41 results about "Bone wax" patented technology

The present invention discloses a kind of degradable bone lacuna inside haemostatic material and preparation method thereof which belongs to biological material field. The purpose of the invention is to solve existing problem that bone wax not easily degraded and absorbed, or degradation production tend to initiate inflammation. The haemostatic material described in the invention is composed of 1-10% medical sodium alginate solution in mass concentration and medical faecula which accounts for 15-40% of mass of sodium alginate solution. Inorganic particulate, antibiotic, bone-inducing factor and haemostatic can be further added. Degradable bone lacuna inside haemostatic material can be prepared by mixing medical sodium alginate solution and medical faecula. The haemostatic material of the invention is easy degraded, the degradation production is innoxious and nonirritant to human organisms, and has good ductibility and mechanical strength.

A fast absorbable bleeding stopping bone wax for promoting bone formation is used for stopping bleeding of vertebra faces in surgical spine operation and is characterized by being prepared from, by mass, 60-75% of poloxamer mixture, 20-30% of chitosan and 5-20% of sodium hyaluronate.

The present invention relates to a water-bath bone wax. It includes one or two copolymers obtained by making polyoxyethlene and polyoxypropylene undergo the process of copolymerization reaction and emulsifying agent anhydrosorbitol aliphatic ester. Said invention also relates to a kit including the invented water-bath bone wax and a preparation method of said water-bath bone wax.

The invention discloses absorbable bone wax with a hemostasis function. The absorbable bone wax is prepared from the following raw materials: solid and water, wherein the solid is prepared from crosslinking hyaluronic acid, calcium phosphate and soluble starch; the weight of water is 20-100% of the weight of the solid; the weight ratio of the solid is that the ratio of the crosslinking hyaluronicacid, the calcium phosphate and the soluble starch is (20-70):(20-50):(0-10). According to the bone wax disclosed by the invention, the defects that traditional bone wax has poor biocompatibility, isnondegradable and affects bone healing can be eliminated. While a good hemostasis effect of the traditional bone wax is kept, the bone wax disclosed by the invention can be naturally degraded in the body without causing late period relevant complications due to residues.

The invention discloses bone wax with a bone repair function and a preparation method thereof. The bone wax is prepared from the following raw materials in percentage by weight: 5% to 45% of polypropylene oxide polyoxyethylene segmented copolymer, 50% to 90% of polypropylene oxide polyoxyethylene random copolymer, 0.1% to 20% of alkylate chitosan and 0.1% to 20% of strontium-doped carbon-containing nano hydroxyapatite, wherein the mass ratio of the alkylate chitosan to the strontium-doped carbon-containing nano hydroxyapatite is 1 to 1. The degradable bone wax with the bone repair function disclosed by the invention has a better hemostatic effect on hemostasis of cancellous bone wound surfaces and simultaneously has an excellent bone repair function; in addition, a bone differentiation effect is improved; the degradable bone wax is hopeful to be widely applied in clinical medicine.

The invention provides absorbable bone wax. The technical scheme is characterized in that the absorbable bone wax comprises a matrix material, an auxiliary material, an emulsifier and a hemostatic factor, wherein the matrix material is a mixture of any two or more of poly-DL-lactic acid, poly-L-lactic acid, polyglycolic acid, polycaprolactone, polyethylene glycol, polyvinyl alcohol, polyether diol, polyether triol, polylactic acid, poly(L-lactide-co-glycolide), a caprolactone-lactide copolymer and a caprolactone-glycolide copolymer; the auxiliary material is any one or a mixture of two of beta-tricalcium phosphate and hydroxyapatite; the emulsifier is any one or a mixture of two of sorbitan fatty acid ester and water soluble cellulose. On account of weight percentage wt%, the matrix material accounts for 20%-90%, the auxiliary material accounts for 10%-80%, and the emulsifier is 1%-20% of the total mass of the matrix material and the auxiliary material.

The present application discloses a material for preparing absorbable biological repairing bone wax as well as a method and application of the bone wax. The absorbable biological repairing bone wax provided in the present application is obtained by physically mixing 20-45 wt% of mineralized collagen, 10-20 wt% of chitosan, 10-30 wt% of calcium sulfate, and 5-30 wt% of water, preferably, the mineralized collagen is a hydroxyapatite-collagen complex. The bone wax provided in the present application can be used for hemostasis on bone wounds, especially cancellous bone wounds, has the advantages that the bone wax is convenient to use, can be arbitrarily shaped, quickly fills wound cracks, has good adhesion, realizes hemostasis, can be gradually degraded and absorbed, and has no toxic and sideeffects on human bodies, and can replace traditional bone wax.

