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Preparation method for nanometer cellulose/polydopamine compound intelligent gel drug sustained-release material

A nanocellulose and polydopamine technology, which is applied in the field of medical materials, can solve the problems of degradation, degeneration and nonlinearity of anticancer active ingredients, and achieve the effects of easy disposal, increased blood concentration, and simple preparation.

Inactive Publication Date: 2017-10-10
QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional hydrogel drug sustained release system has many disadvantages: since hydrogel materials are generally hydrophilic and homogeneous systems, the release curves of the loaded drugs are mostly non-linear.
Studies have found that organic solvents or high heat processes often lead to the degradation and denaturation of many anti-cancer active ingredients

Method used

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  • Preparation method for nanometer cellulose/polydopamine compound intelligent gel drug sustained-release material
  • Preparation method for nanometer cellulose/polydopamine compound intelligent gel drug sustained-release material
  • Preparation method for nanometer cellulose/polydopamine compound intelligent gel drug sustained-release material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] (1) Mix 10 mL of 1 mg / mL polydopamine and 5 mg of tetracycline hydrochloride evenly, stir for 12 hours, centrifuge, pour out the unloaded drug in the upper layer, wash the precipitated components repeatedly with deionized water several times, and obtain drug-loaded Polydopamine dispersion;

[0046] (2) The mass percent concentration is 1% nanocellulose and the polydopamine dispersion liquid of above-mentioned load certain amount of medicine mixes evenly, and the addition amount of polydopamine is 0.2wt% (relative to the quality of nanocellulose), pours into shaper Slowly add calcium chloride solution (2mL) with a concentration of 5% by mass percentage dropwise, and stand still for 24 hours to obtain a nanocellulose / polydopamine composite gel drug sustained release material.

[0047] Detection method

[0048] (1) Place the obtained drug hydrogel preparation in the PBS buffer (pH=5 and pH=7.4) that simulates the physiological environment of the human body, shake horizont...

Embodiment 2

[0058] (1) Mix 10 mL of 1 mg / mL polydopamine and 5 mg of tetracycline hydrochloride evenly, stir for 24 hours, centrifuge, pour out the unloaded drug in the upper layer, and wash the precipitated components repeatedly with deionized water several times to obtain drug-loaded Polydopamine dispersion;

[0059] (2) The mass percentage concentration is 2% nanocellulose and the polydopamine dispersion liquid of above-mentioned load certain amount of medicine mixes uniformly, and the addition amount of polydopamine is 0.2wt% (relative to the quality of nanocellulose), pours into shaper Slowly add calcium gluconate solution (2mL) with a mass percent concentration of 4% in a dropwise manner, and stand still for 24 hours to obtain a nanocellulose / polydopamine composite smart gel drug sustained-release material.

[0060] Detection method

[0061] (1) Place the obtained drug hydrogel preparation in the PBS buffer solution (pH=5 and pH=7.4) of the physiological environment that simulates ...

Embodiment 3

[0067] (1) 10 mL of 1 mg / mL polydopamine and 5 mg of tetracycline hydrochloride were evenly mixed, stirred for 36 hours, centrifuged, the unloaded drug in the upper layer was poured out, and the precipitated components were repeatedly washed with deionized water several times to obtain drug-loaded Polydopamine dispersion;

[0068] (2) Mix the nanocellulose with a mass percentage concentration of 2% and the above-mentioned polydopamine dispersion liquid loaded with a certain amount of medicine, the addition of polydopamine is 0.2wt% (relative to the quality of the nanocellulose), pour into the molding Slowly add calcium chlorate solution (2mL) with a mass percent concentration of 3% in the container, and let it stand still for 24 hours to obtain the nanocellulose / polydopamine composite intelligent gel drug sustained release material.

[0069] Detection method

[0070] (1) Place the obtained drug hydrogel preparation in the PBS buffer (pH=5 and pH=7.4) that simulates the physio...

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Abstract

The invention discloses a nanometer cellulose / polydopamine compound intelligent gel drug sustained-release material and a preparation method thereof. The drug sustained-release material comprises nanometer cellulose, polydopamine and a drug loaded on the polydopamine, can be applied to the field of various drug sustained release and is especially suitable for the aspects of wound treatment, tumor postoperative treatment, and the like. The drug sustained-release material disclosed by the invention can load hydrophilic and hydrophobic drugs, is simply prepared, is mild and is capable of saving cost. The nanometer cellulose and the polydopamine both have biocompatibility, can completely degrade, are easy for waste treatment and are beneficial to environmental protection. The drug sustained-release material is especially suitable for wound healing and later treatment of tumor operation.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a preparation method of a nanocellulose / polydopamine composite gel medicine slow-release material. Background technique [0002] Sustained drug release is the combination of small molecule drugs and polymer materials, using the inherent properties of polymer materials (such as pH sensitivity and temperature sensitivity, etc.) to slowly release drug molecules in polymer carriers. Compared with the traditional drug delivery system, the drug sustained release system can effectively improve the bioavailability of the drug, reduce the number of administrations and improve the stability of the drug. Therefore, the preparation of drug sustained-release materials has aroused extensive interest of researchers. For example, the chitosan acrylate drug composite material developed by Jiangsu Tianzhu Chemical Technology Co., Ltd. can be used in the direction of drug sus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/38A61K47/34A61K31/65A61K31/337A61P17/02A61P35/00
CPCA61K9/06A61K31/337A61K31/65A61K47/34A61K47/38
Inventor 刘莹莹李滨刘超
Owner QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
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