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Compositions comprising dimethylisosorbide, polyols and phenolic or polyphenolic antioxidants for topical application

A technology of dimethyl isosorbide and antioxidant, applied in the fields of skin care and dermatology treatment, can solve the problem of low solubility of antioxidants

Active Publication Date: 2021-07-16
MEDSKIN SOLUTIONS DR SUWELACK AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, many phenolic or polyphenolic antioxidants have low solubility even when dimethylisosorbide is present in the composition at levels that are tolerated by the skin

Method used

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  • Compositions comprising dimethylisosorbide, polyols and phenolic or polyphenolic antioxidants for topical application
  • Compositions comprising dimethylisosorbide, polyols and phenolic or polyphenolic antioxidants for topical application
  • Compositions comprising dimethylisosorbide, polyols and phenolic or polyphenolic antioxidants for topical application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0110] Solubility test of phenolic or polyphenolic antioxidants

[0111] In trying to find suitable solutions to use to dissolve phenolic and polyphenolic antioxidants with small amounts of various individual solvents, the present inventors tested resveratrol and ferulic acid in pure solvents and in different water and solvent mixtures ( Hereinafter referred to as solubility in a solubilizer mixture, mixture or complex).

[0112] Specifically, 10 ml of pure solvent or solubilizer mixture were stirred in a beaker at ambient temperature. A 2 mg amount of phenolic or polyphenolic antioxidant is dispersed in the mixture and stirred. If the mixture becomes clear, the addition of phenolic or polyphenolic antioxidants is repeated until the mixture remains cloudy even after stirring for 10 minutes. Based on this experiment, the maximum solubility was calculated in mass percent (wt %).

[0113] Table 1 shows the results for the solubility of resveratrol and ferulic acid in pure solv...

Embodiment 2

[0128] Preparation of emulsions containing phenolic or polyphenolic antioxidants with or without a mixture of solubilizers

[0129] To assess whether the increased solubility of polyphenols in the solubilizer mixture translates into higher activity of phenolic or polyphenolic antioxidants, preparations containing phenolic or polyphenolic antioxidants (in this case ferulic acid or resveratrol revertyl) with or without a mixture of solubilizers. The final concentrations of solvents in these emulsions were 10% by weight dimethylisosorbide, 10% by weight 1,5-pentanediol and 1% by weight panthenol.

[0130] Lotions containing ferulic acid or resveratrol and without solubilizer blends:

[0131]- Dissolve 900 mg of high molecular weight hyaluronic acid (GfN / Contipro 3010, 1.5 MDa) in 247 g of distilled water, heat to 80° C. and stir for 15 minutes at 1400 rpm and ambient pressure by means of a 1 L vacuum mixer.

[0132] - Add 4.5 g of Sepinov EMT-10 (INCI name: Hydroxyethyl Acrylat...

Embodiment 3

[0153] Emulsion Stability Test

[0154] The stability of the emulsions was thermally tested using a programmable climate chamber (Binder KBF 240) with a 24-hour climate change from -5°C / 0% relative humidity to 40°C / 75% relative humidity.

[0155] Samples were transferred to 10ml glass vials. Emulsions were tested for 30 days and visually inspected daily. All emulsion systems described in Examples 1 and 2 remained visually stable over the 30 days of the test.

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Abstract

The present invention relates to a composition suitable for topical application comprising water, dimethylisosorbide, a polyol and a phenolic or polyphenolic antioxidant. The methods for producing the compositions of the invention are also part of the invention, as are the kits for preparing the compositions. Optionally, for the methods and kits, the phenolic or polyphenolic antioxidants are provided in the form of a lyophilizate. The use of a composition according to the invention for therapy by topical application is also within the scope of the invention.

Description

technical field [0001] The invention belongs to the field of skin care and dermatology treatment. In particular, the present invention relates to compositions suitable for topical application comprising dimethylisosorbide, polyols and phenolic or polyphenolic antioxidants. Background technique [0002] Phenolic or polyphenolic antioxidants are a class of molecules of high interest in skin care and dermatological treatments. Due to their antioxidant properties, they show great potential for use in medical applications and aesthetic treatments. The antioxidant properties of phenols and polyphenols come from their ability to scavenge free radicals. Many potential benefits in cosmetic and medical applications are associated with phenolic molecules. These are, for example, wrinkle reduction, skin lightening / depigmentation, anti-inflammatory effects and protection against UV radiation. Certain phenolic or polyphenolic compounds are also believed to be useful in the treatment o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/49A61K8/34A61Q19/00
CPCA61K8/345A61K8/347A61K8/4973A61Q19/00A61K2800/75A61P39/06A61K31/05A61K31/192A61K31/704A61K8/365A61K8/602A61K8/42A61K31/34A61P17/16A61K2300/00A61K8/06A61K9/0014A61K9/107A61K47/10A61K47/18A61K47/22A61Q19/02A61Q19/08
Inventor M·孔兹F·库尔曼D·贝伦斯
Owner MEDSKIN SOLUTIONS DR SUWELACK AG
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