890results about How to "Rapid hemostasis" patented technology

Provided herein is a novel hemostatic polymer composition comprising a substance containing uncharged organic hydroxyl groups and a substance containing at least one of a halogen atom and an epoxy group, which is characterized as inducing rapid blood coagulation and hemostasis at a wound or bleeding site. Methods of use of the novel polymer composition are also provided.

Provided are a hemostatic clip and a hemostatic clip operation apparatus using the same that can rapidly stop bleeding from a bleeding area of a blood vessel when a middle or large diameter blood vessel partially bleeds during an abdominal operation or a surgery using an endoscope. The hemostatic clip operation apparatus includes a handle, a first gripper configured to primarily stop bleeding from a bleeding area of a blood vessel, a second gripper configured to receive the first gripper and symmetrically bend a closed-loop shaped-hemostatic clip to secondarily clip a periphery of the bleeding area stopped by the first gripper, and a gripper driver configured to connect the handle to the first and second grippers to be interlocked with operation of the handle to operate sequential stopping of bleeding and clipping of the first and second grippers.

Bioabsorbable, water-soluble hemostatic cellulose based gauze matrix structures are described, including one or more species of chitosan, etherized cellulose, nonionic surfactant, water-soluble polysaccharide hydrocolloid and / or gum. Approximately 85% to 95% deacetylated decrystallized chitosan, present in an amount from about 2% to about 15% by weight, is found to be particularly advantageous. Favorable properties are found related to rapid stoppage of bleeding and bioabsorbability, among other properties.

The invention discloses a method for preparing a modified regenerated cellulose / alginate hemostatic composite material, and relates to a method for preparing a hemostatic material, belonging to the technical field of biomedical composite materials. The invention aims to solve the technical problem that an existing alginate material has an unsatisfactory hemostatic effect, poor structure integrity, and relatively low mechanical strength and stability. The method comprises a first step of modification of regenerated cellulose; a second step of preparation of an oxidized regenerated cellulose / sodium alginate water solution; a third step of molding of the hemostatic composite material; and a fourth step of cross-linking and solidification of the hemostatic composite material. According to the modified regenerated cellulose / alginate hemostatic composite material, due to the introduction of a sodium carboxylic acid structure at the C6 site of the regenerated cellulose molecule through the selective oxidization of a TEMPO-NaClO-NaBr oxidation system, the hemostatic property, structure integrity, mechanical strength and stability of the modified regenerated cellulose / alginate hemostatic composite material are improved, and the defects of poor wet strength, low mechanical integrity and easy deformation of ordinary alginate non-woven fabrics are overcome.

The invention disclosed a novel mesoporous silica-based xerogel and its use in hemorrhage control. The mesoporous silica-based xerogel material has tunable mesopores (1-50 nm), high specific surface area (100-1400 m2 / g), macroscopical morphology (powder, film, disc, column, etc.) and adjustable compositions (SiO2, CaO and P2O5, etc.) as well as good biodegradation. The mesoporous silica-based xerogels herein effectively promote the blood clotting under various conditions including slow and severe hemorrhage, even at the blood oozing site of bone defect. Meanwhile, the networks of silica-based xerogel with good elastic and mechanic properties, formed by adsorbing a large amount of water, can modulate the cell behavior and tissue growth, and thus promote the wound healing. Additionally, due to the mesoporous structure, the materials have the potential to load drug, thrombin and bioactive factors, which is favorable for the therapeutical efficacy.

The invention relates to a biocompatible bleed-stopping and bone healing promoting material and a preparation method thereof. The material is applied to the bone surface or bone section of a human body or an animal, and is characterized in that the biocompatible bleed-stopping and bone healing promoting material is modified starch prepared by modifying natural starch serving as a raw material, and comprises one or more than two of modified starch granules, modified starch sponges, modified starch films, modified starch foams or modified starch glues, wherein the molecular weight of the modified starch is 15,000 to 10,000,000, and the water absorption rate is 1 to 100 times; in the natural starch serving as the raw material, the content of the amylopectin is at least no less than 70 percent of the total amount of the raw material. The invention fulfills the aim of stopping bleeding through direct spraying, daubing and pasting the biocompatible bleed-stopping and bone healing promoting material to touch the bone bleeding surface of wound; meanwhile, the biocompatible bleed-stopping and bone healing promoting material has a function of promoting bone healing, and can be used in the bleed stopping in the sternotomy of Cardio-Thoracic Surgery, spinal surgeries and joint surgeries of orthopedics department, Craniotomy and maxillo-facial surgery and the bleed stopping in the process of trauma care.

