The invention discloses a high-efficient culture method for prawns. The method comprises the following steps: before putting young prawns, sufficiently sunning a pond and carrying out disinfection, then filtering water sources, fertilizing water, and diluting fertilized water when the young prawns are placed; when the young prawns are put, pouring powerful effective microorganisms (EM) and beneficial bacteria prawn protecting drugs, wherein the use amounts of EM and the beneficial bacteria prawn protecting drugs are 1 kilogram per mu (a unit of area equal to 0.0667 hectares); while managing young prawns, feeding powdered high nutrient feeds three times a day at regular hours and in fixed quantities, and observing materials on a material platform and lengths of the prawns; during culture of the prawns, within the first month after the prawns are thrown, changing water every five days, wherein 5-10 cm deep water is changed each time, within the first to third months after the prawns are thrown, changing water every seven days, wherein 10-20 cm deep water is changed each time, and starting a waterwheel aerator everyday, wherein the waterwheel aerator operates for 4 to 5 hours in rainy days and 2 to 3 hours in sunny days. Compared with the prior art, the prawns are fed by the powdered high nutrient feeds, thereby being capable of effectively improving the growth and enhancing the immune function of Penaeus monodon to shorten the growth periods of the prawns so as to improve the culture efficiency.