352 results about "Trimethoprim" patented technology

The invention provides a detection method of residual quantities of various veterinary drugs in a culturing or a slaughtering environment. With the method, rapid screening and quantitative detection can be carried out upon 61 drugs of 9 categories. The drugs include chlormycetin, beta lactams (penicillins), quinolones, sulfonamides, trimethoprims, macrolides, tetracyclines, and nitroimidazoles. According to the invention, a soil sample or an environmental water sample is added into a phosphate buffering solution; a filtrate obtained through centrifugation is extracted in a solid phase extraction column, and is eluted; the extraction column is dried by blowing, and is washed by using a methanol solution; an obtained eluent is titrated by using a methanol solution; a chromatogram peak of the sample is detected by using liquid chromatography-tandem mass spectrometry; the chromatogram peak is compared with a standard chromatogram peak, such that a specific variety of the detected drug is accurately determined. According to the invention, the sample solution is subject to liquid chromatography-tandem mass spectrometry multi-reaction monitoring selected ion analysis. Through internal standard correction, the recovering rate is 70-120%, and a relative standard deviation RSD is no larger than 18%. Compared with existing technologies, the analysis efficiency is improved by at least 5 times, and the detection cost is 30% of that of existing technologies.

The invention discloses a preparation method of a novel compound anti-coccidiosis and antibacterial preparation which is prepared by taking sulfachloropyrazine sodium and trimethoprim as raw materials. The preparation method comprises the steps of: taking 0.5kg to 0.7kg of trimethoprim, adding 10l to 14l of glacial acetic acid to form a mixture, heating the mixture slightly to dissolve the trimethoprim and the glacial acetic acid, dropping 200l to 280l of cyclodextrin saturated water solution with at temperature of 75 DEG C, stirring the mixture for 30min, stopping heating and continuously stirring for 5h to obtain a white sediment, filtering the mixture after being rested at room temperature for 12h, drying the sediment at 60 DEG C, sieving the sediment by an 80-mesh sieve, and drying the sediment by P2O5 in vacuum to obtain a clathrate. The clathrate is mixed with 2.5kg to 3.5kg of sulfachloropyrazine sodium and glucose of a proper amount up to 10kg, evenly mixed and made into particles by a fluidized drying granulator to obtain the finished product. The compound anti-coccidiosis and antibacterial preparation has efficient and quick therapeutic effect on explosive coccidiosis (caecal coccidiosis) of poultry, rabbits, and the like, and on mixed infections caused by various bacteria, such as chicken cholera, typhoid and the like.

The invention relates to gravure antibiotic printing ink of cork paper, which is characterized in that the product is composed of the following raw materials by weight: 15 to 35 parts of pigment, 10 to 25 parts of resin, 30 to 60 parts of solvents, 0.5 to 3 parts of antiseptic A and 0.2 to 1 parts of antiseptic B. The mentioned resin is a mixture composed of one selected from polyvinyl butyral, nitrocellulose and polyurethane, and one of modified abietate and polyketone resin; the mentioned solvent is selected from one or more than one of ethyl acetate, n-propyl acetate, isopropyl acetate, ethanol, isopropanol and n-propanol; the mentioned antiseptic A is a nanometer level modified titanium dioxide; and the mentioned antiseptic B is is one selected from sulphadimethoxine, sulphamethazine, trimethoprim and dimethoxypyrimidine. The gravure antibiotic printing ink of cork paper of the invention has reasonable formulation, can realize gravure on cork paper and has antibiotic and bacteriostasis effects.

The invention discloses a compound sulfamonomethoxine / compound sulfamonomethoxine sodium injection which is prepared from main components and auxilary components, wherein the main components comprise 5-20 parts by weight of sulfamonomethoxine / sulfamonomethoxine sodium, 1-4 parts by weight of diclofenac sodium and 1-4 parts by weight of trimethoprim and the auxilary components comprise 0.2-0.4 part by weight of antioxidant, 40-70 parts by weight of organic solvent, 0.2-1 part by weight of regulating reagent and 10-20 parts by weight of water for injection. The injection prepared by the invention can provide effective treatment on secondary infection and mixed infection of streptococcicosis, toxoplasmosis, eperythrozoonosis, colibacillosis, asthma and other diseases, has obvious effect if applied for a long term, strong effect enhanced by several times or dozens of times, hardly generates drug resistance and has the advantages of less consumption, less application times, little irritation and quick treatment effect, can treat both symptoms and root causes, save production cost, improve product additional value and reduce toxic or side effects caused by mismatching of medicaments during treatment.

The invention discloses a compound trimethoprim and doxycycline hydrochloride nanoemulsion preparation. The nanoemulsion preparation is of an oil-in-water type, and the grain size of the nanoemulsion preparation is between 1nm and 100nm. The nanoemulsion preparation is prepared from the following raw materials in weight percentage: 0.01-1.75 percent of trimethoprim, 0.04-6.99 percent of doxycycline hydrochloride, 21.8-35.7 percent of surfactant, 7.94-11.9 percent of cosurfactant, 3.49-4.76 percent of oil and the balance of distilled water. The compound preparation is an oil-in-water type nanoemulsion; the compound preparation is flaxen and transparent in appearance; the grain size of the compound preparation is between 1nm and 100nm, so that the stability is high; and the trimethoprim and the doxycycline hydrochloride in the preparation show up an obvious synergistic effect, The compound nanoemulsion preparation has the advantages of safety, broad spectrum, high efficiency, targeting and slow release.