The invention supplies a biodegradable nanometer channel multi orifice stanching material and manufacturing method which uses chitosan as raw material. It includes orifice making, forming, orifice making agent removing. The multi orifice structure can be gained by adding orifice making agent in preparation, removing it in forming, which emulsifies to form latex, solidifies to form hydrogel, removes the agent by alcohol or ketone solvent, dries the hydrogel, or processes cross linking for the formaldehyde, glutaraldehyde, solidifies chitosan aqueous solution to form hydrogel, removes the agent by water, dries the hydrogel. This material can fast adsorb the moisture in the blood to stanch.

The invention provides an artificial blood vessel loaded with pseudo-ginseng medicines, and a preparation method and application for the artificial blood vessel. The artificial blood vessel sequentially consists of an inner layer, a middle layer and an outer layer which are closely connected with one another; the outer layer consists of nondegradable polymer materials; the middle layer consists of degradable high polymer materials and pseudo-ginseng powder distributed on the surface and / or the inside of the middle layer; the inner layer consists of degradable natural biological materials and pseudo-ginseng powder distributed on the surface and / or the inside of the inner layer; the mass percent of the pseudo-ginseng powder in the inner layer is larger than 5%; the content of the pseudo-ginseng powder in the middle layer is higher than that of the pseudo-ginseng powder in the inner layer; the outer layer is a nondegradable layer and is mainly used for protecting and replacing a blood vessel for a long time; the middle layer is a long-acting antithrombosis layer, can degrade high polymers, and can slowly release medicines so as to realize a long-acting antithrombosis effect; and the inner layer is a quick degrading layer, when the blood vessel is punctured and injured by a foreign object, the pseudo-ginseng medicines wrapped in the blood vessel are directly exposed on a wound, blood is stopped quickly, and the artificial blood vessel is particularly suitable for application to products such as hematodialysis.

The invention discloses a dressing composition used for inhibiting scars and accelerating wound healing and application thereof. The dressing composition consists of chitosan, acidic polysaccharide and panax notoginseng saponins in a weight proportion of 100:10-50:10-100, wherein the chitosan is selected from chitosan, chitosan lactate, acetate and hydrochloride; the acidic polysaccharide is selected from sodium carboxymethyl chitosan, sodium hyaluronate, zinc hyaluronate, sodium alginate and sodium carboxymethyl cellulose; and the panax notoginseng saponins accounts for no less than 40.0 percent of the total weight of ginsenosides Rg1 and Rb1. The formulations of the dressing composition are xerogel powder, capsules, gel membranes, hydrogels and fiber coatings. The dressing composition is used for wounds, burns, scalds, crush injuries, skin ulcers, gastroenteric ulcers and no healing of the wounds, has the advantages of rapid hemostasis, exudate reduction, moisturizing, air permeability, bacteriostasis, inflammation diminishing, itch relieving, no adhesion, effective inhibition of scarring, remarkable reduction of wound healing time and no need of replacing dressings, so that thedressing composition basically meets requirements of perfect functional external dressings.

The invention discloses a degradable medical hemostatic adhesion-resistant material and a preparation method thereof. The invention uses chitosan or derivatives thereof and transparent sodium hyaluronate as main raw materials, adopts methods, such as spray drying, self lamination assembly, and the like to prepare microspheric and gel-type hemostatic adhesion-resistant materials, and medicines and activated substances capable of stimulating hemostasis and antiphlogosis can be compounded and added in the preparation process. The material has high water absorption rate, can rapidly arrest bleeding to form an aquagel protective layer on a wound surface, has favorable tissue adhesiveness, adhesion resistance and bacterinertness, can suit a wound in an irregular shape, truly fully covers the wound surface to fully take the aims of arrest bleeding, resisting adhesion and stimulating wound surface healing, has remarkable postoperative hemostatic adhesion-resistant effects while being used for ear-nose-throat department operations, is convenient to use and brings little pain to patients.

