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Method and device for preparing panaxadiol saponins, panaxatriol saponins, and dencichine

A technology for the preparation of notoginsengdiol and its preparation device, which is applied in the direction of chemical instruments and methods, glycosides, steroids, and steroids, and can solve the problems of no suitable industrial production device and method for notoginsengdiol saponin and notoginsengtriol saponin , to achieve the effect of saving manpower, low extraction efficiency and high production efficiency

Inactive Publication Date: 2020-02-28
李明劲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The object of the present invention is: in order to solve the technical problem that there is no suitable notoginsengdiol saponin and nonoginsanol saponin industrialized production device and method in the prior art, the present invention provides notoginsengdiol, notoginsengtriol saponin and three Qisu preparation method and device thereof

Method used

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  • Method and device for preparing panaxadiol saponins, panaxatriol saponins, and dencichine
  • Method and device for preparing panaxadiol saponins, panaxatriol saponins, and dencichine

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Embodiment 1

[0039] Such as figure 1 As shown, this embodiment provides a preparation device for notoginseng glycol, notoginseng triol saponin and notoginseng, including: a crushing device 1 capable of crushing the head of notoginseng; , water and ethanol or acetone or ethyl ester are stirred in the stirred tank-3; the mixed liquid of notoginseng powder, water and ethanol or acetone or ethyl ester can be heated and ultrasonically extracted after being stirred in the stirred tank-3 Device 4; a filter device 5 capable of filtering the mixed liquid of notoginseng powder, water, ethanol or acetone or ethyl ester extracted by the ultrasonic extraction device 4 and filtering the solid particles and notoginseng in the mixed liquid; An eluting device 15 for eluting the crude product of notoginseng; a decompression concentrator 3 16 capable of removing ethanol in the crude product solution of notoginseng; Miscellaneous device 17; the Sephadex column 18 that can purify the notoginseng in the notogi...

Embodiment 2

[0053] The preparation method of notoginseng glycol, notoginseng triol saponin and notoginseng comprises the following steps:

[0054] S1 crushing: Throwing the head of notoginseng into the crushing device 1 for crushing, so that the head of notoginseng can be completely pulverized into a powder of notoginseng;

[0055] S2 Stirring: Put the notoginseng powder, pure water and ethanol or acetone or ethyl ester into the stirring tank-3 for stirring to obtain a mixed solution of notoginseng powder, pure water and ethanol or acetone or ethyl ester, the pure water and ethanol or The ratio of acetone or ethyl ester is 1:80, and the solid-liquid ratio of the mixed solution of notoginseng powder and pure water and ethanol or acetone or ethyl ester is 20:1;

[0056] S3 Ultrasonic extraction: Put the mixed solution of Panax notoginseng powder, pure water and ethanol in the ultrasonic extraction device 4 and heat it to 50°C, and then perform ultrasonic vibration for 60 minutes. The ultras...

Embodiment 3

[0066] The ethanol aqueous solution of sodium hydroxide is an effective alkaline lotion. When preparing the above lotion, it was accidentally found that when the concentration of sodium hydroxide reached a certain amount, the water phase and the alcohol phase were separated, and the interface was clear and obvious. Further experiments found that the order of adding water, ethanol, and sodium hydroxide did not affect the stratification results, and preliminarily identified that no new substances such as ether were produced in this process. It can be seen from general chemical knowledge that water and ethanol are infinitely miscible, and sodium hydroxide has a high solubility in water and a certain solubility in alcohol. The phenomenon of solution stratification caused by the combination of the three is described in various books and in the United States. Chemical Abstracts did not find relevant reports. In order to know whether other salts and solvents would produce similar dela...

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Abstract

The invention discloses a method and a device for preparing preparing panaxadiol saponins, panaxatriol saponins, and dencichine, and belongs to the technical field of dencichine extraction. The technical problem that no suitable industrial production device and method for preparing panaxadiol saponins and panaxatriol saponins exists in the prior art is solved. The device comprises a crushing device, a stirring kettle I, an ultrasonic extraction device, a filtering device, a stirring kettle II, a liquid separator, a reaction kettle I, a reaction kettle II, a reduced pressure concentrator I, a dryer I, a reduced pressure concentrator II, a vacuum crystallizer, a dryer II, an elution device, a reduced pressure concentrator III, an impurity removal device and a glucan gel column. According tothe method, a large amount of manpower and material resources are saved, and panaxadiol saponins, panaxatriol saponins, and dencichine contained in pseudo-ginseng are obtained at a time through a specific technology, so that the defects in the prior art are overcome, a large amount of resources are saved, the social benefits and economic benefits are clearer, and the economic benefits of comprehensive utilization of pseudo-ginseng are more remarkable.

Description

technical field [0001] The invention relates to the technical field of notoginseng extraction, and more specifically relates to a preparation method of notoginseng glycol, notoginseng triol saponins and notoginseng and a device thereof. Background technique [0002] Panax notoginseng is a precious traditional Chinese medicinal material and a valuable strategic resource of traditional Chinese medicine in my country. It contains a variety of active ingredients. In the past, the active ingredients extracted from Sanqi only targeted a specific component, and the rest of the ingredients were discarded. Or it cannot be used, resulting in a great waste of resources. The commonly used Panax notoginseng saponins preparations in clinical practice are also a mixture of various effective substances, so the positioning is not accurate, and the pharmacological effects even cancel each other out. The existing Panax notoginseng extraction There are major technical flaws in the technology. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J17/00C07C231/24C07C233/56
CPCC07C231/24C07J17/005C07C233/56
Inventor 李明劲
Owner 李明劲
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