312 results about "Large dose" patented technology

A cookie or other food product which is designed to deliver a larger dose of cinnamon or other additive such as fruit extract or rind to a human user without significant introduction of food items detrimental to additive(s)'s expected medicinal action and without an unpleasant taste sensation. The cookie is designed to be chewed as opposed to swallowed and the flavoring of the additive(s) is intended to enhance the cookie as opposed to the flavoring being covered up or concealed by other flavorings.

A method and solution for perioperatively inhibiting a variety of pain and inflammation processes during arthroscopic procedures. The solution preferably includes a vasoconstrictor that demonstrates substantial agonist activity at alpha adrenergic receptors and that is selected for peripheral (local) vasoconstriction and one or more additional pain and inflammation inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for peripheral vasoconstriction and inhibition of pain and / or inflammation while avoiding undesirable side effects associated with systemic application of larger doses of the agents.

A method and solution for perioperatively inhibiting a variety of pain and inflammation processes during arthroscopic procedures. The solution preferably includes a vasoconstrictor that exhibits alpha-adrenergic activity and one or more additional pain and inflammation inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for peripheral vasoconstriction and inhibition of pain and / or inflammation while avoiding undesirable side effects associated with systemic application of larger doses of the agents.

A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral / dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin1 antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin1 antagonist, a bradykinin2 antagonist and a mu-opioid agonist.

A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral / dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin1 antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin1 antagonist, a bradykinin2 antagonist and a mu -opioid agonist.

The present invention is directed to devices and methods for administering at least one effective dose of at least one therapeutic substance to at least one of the maxillary sinuses of a patient in need thereof. Alternate embodiments may comprise administration of the at least one effective dose of at least one therapeutic substance to both maxillary sinuses, where the administered therapeutic substance(s) are either the same or differ from sinus to sinus. Still further alternative embodiments may comprise more than an initial effective dose administered to a patient's maxillary sinus(es), so that the therapeutic substance may be delivered over time, thereby requiring a larger dose be deposited within at least one of the maxillary sinuses so that the maxillary sinus(es) serve as a therapeutic substance depot for long-term release to the target structure(s).

The invention provides an intelligent method based on model predictive control for automatic infusion of large doses of insulin, which is characterized in that: a continuous glucose monitoring system (CGMS) and an insulin pump are used as the basis of hardware; online detection of food is carried out based on a strong tracking filter; when the food is detected, large doses of insulin is transfused immediately, and the amount of insulin depends on historical food; whether the dosage is needed to be increased is judged every 30 minutes based on the model predictive control, and the dosage is designed; when the blood glucose concentration decreases, whether the basic amount of insulin is needed to be maintained is determined according to the predicted blood glucose value; and finally the blood glucose concentration is controlled to be within the safe range. Compared with the existing corresponding technology, the invention has the advantages of high degree of intelligence and fully automatic operation, and the blood glucose control effects can be improved significantly in case that self-management cannot be carried out by patients.

This invention relates to an oral dosage form containing between 1 mg and 100 mg of memantine, wherein said dosage form does not contain 10 mg of memantine or 20 mg of memantine, and wherein said dosage form is not prepared by the patient or a person administering the drug to the patient who divides the dosage form containing a larger dose of memantine. Other aspects of this invention relate to pharmaceutical products comprising said dosage forms and methods of administering memantine and treating disease with said dosage form.

The invention provides active agents, such as paclitaxel, rapamycin, or 17-AAG, encapsulated by safe poly(ethylene glycol)-block-poly(lactic acid) (“PEG-b-PLA”) micelles. The compositions provide effective solubilization of drug combinations, such as paclitaxel, rapamycin, and 17-AAG, as well as others described herein. A significant advantage of PEG-b-PLA as a carrier is that it is less toxic than Cremophor® EL or DMSO, which are used in currently known compositions. Additionally, PEG-b-PLA micelles are easier to handle than DMSO and they do not possess a foul odor, which is a problem with formulations currently in clinical trials. Accordingly, the invention provides stable and biocompatible drug formulations that improve bioavailabilty without causing toxicity. It was also found that larger doses of individual drugs in micelle formulations can be administered compared to non-micelle formulations.

A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral / dental procedures. The solution preferably includes at least one tumor necrosis factor (TNF) soluble receptor at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied locally and perioperatively to a surgical site during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents.

A charged particle beam system for imaging and processing targets is disclosed, comprising a charged particle column, a secondary particle detector, and a secondary particle detection grid assembly between the target and detector. In one embodiment, the grid assembly comprises a multiplicity of grids, each with a separate bias voltage, wherein the electric field between the target and the grids may be adjusted using the grid voltages to optimize the spatial distribution of secondary particles reaching the detector. Since detector lifetime is determined by the total dose accumulated at the area on the detector receiving the largest dose, detector lifetime can be increased by making the dose into the detector more spatially uniform. A single resistive grid assembly with a radial voltage gradient may replace the separate grids. A multiplicity of deflector electrodes may be located between the target and grid to enhance shaping of the electric field.

