607results about How to "Avoid first pass effect" patented technology

The invention relates to a long acting sustained-release formulation containing dopamine-receptor stimulant medicine, which comprises 5-5- wt% of effective dose of dopaminergic acceptor medicaments, and 50-95 wt% of medicinal macromolecular auxiliary materials.

The invention relates to an inhalation spray of antivirus medicines. The inhalation spray comprises the following components in percentage by mass of 0%-30% of antivirus activity agents, 0%-30% of auxiliary agents, 0%-30% of taste masking agents and the balance solvents, wherein the content of the antivirus activity agents and the content of the auxiliary agents are not 0% at the same time. Compared with the prior art, the inhalation spray disclosed by the application has the purpose that during outbreak period of epidemic corona viruses and other viruses, people do not need to occupy medicalresources in short supply and only need to inhale the antivirus medicines into respiratory tracts, medicine administration is accurately targeted, and the objective of preventing virus infection and propagation can be achieved; in addition, through united medication of the antivirus activity agents and the auxiliary agents, besides, various medicines are inhaled into the respiratory tract of a patient, synergistic treatment effects are generated, the viruses are eliminated, and serious respiratory tract and infection and serious pulmonary infection caused by the viruses can be treated; and chloroquine type antivirus medicines and macrocyclic antibiotics are inhaled through spraying for united medication, and the dosage of the medicines can be notably reduced, so that side effects of prolonged QT intervals, Tdp and sudden cardiac death caused by the medicines can be reduced.

The present invention relates to coronary heart disease treating medicine composition, and is especially one kind of medicine composition prepared with Chinese herbal medicine material and through special extraction process and other technological process. Specifically, the medicine composition is prepared with notoginseng, red sage and borneol, and through alkali extraction, concentration, alcohol precipitation, and adding supplementary material.

The invention discloses an aromatic essential oil drug for preventing and treating depression, boosting mood and improving brain function and its composition, which contains main pharmacological active ingredients: vanillin, vanillin salt or isomers of vanillin Any one, two or three mixtures can also be added with other natural spices and native plant essential oils such as rosewood, clove, benzoin essential oils and so on. The medicine of the present invention stimulates the olfactory nerve through the nose and the oral cavity to regulate the olfactory center of the brain and then affect different brain regions, so as to improve brain function, relieve depression, improve mood, and reduce suicide rate, and has quick onset, low concentration, no toxic side effect.

The vagina administrated mifepristone preparation for birth control and health reproduction consists of mifepristone or nanometer mifepristone liposome particle as main component, excipient, osmosis promoter, pH regulator, preservative, surfactant, solvent, water and other pharmaceutically acceptable components, and may be prepared into gel, film or other preparation forms. The vagina administrated mifepristone preparation is absorbed through vagina mucous membrane into blood circulation, and has high bioavailability, lowered dosage, less toxic side effect and less stimulation.

The invention relates to liquid-state lipid micro-particles used for delivering a cerebric medicine through a nose olfactory pathway, a preparation method thereof, and a preparation thereof. The liquid-state lipid micro-particles at least comprise a medicine, a lipid material, a penetrating agent, hydroxyethyl starch, propylene glycol and water. The mass ratio of the medicine to the lipid material is 1:1 to 1:10. The volume ratio of propylene glycol to water is 2:1 to 1:10. The liquid-state lipid micro-particles are advantaged in large drug load, high deformation capacity, simple preparation method, and high entrapment rate. The micro-particles are beneficial for the medicine to be delivered into the brain through the nose olfactory pathway and to provide curative effects. The range of appropriate medicines of the liquid-state lipid micro-particles is large, and the liquid-state lipid micro-particles are especially suitable for hormone, polypeptide, gene or vaccine medicines. With the liquid-state lipid micro-particles, preparations such as aerosols, nasal drops, and gels can be produced, such that requirements of cerebric disease medication can be satisfied.

The invention provides an ozagrel liposome and a preparation method thereof. The Ozagrel liposome consists of ozagrel which is an active substance, lipid used for preparing the liposome, a buffer solution and a propping agent. The preparation method can improve the stability of the ozagrel and is characterized by high drug-load rate and good stability. Experiments prove that the ozagrel liposome prepared by the preparation method of the invention can prolong the in-vivo retention time of the ozagrel which is the active substance, avoid first pass effect, enhance the targeting performance of the ozagrel liposome to blood platelets and endothelial cells in blood vessels, improve curative effect and increase the adaptability of patients, has simple preparation process and low cost and is suitable for industrialized large scale production.

