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Preparation method of collagen-based composite hemostatic powder

The technology of hemostatic powder and hemostatic powder is applied in the field of preparation of collagen-based composite hemostatic powder, which can solve the problems of inability to meet market requirements, troublesome surgical operation, general hemostatic performance, etc., and achieve shortened hemostasis time, excellent hemostasis performance, and good biological properties. Compatibility effect

Active Publication Date: 2016-02-17
BEIJING HOTWIRE MEDICAL TECH DEV CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] 1. Poor adhesion, causing unnecessary trouble to the operation
[0004] 2. The hemostatic performance is general and the function is single, which cannot meet the requirements of the market

Method used

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  • Preparation method of collagen-based composite hemostatic powder
  • Preparation method of collagen-based composite hemostatic powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] 1. Preparation of Panax notoginseng raw material

[0051] At an ultrasonic frequency of 20kHz and a power of 50w, soak the notoginseng powder in 10 times the ethanol solution with a concentration of 75wt% for 15 hours, then repeatedly immerse it in 5 times the ethanol solution with a concentration of 75wt% for 5 hours, and let it stand for 0.5 hours to separate. Combine the two extracts and keep them for other use; dry the residue, add 10 times of water to soak for 15 hours; then repeat soaking with 5 times of water for 6 hours, centrifuge to obtain the filtrate, pass the filtrate directly through the Sephadex column and 0001×7 ion exchange resin was used for filtration chromatography at a flow rate of 0.5ml / min, the filtrates were combined, decolorized with 3% activated carbon, the filtrate was concentrated under reduced pressure, and spray-dried to obtain notoginseng powder.

[0052] 2. Preparation of collagen-based composite hemostatic powder

[0053] (1) Preparatio...

Embodiment 2

[0062] 1. Preparation of Panax notoginseng raw material

[0063] At an ultrasonic frequency of 30kHz and a power of 90w, soak the notoginseng powder in 20 times the ethanol solution with a concentration of 95wt% for 20 hours, then repeatedly immerse it in 10 times the ethanol solution with a concentration of 95wt% for 10 hours, and let it stand for 1.0 hours to separate. Combine the two extracts and keep them for other use; dry the residue, add 15 times of water to soak for 20 hours; then use 10 times of water to repeatedly soak for 10 hours, centrifuge to obtain the filtrate, and pass the filtrate directly through the Sephadex column and 0001×7 ion exchange resin for filtration chromatography with a flow rate of 3ml / min, combined the filtrates, decolorized with 7% activated carbon, concentrated the filtrate under reduced pressure, and spray-dried to obtain notoginseng powder.

[0064] 2. Preparation of collagen-based composite hemostatic powder

[0065] (1) Notoginseng modif...

Embodiment 3

[0074] 1. Preparation of Panax notoginseng raw material

[0075] At an ultrasonic frequency of 40kHz and a power of 120w, immerse the notoginseng powder in 15 times the ethanol solution with a concentration of 90wt% for 18 hours, then repeatedly immerse it in 8 times the ethanol solution with a concentration of 90wt% for 10 hours, and let it stand for 0.8 hours to separate , combine the two extracts, and keep it for other use; dry the residue, add 18 times of water to soak for 18 hours; then use 8 times of water to repeatedly soak for 8 hours, centrifuge to obtain the filtrate, and pass the filtrate directly through the Sephadex column Perform filtration chromatography with 0001×7 ion exchange resin at a flow rate of 0.7ml / min, combine the filtrates, remove color with 5% activated carbon, concentrate the filtrate under reduced pressure, and spray dry to obtain notoginseng powder.

[0076] 2. Preparation of collagen-based composite hemostatic powder

[0077] (1) Notoginseng mo...

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Abstract

The invention discloses collagen-based composite hemostasis powder and a preparation method thereof. The method is characterized by comprising the following steps: modifying type I collagen by using dencichine, preparing the modified type I collagen into a solution with the concentration of 1-2 percent by using polylysine-modified chitosan; preparing medical gelatin into a 1-3% solution; preparing the modified chitosan into a 1-3% solution; blending the three solutions according to a mass ratio of 0.5-1:2-8:8-2; stirring at the temperature of 4-10 DEG C for 8-10 hours, and performing freeze drying to prepare composite sponge; sequentially impregnating the composite sponge in a modifier and a blood coagulation factor in an ultrasonic cleaner, fully washing, performing freeze drying, and grinding by a grinder to prepare the collagen-based composite hemostasis powder. The powder has the effects of rapidly and effectively stopping bleeding, resisting bacteria, diminishing inflammation, relieving pain, promoting wound healing and repairing, has high adhesion property, hydrophilicity, biological degradability and biocompatibility and is low in price and suitable for wound hemostasis or repair.

Description

technical field [0001] The invention relates to a preparation method of a collagen-based composite hemostatic powder, which belongs to the field of hemostatic powder for wound healing and repair. Background technique [0002] In various surgical operations or trauma treatments, reducing bleeding, reducing bleeding time, and isolating the wound from the outside world, avoiding infection, is conducive to the healing of the patient's wound. The main components of conventional clinical powdered hemostatic agents are inorganic substances, or some substances that can quickly stop bleeding, such as thrombin and tranexamic acid, are added to them, but these materials have poor hemostatic effect and have certain immunogenicity. Absorbed by the body or unable to promote tissue regeneration, it can no longer meet people's needs. In recent years, people have developed a class of bioabsorbable hemostatic materials, among which collagen-based hemostatic materials have attracted widesprea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/39A61K38/48A61P7/04A61K31/785
Inventor 但年华刘新华但卫华马文杰富勇
Owner BEIJING HOTWIRE MEDICAL TECH DEV CO LTD
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