353 results about "Trimethoprim" patented technology

The present invention is drawn to a device for the transdermal administration of dextromethorphan, (+)-3-methoxy-17-methyl-9a,13a,14a-morphanin, and salts, prodrugs and metabolites thereof, together with a pharmaceutically acceptable carrier, to a human being or animal in need thereof, to achieve an antitussive effect. The present invention is further drawn to a method of achieving an antitussive effect in a human being or animal which comprises transdermally administering dextromethorphan, (+)-3-methoxy-17-methyl-9a,13a,14a-morphanin, and salts, prodrugs and metabolites thereof, together with a pharmaceutically acceptable carrier.

The invention discloses a compound long-acting terramycin injection for animals and preparing method, which is characterized by the following: incorporating 50-300g supercidin, 20-60g trimethoprim or di-trimethoprim, 100-700g composite organic dissolvent, 20-100g magnesium chloride or magnesium oxide, 20-160g aminoethyl alcohol, 1g-10g anti-oxidant and surplus as injecting water. This invention possesses the advantages pf good drug effect, long operational time and low cost.

The invention relates to soluble powder for treating respiratory diseases of poultry, comprising tylosin tartrate, trimethoprim and auxiliary materials. As an antibiotic medicine, the inventive medicament is mainly used to prevent and treat various respiratory tract infections and chronic respiratory diseases of poultry. The tylosin tartrate and the trimethoprim have compatibility when used together. The soluble powder simultaneously acts on different sensitive organisms and mycoplasma, solves the problem of medicament tolerance caused by solely using tylosin to treat, has good absorption and relatively high safety when orally taken.

A compound florfenicol injection for treating the pneumonia and bacterial lung infection of pig is prepared from florfenicol, doxycycline, dimethyl formamide, magnesium dichloride, polyvinyl pyrrolidone, trimethoprim and propanediol. Its preparing process is also disclosed.

The invention relates to a preparation method for an isophorone diisocyanate (IPDI) prepolymer for coating curing. The preparation method comprises the following steps of: performing reaction on IPDI and polyether polyol for 1-4 hours in a reaction vessel under the existence of a catalyst to prepare the IPDI prepolymer; dropwise adding Trimethoprim (TMP) after being azeotropically dehydrated by a solvent for 2-6 hours step by step; adding trimerization catalyst; and when a theoretical NCO content is reached, adding a polymerization inhibitor to obtain the IPDI prepolymer. Two-step reaction is adopted by the preparation method; on the basis of one-step method, i.e. addition reaction, free IPDI monomers are removed by a trimerization method. The obtained IPDI prepolymer as a coating curing agent has good compatibility and film forming property on hydroxy acrylic resin, and has the advantages that the application range is wide, the strength is high, the yellowing resistance is good, the toxicity is low, the storage stability is high, and a high-solid content product can be obtained.

The invention provides a detection method of residual quantities of various veterinary drugs in a culturing or a slaughtering environment. With the method, rapid screening and quantitative detection can be carried out upon 61 drugs of 9 categories. The drugs include chlormycetin, beta lactams (penicillins), quinolones, sulfonamides, trimethoprims, macrolides, tetracyclines, and nitroimidazoles. According to the invention, a soil sample or an environmental water sample is added into a phosphate buffering solution; a filtrate obtained through centrifugation is extracted in a solid phase extraction column, and is eluted; the extraction column is dried by blowing, and is washed by using a methanol solution; an obtained eluent is titrated by using a methanol solution; a chromatogram peak of the sample is detected by using liquid chromatography-tandem mass spectrometry; the chromatogram peak is compared with a standard chromatogram peak, such that a specific variety of the detected drug is accurately determined. According to the invention, the sample solution is subject to liquid chromatography-tandem mass spectrometry multi-reaction monitoring selected ion analysis. Through internal standard correction, the recovering rate is 70-120%, and a relative standard deviation RSD is no larger than 18%. Compared with existing technologies, the analysis efficiency is improved by at least 5 times, and the detection cost is 30% of that of existing technologies.

The invention relates to a soluble powder for treating livestock and poultry bacterial infection and parasitosis, comprising nortloxacin lactate, trimethoprim and auxiliary materials, the medicament of the invention is taken as antibiotic medicament, is mainly used for treating various diseases and parasitosis caused by sensitive bacterias, has better curative effects for pig toxoplasmosis, pig hydropsy, poultry, rabbit coccidiosis, the nortloxacin lactate and the trimethoprim are compatible with each other for using and generating cooperating action, the medicament of the invention has excellent oral administration absorption effect and high safety.