The invention relates to the field of Chinese medicine preparation, in particular to a method for preparing tripterine nano structure lipid carrier containing traditional Chinese medicine monomer and application of the tripterine nano structure lipid carrier in preparation of transdermal drugs used for treating psoriasis, rheumatoid arthritis, skin cancer and breast cancer. The tripterine nano structure lipid carrier is characterized by comprising the following components in parts by weight: 1 part of tripterine, 5-100 parts of mixed lipid, 0.5-10 parts of phospholipid, 0.1-15 parts of poloxamer-188 and 0.5-10 parts of vitamin E and tocopherol polyethylene glycol succinate, wherein the mixed lipid is composed of solid lipid monoglycerine and liquid lipid octylic acid / caprin according to the weight ratio of 1: 0.1-10: 1. Tripterine is prepared into the nano structure lipid carrier, the tripterine nano structure lipid carrier in a semi-solid or liquid preparation form is applied in a transdermal way, bioavailability of the tripterine can be improved, toxic response of tripterine can be reduced, and the nano structure lipid carrier provided by the invention has great clinical application value in the improvement of the treatment effect of tripterine.

The invention discloses a zinc gluconate orally disintegrating tablet for prevention and treatment of developmental retardation, undernourishment, apocleisis, ulcerative stomatitis, and skin acne, and its preparation. The tablet is prepared by using zinc gluconate as raw material, using bulking agent, crumbling agent, flavoring agent, flow aid, and lubricating agent as adjuvant, using bonding agent or dressing material based on specific situation, or charging right amount of effervescent agent, then using specific preparing procedure and employing a tablet compressing machine for pelleting. The tablet can be taken under the condition of waterless, it has the advantages of fast effect, improved compliance for the patients, and increased curative effect of the medicament.

The invention relates to a mastic rheumatism aerosol and a preparation method thereof. The mastic rheumatism aerosol is an aerosol or a spraying agent prepared by taking the raw material medicines of artificial musk, mastic, myrrh, borneol and draconis sanguis as main materials, adding the auxiliary materials of cinnamon oil, peppermint oil, eugenol type basil oil, methyl salicylate, laurocapram, eucalyptus oil, liquid paraffin, essence, a propellant and the like, extracting and preparing; the product has the effects of dispelling rheumatism, promoting blood circulation, relieving pain, decreasing swelling and the like; and the experiments of a plurality of clinical research organizations show that the mastic rheumatism aerosol has obvious curative effect to rheumatalgia, the pain of bones and muscles, the ache of the waist and legs, sciatica and traumatic injuries.

The invention discloses an enteric-coated tilmicosin sustained release microcapsule and a preparation method thereof, and belongs to the field of tilmicosin preparations. The enteric-coated tilmicosin sustained release microcapsule is prepared from 10wt%-50wt% of raw tilmicosin powder, 40wt%-88wt% of an auxiliary fatty powder material and 2wt%-10wt% of an enteric coating material, wherein the enteric coating material is prepared from one or more of cellulose acetate phthalate, hydroxypropyl methylcellulose phthalate, L-type acrylic resin, S-type acrylic resin, polyvinyl acetate phthalate and hydroxypropyl methylcellulose acetate succinate; the diameter of the prepared microcapsule is 50-200 mu m. The preparation method comprises the steps as follows: the raw tilmicosin powder and the auxiliary material are subjected to primary coating, are subjected to secondary coating with the enteric coating material and then are dried, and a finished product is obtained. According to the enteric-coated tilmicosin sustained release microcapsule and the preparation method thereof, the sustained release purpose is achieved, the acting time of tilmicosin is prolonged, the fluidity and the dispersity of a drug are improved, the pharmacodynamical function is remarkably improved, and the dosage of the drug is reduced.

