77 results about "Deep wounds" patented technology

A method for providing negative pressure wound healing in a deep wound having a cavity includes the steps of (a) fashioning at least a first part of a therapeutic dressing to fit generally within the cavity, (b) operably associating a fluid moving means with the therapeutic dressing for enabling one of compressing the therapeutic dressing and transferring fluid across at least part of the therapeutic dressing, and (c) enabling the fluid moving means in a manner to deliver therapy to the patient. A therapeutic member for use in negative pressure wound healing includes a porous member formed and includes a hydrogel coating on a side thereof.

Assays employing fibronectin-depleted substrates are described to identify invasion inducing agents. Such agents are useful for in vivo wound healing, including but not limited to deep wounds and chronic wounds.

The invention belongs to the technical fields of biomedical materials and medical apparatus, and in particular relates to a thermosensitive dual-administration nanocomposite hydrogel as well as a preparation method and application thereof. The preparation method of the thermosensitive dual-administration nanocomposite hydrogel comprises the following steps: preparing a poly (N-isopropylacrylamide) nano microsphere and loading a growth factor, preparing a poly (N-isopropylacrylamide-co-acrylic acid) nano microsphere and loading an anti-inflammatory drug, and preparing the thermosensitive dual-administration nanocomposite hydrogel. The finished product takes sodium alginate as a matrix phase and uses two poly (N-isopropylacrylamide) based thermosensitive nano gel microspheres which have different LCSTs and are respectively loaded with the anti-inflammatory drug and the growth factor as a dispersion phase; and by controlling the temperature of the composite hydrogel to be higher than or lower than LCST of the nano microspheres, the release of the anti-inflammatory drug and the release of the growth factor are controlled, so that controlled release of the anti-inflammatory drug and the growth factor in inflammatory stage and proliferative stage of a deep wound repairing process is achieved.

For defects that existing hemostasis research and products cannot intelligently perform self-propelling or cannot be driven to forward deep in the wound under the action of external field force, the invention provides a preparation method for a janus structure based rapid hemostatic agent having a directional propulsion function. The preparation method includes performing esterification on microporous starch to unidirectionally grow calcium carbonate particles so as to obtain esterified microporous starch / calcium carbonate Janus particles; fixedly assembling thrombin on the surfaces of the esterified microporous starch / calcium carbonate Janus particles to obtain esterified microporous starch / calcium carbonate Janus particles assembled with the thrombin; mixing the esterified microporous starch / calcium carbonate Janus particles assembled with the thrombin and protonated tranexamic acid powder so as to obtain the janus structure based rapid hemostatic agent having a directional propulsion function. Through the formation of the biphasic heterogeneous Janus structure, the unidirectional and intelligent self-propulsion of hemostatic starch can be realized by cooperating with the protonated tranexamic acid, so that rapid three-dimensional hemostasis on deep wounds, penetrating wounds and irregular wounds such as aortic / venous rupture can be realized.

The invention discloses a method for preparing a medicine-carrying wound dressing based on a supercritical fluid technology. The method comprises the steps of mixing and stirring a chitosan acetic acid water solution with a cellulose sodium sulfate solution, freezing and drying to form a composite wound dressing; coating the composite wound dressing into a filter paper to be put into a high-voltage kettle of a supercritical fluid medicine-carrying system; putting the medicine into the high-voltage kettle in advance, preventing the medicine from directly contacting the composite wound dressing, leading supercritical carbon dioxide to fully act on the composite wound dressing; dipping the medicine into the composite wound dressing; and forming the medicine-carrying wound dressing after decompressing because of dissolving of the supercritical carbon dioxide on the medicine. The method has the advantages of mild operation condition, simple operation process, stable process and no organic solvent residue, and can be applied to treatment of burns and scalds and deep wounds.

The invention provides a multifunctional electrostatic spinning fiber dressing and a preparation method thereof, and belongs to the technical field of polymer medical materials. The fiber dressing isof a micro-nano structure, the electrostatic spinning method is adopted for spinning polymer materials with grafted functional groups into fiber, then, crosslinking is performed to obtain the fiber dressing, and the polymer materials have the function of stimulating macrophage transition. The invention further provides the preparation method of the multifunctional electrostatic spinning fiber dressing. The electrostatic spinning fiber dressing is obtained by grafting functional groups to polymer materials capable of promoting macrophage transition and then performing electrostatic spinning andcrosslinking, the fiber is soft and easy to fold and can well fit a superficial wound, a deep wound can also be filled with the fiber, and the fiber can achieve the multiple functions of stopping bleeding, resisting oxidation, resisting inflammation, resisting bacteria, promoting healing and reducing scars.