The invention relates to the technical field of crude drug, more specifically to a linaloe leaf extract. The invention also discloses its preparation and use in pharmaceuticals and health products.

The invention discloses a preparation method of a highly antibacterial alginate dressing, and belongs to the technical field of preparation of medical dressings. The preparation method comprises the following steps: oxidizing sodium alginate by virtue of sodium periodate, and mixing silver nitrate, zinc nitrate, a trisodium citrate solution and the like so as to obtain a silver-zinc antibacterial agent; then, combining dopamine hydrochloride and the oxidized sodium alginate, wherein the dopamine hydrochloride is attached to the surface of the oxidized sodium alginate through a dopamine polymerization reaction, and on the basis of reducing and chelating effects of the dopamine on silver and zinc irons, silver and zinc are uniformly loaded on the surface of the oxidized sodium alginate by virtue of a method of conducting in-situ reduction on the silver and zinc irons, so that a spinning solution is prepared; and conducting vacuum deaerating, spinning, coagulating, stretching, rinsing, rolling and drying, and making the dressing by virtue of a needle punching technology, so that the highly antibacterial alginate dressing is obtained. The alginate dressing prepared by the invention is excellent in hemostatic and antibacterial effects, the alginate dressing is good in hygroscopic swelling performance and the alginate dressing is capable of effectively protecting wounds and accelerating healing speed of the wounds; and dressing fibers are closely combined, and the alginate dressing is relatively good in mechanical performance and convenient to change.

A composition for nursing the vagina and treating the gynopathic inflammation such as vaginitis contains the chitosan or its cationic derivative (0.1-99 Wt%). Its preparing process is also disclosed.

The invention relates to liquid band-aid and a preparation technology thereof. The liquid band-aid is prepared from the following components in percentage by weight: 5%-20% of a film-forming agent, 4%-12% of a softening agent, 0.1-8% of an antibacterial agent, 3%-10% of a haemostatic and analgetic agent, 1%-5% of a healing agent, and 53%-83% of a solvent. The preparation technology comprises the following steps: adding 5%-20% of the film-forming agent and 53-83% of the solvent into a reactor, and soaking for 1-2 h; heating to 65 DEG C to 70 DEG C so that the film-forming agent completely swells; and sequentially adding the softening agent, the antibacterial agent, the haemostatic and analgetic agent and the healing agent into the reactor under stirring, and uniformly stirring to prepare the liquid band-aid. The liquid band-aid overcomes the defects that the traditional band-aid is not attractive, and the wound can not move freely. The liquid band-aid has the characteristics of being rapid in hemostatic effect, strong in inflammation diminishing and bacteria killing properties, and low in cost, and the wound part can move freely.

The invention relates to a method for preparing thrombin-chitosan self-assembly nano particles and application thereof. The method comprises: adding chitosan into an acetic acid aqueous solution to form a chitosan solution; adding thrombin into a buffer solution to form a thrombin solution; uniformly mixing the thrombin solution and the chitosan solution, adding a crosslinking agent for stirring, pouring the mixture into liquid paraffin for stirring, adding a dispersant, and performing emulsification; and adding the crosslinking agent for crosslinking reaction through water bath, performing filtration and acetone washing, using ethanol for washing and dehydration, and finally performing vacuum drying to obtain the thrombin-chitosan self-assembly nano particles. The method feeds the thrombin and the chitosan according to proportion to prepare thrombin-chitosan which is self-assembled into nano particles for the first time, maintains the stability of the thrombin of the thrombin-chitosan self-assembly nano particles, and gives better play to the comprehensive hemostatic effect of the thrombin and the chitosan of the thrombin-chitosan self-assembly nano particles. The method can be widely applied to tissue hemostasis, tissue sealing and tissue adhesion in the surgical fields such as general surgery, orthopaedics, heat and chest surgery, neurosurgery and gynaecology and obstetrics.

