Alginic acid/chitosan mixed sponge and preparation method

Abstract

The invention discloses a preparation method for alginic acid / chitosan mixed sponge, and belongs to the field of bio-medical materials. The preparation method comprises the steps of uniformly mixing micron or nano-level indissolvable calcium salt powder and a sodium alginate solution to form a suspension; slowly adding a chitosan acid solution to the suspension, and performing stirring to form alginic acid / chitosan gel; and performing homogenization, defoaming and freeze-drying on the alginic acid / chitosan gel to obtain the alginic acid / chitosan mixed sponge. The alginic acid / chitosan mixed sponge prepared with the method is simple in process and low in energy consumption, and can be prepared only by one freeze-drying step; and the sponge has good water absorptivity and softness, can be folded at will, is nontoxic, good in bio-compatibility and safe to degrade, has anti-adhesion performance and other performance, can be widely applied to wound hemostasis and wound repair, and is especially suitable for nursing of severe exudates or deep wounds.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a kind of alginic acid / chitosan blended sponge and its preparation method Background technique [0002] Chitosan is the only cationic polysaccharide containing amino groups in nature, which can attract negatively charged platelets and red blood cells. Due to the hydrophilic nature of the amino group, it can promote the amount of fibrinogen adsorption, thereby increasing platelet adhesion and thrombus formation. The porous structure of the spongy hemostatic material obtained after freeze-drying can induce the infiltration and proliferation of repair cells in the dressing, which can be used for wound covering for a long time and has an obvious effect of promoting wound healing. Chitosan and its derivatives have a good inhibitory effect on bacteria, yeast, fungi and other microorganisms. Chitosan can produce Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pyogen...

AI Technical Summary

Problems solved by technology

[0005] The present invention aims at the problems of complex preparation process, high energy consumption and poor softness of the existing alginic acid / chitosan sponge, and provides a flexible alginic acid / chitosan blended sponge and a preparation method. The alginic acid prepared by the method / Chitosan sponge has a simple process, low energy consumption, and can be prepared by one-step freeze-drying; and the sponge has good water absorption and softness, can be folded arbitrarily, non-toxic, good biocompatibility, safe degradation, Anti-adhesion and other properties can be widely used in wound hemostasis and wound repair, especially suitable for the care of severe exudate or deep wounds

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