877 results about "Large intestine" patented technology

An endoscopic treatment system is designed to suture or resect a lesion while ensuring the ease of insertion into a deep region in the large intestine. The endoscopic treatment system comprises an endoscope and a therapeutic instruments insertion aid into which the endoscope is inserted. The endoscopic treatment system further comprises: a pair of clamp forceps that clamps and lifts a living-body tissue; a lateral hole formed in the therapeutic instruments insertion aid and used to control the position of the living-body tissue clamped and lifted by the pair of clamp forceps or to control the lifting thereof; a ligature used to ligate the living-body tissue whose position or lifting is controlled by the lateral hole; and a cutter used to resect the living-body tissue at a position between a region ligated with the ligature and a region clamped and lifted with the pair of clamp forceps.

A method and apparatus are disclosed for treating obesity includes an artificial fistula created between gastrointestinal organs such as between the stomach and the colon. The method includes selecting an implant comprising a passageway having an internal lumen with an inlet end and an outlet end. The passageway is positioned passing through a first wall of first gastrointestinal organ (for example, passing through the wall of the stomach) and a second wall of a second gastrointestinal organ (for example, passing through the wall of the large intestine) with the inlet end disposed within an interior of the first gastrointestinal organ and with the outlet disposed within an interior of the second gastrointestinal organ.

The invention provides a method and system for treating disorders in parts of the body. A particular treatment can include on or more of, or some combination of: ablation, nerve modulation, three-dimensional tissue shaping, drug delivery, mapping stimulating, shrinking and reducing strain on structures by altering the geometry thereof and providing bulk to particularly defined regions. The particular body structures or tissues can include one or more of or some combination of region, including: the bladder, esophagus, vagina, penis, larynx, pharynx, aortic arch, abdominal aorta, thoracic, aorta, large intestine, sinus, auditory canal, uterus, vas deferens, trachea, and all associated sphincters. Types of energy that can be applied include radiofrequency, laser, microwave, infrared waves, ultrasound, or some combination thereof. Types of substances that can be applied include pharmaceutical agents such as analgesics, antibiotics, and anti-inflammatory drugs, bulking agents such as biologically non-reactive particles, cooling fluids, or dessicants such as liquid nitrogen for use in cryo-based treatments.

Devices and methods for achieving hemostasis and leakage control in hollow body vessels such as the small and large intestines, arteries and veins as well as ducts leading to the gall bladder and other organs. The devices and methods disclosed herein are especially useful in the emergency, trauma surgery or military setting, and most especially during damage control procedures. In such cases, the patient may have received trauma to the abdomen, extremities, neck or thoracic region. The devices utilize removable or permanently implanted, broad, soft, parallel jaw clips with minimal projections to maintain vessel contents without damage to the tissue comprising the vessel. These clips are applied using either standard instruments or custom devices that are subsequently removed leaving the clips implanted, on a temporary or permanent basis, to provide for hemostasis or leakage prevention, or both. These clips overcome the limitations of clips and sutures that are currently used for the same purposes. The clips come in a variety of shapes and sizes. The clips may be placed and removed by open surgery or laparoscopic access.

Devices and methods for achieving hemostasis and leakage control in hollow body vessels such as the small and large intestines, arteries and veins as well as ducts leading to the gall bladder and other organs. The devices and methods disclosed herein are especially useful in the emergency, trauma surgery or military setting, and most especially during damage control procedures. In such cases, the patient may have received trauma to the abdomen, extremities, neck or thoracic region. The devices utilize removable or permanently implanted, broad, soft, parallel jaw clips with minimal projections to maintain vessel contents without damage to the tissue comprising the vessel. These clips are applied using either standard instruments or custom devices that are subsequently removed leaving the clips implanted, on a temporary or permanent basis, to provide for hemostasis or leakage prevention, or both. These clips overcome the limitations of clips and sutures that are currently used for the same purposes. The clips come in a variety of shapes and sizes. The clips may be placed and removed by open surgery or laparoscopic access.

The present invention provides an oral formulation of a cytidine analog, including, 5-azacytidine, for delivery to the lower gastrointestinal tract, including, the large intestine; methods to treat diseases associated with abnormal cell proliferation by treatment with the oral formulations of the present invention; and methods to increase the bioavailability of a cytidine analog upon administration to a patient by providing an oral formulation of the present invention.