The invention provides a preparation method of an oxidized regenerated cellulose hemostatic material with a micro-nano composite structure and relates to a preparation method of an oxidized regenerated cellulose hemostatic material. The invention aims to solve the problems of low hemostatic speed, great effect on environment and uneasiness in decomposition of the existing hemostatic material. The preparation method comprises the following steps: firstly, preparing cellulose solution; secondly, netting fibers in a wet state and reinforcing into a nano layer cellulose non-woven fabric; thirdly, preparing an oxidized nano cellulose non-woven fabric and oxidized viscose staple fibers; and fourthly, cotton-slitting and cotton-carding the oxidized viscose staple fibers prepared in the step 3 and compounding to obtain the oxidized regenerated cellulose hemostatic material with the micro-nano composite structure. The preparation method is applied to the preparation field of the oxidized regenerated cellulose hemostatic material.

A chitosan / carboxymethyl chitosan rapid hemostatic sponge and a preparation method thereof belong to the biomedical material field. The invention solves the following problems: the pure chitosan hemostatic materials have poor toughness and do not have remarkable hemostasis effect; the hemostatic materials clinically commonly used at present have long hemostasis time and limited hemostasis capability toward the wounds with large amount of bleeding during use. The hemostatic material of the invention is prepared from chitosan, carboxymethyl chitosan and glycerin or from chitosan, carboxymethyl chitosan, glycerin and medicines by the process of freeze drying in a vacuum freeze dryer. The hemostatic material of the invention has good toughness, can be bent and folded at will, has short hemostasis time, can be used for treating the wounds with larger amount of bleeding, achieves rapider hemostasis effect in clinical application and can be used for hemostasis in clinical surgeries and promoting wound healing. The method is simple and convenient to operate.

The invention discloses a preparation method of a quick absorption saturation gelation seaweed hemostatic dressing. The method includes the steps of: soaking, rinsing and drying on calcium fiber textile or non-woven products containing alginate, and the carrying out cutting, packaging and sterilizing to obtain the quick absorption saturation gelation hemostatic dressing. The invention also discloses the application of the quick absorption saturation gelation seaweed hemostatic dressing prepared by the above method. The invention is applicable to rapid absorption and removal of a large amount of surgical diffusate in surgical operation process, so as to realize the effects of rapid hemostasis and operation wound clean; the hemostatic dressing is used for burn, scald and other acute and chronic wounds, can cover the wound and prevent moisture loss in body fluids, provide a positive moist environment for wound healing, prevent the wound from effusion and erosion, isolate bacterial infection, and play the effects of stopping bleeding, relieving pain, promoting wound healing, and reducing scar.

For defects that existing hemostasis research and products cannot intelligently perform self-propelling or cannot be driven to forward deep in the wound under the action of external field force, the invention provides a preparation method for a janus structure based rapid hemostatic agent having a directional propulsion function. The preparation method includes performing esterification on microporous starch to unidirectionally grow calcium carbonate particles so as to obtain esterified microporous starch / calcium carbonate Janus particles; fixedly assembling thrombin on the surfaces of the esterified microporous starch / calcium carbonate Janus particles to obtain esterified microporous starch / calcium carbonate Janus particles assembled with the thrombin; mixing the esterified microporous starch / calcium carbonate Janus particles assembled with the thrombin and protonated tranexamic acid powder so as to obtain the janus structure based rapid hemostatic agent having a directional propulsion function. Through the formation of the biphasic heterogeneous Janus structure, the unidirectional and intelligent self-propulsion of hemostatic starch can be realized by cooperating with the protonated tranexamic acid, so that rapid three-dimensional hemostasis on deep wounds, penetrating wounds and irregular wounds such as aortic / venous rupture can be realized.

The invention discloses a dry powder modified disinfection agent which comprises adsorbents, an anti-bacterial agent and conditioning agents, wherein the adsorbents account for 93 to 95 percent by weight, the anti-bacterial agent accounts for 3 to 5 percent by weight, and the conditioning agents account for 1 to 4 percent by weight; the adsorbents are three or more of smectite, attapulgite, diatomite, gypsum, alunite, activated clay, kaolinite, talcum powder and activated carbon; the anti-bacterial agent comprises natural plant essential oil; the conditioning agents comprise perfume and borneol. The dry powder modified disinfection agent is used for adjusting and improving of the environment of a hog house, disinfection sterilization of piglet delivering and wounds, and disinfection drying of bacterial diarrhea, and further used for adjusting and improving of the internal environment of cowsheds, henhouses, duck sheds and other livestock breeding houses, disinfection sterilization of livestock wounds, and disinfection drying of bacterial diarrhea.

