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Artificial blood vessel loaded with pseudo-ginseng medicines, and preparation method and application for artificial blood vessel

A technology of artificial blood vessels and Panax notoginseng, which is applied in the field of medical devices to achieve and sustain antithrombotic and good antithrombotic effects

Active Publication Date: 2012-11-21
MEDPRIN REGENERATIVE MEDICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] At present, there is no report on the use of Panax notoginseng in artificial blood vessels

Method used

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  • Artificial blood vessel loaded with pseudo-ginseng medicines, and preparation method and application for artificial blood vessel
  • Artificial blood vessel loaded with pseudo-ginseng medicines, and preparation method and application for artificial blood vessel
  • Artificial blood vessel loaded with pseudo-ginseng medicines, and preparation method and application for artificial blood vessel

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Experimental program
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Embodiment

[0065] (1) Preparation of the outer layer:

[0066] ①Dry polyurethane (BASF, 1180A polyether polyurethane) at a constant temperature of 70°C for 4 hours, put the dried polyurethane material into the barrel of the extruder, set the processing conditions: shear rate: 60r / min, the first stage Temperature: 155°C, temperature in the second stage: 165°C, temperature in the third stage: 180°C, die temperature: 180°C, after shearing, melting, extrusion and cooling to form the outer layer of the artificial blood vessel, control the die size and traction The pipe material with a wall thickness of 0.2 mm is obtained at a high speed, which is the outer layer of the artificial blood vessel.

[0067]② Dry polyvinylidene fluoride (Arkema, Kynar740) at a constant temperature of 90°C for 4 hours, add the dried polyvinylidene fluoride material into the barrel of the extruder, set the processing conditions: shear rate: 110r / min, the first The temperature of the first stage: 175℃, the temperatur...

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Abstract

The invention provides an artificial blood vessel loaded with pseudo-ginseng medicines, and a preparation method and application for the artificial blood vessel. The artificial blood vessel sequentially consists of an inner layer, a middle layer and an outer layer which are closely connected with one another; the outer layer consists of nondegradable polymer materials; the middle layer consists of degradable high polymer materials and pseudo-ginseng powder distributed on the surface and / or the inside of the middle layer; the inner layer consists of degradable natural biological materials and pseudo-ginseng powder distributed on the surface and / or the inside of the inner layer; the mass percent of the pseudo-ginseng powder in the inner layer is larger than 5%; the content of the pseudo-ginseng powder in the middle layer is higher than that of the pseudo-ginseng powder in the inner layer; the outer layer is a nondegradable layer and is mainly used for protecting and replacing a blood vessel for a long time; the middle layer is a long-acting antithrombosis layer, can degrade high polymers, and can slowly release medicines so as to realize a long-acting antithrombosis effect; and the inner layer is a quick degrading layer, when the blood vessel is punctured and injured by a foreign object, the pseudo-ginseng medicines wrapped in the blood vessel are directly exposed on a wound, blood is stopped quickly, and the artificial blood vessel is particularly suitable for application to products such as hematodialysis.

Description

technical field [0001] The invention belongs to the field of medical devices, in particular to an artificial blood vessel loaded with notoginseng medicine, its preparation method and application. Background technique [0002] At present, the death toll of cardiovascular and cerebrovascular diseases in the world ranks first among all diseases, the recurrence rate is the highest, and the disability rate is the highest. Cardiovascular and cerebrovascular diseases have become the number one killer that endangers human health. With the development of the economy and the improvement of living standards, the lifestyle and dietary structure of the Chinese population have undergone significant changes. Excessive intake of high-fat, high-protein, and high-calorie foods, reduced exercise, and aggravated population aging have contributed to the prevalence of cardiovascular diseases in China. The incidence rate increased rapidly. [0003] As a substitute for many severely stenotic or o...

Claims

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Application Information

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IPC IPC(8): A61F2/06A61L27/54
Inventor 赖奎霖詹泽丰徐弢袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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