The invention discloses a bone wax applying device for neurosurgery, which comprises a transparent barrel body, wherein the upper end of the transparent barrel body is opened; the inner wall of the transparent barrel body is in sliding connection with the side surface of a moving block; the upper surface of the moving block and the lower end of a screw rod are rotatably connected through a bearingseat; the upper end of the screw rod extends to the upper part of the transparent barrel body; the upper end of the screw rod is fixedly connected with a handle; a discharge pipe is fixedly arrangedat the discharge port at the lower end of the transparent barrel body, the outer side surface of the discharge pipe is clamped with the inner wall of a clamping pipe, a doctor does not need to contacta bleeding bone surface, so that cross infection is prevented, hot air is sprayed out through a spray head of an air heater, and the spray head is facing a sponge block, and the hot air prevents thebone wax on the sponge block from solidifying to guarantee the applying efficiency of the bone wax; an illuminating lamp is used for illuminating the bleeding bone surface and is convenient for applying the bone was by the doctor; a scale is convenient for observing the use condition of the bone wax by the doctor; the sponge block is fixed on the lower surface of the clamping pipe through an adhesive ring, the replacement of the sponge block is convenient, and the working strength of the doctor is reduced.

The present invention provides a minimally invasive surgical applicator device. The device is useful in the application of bone wax during surgical procedures to halt or reduce bone bleeding. The device may be sterilized for re-use or may be made disposable.

The invention discloses an in-situ inoculating operation method for a cerebral tumor tissue block animal. The method comprises the following steps: (a) taking a cerebral tumor tissue, and shearing the cerebral tumor tissue into tumor tissue particles; (b) placing the tumor tissue particles into a needle tube of a tissue block injection needle, and carrying out quantifiable indwelling control on the tumor tissue particles; (c) anaesthetizing the animal, dissecting the skin on the surface of the animal skull, and boring a hole on the animal cranial bone; (d) inserting the tissue block injection needle along a cranial bone hole, and slowly injecting the tumor tissue particles; and (e) slowly pulling out the needle, sealing the cranial bone hole by bone wax, and suturing the scalp. The method can ensure the original tissue structural property of an inoculated tumor tissue, provides a tumor model with high simulation degree for tumor research, can ensure the vitality of inoculated cells, has high tumor transplantation success rate, can realize quantification of cell number in the inoculated tumor tissue and positioning of inoculation in the tumor tissue animal brain, has short operation time, and can meet the requirement of needing large amount of animal models in once experiment.

The invention provides biodegradable hemostatic bone wax. The preparative components are composed of acetic acid, glycerin and keratin, wherein a mass ratio of the acetic acid to glycerin to keratin is 1: (1-3): (8-10). The preparation method comprises the following steps: adding keratin into an acetic acid solution, and continuously stirring in a thermostatic water bath; and adding glycerin, anduniformly stirring and mixing. The hemostatic bone wax disclosed by the invention has degradability, excellent plugging performance and rapid hemostatic performance.

The invention discloses a bone wax manufacturing device for the orthopedics department. The device comprises a bottom plate and is characterized in that the upper side of the bottom plate is fixedly connected with the lower sides of two vertical plates of a U-shaped plate I; the upper side of the bottom plate is fixedly connected with an electric push rod; the upper side of the bottom plate is fixedly connected with the lower ends of symmetrical guide rods; the two guide rods are positioned in the U-shaped plate I; the upper side of a transverse plate of the U-shaped plate I is fixedly connected with the lower sides of two vertical plates of a U-shaped plate II; one end of the upper side of the transverse plate of the U-shaped plate I is fixedly connected with the lower ends of symmetricalarc-shaped rods; and the lower side of the U-shaped plate I is fixedly connected with the upper end of an annular ring. The invention relates to the field of bone wax manufacturing, specifically to abone wax manufacturing device for the orthopedics department. According to the device, after beeswax in a raw material barrel is heated and melted through a snake-shaped electric heating wire, the melted beeswax is directly injected into a stirring barrel containing Vaseline by adjusting the angle of the raw material barrel, and beeswax waste caused when the beeswax is transferred is avoided.

The invention discloses absorbable bone wax having a function of promoting bone repair and a preparation method thereof, falling within the technical field of biomedical materials. The absorbable bone wax comprises the following components in mass percentage: 10%˜50% polyoxypropylene polyoxyethylene block copolymer, 50%˜90% polyoxypropylene polyoxyethylene random copolymer, 0%˜20% strontium substituted hydroxyapatite and 0%˜20% microcrystalline cellulose. The absorbable bone wax has good biocompatibility and degradability, can provide good physiological conditions for absorption in vivo, has excellent mechanical and hemostatic properties, and promotes bone repair.