The invention relates to a method for preparing a veterinary oxytetracycline-artemisinin injection and clinical application of the veterinary oxytetracycline-artemisinin injection. Raw materials of the injection mainly comprise oxytetracycline, artemisinin, trimethoprim, flunixin meglumine, magnesium oxide or magnesium chloride, an antioxidant, a pH regulator, a compound organic solvent and water. As a veterinary compound preparation, the veterinary oxytetracycline-artemisinin injection is mainly used for treating infectious diseases and secondary infection which are caused by sensitive gram positive bacteria and negative bacteria, eperythrozoon, rickettsia and mycoplasma. The method for preparing the veterinary compound oxytetracycline-artemisinin injection is simple, the production process is mild, the chelating temperature is low, the stability is high, and the injection is convenient to use and is suitable for industrialized production.

Disclosed is a compound sulfonamide turbid agent which comprises the following constituents (by weight percent): sulfadiazine 8-12, sulfamethoxazole 4-8, sulfamethoxydiazine 2-6, trimethoprim 2-6, and medicinal auxiliary materials including acid-base scale modifier, suspension auxiliary agent, acidifying agent, anti-oxidant, stabilizer and purified water.

The invention relates to a compound sulfamonomethoxine sodium injection for veterinary use and a preparation method thereof, and belongs to the technical field of medicines for veterinary use. The raw material components of the compound sulfamonomethoxine sodium injection for veterinary use comprise sulfamonomethoxine sodium, dexamethasone sodium phosphate, trimethoprim, imidocarb, astragalus polysaccharide, organic solvent and water for injection. As a special compound preparation for veterinary use, the injection has remarkable efficacy on strengthening resistance of livestock and poultry, and treating mixed infection and severe diseases caused by a plurality of pathogenic bacteria and viruses. The injection has the advantages of convenient use, short treatment course, low drug resistance and the like.

The invention relates to a method for simultaneously detecting 15 antibiotics in aquaculture sediment by combining microwave extraction-solid phase extraction pretreatment with a liquid chromatography-mass spectrometry (LC-MS) technology. The method comprises the following steps: step (1) pretreating sediment samples, adding internal standard substances sulfamethoxazole-13C6, norfloxacin-D5, penicillin G potassium salt-D5, tetracycline-D6, olaquindox-D4, amoxicillin-13C6 and trimethoprim-D3 indicating a recovery rate, adding an acetonitrile-phosphate buffer solution for microwave extraction ofextraction liquid; step (2) performing solid phase extraction, enrichment and purification on target antibiotics; and step (3) quantitatively detecting 15 antibiotics of seven types in sediment witha liquid chromatograph / mass spectrometer. The method can simultaneously detect residues of 15 antibiotics containing 8 new antibiotics in the aquaculture sediment at a time by optimizing the internalstandard substances, screening appropriate pretreatment method and optimizing detection conditions, and has the advantages of high recovery rate, high sensitivity, high stability, low detection limit,more true and reliable detection results and the like.

The invention relates to compound tylosin injection for animals and a preparation method thereof. The injection consists of tylosin, doxycycline hydrochloride, trimethoprim, aminophylline, dexamethasone sodium phosphate, organic solvent and injection water. As a dedicated compound preparation for animals, the injection has special effect for treating respiratory tract infection caused by livestock and poultry sensitive bacteria and mycoplasmosis of pigs and poultry. The method has the advantages of convenient use, short course of treatment, low drug resistance and the like.

The invention discloses a method for simultaneously detecting the medicaments such as furazolidone, diazepam, trimethoprim, acetaminophen and ibuprofen in water. The method comprises the following steps of: filtering a water sample to remove suspended matter; adjusting the pH of the water sample to be 2 to 4; activating hydrophile-lipophile balance (HLB) solid phase extraction column by using acetone, methanol, ammonium acetate-containing formic acid aqueous solution and ultrapure water in sequence; after the enrichment is finished, drying the HLB solid phase extraction column under the protection of nitrogen and eluting the HLB solid phase extraction column; collecting eluant, and drying the eluant by blowing a nitrogen flow; adding acetonitrile to dissolve the residue; and quantitatively detecting the concentration of the five medicaments. By the method, the water sample pretreatment is environment-friendly, easy to operate, large in enrichment factor, and high in reproducibility; and the content of the five common medicaments in a water environment can be analyzed quickly and accurately.

