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Dencichine-containing medicinal toothpaste and preparation method thereof

A technology of notoginseng and toothpaste, which is applied in the fields of pharmaceutical formulation, dentistry, medical science, etc., can solve the problems of medicated toothpaste without notoginseng.

Inactive Publication Date: 2011-08-10
YUNNAN QIDAN PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the drug toothpaste containing notoginseng in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1) Select the following components by weight percentage: sorbitol 50%, glycerin 10%, polyethylene glycol 400 2%, silicon dioxide (H) 10%, silicon dioxide (MII) 11%, carboxymethyl cellulose Sodium 1%, sodium lauryl sulfate 2.2%, sodium saccharin 1%, sodium fluoride 0.4%, methyl ester 0.05%, notoginseng 0.05%, orange juice flavor 1%, the rest is deionized water.

[0032] 2) Put 0.005kg of notoginseng, 0.04kg of sodium fluoride, 0.005kg of methyl ester, 0.1kg of sodium carboxymethylcellulose, 5kg of sorbitol, 1kg of glycerin, 0.2kg of polyethylene glycol 400 and 0.1kg of saccharin into the Stir in 1.13kg of ionized water until the sodium saccharin dissolves, mix with 1kg of silicon dioxide (H), 1.1kg of silicon dioxide (MII), and 0.22kg of sodium lauryl sulfate, and send it into the paste making machine, stirring and grinding at high speed 25 to 40 minutes, vacuum degassing; add 0.1 kg of orange juice essence, and then stir and grind for 10 to 25 minutes to obtain a toothp...

Embodiment 2

[0034] 1) Select the following components by weight percentage: sorbitol 45%, glycerin 10%, polyethylene glycol 400 3%, silicon dioxide (H) 8%, silicon dioxide (MII) 16%, carboxymethyl cellulose Sodium plain 1.1%, sodium lauryl sulfate 2%, sodium saccharin 2%, sodium fluoride 0.25%, hydroxyethyl cellulose 0.2%, notoginseng 0.08%, strawberry essence 1.3%, and the rest is deionized water.

[0035] 2) Add notoginseng 0.008kg, sorbitol 4.5kg, glycerin 1kg, polyethylene glycol 400 0.3kg, sodium carboxymethylcellulose 0.11kg, sodium fluoride 0.025kg, hydroxyethylcellulose 0.02kg and saccharin 0.2 kg into 1.107kg of deionized water and stirred until the sodium saccharin is dissolved, mixed with 0.8kg of silicon dioxide (H), 1.6kg of silicon dioxide (MII), and 0.2kg of sodium lauryl sulfate, and sent into the paste making machine , high-speed stirring and grinding for 25 to 40 minutes, and vacuum degassing; adding 0.13 kg of strawberry essence, stirring and grinding for 10 to 25 minut...

Embodiment 3

[0037] Select the following components by weight percentage: sorbitol 47.5%, glycerin 12.5%, polyethylene glycol 400 5%, silicon dioxide (H) 9.5%, silicon dioxide (MII) 10.5%, sodium carboxymethyl cellulose 0.8%, hydroxyethyl cellulose 0.6%, sodium lauryl sulfate 2.5%, aspartame 0.5%, sodium fluoride 0.3%, methyl ester 0.05%, notoginseng 0.1%, bamboo leaf essence 1%, The rest is deionized water.

[0038] 0.01kg of notoginseng, 4.75kg of sorbitol, 1.25kg of glycerin, 0.5kg of polyethylene glycol 400, 0.08kg of sodium carboxymethylcellulose, 0.03kg of sodium fluoride, 0.06kg of hydroxyethylcellulose and aspartame Put 0.05kg of sweetener into 0.915kg of deionized water, stir and dissolve, mix with 0.95kg of silicon dioxide (H), 1.05kg of silicon dioxide (M Ⅱ), 0.25kg of sodium lauryl sulfate, and send it into the paste making machine , high-speed stirring and milling for 25-40 minutes, vacuum degassing; adding 0.1 kg of bamboo leaf essence, stirring and milling for 10-25 minutes...

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PUM

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Abstract

The invention discloses dencichine-containing medicinal toothpaste, which comprises, by weight percentage, the following constituents: 15%-75% of humectant, 0.5%-2% of binding agent, 0.5%-3% of sweetener, 1.5%-3% of foaming agent, 0.8%-2% of odorant, 15%-60% of abradant and 0.05%-1% of dencichine; and the rest of deionized water, wherein the medicinal constituent is the dencichine. The perpetration method of the dencichine-containing medicinal toothpaste comprises the following steps of: firstly, adding the dencichine into the toothpaste as the main constituent for stopping bleeding, then, determining the effective ratio of the dencichine being independently added or added with other constituents into the toothpaste. Except for the function of cleaning teeth, the dencichine-containing medicinal toothpaste can obviously improve the function of stopping bleeding and effectively reduce dental problems such as gingival bleeding.

Description

technical field [0001] The invention relates to an oral health product, in particular to a medicinal toothpaste containing notoginseng and a preparation method thereof. Background technique [0002] Notoginseng, also known as Tianqi acid, Neurotokin, chemical name β-oxalyl-L-α, β-diaminopropionic acid, is a non-protein amino acid contained in legumes and Araliaceae plants. Pharmacological experiments have shown that notoginseng has obvious preventive and therapeutic hemostatic effects in various bleeding models, and shows good hemostatic effect at low doses. Panax notoginseng, notoginseng stems, leaves and flowers all contain notoginseng. Bleeding gums is one of the common symptoms in the Department of Stomatology, and people have paid attention to improving the efficacy of oral health care. In the prior art, there is no report of a medicated toothpaste containing notoginseng. Contents of the invention [0003] The invention provides a medicinal toothpaste containing no...

Claims

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Application Information

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IPC IPC(8): A61K8/44A61K8/73A61Q11/00
Inventor 高明菊崔秀明赵爱刘葛亮辛永鹏
Owner YUNNAN QIDAN PHARMA CO LTD
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