A device and method for treatment of post-operative surgical site wounds. Device includes an elongated hollow shaft that spans from the wound closure to the deep wound area, the internal end abutting a wound dressing and the external end connecting to a device that can provide negative-pressure suction and irrigation. Device providing one or more of irrigation, suction, and / or local antibiotic delivery to deep infections through a closed-wound. The method for removal includes narrowing a removal element relative to the long axis, collapsing the wound dressing; removing the wound dressing through the elongated shaft; and removing the device through a closed wound, avoiding a second removal surgery.

Assays employing fibronectin-depleted substrates are described to identify invasion inducing agents. Such agents are usefull for in vivo wound healing, including but not limited to deep wounds and chronic wounds.

The invention discloses a preparation method for alginic acid / chitosan mixed sponge, and belongs to the field of bio-medical materials. The preparation method comprises the steps of uniformly mixing micron or nano-level indissolvable calcium salt powder and a sodium alginate solution to form a suspension; slowly adding a chitosan acid solution to the suspension, and performing stirring to form alginic acid / chitosan gel; and performing homogenization, defoaming and freeze-drying on the alginic acid / chitosan gel to obtain the alginic acid / chitosan mixed sponge. The alginic acid / chitosan mixed sponge prepared with the method is simple in process and low in energy consumption, and can be prepared only by one freeze-drying step; and the sponge has good water absorptivity and softness, can be folded at will, is nontoxic, good in bio-compatibility and safe to degrade, has anti-adhesion performance and other performance, can be widely applied to wound hemostasis and wound repair, and is especially suitable for nursing of severe exudates or deep wounds.

The invention discloses a phallic allogeneic accellular patch thickening and lengthening surgery. The surgery comprises the following steps that a V-shaped incision with the length of 4.0 cm is incised from the middle of the symphysis pubis to the two sides of the base of the penis, the skin and the subcutaneous tissue are sequentially incised, blunt dissection is performed to enable the penis, the shallow suspensory ligaments and the deep suspensory ligaments to be completely exposed, and an electrotome is utilized to transversely and downwards incise all the shallow suspensory ligaments and the deep suspensory ligaments to the crural penis; strict blood stopping is performed, a deep wound is washed with a gentamicin aqueous solution and sutured with a NO.7 suture in the mode of double number eight, the superficial fascia is longitudinally and closely sutured with a NO.4 suture, and the subcutaneous tissue and the skin are interruptedly sutured with a NO.1 suture. The phallic allogeneic accellular patch thickening and lengthening surgery has the advantages of being little in surgical trauma, short in surgical time, safe, painless, little in bleeding, rapid in postoperative recovery, high in anti-infection ability and ideal in treatment effect.

The invention relates to a disposable hemostatic dressing wound leading-in first-aid hemostasis instrument, and belongs to the field of medical apparatuses and instruments. The instrument comprises a hemostatic material loading component and a pushing component. The hemostatic material loading component is used for storing compression-pill-shaped or flake chitosan hemostatic materials, and the front end is packaged through waterproof and breathable silica gel materials; and the pushing component is used for rapidly pressing the hemostatic materials into a wound. The disposable hemostatic dressing wound leading-in first-aid hemostasis instrument is particularly rapid and reliable in hemostatic effect on firearm wounds, penetration wounds and deep pricking wounds which are smaller in body surface penetration wound, large in internal wound and large in bleeding amount in battlefield rescuing. The disposable hemostatic dressing wound leading-in first-aid hemostasis instrument has the advantages that the efficient hemostatic materials are led into the deep wounds; as for tissue deep bleeding parts where bleeding stopping through a tourniquet or pressing is not suitable, the device can achieve the effects of accurate positioning, rapid bleeding stopping and hemorrhagic shock and dead preventing. When traumas accidentally occur, self rescuing or other rescuing can be carried out, and the valuable rescuing time can be won. The device has the advantages of being efficient in bleeding stopping, easy and convenient to operate, low in cost, convenient to carry, long in storage time and convenient to use.

