The invention provides a digestive tract system simulation device, which includes a simulated oral cavity, a simulated esophagus, a simulated stomach, a simulated small intestine, a simulated large intestine, and a simulated anus and switches thereof; There are acid storage chambers, buffer storage chambers, digestive enzyme storage chambers, lye storage chambers and their flow controllers, as well as sensors for pH, pressure and enzymes; the central control unit is used to set the overall parameters of the simulated digestive tract , receive the detection results fed back by the sensor, adjust the flow controller, analog switch, electric control driver action range and action duration, etc., and save various parameters in the data storage unit, and output through the data output interface. The invention can simulate the peristaltic action of the digestive tract, and can achieve the purpose of controlling the running time of the simulated digestive tract through the control of the action range and action time. It has the advantages of simple system structure, long working time, many simulation parameters and comprehensive functions.