The invention belongs to the technical field of medical instruments and provides an auxiliary relaxation instrument used in surgical suturing. The auxiliary relaxation instrument is of a rounded cuboid and includes a relaxation layer (1), an adsorbed layer (2), stitching holes (3) and observing holes (4), wherein the relaxation layer (1) is arranged on the adsorbed layer (2), and the relaxation layer (1) and the adsorbed layer (2) are closely combined; the stitching holes (3) and the observing holes (4) penetrate through the relaxation layer (1) and the adsorbed layer (2); the stitching holes (3) are arranged in two rows and are symmetrical in a left-right mode. According to the auxiliary relaxation instrument, in the fully intradermal suturing process of a wound, the skin relaxation suture technology is simplified, and meanwhile moderate pressure is exerted on the wound to reduce bleeding. Therefore, it is guaranteed that the distances between stitches are equal in the manual interrupted suturing process, scar hypertrophy and suture cutting effects due to overlarge skin tension are prevented, and finally the skin relaxation instrument achieves the purposes of accelerating wound closure, bringing convenience to wound dressing change and wound observation and preventing the scar hypertrophy.

The invention discloses a cross-linked sodium hyaluronate biomembrane and a preparation method thereof. The cross-linked sodium hyaluronate biomembrane is prepared by: conducting freeze drying on a prepared gel with a crosslinking degree up to 60%-80%, and then pressing the freeze-dried gel into a membrane. The preparation method of the gel includes: acquiring cross-linked sodium hyaluronate dry powder, then washing the collected sieved powder by dimethyl sulfoxide (DMSO); washing the DMSO washed powder by ethanol; then conducting vacuum drying to obtain cross-linked sodium hyaluronate powder; fully swelling the powder, performing purification for 6-10h at a room temperature of 15-35DEG C, then carrying out homogenization micronization treatment in a high-speed dispersion machine, and then collecting the uniform gel particles, thus obtaining the cross-linked sodium hyaluronate gel used for biomembrane preparation. The cross-linked sodium hyaluronate biomembrane prepared by the method provided by the invention has is pyrogen-free, sterile, free of residual crosslinking agent, and has low cytotoxicity. With long residence time in vivo, the biomembrane has good anti-adhesion effect, good biocompatibility and tissue repair performance.

The invention discloses a chitosan-based hydrogel, and a preparation method and application thereof. The chitosan-based hydrogel is prepared with chitosan or a derivative thereof as a raw material bygrafting an ortho-phenyl dihydroxyl group compound onto the main chain of the raw material and then performing cross-linking via a cross-linking agent. The preparation method for the hydrogel comprises the following steps: firstly grafting an ortho-phenyl dihydroxy group onto chitosan or the derivative thereof to allow a product to have wet adhesion; and then, performing a cross-linking reaction to form the hydrogel material with sufficient mechanical strength and viscoelasticity. The hydrogel material has wet adhesion, hemostasis and wound healing promotion functions, and has good applicationprospects in tissue engineering and skin repairing.

The invention relates to a hemostatic gel suppository, which is characterized in that the hemostatic gel suppository is compounded by sodium carboxymethyl cellulose and other gels. The suppository has shape of hollow thin shell. The hemostatic gel suppository has the advantages that the hemostatic gel suppository has stronger induction function for the aggregation of platelet, can accelerate the deformation, adhesion, aggregation and release of the platelet so as to accelerate human physiological hemostasis, can activate blood clotting factors XII at a bleeding part to accelerate blood clotting, quickly absorbs water in blood and tissue fluid to form a gel closed blood capillary end face so as to function as mechanical blockage and stanch, can be firmly adhered to a wound surface to mechanically press the wound surface so as to stanch, does not adhere to the skin, has the function of inhibiting bacteria growth, and is accepted more easily by a patient.

