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Medicinal sustained-release and hemostatic composition and preparation method thereof

A composition and drug technology, applied in medical science, absorbent pads, bandages, etc., can solve problems such as application restrictions, virus infection, hemostasis function dependence, etc., and achieve great economic and social benefits

Inactive Publication Date: 2010-09-22
北京博恩康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hemostatic materials reported at present mainly include powders (zeolite, collagen powder and potato starch), porous sponges (gelatin sponge, collagen sponge), oxidized regenerated cellulose and fibrin glue, etc., and they have certain weak points respectively: gelatin and Collagen has poor tissue adhesion, and the hemostatic function of both depends on sufficient platelets and coagulation factors, so the application is limited; fibrin glue is derived from blood, which may cause viral infection; porous zeolite and potato starch absorb The water in the blood will release a lot of heat, causing wound inflammation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 1 gram of deacetylation degree is that 40% chitosan is dissolved in 100ml 0.2% (v / v) acetic acid solution, and adds 0.1 gram of medicine tranexamic acid to obtain the acetic acid solution A of chitosan and medicine; Add it dropwise into emulsifier 10% paraffin solution B, stir at room temperature for 10 minutes at high speed, add 5 grams of crosslinking agent tripolyphosphate, and continue stirring at room temperature for 10 minutes to obtain drug-loaded chitosan microspheres C; 1 gram of deacetylated Chitosan with a density of 40% (molecular weight between 20,000 and 300,000) was dissolved in 100ml of 0.2% (v / v) acetic acid solution, stirred at room temperature at high speed for 10 minutes, then added 0.1 g of hyaluronic acid, and continued to stir at room temperature for 10 minutes to obtain Mixed solution D of chitosan and hyaluronic acid; 1 gram of drug-loaded chitosan microspheres C is placed in 20 ml of mixed solution D and stirred at room temperature for 10 min, p...

Embodiment 2

[0038] 1 gram of deacetylation degree is that 60% chitosan is dissolved in 100ml 1% (v / v) acetic acid solution, and adds 0.1 gram of medicine tranexamic acid to obtain the acetic acid solution A of chitosan and medicine; Add dropwise into emulsifier 20% paraffin solution B, stir at room temperature at high speed for 10 min, add 0.5 g of cross-linking agent tripolyphosphate, and continue stirring at room temperature for 100 min to obtain drug-loaded chitosan microspheres C; 1 g of deacetylated 60% chitosan (molecular weight is between 100,000-500,000) is dissolved in 100ml of 1% (v / v) acetic acid solution, 50ml of 1wt% hyaluronic acid solution is added, stirred at room temperature at high speed for 10min to obtain chitosan and Mixed solution D of hyaluronic acid;

[0039] Put 0.1 gram of drug-loaded chitosan microspheres C in 20 μl of mixed solution D and stir at room temperature for 10 minutes, place in a rectangular mold, freeze-dry the mixed solution D containing drug microsph...

Embodiment 3

[0041] 1 gram of deacetylation degree is that 80% chitosan is dissolved in 100ml 2% (v / v) acetic acid solution, and adds 0.1 gram of medicine tranexamic acid to obtain the acetic acid solution A of chitosan and medicine; Add dropwise into emulsifier 5% paraffin solution B, stir at room temperature for 10 minutes at high speed, add 10 grams of cross-linking agent tripolyphosphate, and continue stirring at room temperature for 10 minutes to obtain drug-loaded chitosan microspheres C; 1 gram of deacetylated Chitosan with a density of 80% (molecular weight between 0.5 million and 200,000) was dissolved in 100ml of 2% (v / v) acetic acid solution, and 100ml of 2wt% sodium hyaluronate solution was added to continue high-speed stirring at room temperature for 20 minutes to obtain a shell Mixed solution D of polysaccharide and hyaluronic acid; put 1 gram of drug-loaded chitosan microspheres in 30ml mixed solution D and stir at room temperature for 10min, place in a rectangular mold, and ...

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PUM

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Abstract

The invention discloses a medicinal sustained-release and hemostatic composition and a preparation method thereof, which belong to the technical field of novel hemostatic materials. The medicinal sustained-release and hemostatic composition comprises the composition of a medicament-loaded chitosan microsphere, chitosan and hyaluronic acid, wherein the medicament-loaded chitosan microsphere comprises medicinal grade chitosan and medicinal grade tranexamic acid. The novel hemostatic composition is prepared by using chitosan and the hyaluronic acid as a main hemostatic matrix, combining chitosan medicament sustained-release microsphere composite medicament, namely tranexamic acid, utilizing the special property of the chitosan with a hemostatic function and a medicament sustained-release function, and adopting the composition of the hyaluronic acid with good hemostatic function and high biocompatibility and the chitosan as the main matrix. The novel hemostatic composition has the advantages of stopping bleeding rapidly and releasing medicament / factors continuously and stably in a certain time, along with great economic and social benefits.

Description

technical field [0001] The invention belongs to the technical field of new hemostatic materials, and in particular relates to a slow-release absorbable hemostatic composition of drugs or biological factors with simple preparation, good biocompatibility, remarkable effect and therapeutic function and a preparation method thereof. Background technique [0002] In the first aid treatment of sudden accidents and trauma hemostasis during surgery, it is very important for patients to effectively and quickly stop bleeding locally. The hemostatic materials reported at present mainly include powders (zeolite, collagen powder and potato starch), porous sponges (gelatin sponge, collagen sponge), oxidized regenerated cellulose and fibrin glue, etc., and they have certain weak points respectively: gelatin and Collagen has poor tissue adhesion, and the hemostatic function of both depends on sufficient platelets and coagulation factors, so the application is limited; fibrin glue is derived...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/32A61L15/44
Inventor 甘少磊胡堃
Owner 北京博恩康生物科技有限公司
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