The invention provides an enzyme linked immunosorbent assay kit for detecting a trimethoprim medicament and application thereof. The enzyme linked immunosorbent assay kit comprises an enzyme label plate coated with envelope antigen, an enzyme marker, trimethoprim specificity antibody working solution (when the enzyme label plate is coated with the envelope antigen and the enzyme marker is enzyme-labeled anti-antibody or the enzyme label plate is coated with the envelop antigen and the enzyme marker is the enzyme-labeled antigen), trimethoprim standard solution, substrate developing solution, stop solution, concentrated washing solution and composite solution. The invention also discloses a method for detecting the trimethoprim by applying the enzyme linked immunosorbent assay kit. The method comprises the following steps of: performing sample pretreatment; detecting by the kit; and analyzing a detection result. The enzyme linked immunosorbent assay kit provided by the invention can be used for detecting the residual amount of the trimethoprim in a honey sample, has the advantages of simple operation, low expense and high sensitivity, can be monitored in field, and is suitable for screening mass samples.

The invention discloses a preparation method of a novel compound anti-coccidiosis and antibacterial preparation which is prepared by taking sulfachloropyrazine sodium and trimethoprim as raw materials. The preparation method comprises the steps of: taking 0.5kg to 0.7kg of trimethoprim, adding 10l to 14l of glacial acetic acid to form a mixture, heating the mixture slightly to dissolve the trimethoprim and the glacial acetic acid, dropping 200l to 280l of cyclodextrin saturated water solution with at temperature of 75 DEG C, stirring the mixture for 30min, stopping heating and continuously stirring for 5h to obtain a white sediment, filtering the mixture after being rested at room temperature for 12h, drying the sediment at 60 DEG C, sieving the sediment by an 80-mesh sieve, and drying the sediment by P2O5 in vacuum to obtain a clathrate. The clathrate is mixed with 2.5kg to 3.5kg of sulfachloropyrazine sodium and glucose of a proper amount up to 10kg, evenly mixed and made into particles by a fluidized drying granulator to obtain the finished product. The compound anti-coccidiosis and antibacterial preparation has efficient and quick therapeutic effect on explosive coccidiosis (caecal coccidiosis) of poultry, rabbits, and the like, and on mixed infections caused by various bacteria, such as chicken cholera, typhoid and the like.

The invention discloses a preparation method for a low free toluene diisocyanate (TDI) polyurethane pre-polymer curing agent. The preparation method for the low free TDI polyurethane pre-polymer curing agent comprises that a composition A and a composition B are put into a reaction kettle, nitrogen is injected and mixed, a molten composition C is added, and thus TDI / Trimethoprim (TMP) pre-polymer is obtained through reaction; a composition E is added, heated to 60-80 DEG C and reacted for 30-60 minutes; a composition D is added and reacted for 2-6 hours; and the low free TDI polyurethane pre-polymer curing agent with free TDI content which is lower than 0.4 % is obtained. The composition A is 2,4-TDI or TDI-80, the composition B is solvent with boiling point which is less than or equal to 200 DEG C, the composition C is trimethylolpropane which is dewatered by agent, the composition D is an aliphatic compound which contains 1-3 hydroxyls, and the molecular weight is 60-3000, and the composition E comprises one or a plurality of four kinds of diphenyl methane diisocyanates, namely, E-1, E-2, E-3 and E-4. The pre-polymer curing agent which is prepared by the preparation method for the low free TDI polyurethane pre-polymer curing agent is low in viscosity and good in stability.

The invention discloses a method for preparing a complete antigen from a trimethoprim semiantigen compound T1 and a use of the complete antigen, and belongs to the technical field of biochemical engineering. An amino group at one end of a pyrimidine nucleus is derived to form active carboxyl, a trimethoprim carboxyl derivative (TMP-HS) with a single specific structure is obtained by purification, the derivative is the trimethoprim semiantigen compound T1, and the trimethoprim semiantigen compound T1 is coupled to a carrier protein to form the trimethoprim complete antigen T1-MA-BSA. The antigen or antibody can be used for building an enzyme-linked immunosorbent assay adsorption analysis method and a colloidal gold test paper rapid-detection method so that trimethoprim residue in foods can be fast detected.

The invention relates to a veterinary compound sulfadiazine sodium injection and a preparation method thereof. The veterinary compound sulfadiazine sodium injection comprises sulfadiazine sodium, enrofloxacin, flunixin meglumine, trimethoprim, dexamethasone sodium phosphate, an organic solvent and water for injection. The injection serving as a veterinary special compound preparation has a special treating effect on various infectious diseases, mixed infections and systemic infections of the digestive system, the respiratory system, the urinary system and the skin soft tissue caused by sensitive bacteria and mycoplasmas of oxen, swines, poultries, canines, cats and aquatic animals The injection has the advantages of convenient use, short period of treatment, low medicament resistance and the like.

