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Pharmaceutical composition for treating metrorrhagia and metrostaxis, pharmaceutical preparation and application and preparation method of pharmaceutical preparation

A technology for the treatment of metrorrhagia and composition, which is applied in the directions of drug combination, drug delivery, medical preparations containing active ingredients, etc., can solve the problems of unclear mechanism of action of active ingredients, large dosage, etc., and can solve the problem of large dosage of drugs , Fast curative effect, improve the effect of side effects

Inactive Publication Date: 2014-07-23
张孝珍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The technical problem to be solved by the present invention is to overcome the defects of large dosage, active ingredients and unclear mechanism of action in the existing pharmaceutical preparations for the treatment of uterine bleeding and functional uterine bleeding, and to provide a new drug with rapid curative effect, safety and reliable quality. Controlled pharmaceutical composition for treating metrorrhagia and preparation method thereof

Method used

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  • Pharmaceutical composition for treating metrorrhagia and metrostaxis, pharmaceutical preparation and application and preparation method of pharmaceutical preparation
  • Pharmaceutical composition for treating metrorrhagia and metrostaxis, pharmaceutical preparation and application and preparation method of pharmaceutical preparation
  • Pharmaceutical composition for treating metrorrhagia and metrostaxis, pharmaceutical preparation and application and preparation method of pharmaceutical preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Embodiment 1: the preparation of hard capsule

[0037] Take 18g notoginseng saponin R1, 9g notoginseng, 1.2g pagoda saponin II, 0.9g pagoda saponin VI, 28g mongoside, 2.5g Atractylodes macrocephala, 3.6g Fangfeng charcoal, 1.2g Dipsacus, 0.24g sea octopus , agrimony 1.2g, antler gum 1.3g. Add 140 g of pregelatinized starch and 10 g of dry starch, mix evenly, and pack separately to prepare 1000 hard capsules, each with about 57.1 mg of active ingredient.

Embodiment 2

[0038] Embodiment 2: the preparation of soft capsule

[0039] Take 15g notoginseng saponin R1, 5g notoginseng, 1.0g pagoda saponin II, 0.6g pagoda saponin VI, 24g mongoside, 2g Atractylodes macrocephala, 3g Fangfeng charcoal, 1g Dipsacus, 0.3g sea octopus, Agrimony 1.1g, 1.2g of deer horn gum; heat and melt 433g of soybean oil and 23g of beeswax, and after cooling to room temperature, add the above-mentioned drug raw materials, mix well, grind the colloid for 15 minutes, and press into 1000 soft capsules, each active ingredient is about 45.6 mg.

Embodiment 3

[0040] Embodiment 3: the preparation of tablet

[0041] Take 15g notoginseng saponin R1, 5g notoginseng, 1.0g pagoda saponin II, 0.6g pagoda saponin VI, 24g mongoside, 2g Atractylodes macrocephala, 3g Fangfeng charcoal, 1g Dipsacus, 0.3g sea octopus, Agrimony 1.1g, 1.2g of deer horn glue; add 110g of compressible starch, 70g of microcrystalline cellulose, 1g of magnesium stearate, mix thoroughly, granulate with 8% starch slurry, granulate, compress into tablets, and coat with film, that is 1000 tablets were obtained, each with about 68.7 mg of active ingredient.

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Abstract

The invention relates to a pharmaceutical composition for treating metrorrhagia and metrostaxis, a pharmaceutical preparation and application and a preparation method of the pharmaceutical preparation. The pharmaceutical composition and the pharmaceutical preparation contain single components of radix notoginseng, rhizoma paridis and herba cirsii, preferably contain notoginsenoside r1, dencichine, polyphyllin ii, polyphyllin I and linarin. The preparation method comprises the following steps: adding auxiliary materials to the selected medicinal material extracts, and preparing the pharmaceutical preparation by adopting the conventional preparation technology. The pharmaceutical composition and the pharmaceutical preparation prepared thereby acquire an unexpected treatment effect when being applied to treat various gynecological diseases such as metrorrhagia and metrostaxis, morbid leucorrhoea, functional uterine bleeding, blood heat and blood stasis and the like, and the technical difficulty that the toxicity is high while the metrorrhagia and metrostaxis disease is treated can be solved.

Description

technical field [0001] The invention relates to the technical field of drugs for treating metrorrhagia, in particular to a pharmaceutical composition, a pharmaceutical preparation, an application and a preparation method for treating metrorrhagia and women's functional uterine bleeding. Background technique [0002] Metrorrhagia and metrostaxis refers to women's non-periodic uterine bleeding. Its onset is sudden, violent, and a large amount of bleeding is called "metrorrhagia"; And menopausal women more common. Although the bleeding conditions of metrorrhagia and leakage are different, they often transform into each other during the course of the disease. If the volume of metrorrhagia decreases, it may transform into metrorrhagia, and the development of leakage may become metrorrhagia. In Western medicine, functional uterine bleeding, female genital inflammation, and vaginal bleeding from tumors all belong to the category of metrorrhagia. Metrorrhagia is a more serious and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61K9/48A61K9/30A61K9/16A61P15/00A61P7/04
Inventor 张孝珍杨克让
Owner 张孝珍
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