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Bitterness aversion preparation and preparation method thereof, and anti-bite pen

A kind of preparation and bitterness technology, which is applied in the direction of penholders, pharmaceutical formulas, medical preparations with non-active ingredients, etc., can solve the problems of inconvenient to carry and use, damage to the digestive tract, hand skin, and can only be painted on nails, etc., to promote hand care. Skin repair, nail growth promotion, easy to carry and use

Inactive Publication Date: 2019-07-23
瑞雅科医药(北京)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are no relevant compliant products that have obtained registration certificates in the market. Although related auxiliary correction products can also be purchased, such as Bite-x made in Germany, MAMALA-STOP made in Switzerland, and sirwhiston made in Japan, etc., they are all e-commerce. The method of purchasing agents to enter the domestic market is to enter the Chinese market without the relevant domestic product registration procedures and formal import channels, and all of them are produced abroad. The common disadvantage is that they are all bottled, which is inconvenient to carry and use. Use a small brush to apply repeatedly on your fingers and Contact with the liquid in the bottle can easily lead to cross-contamination and deterioration
The disadvantage of Sirwhiston is that it is not easy to dry after application, and the bitter taste is easily worn off or washed off by water. It is very troublesome to apply it once after washing hands, and it needs to add high concentration of preservatives to prolong the shelf life. This is harmful to children's lips, Digestive tract, hands and skin are hurt
Bite-x, MAMALA-STOP and other products have obvious disadvantages. They can only be painted on nails, not on the skin of the hands. The products have obvious irritating smell of nail polish, and contain harmful substances such as benzene, acetone, and formaldehyde, which will be harmful to children. Nail bed and body damage

Method used

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  • Bitterness aversion preparation and preparation method thereof, and anti-bite pen
  • Bitterness aversion preparation and preparation method thereof, and anti-bite pen

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A bitter aversive preparation, by mass, comprising:

[0040] 85 parts of carrier solvent, 3 parts of bitter substances and 8 parts of additives.

[0041] Further, the carrier solvent includes isopropanol and ethyl acetate, wherein:

[0042] The mass ratio of isopropanol to ethyl acetate is 60:25.

[0043] Further, the bitter substance is denatonium benzoate.

[0044] Further, the additive includes isosorbide dimethyl ether, biotin, acrylic acid (ester) / methyl methacrylate copolymer, pomelo fruit extract, wherein:

[0045] The mass ratio of isosorbide dimethyl ether: biotin: acrylic acid (esters) / methyl methacrylate copolymer: pomelo fruit extract is 2:0.02:7:1.

[0046] A preparation method of the above-mentioned bitter taste aversion preparation, comprising:

[0047] (1) Dissolve isosorbide dimethyl ether in ethyl acetate in proportion, and stir at 20 rpm at 35°C for 10 minutes to obtain solution A;

[0048] (2) Add isopropanol in proportion to the solution A obtain...

Embodiment 2

[0054] A bitter aversive preparation, by mass, comprising:

[0055] 90 parts of carrier solvent, 4 parts of bitter substances and 12 parts of additives.

[0056] Further, the carrier solvent includes isopropanol and ethyl acetate, wherein:

[0057] The mass ratio of isopropanol to ethyl acetate is 70:20.

[0058] Further, the bitter substance is bittern-S (benzyldiethyl[(2,6-xylylcarbamoyl)methyl]ammonium saccharin).

[0059] Further, the additive includes isosorbide dimethyl ether, biotin, acrylic acid (ester) / methyl methacrylate copolymer, pomelo fruit extract, wherein:

[0060] The mass ratio of isosorbide dimethyl ether: biotin: acrylic acid (esters) / methyl methacrylate copolymer: pomelo fruit extract is 3:0.1:8:3.

[0061] A preparation method of the above-mentioned bitter taste aversion preparation, comprising:

[0062] (1) Dissolve isosorbide dimethyl ether in ethyl acetate in proportion, and stir at 50° C. at a speed of 15 rpm for 5 minutes to obtain solution A;

...

Embodiment 3

[0069] A bitter aversive preparation, by mass, comprising:

[0070] 87 parts of carrier solvent, 3.5 parts of bitter substances and 10 parts of additives.

[0071] Further, the carrier solvent includes isopropanol and ethyl acetate, wherein:

[0072] The mass ratio of isopropanol to ethyl acetate is 65:22.

[0073] Further, the bitter substance is sucrose caprylate.

[0074] Further, the additive includes isosorbide dimethyl ether, biotin, acrylic acid (ester) / methyl methacrylate copolymer, pomelo fruit extract, wherein:

[0075] The mass ratio of isosorbide dimethyl ether: biotin: acrylic acid (ester) / methyl methacrylate copolymer: pomelo fruit extract is 2.5: 0.05: 7.5: 2.

[0076] In order to realize the second invention purpose, the present invention adopts the following technical solutions:

[0077] A preparation method of the above-mentioned bitter taste aversion preparation, comprising:

[0078] (1) Dissolve isosorbide dimethyl ether in ethyl acetate in proportion,...

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Abstract

The present invention discloses a bitterness aversion preparation. The bitterness aversion preparation comprises 85-90 parts of a carrier solvent, 3-4 parts of a bitter substance and 8-12 parts of anadditive. A preparation method of the bitterness aversion preparation comprises the following steps: (1) dissolving dimethyl isosorbide in ethyl acetate in proportion and conducting even stirring to obtain a solution A; (2) adding isopropanol to the solution A and conducting stirring and mixing to obtain a solution B; (3) adding the bitter substance into the solution B, conducting stirring until the bitter substance is completely dissolved, then adding an acrylic acid (acrylate) / methyl methacrylate copolymer, and conducting sealed stirring to obtain a solution C; and (4) adding a pomelo fruitextract while stirring to the solution C, and conducting even mixing to obtain the bitterness aversion preparation. An anti-bite pen is provided with a water absorbent cotton pen core and the bitterness aversion preparation is filled into the water absorbent cotton pen core. The bitterness aversion preparation, the preparation method thereof, and the anti-bite pen disclosed by the invention havethe following beneficial effects: 1, a bitterness effect is good; and 2, cross-contamination is not caused.

Description

technical field [0001] The invention relates to a bitter taste aversion preparation, a preparation method thereof and an anti-bite pen. Background technique [0002] According to the survey data of American psychologists, among children aged 6 to 12, the incidence rate of children who suck their fingers "often" and "almost all day" is 12%; while the incidence rate of children who bite their nails is as high as 44%. In addition, psychologists have also investigated and proved that among 14-year-old children, 55% of them have nail biting behaviors to varying degrees. Psychologists believe that thumb-sucking and nail-biting are behavioral disorders with a high incidence in childhood, and once addicted, they are very stubborn. The currently recognized correction method is to apply a bitter aversive agent on the bitten part, so that the patient will feel disgusted with the nail after biting the bitter taste, and form a new conditioned reflex mechanism to achieve the purpose of ...

Claims

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Application Information

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IPC IPC(8): A61K31/4188A61K31/167A61K31/7024A61P17/02A61P25/00A61K47/46A61K47/32B43K3/00
CPCA61K9/0014A61K31/167A61K31/4188A61K31/7024A61K47/32A61K47/46A61P17/02A61P25/00B43K3/00A61K2300/00
Inventor 任立
Owner 瑞雅科医药(北京)有限公司
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