The present invention is related to pharmaceutical dosage forms of ribavirin which are designed to increase patient compliance to a ribavirin therapy. Examples of such dosage forms include 400 mg to 600 mg tablets. These dosage forms are bioequivalent to multiple doses of tablets containing small amounts of ribavirin.

The invention discloses an oral disintegrating tablet and a preparation method thereof, and especially discloses an oral disintegrating tablet containing a bicomponent as a binder, and a preparation method thereof. The oral disintegrating tablet of the invention is prepared through adopting a lyophilizing process, and components of the tablet comprise effective doses of drug active components, a skeleton supporting agent, the binder, and a suspending aid, wherein the binder comprises pullulan and an auxiliary binder. The preparation method which utilizes the compound use of pullulan and the auxiliary binder in a specific application amount range solves problems of slow disintegration and incomplete dissolving-out when the lyophilized oral disintegrating tablet loads a large dose of the drug. Compared with lyophilized oral disintegrating tablets which are prepared with the prior art and have large drug loading doses, the lyophilized oral disintegrating tablet prepared in the invention, which has the advantages of rapid disintegration and complete dissolving-out, has a very good application value.

The invention discloses a temporary blocking agent, a composite blockage removal agent and a combined blockage removal method using the temporary blocking agent and the composite blockage removal agent, relating to temporary blocking agents, composite blockage removal agents and combined blockage removal methods. The temporary blocking agent, the composite blockage removal agent and the combined blockage removal method are used for solving the technical problems in a polymer flooding process that the difficulty in polymer injection is caused due to the fact that a polymer is subjected to blockage in a porous medium, and when the blockage removal agent is used directly, the blockage removal agent can preferentially enter unblocked stratums and cannot sufficiently unblock blocked stratums are solved. The temporary blocking agent consists of a surfactant and a freeze promoter. The composite blockage removal agent consists of a host and an initiator. According to the combined blockage removal method, the unblocked stratums are blocked in advance by using the temporary blocking agent so as to enable more subsequently-injected large-dose low-viscosity blockage removal agent to selectively enter the stratums required for being unblocked, the well shut-in is carried out for 2-3 days so as to enable the blockage removal agent and blockages to react fully, and then, the aim of unblocking is achieved.

The present disclosure relates to systems, methods, and formulations for the pulmonary administration of one or more therapeutic agents, in dry powder form, in a single, large dose quantity. These formulations, methods, and systems are useful in the treatment of patients suffering from toxic or harmful gas exposure, such as nerve gas exposure, as well as in the treatment of patients suffering from diseases of the pulmonary system, including tuberculosis, cystic fibrosis, and chronic obstructive pulmonary disease (COPD).

Interstitial cystitis and related GAG-deficient conditions of the bladder and urinary tract are treated by instillation of high dose chondroitin sulfate, such as 400 mg / 20 mL. The higher dose of chondroitin is effective for the rapid reduction of symptoms, particularly in patients with severe and otherwise recalcitrant cystitis.

The invention discloses the weight ratio of cotton-3'-glucosidase, meletin-3'-glucosidase and isoquercitrin in total flavone extract of abelmoschus manihot. The total flavone extract of abelmoschus manihot has definite effective ingredients, more stable quality, more completed effective ingredients, better and more stable curative effect, safety and reliability, simple preparing process and low cost, is suitable for industrial production, has better effective ingredient ratio, high content and high quality and solves the problem of large dose of abelmoschus manihot.

The invention provides xanthan gum fracturing fluid, and a preparation method and application thereof. The xanthan gum fracturing fluid comprises xanthan gum and auxiliary additives. The xanthan gum fracturing fluid has the advantages of high viscosity and high sand-carrying capacity, and can serve as large-dose 'quick water' and 'prepad fluid' in the fracturing process or serve as sand-carrying fluid in the fracturing process.

The present invention is directed to devices and methods for administering at least one effective dose of at least one therapeutic substance to at least one of the maxillary sinuses of a patient in need thereof. Alternate embodiments may comprise administration of the at least one effective dose of at least one therapeutic substance to both maxillary sinuses, where the administered therapeutic substance(s) are either the same or differ from sinus to sinus. Still further alternative embodiments may comprise more than an initial effective dose administered to a patient's maxillary sinus(es), so that the therapeutic substance may be delivered over time, thereby requiring a larger dose be deposited within at least one of the maxillary sinuses so that the maxillary sinus(es) serve as a therapeutic substance depot for long-term release to the target structure(s).

