adhered to a wound surface to mechanically block a blood vessel crevasse, and meanwhile, the physical barrier can be used for isolating a wound to play a certain anti-adhesion action; the material contains bletilla striata and radix notoginseng and has the effects of stopping bleeding, resisting bacteria, diminishing swelling and promoting tissue regeneration, and the carboxymethyl chitosan is an important water-soluble chitosan derivative and has many medical effects such as promoting wound healing, stopping bleeding, inhibiting scars, easing pain and inhibiting bacteria; and the traditional Chinese medicine nano-composite is non-toxic and non-irritant and has hemostatic and antibacterial dual effects.

The invention provides an engineering bacterium for synthesizing dencichine, the engineering bacterium comprises a host bacterium and a plasmid vector transferred into the host bacterium, and an enzyme for coding and synthesizing oxalyl coenzyme A and a gene of 2, 3-diamino propionic acid N-oxalyltransferase BAHD are introduced into the plasmid vector at the same time. Three ways for synthesizing the oxalyl-coenzyme A enzyme are as follows: acylation glyoxylate dehydrogenase panE, glyoxylate dehydrogenase Gloxdh and oxalyl-coenzyme A ligase AAE, and oxaloacetic acid hydrolase Oah and oxalyl-coenzyme A ligase AAE. And a gene for coding and synthesizing the 2, 3-diaminopropionic acid biosynthase is also introduced into the plasmid vector. The engineering bacteria are optimized in manners of enhancing an upstream path, inhibiting competition and the like so as to improve the production capacity of dencichine. Therefore, the dencichine produced by using the engineering bacteria has the advantages of simple method, low cost, high conversion rate and the like, and is beneficial to industrial production and cost reduction.

Disclosed are uses of drugs for treating thrombocytopenia, in particular the use of dencichine in preparation of drugs for treating thrombocytopenia. By adding pharmaceutically acceptable conventional adjuvant material, dencichine can be prepared into an oral preparation or an injection. A pharmacodynamic trial shows that the dencichine can effectively inhibit the thrombocytopenia caused by chemotherapy drugs, and treat thrombocytopenic purpura with obvious curative effect and low toxic side effects.

The invention belongs to the technical field of a traditional Chinese medicine, and discloses a medicine composition containing dencichine and notoginsenoside R1 and a preparation thereof. Raw materials of the medicine composition comprise the dencichine and the notoginsenoside R1. The pharmacology experiment shows that the medicine composition has a synergistic effect. Compared with Xueshuantong injection, the medicine composition has a better pharmacological effect.

The invention relates to an application of a medicament for treating thrombocytopenia and in particular relates to an application of dencichine to preparation of a medicament for treating thrombocytopenia. Dencichine can be prepared into oral preparations or injections by adding pharmaceutically acceptable conventional adjuvants. Pharmacodynamic tests indicate dencichine can be used for effectively inhibiting thrombocytopenia caused by chemotherapy drugs and treating thrombocytopenic purpura, and has obvious curative effects and low toxic and side effects.