The invention discloses a modified fluororubber sealing gasket used for an engine. The modified fluororubber sealing gasket comprises, by weight, 50-70 parts of maleic anhydride modified fluororubber, 20-30 parts of polyether urethane rubber, 10-20 parts of polypropylene, 5-15 parts of methyl vinyl silicone rubber, 1-3 parts of titanate coupling agents TMC-TTS, 0.8-1.6 parts of dicumyl peroxide, 1-3 parts of potassium peroxodisulfate, 1-3 parts of 2-thiol group benzimidazole, 5-8 parts of magnesium hydrate, 20-30 parts of polytetrafluoroethylene fiber, 5-10 parts of carbon fiber, 5-10 parts of ceramic fiber, 5-15 parts of white carbon black, 8-17 parts of talcum powder, 1-3 parts of anti-ageing agents, 1-3 parts of triphenyl phosphate, 1-3 parts of dibutyl phthalate, 1-2 parts of stearic acid, 0.5-1.5 parts of liquid paraffin and 1-3 parts of naphthenic oil. The invention further discloses a preparation method of the modified fluororubber sealing gasket. The product has good shock absorption performance and a good mechanical property, and the preparation method is simple.