New type X ray tube is capable of generating X beam of rays with high spatial coherence, large dose, and large emission angle. Anode in extended electron beam or ion beam bomb structure, or structured electron beam or non-structured ion beam bomb is adopted in the invention to generate parallel-arranged linear array of emitter of X ray. Modes in structured electron or ion beam emitter, or structured grid, or electron or ion beam scan are adopted to realize emitter of X ray. Parallel-arranged periodic structure composed of high Z metal strips with narrow enough line width is adopted for structured anode. The disclosed X ray tube is workable under mode of continuous operation, or mode of pulse operation; and capable of outputting hard X ray or soft X ray. The invention is applicable to fundamental research in areas of biology, medical science, and material science etc. or in use for areas of disease diagnosis, industrial non-destructive inspection, online test etc.

The invention relates to a wastewater treatment agent, and especially relates to a special efficient polyaluminum chloride for printing and dyeing wastewater, and a preparation method thereof. The technical problems of large dose, low COD removal rate and use restriction of and high use cost of polyaluminum chloride in the prior art and low COD removal rate and high use cost of some composite polyaluminum chloride which are certainly applied are solved in the invention. The preparation method comprises the following steps: adding an aluminum-containing raw material into hydrochloric acid, and stirring for fully reacting to obtain a salt with the basicity of 60-90% and a polyaluminum chloride liquid of aluminum trioxide and with the concentration of 4-16%; and adding enough inorganic acid into the polyaluminum chloride liquid into a stirring tank, and fully reacting to prepare the special efficient polyaluminum chloride for printing and dyeing wastewater.

The invention discloses a Siraitia grosvenorii high dietary cellulose fruit powder which is prepared by the following components in percentage by weight: 0.5-1% of Siraitia grosvenorii aspartame liquid, 25-40% of Siraitia grosvenorii nutrient liquid and the balance of Siraitia grosvenorii cellulose liquid. The Siraitia grosvenorii high dietary cellulose fruit powder obtained by the proportion keeps active ingredients of Siraitia grosvenorii, is rich in Siraitia grosvenorii dietary cellulose, is a high cellulose fruit powder, can be used as a dietary replenisher, a drug filler and a functionalfood, and can not have excessive sweetness even in the use of large doses. Because Siraitia grosvenorii residues are subjected to special acid and alkali treatment, the retention period of the Siraitia grosvenorii high dietary cellulose fruit powder obtained by the proportion is not restricted by the oxidation problem of unsaturated fatty acids in Siraitia grosvenorii seeds, and the defects of off-odor and deterioration of fruit powder due to Siraitia grosvenorii seed fat, Siraitia grosvenorii epidermal waxiness, and the like in a dried fruit grinding method are directly overcome.

A high calcium flyash self compacting concrete with a large dose and a low cost used for filling the square steel tube, which is including: common portland cement, flyash, micro silica powder, water, sand, detritus, exciting agent and slow setting water reducing agent, wherein the content of the common portland cement is 9.0-10.0%, the content of the flyash is 9.0-10.0%, the content of the micro silica powder is 1.2-2.0%, the content of the water is 7.5-8.0%, the content of the sand is 24-30%, the content of the sand is detritus is 40-47%, the content of the exciting agent is 0.5-1.0%, the content of the slow setting water reducing agent is 0.1-0.3%. The invention fully uses the lateral reactivity of the high calcium flyash, reuses the wastes resource, has a low cost to produce the concrete which is suitable for filling the steel pipes and has a high fluidity and a high strength and a good continuable dilatability.

The invention discloses an organic pollutant enriching device and method for pretreatment of a water sample with bulk mass. The organic pollutant enriching device comprises a water storage tank, a peristaltic pump, an enriching column and a valve, wherein the enriching column comprises a glass tube, as well as two layers of glass cotton and a layer of resin which are arranged at the lower end of the glass tube; the resin is arranged between the two layers of glass cotton; water delivery hoses on the upper end of the glass tube are connected with the water storage tank; the lower end of the glass tube is provided with a drain tube on which the valve is arranged; and the water delivery hoses are all connected with the peristaltic pump. The method comprises the following steps of: a. regulating the peristaltic pump to ensure that the adding speed of the water sample is 10-120mL / min; b. introducing the water sample to the enriching column, retaining substances with large particles above the upper layer of glass cotton in the enriching column, and enriching organic matters in the water by using the resin. By means of the device and method disclosed by the invention, the defect that the simultaneous treatment on a water sample with large dose and various samples can not be realized by using a traditional solid-phase extracting device is effectively overcome, meanwhile, different types of organic matters in same batch of water samples can be enriched.

