The invention discloses an Al-Cu-Mg-Ag alloy with high heat resistance, the components of which by weight percentage are: 4.6-6.6 percent of Cu, 0.4-0.65 percent of Mg, 1-1.5 percent of Ag, 0-0.06 percent of Fe, 0-0.06 percent of Si, 0.25-0.35 percent of Mn, 0.1-0.2 percent of Zr and the rest is Al. In the invention, the content of Ag in the Al-Cu-Mg-Ag alloy is increased and the atomic ratio of the Ag / Mg is properly increased, which results in that the alloy matrix has more Ohm phase nucleation sites and the Al-Cu-Mg-Ag alloy has more Ohm phases under high temperature, the alloy matrix obtains large amount of dispersed and fine strengthening phases to ensure that the Al-Cu-Mg-Ag alloy has excellent high-temperature short-time tensile property, high temperature stress rupture property, and good structure property and stability after long term thermal exposure; furthermore, the room temperature mechanical properties of the Al-Cu-Mg-Ag alloy of the invention is also superior to that of the existing Al-Cu-Mg-Ag alloy.