38 results about "Dimethyl isosorbide" patented technology

A composition is disclosed for treating the skin comprising an acylated short chain bioactive peptide and Lycium barbarum extract product. Also disclosed is a method for topically administering the composition in an amount therapeutically effective to reduce wrinkles by building the dermal fibroblast matrix. The composition may contain dimethylisosorbide or ethoxydiglycol as solubilizing and penetration enhancers for the hydrophobically modified peptide.

A composition is disclosed for treating the skin comprising an acylated short chain bioactive peptide and Lycium barbarum extract product. Also disclosed is a method for topically administering the composition in an amount therapeutically effective to reduce wrinkles by building the dermal fibroblast matrix. The composition may contain dimethylisosorbide or ethoxydiglycol as solubilizing and penetration enhancers for the hydrophobically modified peptide.

A method for preparing a dialkyloxydianhyrohexitol (dimethylisosorbide) composition by etherification of dianhydrohexitol (isosorbide). The aim is to achieve a “clean” method that avoids the use of a methylation agent such as dimethyl sulfate or methyl chloride, which generates stoechiometric quantities of salts, or expensive dialkyl-carbonates, wherein only one of the two methyl groups participates in the preparation of mixed isosorbide ethers. The method involves using at least one O-alkylation agent and a catalyst including an acid or an acid salt, preferably a catalyst having Lewis or BrØnsted acid properties. A device for carrying out the method wherein the device includes a vaporization oven and a reaction oven is also described.

The present invention is a composition and method of treatment for skin disorders, conditions, and severe skin dryness in general through topical systematic and periodic application of a formulation that generally may include salicylic acid, glycolic acid, urea, dimethyl isosorbide, ethoxydiglycol, barrier repair agents, anti-irritants, humectants, and also has an acidic pH formulation.

A composition comprising a solubilized magnolol analog comprising at least one magnolol analog chosen from propyl magnolol, isopropyl magnolol, butyl magnolol, and isobutyl magnolol, and dimethyl isosorbide. These solubilized analogs are useful in personal care, oral care, and home care compositions to provide anti-bacterial activity and reducing the expression of pro-inflammatory mediators.

The invention provides a skin-refreshing essence set. The skin-refreshing essence set comprises an essence emulsion, and an essence No.1, an essence No.2, an essence No.3 and an essence No.4 which areused in sequence. The essence emulsion comprises the following components: water, glycerol, 1,3-propylene glycol, dimethyl isosorbide, dipropylene glycol, inositol, isoprene glycol, hydroxydecyl ubiquinone, cetyl ethyl hexanoate and the like. The essences comprise the following components: water, 1,3-propylene glycol, dipropylene glycol, lactic acid, 1,2-pentanediol, chondrus crispus, butanediol,hydrolyzed royal jelly protein and the like. The skin-refreshing essence set disclosed by the invention contains the hydroxydecyl ubiquinone (idebenone) and various beautifying and skin-refreshing components, can effectively soften cuticle, improve skin absorption capacity and water content, supplement skin nutrients, strengthen skin protection capacity, endow the skin with elastic and compact feeling, and make the skin smooth, fine, fresh, alive and glossy; and the essence set can effectively repair skin problems, improve various skin troubles such as coarse pores, rough pores and dark skin,and create young and plump skin.

The invention relates to a composition suitable for topical application comprising water, dimethyl isosorbide, a polyol and a phenolic or polyphenolic antioxidant. A method for producing the composition is also part of the invention, as is a kit for making the composition. Optionally, the phenolic or polyphenolic antioxidant is provided in the form of a lyophilisate for the method and the kit. Theuse of the composition for a treatment by topical application is also within the scope of the invention.

A filter material adapted for use as a filter element of a smoking article is provided, the filter material being in the form of a fibrous tow that includes a plurality of filaments of a degradable polyester and a plasticizer composition applied thereto, the plasticizer composition and the degradable polyester having a Relative Energy Difference calculated using Hansen Solubility Parameters of less than about 1.3. Exemplary degradable polyesters include polyglycolic acid, polylactic acid, polyhydroxyalkanoates, polycaprolactone, polybutylene succinate adipate and copolymers or blends thereof. Exemplary plasticizer compositions include one or more of dimethylisosorbide, propylene carbonate, methylbenzyl alcohol, glycerol carbonate acetate, glycerol carbonate ethyl ether, and mixtures thereof, optionally in combination with triacetin. Filter elements and smoking articles, such as cigarettes, that contain the filter material are also provided.

