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A pharmaceutical composition containing notoginseng and notoginseng saponin r1 and its preparation

A technology of Panax notoginseng saponins and compositions, applied in the field of medicine, can solve problems such as hidden dangers of safety, adverse reactions, and untraceability of doctors and patients

Inactive Publication Date: 2015-11-18
吴静
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Xueshuantong injection has a good clinical effect, but its main component is notoginseng saponins, which is a multi-component injection. In clinical application, adverse reactions occur and cannot be traced back, which brings potential safety hazards to doctors and patients

Method used

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  • A pharmaceutical composition containing notoginseng and notoginseng saponin r1 and its preparation
  • A pharmaceutical composition containing notoginseng and notoginseng saponin r1 and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Preparation of Panax notoginseng:

[0025] (1) Take 50g of Panax notoginseng, dry it at 55°C, and crush it to 120 mesh;

[0026] (2) Add notoginseng powder into 1000 ml of ethanol solution with a concentration of 80% by mass, then add 0.5 g of glycoside hydrolase, stir evenly, and conduct sealed enzymolysis and leaching at 50° C. for 72 hours;

[0027] (3) Filter the reaction solution after enzymolysis, concentrate the filtrate and put it on a 300-mesh polyamide chromatography separation column, first elute with 90% ethanol solution with a mass percentage concentration, then elute with 100% ethanol, and collect 100% ethanol The eluent of ethanol was concentrated to obtain the crude product of notoginseng, and its purity was 60%;

[0028] (4) Dissolve the above-mentioned notoginseng crude product in hot water, put it on a 600-mesh polyamide chromatography column, first elute with 90% ethanol solution with a mass percentage concentration, then elute with 100% ethanol, an...

Embodiment 2

[0030] Preparation of Panax notoginseng:

[0031] (1) Take 50g of Panax notoginseng, dry it at 40°C, and crush it to 100 mesh;

[0032] (2) Add notoginseng powder into 500ml of ethanol solution with a concentration of 40% by mass, and then add 2.5g of glycoside hydrolase, stir evenly, and conduct sealed enzymolysis and leaching at 46°C for 62 hours;

[0033] (3) Filter the reaction solution after enzymolysis, concentrate the filtrate and put it on a 100-mesh polyamide chromatography separation column, first elute with an ethanol solution with a mass percentage concentration of 70%, then elute with 100% ethanol, and collect 100% ethanol The eluent of ethanol is concentrated to obtain the crude product of notoginseng, and its purity is 50%;

[0034] (4) Dissolve the above-mentioned notoginseng crude product in hot water, put it on a 300-mesh polyamide chromatography column, first elute with an ethanol solution with a concentration of 85% by mass percentage, then elute with 100%...

Embodiment 3

[0036] Preparation of Panax notoginseng:

[0037] (1) Take 50g of Panax notoginseng, dry it naturally, and crush it to 90 mesh;

[0038] (2) Add notoginseng powder into 400 ml of ethanol solution with a concentration of 60% by mass, then add 2 g of glycoside hydrolase, stir evenly, and conduct sealed enzymolysis and leaching at 45° C. for 32 hours;

[0039] (3) Filter the reaction solution after enzymolysis, concentrate the filtrate and put it on a 200-mesh polyamide chromatography separation column, first elute with an ethanol solution with a mass percentage concentration of 70%, then elute with 100% ethanol, and collect 100% ethanol The eluent of ethanol was concentrated to obtain the crude product of notoginseng, and its purity was 53.5%;

[0040] (4) Dissolve the above-mentioned notoginseng crude product in hot water, put it on a 400-mesh polyamide chromatography column, first elute with an ethanol solution with a concentration of 87% by mass percentage, then elute with 1...

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Abstract

The invention belongs to the technical field of a traditional Chinese medicine, and discloses a medicine composition containing dencichine and notoginsenoside R1 and a preparation thereof. Raw materials of the medicine composition comprise the dencichine and the notoginsenoside R1. The pharmacology experiment shows that the medicine composition has a synergistic effect. Compared with Xueshuantong injection, the medicine composition has a better pharmacological effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing notoginseng and notoginsenoside R1 and its preparation. Background technique [0002] Panax notoginseng, also known as Tianqi or Jinbuhuan, is the dry root of Panax notoginseng (Burk.) F.H.Chen, a plant of the genus Panax notoginseng in the family Araliaceae. "Compendium of Materia Medica" says that Sanqi "stops bleeding, disperses blood and relieves pain. For those who are wounded by golden blade arrows, fall, and stick, sores that bleed more than usual, chew them and apply them, or mix them at the end, and the blood will stop immediately. It is also responsible for vomiting blood, epistaxis, and bleeding Bloody dysentery, menstrual bleeding in metrorrhagia, persistent bleeding after childbirth, pain in blood circulation, red eyes, pain and swelling, tiger bites and snake bites." "Medicine Zhongzhong Shenxilu" said that it "r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K47/18A61P7/02A61P9/10A61P9/00A61P27/02A61K31/198
Inventor 吴静
Owner 吴静
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