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In-situ gel for injecting flunixin meglumine and preparation method thereof

A technology of flunixin meglumine and in-situ gel, which is applied in the field of in-situ gel for flunixin meglumine injection and its preparation, can solve the problems of time-consuming animals, stress, etc., and achieve convenient administration , good physiological compatibility, low irritation effect

Inactive Publication Date: 2013-08-07
NANJING AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Flunixin meglumine has been marketed for injection In veterinary clinics, a course of treatment often requires repeated administration several times, frequent injections are time-consuming and easily cause animal stress

Method used

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  • In-situ gel for injecting flunixin meglumine and preparation method thereof
  • In-situ gel for injecting flunixin meglumine and preparation method thereof
  • In-situ gel for injecting flunixin meglumine and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1% flunixin meglumine in situ gel for injection (calculated as flunixin)

[0026] prescription

[0027]

[0028] Preparation method: Take an appropriate amount of water for injection, add the prescribed amount of flunixin meglumine, and stir to dissolve; dissolve sodium tartrate and sodium benzoate with a small amount of water for injection respectively, and add them to the above-mentioned flunixin meglumine solution; Sprinkle the gel matrix and sodium carboxymethyl cellulose on the liquid surface, refrigerate at about 4°C until a clear, lump-free solution is obtained, filter through a 0.22 μm microporous membrane; dilute to volume with water for injection, and stir well , that is.

[0029] The prepared in situ gel was evaluated in vitro, including gelation temperature, gelation time, thermal reversibility, release rate, viscosity, pH value, etc. The measurement methods of each item are as follows, the measurement results are shown in Table 1, and the in vitro rele...

Embodiment 2

[0037] 2% flunixin meglumine in situ gel for injection (calculated as flunixin)

[0038] prescription

[0039]

[0040] Preparation method: Take an appropriate amount of water for injection, add the prescribed amount of flunixin meglumine, and stir to dissolve; dissolve sodium benzoate with a small amount of water for injection, and add it to the above-mentioned flunixin meglumine solution; then add the prescribed amount of gel matrix Sprinkle it with povidone on the liquid surface, refrigerate at about 4°C until a clear, lump-free solution is obtained, filter through a 0.22μm microporous membrane; dilute with water for injection, stir evenly, and obtain. The in vitro performance evaluation method is the same as in Implementation 1, and the results are shown in Table 1, and the in vitro release results are shown in the accompanying drawings.

Embodiment 3

[0042] 5% flunixin meglumine in situ gel for injection (calculated as flunixin)

[0043] prescription

[0044]

[0045]

[0046] Preparation method: Take an appropriate amount of water for injection, add the prescribed amount of flunixin meglumine, and stir to dissolve; soak the carbomer with an appropriate amount of water for injection, adjust to dissolve with benzalkonium bromide and sodium hydroxide aqueous solution, and add to the above Flunixin meglumine solution; then sprinkle the prescribed amount of gel matrix on the liquid surface, refrigerate at about 4°C until a clear, lump-free solution is obtained, filter through a 0.22 μm microporous membrane; use water for injection After constant volume, stir well, that is. First, other operations and in vitro performance evaluation methods are the same as in implementation 1. The results are shown in Table 1, and the in vitro release results are shown in the accompanying drawings.

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Abstract

The invention belongs to the field of a special pharmaceutical preparation for animals, and relates to an in-situ gel preparation for injecting flunixin meglumine and a preparation method thereof. The in-situ gel preparation is prepared from water as a solvent, flunixin meglumine, in-situ gel matrix known in the field, and other pharmaceutical necessary auxiliary materials. The preparation method is clarified. The preparation disclosed by the invention is liquid which freely flows at room temperature; sold or semi-solid gel is formed after dosing by intramuscular injection or subcutaneous injection; drug release is delayed; the lasting time is long; just one-time dosing in a course of treatment is achieved; and the in-situ gel has the advantages that the in-situ gel is simple to prepare, stable in property, convenient to dose, strong in animal adaption, and the like. The preparation disclosed by the invention has the effects of relieving fever, easing pain, diminishing inflammation and the like, and is used for preventing and treating diseases of animals such as pigs, sheep, dogs, cats, cattle and birds.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations for animals, and relates to an in-situ gel for flunixin meglumine injection with a suitable phase transition temperature and a preparation method thereof. Background technique [0002] Flunixin Meglumine (Flunixin Meglumine, FM) is the meglumine salt of flunicin, which is a special non-steroidal antipyretic, analgesic and anti-inflammatory drug for animals. Named Banamine) listed for use. The drug has strong antipyretic, analgesic and anti-inflammatory effects, and the analgesic effect is equivalent to that of conventional doses of morphine, but there is no morphine tolerance and dependence; the anti-inflammatory effect is 4 times that of phenylbutazone, ketobufen 2 times; and can be shared with antibacterial drugs to relieve disease symptoms. [0003] In veterinary medicine, flunixin meglumine is mainly used to prevent or relieve inflammation and pain in various animals, such as relie...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/34A61K31/44A61P29/00A61P1/12A61P1/00A61P11/00A61P19/02A61P15/14A61P15/00A61P27/02
Inventor 余祖功耿智霞郭凡溪王延映
Owner NANJING AGRICULTURAL UNIVERSITY
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