A pharmaceutically active composition suitable for topical application to the nails contains undecylenic acid and tolnaftate. The composition also employs a urea-based component, a monohydric alcohol such as isopropanol, a diol such as propylene glycol, dimethyl isosorbide, and a carboxylic acid other than undecylenic acid, preferably lactic acid.

Topical skin treatment formulation containing salicylic acid or a derivative thereof, dissolved in a solvent system comprising (i) dimethyl isosorbide; (ii) a C1 to C9 alkyl salicylate; and (iii) a glyceryl fatty acid ester. The solvent system may also comprise an alcohol, a polyoxyalkylene-based solvent, and / or a C1 to C4 alkyl glucose ester. The formulation may be used in the treatment of acne. The solvent system improves the targeted delivery of the salicylic acid or derivative to relevant sites on the skin.

Diesel cycle fuel compositions are described containing at least one dianhydrohexitol compound according to the general formula 2 and / or itsderived hydrocarbyl ethers or nitric ethers compounds, where the R′ and R″ substituents are both H or one or both of R′ and R″ is alkyl, cycloalkyl or phenyl, or one or both are —NO2. A preferred fuel composition is that containing dimethyl isosorbide (DMI) added or not of isosorbide dinitrate (ISDN) as ignition improver. The dianhydrohexitols compounds form compositions with at least one of the components selected among petroleum-derived diesel fuel, biodiesel, ethanol and water. The mixture of DMI and ISDN has excellent cetane number (IQT). Still, the oxygenated nature of the dianhydrohexitols and related compounds of the fuel compositions inhibits soot formation upon burning of the said Diesel cycle fuel compositions.

A filter material adapted for use as a filter element of a smoking article is provided, the filter material being in the form of a fibrous tow that includes a plurality of filaments of a degradable polyester and a plasticizer composition applied thereto, the plasticizer composition and the degradable polyester having a Relative Energy Difference calculated using Hansen Solubility Parameters of less than about 1.3. Exemplary degradable polyesters include polyglycolic acid, polylactic acid, polyhydroxyalkanoates, polycaprolactone, polybutylene succinate adipate and copolymers or blends thereof. Exemplary plasticizer compositions include one or more of dimethylisosorbide, propylene carbonate, methylbenzyl alcohol, glycerol carbonate acetate, glycerol carbonate ethyl ether, and mixtures thereof, optionally in combination with triacetin. Filter elements and smoking articles, such as cigarettes, that contain the filter material are also provided.

The invention discloses acne removing, skin tendering and whitening essence and a preparation method thereof, and relates to the technical field of cosmetics. The essence comprises the following components in percentage by weight of a phase A including 0.05-0.1% of EDTA disodium, 0.15-0.4% of hydrolyzed sclerotium gum, 0.15-0.25% of xanthan gum, 0.2-1% of allantoin, 0.1-1% of methylparaben, 5-10%of glycerol, 5-8% of butanediol and 0.005-0.1% of polyquaternium-73; a phase B including 1-3% of carnosine, 2-4% of nicotinamide, 1-5% of acetylchitosamine, 2-6% of alpha-arbutin and 0.04-0.2% of sodium hyaluronate; and a phase C including 1-4% of dimethyl isosorbide, 0.3-1% of phenoxyethanol, 0.005-1% of essence and 82-100% of water. According to the acne removing, skin tendering and whitening essence and the preparation method thereof, acne-removing and skin-whitening essence cream is prepared through reasonable use and matching of various components and a special process; the synergistic effect among the components is very outstanding; the acne-removing and skin-whitening essence cream not only can efficiently inhibit formation of melanin to achieve an excellent whitening effect, but also has the prominent blackhead-removing, acne-removing and anti-inflammatory effects to achieve the skin-whitening and acne-removing effects of comprehensive conditioning; and the essence has advantages of simple preparation process, easiness in control and easiness in operation.

The present invention provides a topical pharmaceutical formulation comprising uracil and a penetration enhancer and a method of administering the same. Also provided is a method of treating or preventing a skin disease associated with the administration of 5-fluorouracil or a precursor or prodrug thereof, such as capecitabine. The penetration enhancer is selected from the group consisting of dimethyl isosorbide, isopropyl myristate, isopropyl palmitate, octyldodecanol, oleic acid, oleyl alcohol, polyoxyglyceride, pyrrolidone, thymol, trioctyl extract, triolein, myristic acid, medium chain triglyceride, linoleic acid, lauric acid, sugar furfuryl alcohol, glyceryl monooleate, ethyl oleate and dimethyl sulfoxide; and dibutyl sebacate and mixtures thereof.