The invention discloses a bone wax smearing gun. The gun comprises a gun head for smearing bone wax, a gun body connected with a gun head pipeline and used for storing the bone wax and a push injection device for injecting the bone wax; the gun head comprises a spray head and the gun head pipeline, the spray head is connected with the gun head pipeline through a rotating directional joint, and therotating directional joint can change the angle of the spray head; the gun body is formed by detachably connecting a first gun body part and a second gun body part; the push injection device comprises a push injection piston, a push injection rod and a handle, one end of the push injection rod is connected with the push injection piston, and the other end of the push injection rod is connected with the handle. According to the bone wax smearing gun of the technical scheme, spray head smearing is adopted for replacing conventional finger smearing, the infection caused when the fingers are scratched is avoided, and the hemostatic effect is improved at the same time.

The invention relates to a bone wax mixing device, in particular to a bone wax mixing device for hemostasis in a neurosurgery operation, mainly provides the bone wax mixing device for hemostasis in the neurosurgery operation, which is used for uniformly stirring beewax and vaseline by a machine, automatically scraping redundant liquid and reducing the operation amount. The bone wax mixing device for hemostasis in a neurosurgery operation comprises a bottom plate, wherein the top of the bottom plate is connected with a mounting frame; a mixing and stirring mechanism which is arranged on one side of the top of the mounting frame; and a raw material placing mechanism which is arranged on the mounting frame. By arranging the mixing and stirring mechanism and the raw material placing mechanism, the heated vaseline and beeswax are stirred, so that the basic functions of the device are realized.

The invention discloses an antibacterial absorbable bone wax for promoting osteogenesis. The bone wax comprises the following components in parts by weight: 60-90 parts of an alkylene oxide copolymer,5-30 parts of a shaping agent, 2-30 parts of a thickening agent and 5-30 parts of a calcium sulfate-based repair component. The absorbable bone wax has good hemostatic performance and degradation performance, can be completely absorbed by a human body, promotes bone tissue regeneration, has a good continuous antibacterial effect and prevents wound infection. And the related preparation method issimple, is convenient to operate clinically, can meet the requirements of different patients, and is expected to be widely applied.

A dispenser comprising a tubular housing, an adjustable base configured to move from one end of the tubular housing to a second end of the tubular housing and bone wax disposed within the tubular housing.

The invention discloses a preparation method of absorbable spongy bone wax with hemostatic and bone healing promoting functions. The preparation method comprises the following steps: uniformly mixingquaternized chitosan / modified starch composite microspheres with beta-tricalcium phosphate and a silk fibroin solution, and performing freeze drying to obtain the absorbable spongy bone wax. The absorbable spongy bone wax with hemostatic and bone healing promoting functions is prepared by combining a specific raw material ratio with a preparation process. Due to the fact that the raw materials have good biocompatibility and can be absorbed by the human body, the prepared spongy bone wax can be absorbed by the human body, residues are avoided, and bone wound healing is facilitated. Secondly, due to the action of the quaternized chitosan / modified starch composite microspheres, the bone wax has a good hemostatic effect, has certain antibacterial and anti-inflammatory effects, and has a good effect of promoting bone wound healing. Beta-TCP with bone induction and bone guidance effects is also added into the bone wax, so that the bone wax can promote repair of bone defect parts in bone wounds.

The invention discloses a modeling method of a mouse hypertensive cerebral hemorrhage model, which comprises the following steps of: puncturing and taking blood from the left ventricle of a mouse, exposing a skull surgery field by wiping and cleaning soft tissues covering the skull, drilling after determining a needle insertion point on the surface of the skull, injecting autologous blood at the drilling position through a brain stereotaxic instrument, and then injecting the autologous blood into the mouse hypertensive cerebral hemorrhage model; and after injection is completed, sealing the drilled hole with bone wax, disinfecting the incision, and suturing the skin. According to the method, arterial blood is taken through left ventricle puncture, the survival rate of a mouse is not reduced on the premise that sufficient arterial blood is extracted, autologous arterial blood is accurately injected back into the tail shell core of the basal segment in the brain through a mouse brain locator, and stable hematoma is formed. The method provides guarantee for subsequent experiments, is beneficial to experimental contrast research, is very similar to clinical pathological changes and disease outcome of hypertension patients, and has important significance on disease outcome and treatment schemes after cerebral hemorrhage.