The invention discloses a growth factor compound dressing capable of adhering a tissue fissure and a preparation method thereof. The compound dressing comprises an alginate gel layer and a non-woven fabric layer, wherein the alginate gel layer is prepared from sodium alginate, calcium carbonate, glucolactone, glycerinum, sodium carboxymethyl cellulose, allantoin, alpha-cyanoacrylate, cell growth factors and a protective agent. The dressing can be used for replacing a suture line to a certain extent, radically effectively promoting wound healing to prevent pains of surgical suturing for patients with relatively deep wounds, and effectively reducing generation of scars.

A germicidal absorptive material for use in surgical packings, wound bandages, sanitary tampons and bed sore prevention and / or treatment uses is provided by a foam-like matrix of hydrophilic polyurethane polymer to which application-specific loads of a germicidal disinfectant dye have been made. Polyurethane polymer of various densities and thicknesses exhibits an exceptional ability to absorb different levels of a number of disinfectant dyes, both basic and acidic, such as gentian violet and methylene blue, respectively. The relationship between dye-load and application-specific uses permits a totally-bound gentian violet pad to be used as a conventional bandage or pad on a surface wound with the capability of preventing the incursion of external pathogens from entering the wound through the pad, where the pathogens are killed by the bound-dye. The wound exudate is absorbed safely by the pad, where wound-originating pathogens are also killed. When the loaded dye's concentration is saturated by exceeding the bound-dye limit, the limited free-dye is available to be delivered to the wound, particularly deep wounds, to rapidly kill pathogens in the wound. The free dye delivery pad can then be replaced by the bound-dye pad to absorb the wound exudate.

The invention discloses efficient hemostatic sponge. The efficient hemostatic sponge is prepared from the following raw materials in percentage by mass: 35%-60% of chitosan, 0.1%-0.5% of thrombin, 1%-3% of polyglutamic acid, 9% of sodium chloride, 20%-35% of sodium alginate, 5%-15% of sodium hyaluronate and 1%-5% of calcium chloride. The efficient hemostatic sponge comprises a surface layer and an inner layer, wherein the surface layer is an antibacterial hemostatic layer containing chitosan, thrombin, polyglutamic acid and sodium chloride; and the inner layer is a gel layer containing sodium alginate, sodium hyaluronate and calcium chloride. The inner layer of the hemostatic sponge is in direct contact with a wound and is capable of absorbing moisture in blood to form gel to block the wound so as to realize primary hemostasis; concentrated blood penetrates through the gel layer to enter the surface layer so as to realize further hemostasis with the combined action of thrombin and chitosan; immobilized thrombin on an outer layer in the hemostatic sponge is capable of enhancing the stability, preserves efficient hemostatic activity and is unlikely to enter blood to cause a thrombus risk; and the efficient hemostatic sponge is particularly applicable to rapid hemostasis of serious bleeding caused by deep wounds, arteriorrhexis and the like.

The invention discloses a super water absorbent medical hemostatic material and a preparation technology thereof. The hemostatic material comprises the following components: chitosan, crosslinked polyacrylic acid, starch acrylic acid graft copolymer, plant polysaccharide, cervus and cucumis polypeptide, sephadex gel, aluminum phosphate, coconut shell fiber, bamboo flour, beta-carotene, vitamin E acetate, povidone-iodine, trimethylolpropane triglycidyl ether, propylene oxide, granatenine, humic acid, saponins of colubrina asiatica, benzyl acetate, and azone. The provided medical hemostatic material has a good hemostatic effect, the hemostatic speed is quick, at the same time, the absorption rate is high, and the absorption amount is large, so the hemostatic material is very suitable for large and deep wounds and wounds with a large amount of bleeding, and at the same time, the hemostatic material promotes the healing of the wounds.

Assays employing fibronectin-depleted substrates are described to identify invasion inducing agents. Such agents are useful for in vivo wound healing, including but not limited to deep wounds and chronic wounds.

The invention provides antibacterial medical hemostasis absorbent cotton gauze, which consists of medicine dressing and a tissue material carrying the medicine dressing, wherein the medicine dressingis prepared from traditional Chinese medicine and western medicine; the tissue material carrying the medicine dressing is blended by scleroprotein fiber and cotton fiber. The hemostasis and the antibacterial effects are integrated; the obvious effects are achieved on abnormal bleeding in operations of lung, liver, pancreas, adrenal gland and the like, the bleeding except for obstetrics departmentand postpartum hemorrhage, urinary tract bleeding and the like; in addition, the antibacterial medical hemostasis absorbent cotton gauze can be used under the conditions of great and deep wound and great bleeding quantity; the hemostasis is fast; the wound surface wound recovery is facilitated; meanwhile, the antibacterial spectrum is wide; the sterilization power is strong; the action is fast; the effectiveness can also be achieved on pseudomonas aeruginosa, klebsiella, escherichia coli, enterobacter, staphylococcus, mycoplasma and chlamydia; in addition, good effects are achieved on trimethoprim drug resistant bacteria, penicillin drug resistant staphylococcus aureus andtylosin or tiamulin drug resistant mycoplasma.