The invention provides a pharmaceutical composition for controlling bacterial infectious diseades of livestock and poultry. The pharmaceutical composition is characterized in that 14 Chinese herbal medicines (include persicaria perfoliata, polygonum cuspidatum, dandelion, acalypha australis, pulsatilla chinensis, glossy privet fruit, phyllanthus urinaria, sanguisorba officinalis, radix bupleuri, trifoliate orange leaf, sculellaria barbata, euphorbia humifusa, cyrtomium fortune and hawthorn) are selected from the general 60 Chinese herbal medicines by screening through a flat paper piece bacterial inhibiting method, wherein the 14 Chinese herbal medicines have a large inhibition zone and high effect; and the 14 Chinese herbal medicines are dried, crushed and uniformly mixed to obtain the pharmaceutical composition. The experimental study shows that the bacteriostatic test effect of the obtained pharmaceutical composition is obviously improved after adding trimethoprim (TMP) and sulfamonomethoxine to the Chinese herbal medicines. The pharmaceutical composition having good effect on controlling the bacterial infectious diseades of livestock and poultry can be directly added to the feed of livestock and poultry, and brings satisfaction effect in clinic.

The invention relates to an injection calcium folinate composite and a preparation method thereof. The calcium folinate composite prepared through the method is mainly used as detoxicant of a folic acid antagonist (such as methotrexate, pyrimethamine or trimethoprim and the like). The injection calcium folinate composite is clinically used for preventing serious toxic actions caused by excessive methotrexate or large dose treatment. The injection calcium folinate composite comprises calcium folinate and mannitol. The preparation method comprises the steps of: 1, preparing: placing the calciumfolinate and the mannitol in a preparing tank according to the weight ratio of 1:(0.1-0.5), adding injection water, adding active carbon for boiling for 20min; 2, aseptically filtering, packaging, half-plugging; and 3, freeze-drying in vacuum to obtain the injection calcium folinate composite. The injection calcium folinate composite has the advantages of simple formula, advanced process, uniformand stable quality, thorough moisture drying and better dissolvability.

The invention relates to gravure antibiotic printing ink of cork paper, which is characterized in that the product is composed of the following raw materials by weight: 15 to 35 parts of pigment, 10 to 25 parts of resin, 30 to 60 parts of solvents, 0.5 to 3 parts of antiseptic A and 0.2 to 1 parts of antiseptic B. The mentioned resin is a mixture composed of one selected from polyvinyl butyral, nitrocellulose and polyurethane, and one of modified abietate and polyketone resin; the mentioned solvent is selected from one or more than one of ethyl acetate, n-propyl acetate, isopropyl acetate, ethanol, isopropanol and n-propanol; the mentioned antiseptic A is a nanometer level modified titanium dioxide; and the mentioned antiseptic B is is one selected from sulphadimethoxine, sulphamethazine, trimethoprim and dimethoxypyrimidine. The gravure antibiotic printing ink of cork paper of the invention has reasonable formulation, can realize gravure on cork paper and has antibiotic and bacteriostasis effects.

The invention discloses a compound sulfamonomethoxine / compound sulfamonomethoxine sodium injection which is prepared from main components and auxilary components, wherein the main components comprise 5-20 parts by weight of sulfamonomethoxine / sulfamonomethoxine sodium, 1-4 parts by weight of diclofenac sodium and 1-4 parts by weight of trimethoprim and the auxilary components comprise 0.2-0.4 part by weight of antioxidant, 40-70 parts by weight of organic solvent, 0.2-1 part by weight of regulating reagent and 10-20 parts by weight of water for injection. The injection prepared by the invention can provide effective treatment on secondary infection and mixed infection of streptococcicosis, toxoplasmosis, eperythrozoonosis, colibacillosis, asthma and other diseases, has obvious effect if applied for a long term, strong effect enhanced by several times or dozens of times, hardly generates drug resistance and has the advantages of less consumption, less application times, little irritation and quick treatment effect, can treat both symptoms and root causes, save production cost, improve product additional value and reduce toxic or side effects caused by mismatching of medicaments during treatment.

The invention provides a trimethoprim hapten as well as a colloidal gold detection device and a preparation method of the trimethoprim hapten. The trimethoprim hapten has a chemical structural formula shown as the formula (1). With the adoption of the technical scheme provided by the invention, the trimethoprim hapten and the colloidal gold detection device are strong in specificity, high in detection sensitivity, high in accuracy and good in repeatability, and can be used for rapidly and simply detecting the residues of trimethoprim; any instrument and equipment are not needed and the trimethoprim hapten and the colloidal gold detection device are convenient to carry and low in detection cost; a test strip is simple to use and is not required to be operated by professionals; test paper is easy to produce and low in cost, and the detection requirements on the residual amount of the trimethoprim in food safety detection are met.