The invention discloses a medical device placing frame comprising a frame body, tray layers, fixed bolts, hangers and a rectangular storage container, wherein the tray layers are arranged in the frame body, and are provided with left trays and right trays, the fixed bolts are arranged at the lower end of the frame body, the hangers are arranged on the two sides of the frame body and used for hanging sundries, and the rectangular storage container is arranged on the right side of the frame body and can hold commonly used devices, suction apparatuses, bone waxes and other commonly used articles; and the hangers on the two sides of the frame body can be used for hanging plastic bags in which wastes generated by surgery can be arranged. Compared with the prior art, the medical device placing frame has the advantages that a laminated frame structure is adopted, so that surgical instruments and various articles used in the surgery can be arranged reasonably and effectively, and in the surgery, an operating table can be kept neat and clean, the articles can be arranged in order, and can be transferred rapidly and accurately, and further the success rate of the surgery cooperation is increased.

The present invention is directed to a device for delivering a sealant to a tissue, comprising a sealant compartment, a cooling gas compartment, and a heater, all disposed inside a unified housing; with heater configured for rendering the sealant liquid or semi-liquid or molten and flowable; with sealant compartment configured for expressing the sealant in a flowable form from device via an exit nozzle; with gas compartment configured for expressing a cooling gas via a gas expression port; with exit nozzle and gas expression port co-directed into the same direction.

Surface preparation for sliding surfaces can enhance wear performance for surgical instruments such as surgical staplers which include reusable mechanisms that are used multiple times with single use reload cartridges. To reduce the potential for galling wear in a metal-to-metal sliding engagement, a combination of surface hardening, surface finish, and surface coatings can be applied to metallic components of a surgical instrument. Surface hardening techniques can allow further manufacturing operations such as welding without compromising the strength of the underlying metal substrate. With stainless steel metal substrates, as surface or case hardening techniques can reduce corrosion resistance, a surface coating can be applied to inhibit surface oxidation as well as provide a barrier to metal-to-metal contact. A further lubricious coating layer such as a bone wax coating layer can enhance galling resistance.

The present application discloses a material, method and application for preparing absorbable biorepair bone wax. The absorbable biorepair bone wax provided by the application is to physically co-polymerize mineralized collagen, chitosan, calcium sulfate and water in proportions of 20-45wt%, 10-20wt%, 10-30wt%, and 5-30wt%. Mixed, preferably, the mineralized collagen is hydroxyapatite-collagen complex. The bone wax provided by this application can be used for hemostasis on bone wounds, especially cancellous bone wounds. It has the advantages of convenient use, arbitrary shaping, fast filling of wound cracks, good adhesion, hemostasis can be gradually degraded and absorbed, and has no toxic and side effects on the human body. , can replace traditional bone wax.

The invention discloses an absorbable bone wax composition, the base of which comprises fatty acid glyceride and a degradable polymer, the weight content of the fatty acid glyceride is 40% to 85%, and the weight content of the degradable polymer is 15% to 60%. The fatty acid glyceride is selected from glyceryl stearate, glyceryl palmitate, glyceryl linoleate and glyceryl laurate. The degradable polymer monomer is selected from lactide, glycolide, caprolactone, ethylene oxide, propylene oxide. The molecular weight of the degradable polymer is 500-5000. The absorbable bone wax composition of the present invention can be degraded and absorbed, and has good mechanical properties, good biocompatibility and safety, and can be applied clinically to hemostasis of bone wounds and filling of bone defects. The ingredients make bone wax have a good hemostatic effect.

Disclosed is absorbable bone wax and a preparation method thereof. The preparation method comprises the steps of: 1) mixing polyoxypropylene polyoxyethylene block copolymer (PEG-PPG-PEG) and polyoxypropylene polyoxyethylene random copolymer (PEG-PPG), and stirring evenly under heating to obtain a liquid mixture; 2) under mechanical stirring and heating condition, adding hemostatic starch microspheres to the liquid mixture obtained in step 1) to obtain a uniformly-mixed liquid; and 3) adding a bone repair material to the uniformly-mixed liquid obtained in step 2), and mixing uniformly to obtain a mixed solution, then pouring the mixed solution into a mold or sub-packaged bottle, and leaving at room temperature for solidifying and shaping to give the absorbable bone wax. The absorbable bone wax of the present invention can achieve the effect of rapid hemostasis, changing the relatively single hemostasis method with traditional bone wax which only depends on physical sealing.