The present invention discloses a plant material to which bacteriophage has been attached, wherein the bacteriophage retains infectivity. The plant material includes fruits, vegetables, leaves, stems, flowers, roots, tubers, seedlings and seeds. Plant diseases and animal diseases can be treated. A separate composition comprises a carrier selected from (i) a filament, (ii) a planar material, and (iii) particles and / or beads, and bacteriophage covalently attached thereto, wherein the bacteriophage retains infectivity, and is useful in treatment or prevention of bacterial infection in a deep wound.

A packing strip probe is used to medically treat a sub-dermal cavity that is created by an abscess, an ulcer, or a deep wound. The probe comprises a rod, a blunt tip, and a probing tip. The rod is the main structure of the probe, and the blunt tip and the probing tip are located on opposite ends of the rod. The blunt tip is used to open up the sub-dermal cavity and to gently debride the sub-dermal cavity. The probing tip is used to aggressively debride the sub-dermal cavity and guide a packing strip into the sub-dermal cavity. The probing tip comprises tines, slots, and a rounded end. The tines can be used to either aggressively debride the sub-dermal cavity or wrap and insert the packing strip into the sub-dermal cavity.

The invention discloses a method for preparing a medical multilayer placental tissue implant. The method for preparing the medical multilayer placental tissue implant comprises the following steps of obtaining a qualified placental tissue material, separating amnion and chorionic tissue from the placental tissue material, treating the amnion and the chorionic tissue, removing blood, cells and DNA, disinfecting decellularized tissue, conducting lamination drying, cutting, and completing preparation. The medical multilayer placental tissue implant has a better adhesion effect on deep wounds, and is strong in toughness and not easy to tear.

The invention discloses a wound measuring and recording system. The system comprises a data processor and an electronic recording pen. The system comprises the following steps: a data processor scansa code of a patient and inputs basic information of the patient; the data processor periodically photographs the wound of the patient and then processes the obtained wound picture according to a preset wound comparison processing standard so as to obtain first wound data including the area of parts of the wound, the percentage of occupation compared with the wound picture and the size of the totalarea of the skin with the abnormal wound; the wound depth is measured, a sterile cotton swab or a sterile catheter stretch into the deep wound to obtain wound depth information as second wound data,and the second wound data is input into the data processor; and recording, tracking and feedback of wound quality and the wound depth are carried out in real time according to the obtained first wounddata and the obtained second wound data. The system can easily and conveniently detect the area and depth of the wound so as to play an auxiliary role in judging and treating the wound.

A First Responder device for treating blood flow from a deep wound or a bodily cavity comprises an inflatable balloon, a first chamber accommodating a liquid arranged for inflating the balloon, a second chamber accommodating a cooling agent capable of dissolving in the liquid when coming in contact therewith, thereby lowering the temperature, a rupturable seal between the first and second chambers, and a structure for forcing the liquid out of the first chamber into the inflatable balloon, and for rupturing the rupturable seal.

A germicidal absorptive material for use in surgical packings, wound bandages, sanitary tampons and bed sore prevention and / or treatment uses is provided by a foam-like matrix of hydrophilic polyurethane polymer to which application-specific loads of a germicidal disinfectant dye have been made. Polyurethane polymer of various densities and thicknesses exhibits an exceptional ability to absorb different levels of a number of disinfectant dyes, both basic and acidic, such as gentian violet and methylene blue, respectively. The relationship between dye-load and application-specific uses permits a totally-bound gentian violet pad to be used as a conventional bandage or pad on a surface wound with the capability of preventing the incursion of external pathogens from entering the wound through the pad, where the pathogens are killed by the bound-dye. The wound exudate is absorbed safely by the pad, where wound-originating pathogens are also killed. When the loaded dye's concentration is saturated by exceeding the bound-dye limit, the limited free-dye is available to be delivered to the wound, particularly deep wounds, to rapidly kill pathogens in the wound. The free dye delivery pad can then be replaced by the bound-dye pad to absorb the wound exudate.