The invention discloses a preparation method for efficient anti-bacterial composite hemostatic sponge. The preparation method comprises the following steps: S1, adding sodium chloride and phosphonium salt into a sodium alginate solution to obtain a solution A; S2, adding an emulsifier into dispersion liquid to obtain a solution B, and preparing a 4 to 6 percent calcium chloride solution to serve as a solution C; S3, adding the solution A into the solution B in a water-oil ratio of 1 to (3-7) by an emulsion-crosslinking method, stirring to form an emulsion, adding the solution C into the emulsion for reacting, curing, centrifuging, washing and drying to obtain porous alginate drug-carrying microspheres; S4, dissolving chitosan hydrochloride into water to obtain an aqueous solution, adding the porous alginate drug-carrying microspheres prepared in the step S2 and a hemostatic medicament, performing freeze drying repeatedly, washing and sterilizing to obtain the hemostatic sponge. The hemostatic sponge has high water absorptivity, can rapidly stop bleeding, plug wounds, inhibit wound infection and effectively promote healing of the wounds; the thrombus risk is avoided.

The invention relates to a self-crosslinked hydroformylated bacterial cellulose porous nano-material and a preparation method thereof. The material comprises bacterial cellulose, polysaccharides or polypeptides, an antibacterial agent and a foaming agent. The preparation method comprises the following steps: dissolving the polysaccharides or polypeptides, stirring the polysaccharides or polypeptides to form a solution, adding a certain amount of dispersed hydroformylated bacterial cellulose, a certain amount of the antibacterial agent (or antibacterial sol) and a certain amount of the foaming agent to the solution, stirring all above materials to make bubbles uniformly exist in the obtained mixed solution, pouring the mixed solution to a die, quenching the above sample, placing the quenched sample in a vacuum lyophilizer, and carrying out vacuum drying to prepare the self-crosslinked degradable polysaccharide or polypeptide composite hydroformylated bacterial cellulose functional porous nano-material. The material has the inherent good mechanical performances of a porous material, also as the advantages of good biocompatibility, fast dry state wetting rate, good attachment to skins, and good antibacterial function, and can be used as various medical wound repairing materials, multifunctional wound dressings and novel tissue engineering scaffolds.

The invention provides a chitosan-nanofiber hemostatic material and a preparation method thereof. The chitosan-nanofiber hemostatic material is a core-shell nanofiber, wherein chitosan forms the shell of the nanofiber, polyvinyl alcohol forms the core of the nanofiber, and the diameter of the core-shell nanofiber is 100nm-20Mum. According to the invention, a coaxial electrospinning technology is adopted to prepare the nanometer material with a chitosan-polyvinyl alcohol (CS-PVP) core-shell structure, and the nanometer material has high chitosan content and a high specific surface and is used for hemostasis on living organisms. Experiments prove that the chitosan-polyvinyl alcohol nanofiber, provided by the invention, has good biocompatibility and excellent hemostasis performance, reserves the good water-absorption and fiber forming property of a PVP material, combines the excellent antibacterial hemostasis performance of a CS material, and can be clinically used for wound hemostasis. The preparation method is simple and fast, and has high efficiency.

The invention discloses an injectable type self-healing hemostatic material as well as a preparation method and application thereof. The injectable type self-healing hemostatic material is obtained by self-assembling macromolecular microgel particles with surface charges through electrostatic interaction between the particles or the particles and macromolecules. The electrostatic action between the microgel particles or the particles and the macromolecules is physical crosslinking and has reversibility, so the hemostatic material prepared by the method has high injectability, self-healing capability and high mechanical strength, does not need to introduce chemical crosslinking reaction in the injection and solidification process, is different from chemical macromolecules, does not introduce a micromolecular crosslinking agent, has high biocompatibility, can be degraded and absorbed, does not have toxic or side effects, has high safety and makes wide application in the field of biomedicine possible.

The invention provides high-purity collagen sponge with biological activity and a preparation method of the high-purity collagen sponge. High-purity collagen with the purity higher than 99% is prepared through purification procedures of special enzymolysis, self-assembly, gel chromatography, dialysis and the like of achilles tendon of animals, and the collagen sponge is prepared through a special freeze drying procedure. According to the high-purity collagen sponge with biological activity and the preparation method of the high-purity collagen sponge, the prepared collagen sponge has a complete two-time self-assembly triple-helical structure, has a flat and fine surface and soft texture, can be used for natural cavity filling and rapid hemostasis of a wound, can be used for rapidly stopping bleeding to prevent hematopedesis of the wound and has low immunogenicity, and safety of the collagen sponge is better guaranteed.