The present invention relates to a composition comprising one or more minerals selected from the group consisting of selenium, molybdenum or tungsten, which is carried out galenically or chemically in a way that the mineral or minerals are released completely or in part, just before, during or shortly after arrival at the large intestine, and their use in the manufacture of a medicament for administering to a mammal for the prevention or reduction of gas formation in the colon thus conditioned abdominal complaints, particularly bloatings, meteorism or abdominal cramps. Furthermore, the invention relates to a procedure for the isolation of acetogenic and butyrogenic bacterial strains that are suitable for therapeutic purposes outlined above.

An endoscopic treatment system is designed to suture or resect a lesion while ensuring the ease of insertion into a deep region in the large intestine. The endoscopic treatment system comprises an endoscope and a therapeutic instruments insertion aid into which the endoscope is inserted. The endoscopic treatment system further comprises: a pair of clamp forceps that clamps and lifts a living-body tissue; a lateral hole formed in the therapeutic instruments insertion aid and used to control the position of the living-body tissue clamped and lifted by the pair of clamp forceps or to control the lifting thereof; a ligature used to ligate the living-body tissue whose position or lifting is controlled by the lateral hole; and a cutter used to resect the living-body tissue at a position between a region ligated with the ligature and a region clamped and lifted with the pair of clamp forceps.

The invention provides a method and system for treating disorders in parts of the body. A particular treatment can include on or more of, or some combination of: ablation, nerve modulation, three-dimensional tissue shaping, drug delivery, mapping stimulating, shrinking and reducing strain on structures by altering the geometry thereof and providing bulk to particularly defined regions. The particular body structures or tissues can include one or more of or some combination of region, including: the bladder, esophagus, vagina, penis, larynx, pharynx, aortic arch, abdominal aorta, thoracic, aorta, large intestine, sinus, auditory canal, uterus, vas deferens, trachea, and all associated sphincters. Types of energy that can be applied include radiofrequency, laser, microwave, infrared waves, ultrasound, or some combination thereof. Types of substances that can be applied include pharmaceutical agents such as analgesics, antibiotics, and anti-inflammatory drugs, bulking agents such as biologically non-reactive particles, cooling fluids, or dessicants such as liquid nitrogen for use in cryo-based treatments.

A method and apparatus are disclosed for treating obesity includes an artificial fistula created between gastrointestinal organs such as between the stomach and the colon. The method includes selecting an implant comprising a passageway having an internal lumen with an inlet end and an outlet end. The passageway is positioned passing through a first wall of first gastrointestinal organ (for example, passing through the wall of the stomach) and a second wall of a second gastrointestinal organ (for example, passing through the wall of the large intestine) with the inlet end disposed within an interior of the first gastrointestinal organ and with the outlet disposed within an interior of the second gastrointestinal organ.

A colonoscope as an endoscope has an insertion tube for insertion in a patient's gastrointestinal tract. A head portion is disposed at an end of the insertion tube, for inspecting a large intestine. In combination with this, a device for insertion guide includes a base tube mounted on the head portion. Two propulsion fins are disposed on the base tube to extend in an axial direction of the head portion. A driving mechanism with balloons shifts the propulsion fins between closed and open positions. The propulsion fins, when in the closed position, are disposed to extend along the head portion, and when in the open position, are deployed in a radial direction by setting a distal fin end thereof away from the head portion, to propel the head portion inserted in the large intestine. Furthermore, the balloons set the propulsion fins in the open position alternately with one another.

The invention provides a lactobacillus helveticus microcapsule as well as the preparation and application thereof, pertaining to the embedding technology of lactobacillus helveticus and aiming at microencapsulating the lactobacillus helveticus so as to solve the problems of low embedding efficiency and embedding yield in single-layer or double-layer embedment. The technical proposal adopted by the invention is that isolated soy protein, microporous starch and sodium alginate are respectively taken as the first, the second and the third layers of wall materials for microencapsulation; the three-layer embedment is carried out to the lactobacillus helveticus for the first time, wherein, in the process of preparing bacterial suspension, an orthogonal optimization protective agent is adopted to improve the livability after freeze drying. The microcapsule of the invention has strong heat resistance and acid resistance, solves the inactivation problem caused by gastric acid, digestive enzyme and antibiotic, etc. to active bacillus, is capable of releasing when reaching large intestine, and balances intestinal flora. The reusability of fermented milk is good. The lactobacillus helveticus used by the invention enriches the variety of probiotic bacteria microcapsule and is a good dietary supplement.