The invention discloses a heat stress resistant plant extractive feed additive which is prepared from the following components in percentage by weight: 25-30% of spinadate seed extractive, 25-30% of Coptis chinensis extractive, 13-18% of Scutellaria baicalensis extractive, 13-18% of pericarpium citri reticulatae and 10-15% of 98% betaine. The feed additive can be used for effectively improving the heat stress resistant capability of livestock, has the advantages of no toxic or side effect and no pesticide residue, and is favorable for the health of animals and people. The product is microchemical. Because of adopting the processing technology of dipping, condensing and spraying to dry, the defects of large dose and unstable effective ingredient content because direct smashing and adding are adopted in the prior art can be solved. According to the heat stress resistant plant extractive feed additive, high temperature stress can be effectively resisted, the antioxidant enzyme activity in the livestock can be improved, animals are accelerated to grow, the disease incidence is lowered, and the feed conversion efficiency is improved.

The invention discloses a method for deoxidization by combining compound drugs and UV, which relates to a deoxidization method. The method solves problems of expensive equipment, complex operation and slow deoxidization speed in the conventional physical deoxidization technology, and also solves the problems of expensive catalysts, large dose, contained heavy metals and slow deoxidization speed in the chemical deoxidization technology. The method comprises the following step: adding deoxidization compound drugs into a reaction system, and irradiating with ultraviolet to finish the deoxidization. The method can efficiently and stably remove dissolved oxygen in air and water without expensive equipment and components, and has advantages of simple operation, safety, fast deoxidization speed, no need of expensive catalysts, no contained heavy metals, less dose, cost conservation, less effect on water quality and no special requirements on air impurities in the reaction system, and water quality indexes such as pH value in water, temperature, salinity, organics and the like. Therefore, the method can be widely applied to deoxidization in air and water.

The invention discloses a laying period compound premix capable of improving the intestinal health of laying hens, and applications of the laying period compound premix, belonging to the technical field of feed compositions. A compound enzyme preparation containing beta-mannase, beta-glucanase, acid protease and phytase is used for removing antinutritional factors in soybean meal; yeast cell wall type myeotoxin adsorbents are used for effectively removing mycotoxin which is brought by the use of corn in a large dose and influences the intestinal health; and stomach strengthening acid is used for effectively adjusting the pH value of intestines. Wood dust prepared by using the compound premix provided by the invention has the advantages of soft texture, high cellulose content, intestine scratching prevention and pollution-free properties, and is capable of effectively improving the digestion and absorption functions of laying hens, thereby having good performance in bearing and water absorption. Through systemic and scientific application of the above comprehensive measures, the optimum intestinal health of the laying hens in the laying period is ensured; the immunity and the disease-resistant capability of the laying hens are improved; the best laying performance of the laying hens is achieved; the water content of manure is reduced; and the maximum economic benefits of farms using the premix are obviously improved.

The present invention relates to an X-ray line array detector in which a bundle of light-guide fibers is provided between an emergent surface of a flicker body and an incident surface of an array of photosensors, and the bundle of light-guide fibers has at least one bend, or an incident direction and an emergent direction are not in a same line, so that X-rays transmitting through the flicker body can not irradiate photosensors and integrated circuits behind them, and that damage resulting from long-term use or a large dose of X-ray radiation can be avoided, thereby prolonging lifetime of the line array detector. Further, a shielding body provided between the emergent surface of the flicker body and the incident surface of the array of photosensors can further shield the photosensors and their integrated circuits from interference of X-rays, so that good protection of the photosensors and their integrated circuits is achieved, thereby enhancing greatly anti-radiation performance of the detector and doubling the lifetime.

The invention discloses a side-flow circulation BAF (Biological Aerated Filter) intensified dephosphorization system and a method for treating urban sewage with the dephosphorization system, belonging to the field of water treatment. The invention aims at solving the technical problems such as poor dephosphorization effect, carbon source loss in pre-dephosphorization, large dosing quantity in post-dephosphorization, large investment in project, restraint to microbiological activity in synchronous dephosphorization and over-high frequency of back wash. The BAF intensified dephosphorization system is internally provided with a reaction tank and a sedimentation tank. The side-flow circulation chemistry-biology combined deep dephosphorization system is used for treating urban sewage. Removal rate of COD (chemical oxygen demand) can achieve 92%-95%, removal rate of total nitrogen can achieve above 80% and removal rate of TP (Tea Polyphenols) can achieve above 95%. Compared with that of single two-stage BAF, the removal rate of TP is improved by 55%-60%; compared with that of post-chemical intensification, the construction investment can be saved and expenditure of chemical agents can be saved by about 10%; and compared with that of synchronous chemical intensification, the period of back wash can be prolonged 6-8 days, therefore, energy consumption is lowered.