The invention relates to a long acting compound sulfamonomethoxine suspension which consists of 10g of sulfamonomethoxine, 2g of trimethoprim, 0.3g of sodium hydroxide, 0.3g of carboxymethylcellulose sodium, 30g of propylene glycol and 0.05g of tween-80. A preparation method thereof comprises the steps that: (1) the carboxymethylcellulose sodium swells by using 20ml of water used for injection; (2) then the propylene glycol is added; (3) the sodium hydroxide is dissolved with 5ml of water for standby; (4) the products of Step (1) and Step (2) are placed upside down in a beaker, added with the trimethoprim, the sulfamonomethoxine and the tween-80 in sequence and stirred while being adding; the sodium hydroxide is used for adjusting and controlling the pH value to be 5.3 to 5.6; and (5) the solution is put into a colloid mill so as to be milled for 10 minutes, thus obtaining the compound sulfamonomethoxine suspension. The veterinary drug has the advantages of long half life, less untoward effects, good curative effect, and the like.

Disclosed are fungicidal mixtures, compositions and methods for controlling plant diseases relating to combinations comprising (a) at least one compound selected from phenylamidines of Formula I, N-oxides, and agriculturally suitable salts thereof (I) wherein A is C3alkylene, optionally substituted with one or two methyl; W is CR5R6R7 or SiR8R9R10; and R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are as defined in the disclosure; and (b) at least one compound selected from alkylenebis(dithiocarbamate) fungicides, compounds acting at the bc1 complex of the fungal mitochondrial respiratory electron transfer site, cymoxanil, compounds acting at the demethylase enzyme of the sterol biosynthesis pathway, morpholine and piperidine compounds that act on the sterol biosynthesis pathway, phenylamide fungicides, pyrimidinone fungicides, chlorothalonil, carboxamides acting at complex II of the fungal mitochondrial respiratory electron transfer site, quinoxyfen, metrafenone, cyflufenamid, cyprodinil, copper compounds, phthalimide fungicides, fosetyl-aluminum, benzimidazole fungicides, cyazofamid, fluazinam, iprovalicarb, propamocarb, validamycin, dichlorophenyl dicarboximide fungicides, zoxamide and dimethomorph, and their agriculturally suitable salts.

The invention aims to disclose a compound sulfamonomethoxine sodium solution and a preparation method of the compound sulfamonomethoxine sodium solution. The compound sulfamonomethoxine sodium solution comprises 100ml of the following components: 5-20g of sulfamonomethoxine sodium, 1-5g of trimethoprim, 20-70ml of an organic solvent, 0.1-0.5g of an antioxidant and 0.1-0.5g of a metal complex. Compared with an injection liquid, the prepared compound sulfamonomethoxine sodium solution has the advantages of convenience for administration, resource economization, wide application, strong product activity, high bioavailability, stable efficacy, obvious effect, stable shape and properties, slow degradation of main drugs, capability of continuously keeping bioactivity and the like, and thus the aim of the invention is realized.

The invention relates to a method for preparing a complete antigen from a trimethoprim hapten T2 and application of the complete antigen, belonging to the technical field of biochemical industry. The method comprises the following steps: deriving active carboxyl group by utilizing amino group on one end of pyrimidine nucleus, purifying to obtain a single specific-structure trimethoprim carboxyl derivative (TMP-HS) which is trimethoprim hapten T2, and coupling the hapten T2 with a carrier protein to form the trimethoprim complete antigen. The antigen or antibody can be used for establishing an enzyme linked immunosorbent assay analysis method or colloidal gold test paper quick detection method, thereby being used for quickly detecting trimethoprim residues in food.

The invention discloses a florfenicol soluble powder and a preparation method thereof. The florfenicol soluble powder comprises the following components in parts by weight: 21.5-26.5 parts of florfenicol, 70.9-75.5% of inclusion agent, 0.8-1.5% of trimethoprim, 0.8-1 part of dispersing agent and 0.5-0.8 part of latent solvent. According to the florfenicol soluble powder and the preparation methodthereof disclosed by the invention, a molecular inclusion technology is adopted for solving the insoluble problem of florfenicol in water and greatly promoting the bioavailability of the product; through the improvement of technological parameters, the bulk density of common centrifugal spray technical products can be increased and the bulk density of products can reach up to the level more suitable for fodder enterprises and cultivation terminals; the product liquidity is promoted, the usage amount of packing materials is saved and the obvious social and economic benefits are created.