An implantable digestive organ is provided for the transport of materials through the digestive tract and in one particular application to an artificial large bowel for replacing all or part of a colon or large bowel. The prosthetic organ of one embodiment includes an outer support structure, an expandable member or members located within the outer support structure, and a flexible inner member forming a conduit for the passage of material. The flexible inner member is located within the outer member and the expandable member or members are located between the inner member and the outer support structure. The expandable members are expanded and contracted, or inflated and deflated to provide a pumping action that pumps the material through the organ. The prosthesis may also include valves or sphincters at the entrance and / or exit points of the organ where material moves into and out of the prosthesis. An implantable pump unit may be included for inflating and deflating the expandable members according to a desired sequence.

The present invention is directed to a floating anchor, which can be inserted into the esophagus, stomach, small intestine, large intestine, or rectal cavity and reverts to a bent shape when placed therein.

Differential gene expression associated with histopathologic features of colorectal disease can be performed with nucleic acid arrays. Such arrays can comprise a pool of polynucleotide sequences from colon tissues, and the detection of the overexpression or underexpression of polynucleotide sequences (or subsequences or complements thereof) from this pool can provide information relating to the detection, diagnosis, stage, classification, monitoring, prediction, prevention or treatment of colorectal disease.

A coating dispersion soluble in the lower digestive tract which is prepared by blending a hydroxypropyl methylcellulose acetate succinate (HPMCAS) soluble at around pH 7 with a conventional plasticizer and an anion surfactant and further adding an acid, wherein the HPMCAS has an average particle size of 10 μm or less and is dispersed at a concentration of 2 to 20% by weight, and the acid is used in an amount of 1 to 10 parts by weight per 100 parts by weight of HPMCAS, and a sustained release coated preparation capable of releasing a medicament in the large intestine at the lower digestive tract, which is prepared by coating a medicament-containing solid preparation such as a granular core with the coating dispersion.

A simulation device of alimentary canal consists of simulated oral cavity, simulated oesophagus, simulated stomach, simulated small intestine, simulated big intestine, simulated anus and its switch, motor actuators set separately in said simulated organs, acid liquor storage chamber, buffer liquor storage chamber, digestive enzyme storage chamber, alkali liquor storage chamber, flow rate controllers set separately in said chambers, transducers of pH value and pressure as well as enzyme. It is featured as using central control unit to control said actuators and to set various parameters of complete alimentary canal.

The invention discloses a method for processing cured meat, which mainly comprises the following steps: a, selecting materials, refrigerating and slitting; b, smearing spice, kneading and standing; c, cleaning; d, airing and hanging; and e, smoke curing. The method for processing the cured meat has the following characteristics: firstly, the selected spice is prepared by mixing green tea, wild pepper, anise, tsaoko, geranium, ganoderma lucidum, patchouli and cumin, the selection of the spice is scientific and the using amount is reasonable, wherein the green tea component not only can inhibit the generation of nitrite but also can inhibit the absorption of human large intestines on fat so that the cured meat reduces the burden of the human intestines and stomach caused by the fat at the same time of having unique fragrance; and secondly, the method strictly controls various process indexes during processing, and adopts active carbon to absorb benzopyrene in fume mist at a smoke curing stage so that the nitrite residue in a cured meat product is little, the benzopyrene content is low, and the cancer risk of the human body caused by the salt-cured product is further reduced.

This invention relates to a protection method for embedding intestinal probiotic bacteria. The method comprises: (1) culturing intestinal probiotic bacteria in a fermentation tank in large scale so that the number is 1.5*109 cfu / mL, and centrifuging in a high speed to obtain bacterial mud; (2) adding special embed-protecting agent so that the ratio of the embed-protecting agent to bacterial mud is 0.1 : (0.1-10.0), and freeze-drying to obtain active microbe strain containing inner-embedding layer as Pa; (3) preparing middle-layer embedding agent as B1; (4) mixing Pa and B1 at a ratio of 1 : (0.1-3) to obtain a middle-emdedding layer; (5) subjecting the active bacteria containing middle-embedding layer to outer-layer embedding, and naturally drying to obtain active bacteria containing three embedding layers. The method can make intestinal probiotic bacteria target-propagate after safely reaching small intestine and large intestine.