The invention relates to an intraoral skin anastomat which comprises a sheath shell, a pushing block, clamping pincers and an anastomosis nail. The sheath shell is a hollow cuboid strip, the upper endof the sheath shell is open, a cylindrical shaft is arranged at the end opening, and a spring catch is arranged on the inner center line. The pushing block is a cuboid strip, an isosceles triangle groove is formed in the lower end of the pushing block, a rectangular through hole-spring hole is formed in the middle section of the pushing block, and a spring is arranged in the spring hole; the pushing block is arranged in the sheath shell, and the spring catch is arranged in the spring hole. The clamping pincers achieve the opening and closing functions of the pincers with a sheath shell cylindrical shaft as the axis, pincer mouths are two sections of arcs, a groove with the arc section is formed in the inner side center line, a spring piece is arranged between pincer arms, the pincer armsare arranged in the isosceles triangle groove, and the tail ends of the pincer arms make contact with the waist line of the isosceles triangle groove. The two ends of the anastomosis nail are providedwith metal wires with the same curvature as the clamping forceps, and the outer diameter is the same as the inner diameter of the clamping forceps groove. The skin anastomat is suitable for anastomosis of wounds in the oral cavity and also suitable for anastomosis of narrow and deep wounds.

The invention relates to a flexible application aid for the treatment of wounds. The application aid can be used in particular for the debridement and / or cleansing of wounds, including the skin surrounding the wound. The application aid according to the invention including a flexible or elastically deformable application wand, facilitates debridement of superficial to deep wounds without the risk of injury to the wound.

The invention provides an antibacterial cationic injectable hydrogel and a preparation method thereof. According to the antibacterial cationic injectable hydrogel dressing provided by the invention, hydrogel is obtained by self-crosslinking multi-arm polyethylene glycol, of which the end group is modified by phthalic dialdehyde, as a cross-linking agent with a cationic polymer in a solvent. The antibacterial cationic injectable hydrogel dressing provided by the invention can form gel without participation of catalase, and the obtained antibacterial cationic injectable hydrogel dressing has better gel forming time, does not form gel too slowly or too fast, can be injected for in-situ molding, and can be used for treating deep wounds (hydrogel in the prior art is too fast or too slow in gelling and can only be directly made into gel to be used for superficial wounds); moreover, the mechanical strength of the gel can be improved; and the dressing also has good biocompatibility, degradability and antibacterial property, and good repair promotion capability.

The invention discloses injectable hemostatic cryogel for promoting tissue regeneration and a preparation method and application thereof. The preparation method comprises the following steps: ultrasonically dispersing polydopamine, chitosan and collagen in deionized water, adding glacial acetic acid, and stirring until dissolving; and dissolving oxidized dextran in deionized water, adding an oxidized dextran solution into a mixed solution under vigorous stirring, transferring to a refrigerator for a reaction, and melting at room temperature to obtain the injectable hemostatic cryogel for promoting tissue regeneration. The aperture of the cryogel is 50-200 [mu] m, and the cryogel is provided with interconnected macroporous structures and stable mechanical strength, can be conveyed to a narrow and deep wound through an injector after being compressed and fixed, quickly recovers to block the wound and form a physical barrier after sucking blood, and activates a blood coagulation process through concentrated blood to achieve a hemostasis effect. The cryogel prepared by the invention has rapid shape recovery capability, injectability, good hemostatic capability and the like.

The invention relates to an ointment for treatment of scalds. The ointment comprises, by weight, 2-5 parts of borneol, 4-7 parts of boric acid, 250-350 parts of zinc oxide and 450-550 parts of vaseline. The ointment has the advantages that various components achieve a synergistic effect; boric acid and sulfonamide crystals cooperatively achieve the effect of inhibiting the growth of granulation tissue, so that scar formation and growth are weakened; vaseline which is oily is used for moisturizing the skin so that the problems of scar formation and pigmentation can be effectively reduced, and the skin can gradually recover to the normal color of healthy skin. For second-level burns and scalds and second-level deep wounds, treatment can be achieved without scars. For third-level burns, recovery can be achieved without skin grafting surgery, and scar formation is minimized. The ointment can quickly relieve pain in a few minutes and has a short treatment period and a quick effect without scars.