The invention discloses a preparation method of
flunixin meglumine the preparation method, and the method specifically comprises the following steps: (1) adding 2-chloronicotinic acid and 2-methyl-3-
trifluoromethyl aniline into a
sodium hydroxide water solution for stirring, adding
ethylene glycol as well as a
phase transfer catalyst and p-toluenesulfonic acid and
copper oxide, controlling the temperature and time, adjusting the pH value of the solution, stirring, standing, layering, stirring, filtering, washing
filter cake, and
drying to obtain flunixin; and (2) reacting the flunixin obtainedin the step (1) with N-methylglucosamine in
isopropyl alcohol, and meanwhile, adding a filler; carrying out heating
reflux, filtering, cooling, stirring and crystallizing, carrying out
crystal suction
filtration, and washing crystals with isopropanol to obtain the
flunixin meglumine. The preparation method of the
flunixin meglumine is convenient and simple in operation, the reflecting efficiencyis high, the
reaction temperature is low, the reaction time is short, and the cost is low; moreover, the prepared flunixin
meglumine is high in purity and high in yield.