The invention discloses meal replacement powder with balanced nutrients. The meal replacement powder comprises the following components: millet, lotus roots, buckwheat, coix seeds, oat, black kerneled rice, Chinese yam, lotus seeds, yellow corn, potatoes, Chinese chestnuts, black sesame seeds, konjak, fermented black beans, Chinese wolfberry fruits, walnuts, mulberries, red jujubes, radix puerariae, olive oil, perilla seed oil, maltodextrin, whey protein concentrate, L-malic acid, L-carnitine and milk calcium. The invention further discloses a preparation method of the meal replacement powder with balanced nutrients. After the meal replacement powder is eaten for a long term, the effects of controlling postprandial blood sugar, nourishing the liver, nourishing the kidney, protecting heart and cerebral vessels, and recuperating the spleen, the stomach and large intestines can be obtained, and the nutrient and health status of people can be effectively improved and promoted.

A system, method, and computer-readable medium for the collecting and storing of environmental data, and generating a user report of the environmental data, the user report providing document compliance with U.S. Food and Drug Administration requirements. The collected and stored environmental data includes a wide variety of manufacturing facility parameter data, including but is not limited to, the presence of viable microbiological organisms, the presence of particulates and other environmental conditions within the facility, such as humidity, pressure, temperature, water quality (e.g., pH, conductivity, total organic content (TOC), endotoxin, coliform, and metals), and the respective amounts of different materials involved in the manufacture of the end product(s).

An insertion support tool which is detachably attached to a large-intestine endoscope including an elongated inserting portion which is inserted into a lumen is provided, and an external sheath which is extendable and contractible in an inserting direction of the inserting portion and a cover member which is arranged outside the external sheath and held in a state where it covers the external sheath when the external sheath is contracted are provided to this insertion support tool.

The invention relates to novel inulin products and compositions thereof, to their manufacture, to their use for modifying and modulating the bacterial flora and the fermentation pattern of inulin in the large intestine of humans, mammals or other vertebrates, to their use for providing improved inulin-associated nutritional effects / benefits, as well as to their use for the manufacture of consumer products and compositions for providing said effects / benefits in healthy, disfunctioned and diseased humans, mammals and other vertebrates. The novel inulin products consist of a particular mixture of an easily fermentable inulin (EFI) component and a hardly fermentable inulin (HFI) component. The nutritional effects / benefits include dietary fibre effects, improved mineral absorption, particularly calcium and magnesium, bone mineral density increase, reduction of bone mineral density loss, modulation of lipid metabolism, stimulation of the immune system, and anti-cancer effects. The novel inulin products are particularly suitable for the manufacture of a composition or a medicament for preventing, for postponing and / or for treating osteoporosis in humans, particularly in post-menopausal women and elderly people.

The invention relates to a method for treating, controlling, or preventing cancerous cell phenotypes and growths in an animal involving the administration of gaseous nitric oxide to one or administration sites in a body. The invention generally is capable of treating cancers found in or on the adrenal gland, bladder, bones, brain, breast, cervix, colon, colorectum, esophagus, gastrointestinal tract, heart, kidney, liver, large intestine, lungs, mouth, ovaries, pancreas, parathyroid, pituitary gland, prostate, salivary gland, skin, small intestine, spleen, stomach, thymus, thyroid, testicles, urinary tract, uterus, vagina, and so forth.

An implantable digestive organ is provided for the transport of materials through the digestive tract and in one particular application to an artificial large bowel for replacing all or part of a colon or large bowel. The prosthetic organ of one embodiment includes an outer support structure, an expandable member or members located within the outer support structure, and a flexible inner member forming a conduit for the passage of material. The flexible inner member is located within the outer member and the expandable member or members are located between the inner member and the outer support structure. The expandable members are expanded and contracted, or inflated and deflated to provide a pumping action that pumps the material through the organ. The prosthesis may also include valves or sphincters at the entrance and / or exit points of the organ where material moves into and out of the prosthesis. An implantable pump unit may be included for inflating and deflating the expandable members according to a desired sequence.

The invention discloses an E. coli BL21(pETDuet-ydjLnox) containing a 2R,3R-butanediol dehydrogenase gene ydjL and an NADH oxidase gene nox, wherein the strain is preserved in the 'China Center for Type Culture Collection' on December 23 in 2008, and the preservation number is CCTCC NO: M 208259. The invention also discloses application of a gene recombination bacterium in producing chiral S-AC by catalyzing meso-BD, producing chiral R-AC by catalyzing 2R,3R-BD and producing chiral pure 2S,3S-BD by splitting a 2,3-BD mixture. The concentration of a chiral AC prepared from the recombinant E. coli can reach over 6 grams per liter (the ee value is more than or equal to 96 percent); and the ee value of the chiral pure 2S,3S-BD is more than or equal to 98 percent, and the regeneration of a cofactor is achieved, thus the gene recombination bacterium has great industrial application prospect.

