The invention discloses a
drug double layer core
osmotic pump tablet and the preparation method. The
drug or the
solid dispersion of the
drug is mixed uniformly with penetrating agent, thickener and filler, added with
adhesive to produce soft material and
granulation, baked, and added with
lubricant, and then drug layer core tablet material is produced. The penetrating agent,
expansive agent and the filler are mixed uniformly, are added with
adhesive to produce soft material and particles, are baked and are added with
lubricant, and then promoting layer core tablet material is produced. The drug layer core tablet material and the promoting layer core tablet material are punched by a preforming
machine with a needle punch to produce double layer core tablet of drug layer with concave holes.
Coating liquid containing semi-permeable
polymer changes the double layer core tablet of drug layer with concave holes into coated tablet in the
coating pot, which is baked to produce double layer core
osmotic pump tablet. The double layer core
osmotic pump tablet prepared by the invention is similar to zero level release drugs. The invention disuses the slotting process after
coating in preparing double layer core osmotic pump tablets without resorting to expensive
laser drilling
machine, simplifies the preparation process, reduces the cost and fits for industrial production.