Qualitative and quantitative electrochemiluminescent assays for analytes of interest present in multicomponent liquids are provided. These methods comprise contacting a sample with a reagent labeled with an electrochemiluminescent chemical moiety and capable of combining with the analyte of interest, exposing the resulting sample to electrochemical energy and detecting electromagnetic radiation emitted by the electrochemiluminescent chemical moiety. Further provided are methods for detecting and identifying the presence of a multiplicity of analytes in a liquid food or food homogenate. These methods comprise immersing a diagnostic reagent holder, provided with a multiplicity of reagents, into the food or food homogenate, removing the diagnostic reagent holder from the liquid food or food homogenate, and detecting and identifying the presence of a multiplicity of analytes of interest bound to the diagnostic reagent holder, thereby detecting and identifying the presence of a multiplicity of analytes of interest in the food or food homogenate. The invention further provides an enzyme immunoassay for coliform bacteria. This assay comprises inoculating a sample into a suitable medium for coliform reproduction, immobilizing coliforms present in the medium to a suitable surface, treating the surface with an antibody directed to the immobilized coliforms and detecting the presence of the immobilized coliforms immobilized to a suitable surface.

The invention discloses a food composition suitable for a hypertension hyperlipidemia hyperglycemia population, which comprises rice, millet, black rice, yam, lotus roots, oat, tartary buckwheat, lotus seeds, pearl barley, yellow corns, potatoes, hazelnuts, Chinese chestnuts, konjak, black sesame, shiitake mushrooms, lycium barbarum, dried mulberries, dried seedless grapes, dates, salt black beans of soybeans, hawthorn powder, carrot powder, tomato powder, puerarin powder, concentrated whey protein, soy isolate protein, camellia oil, purple perilla seed oil, maltodextrin, L-malic acid, L-carnitine and milk calcium. The invention further discloses a preparation method of the food composition suitable for the hypertension hyperlipidemia hyperglycemia population. After the food composition is taken usually, balanced nutrition can be ensured when effects of effectively reducing a blood pressure, blood fat and blood sugar are achieved; meanwhile, the food composition also has effects of conditioning important organs of a human body, such as livers, kidneys, spleen, stomach, large intestine and the like, protecting the heart, improving blood vessel elasticity, reducing the blood viscosity and preventing the Alzheimer disease.

The invention discloses a probiotic double-layer microcapsule and a preparation method thereof. The prepared probiotic double-layer microcapsule is not dissolved in a stomach and small intestines, andis degraded within 20 min after reaching large intestines, so that probiotics can be better colonized in intestinal tracts, further improve the intestinal environment of a host and be beneficial to intestinal health. Resistant starch is added as a probiotic, the survival rate of bacteria is significantly improved and the tolerance of the probiotic in the gastrointestinal environment is enhanced.The microencapsulation is performed for two times, microcapsules having a multi-layer system are established, the shortcomings of conventional single-layer microcapsules that easily lose water are overcome, the stability of the microencapsules is enhanced, and the microencapsules play a better role in various probiotic products; the microencapsules can better protect the bacteria, prolong the storage period of the bacteria by at least twice or more, have good dispersity and solubility in the intestinal tracts, and are suitable for storage in air / liquid multi-environments and addition in different types of food.

The invention relates to a traditional Chinese medicinal composition with the gastrointestinal tract improvement function and a preparation technology thereof. Great changes have been taken place in life modes of modern people than ever before, many people are sedentary, diet tests show that foods are too refined and intake celluloses are less and less, some people drinks too much wines, many reasons lead to the digestion function abnormality, and large intestine constipation is a most common phenomenon, brings unspeakable pains to many people and influences the body health. The traditional Chinese medicinal composition of the invention comprises 335-1005 parts of aloe, 134-402 parts of Chinese angelica, 134-402 parts of Radix Ophiopogonis and 67-201 parts of Fructus aurantii. A dosage form which is convenient for oral intake and carrying is prepared through adopting advanced pharmaceutical equipment, and reasonably extracting and refining effective components in medicines and separating impurities through scientific technologies, so the intestine moistening and bowel relaxing function is realized, thereby the constipation pains of many people can be released.