The invention relates to a compound liquorice tablet and a preparation process thereof. The compound liquorice tablet comprises the following raw materials: liquorice root extracts, opium powder, camphor, star anise oil, sodium benzoate, an adsorbent and a corrective. The preparation process comprises the following steps: adding the adsorbent in the raw material composition, and hiding special foul smell of the camphor and the star anise oil by adopting an adsorption method to eliminate the foul smell; adding the corrective in the raw material composition to enable the compound liquorice tablet to have satisfactory mouthfeel. Therefore, the compound liquorice tablet prepared by the invention is suitable for being taken orally, excellent in mouthfeel, good in clinical effects, and high in bioavailability. Meanwhile, through the improvement on the process, especially, a manner of performing direct tabletting on powder is adopted, so that the compound liquorice tablet is remarkably improved in process level, stable in quality and stable in effect; the production cost of the product is further reduced, and the tablet can serve patients better.

The invention discloses a pharmaceutical composition for treating diseases including epidemic type B encephalitis and hepatic coma, which has the advantages of wherein the bolus has the advantages of high biological availability, quick-speed medicine release, quick-speed effect, less toxic and side effects, higher medicinal content, smaller amount of administration, accurate administration dosage, easy administration, low price, and facilitated carrying. The preparation is prepared through the conventional injection extracting processes.

The invention discloses a transdermal medicament delivery system containing a donepezil compound, a transdermal preparation and a preparation method. The transdermal medicament delivery system comprises the following components in percentage by weight: 0.1 to 50 percent of donepezil or acid radical salt thereof, 1 to 95 percent of skeleton polymer, 0.1 to 60 percent of transdermal penetration enhancer, 0 to 10 percent of cross linker, 0.5 to 60 percent of humectant, 0.02 to 10 percent of bacteriostatic agent, 0.02 to 30 percent of pH regulator and 0 to 90 percent of solvent. The system is used for treating light, medium and severe senile dementia, can maintain long-time stable medicament delivery of at least 3 days, has better performance, is convenient for medicament delivery, and can reduce the administration frequency and increase the compliance of patients; and meanwhile, the transdermal path avoids first-pass effect on gastrointestinal tracts and liver due to oral administration of medicaments, and the system has higher bioavailability and obvious advantages in medicinal application.

A composite suppository for treating pile, phlebitis and phlebeurysma is prepared from micro-granular diosmin and hesperidin, matrix for suppository and additive.

The invention relates to a preparation method of a ginseng micro-powder tablet. The method includes the following steps of selecting raw materials, conducting drying, sterilizing, freezing grinding, dry granulating and tabletting, and obtaining the ginseng micro-powder tablet. The invention further provides the ginseng micro-powder tablet prepared through the method. The ginseng micro-powder tablet is attractive in appearance and low in surface pitting rate and fracture rate, and the hardness, the disintegration degree and friability of the ginseng micro-powder tablet meet the requirements for tablet quality. According to the method, the extraction process is omitted, a large amount of ethyl alcohol for extraction solvent can be saved, the production cycle is greatly shortened, and production cost can be greatly reduced. Most importantly, all natural ingredients of ginseng are kept.

The invention relates to a compound preparation of an external use pharmaceutical composition for treating swelling and pain, which is a gel binder for treating swelling, and also provides its preparation method. The gel binder is prepared by 20-50% of swelling and pain medicine of the external use pharmaceutical composition for treating swelling and pain as well as proper pharmaceutical excipients. The gel binder for treating swelling is composed of a back lining layer, an ointment-containing body and a cover lining layer. The ointment-containing body, namely the kernel part, is prepared from the swelling and pain medicine, a basic polymer, a cross-linking agent, an organic acid, an excipient, a humectant, an adhesive and the like in certain ratio. The gel binder has the advantages of fast effect, good moisture preservation, high permeability and comfortable use. The product has merits of convenient usage, small irritation on skin and high compliance of patients.

The invention discloses novel levo-carnitine hydrogel patch and a preparation method thereof. According to the hydrogel patch, levo-carnitine is used as an active ingredient of medicines. The levo-carnitine hydrogel patch consists of a medicine-containing matrix layer, a backing layer and a protective layer, wherein the medicine-containing matrix layer comprises the levo-carnitine, a hydrogel matrix, a transdermal enhancer and a filling agent, wherein a mass ratio of the levo-carnitine to the hydrogel matrix is 1:(20-300), the transdermal enhancer accounts for 1 to 2 mass percent of the mass of the hydrogel matrix, and a tackifier accounts for 1 to 5 mass percent of the mass of the hydrogel matrix. According to the levo-carnitine hydrogel patch, the medicines can be released stably by the specific transdermal enhancer used by the levo-carnitine, and the accumulative transit dose within 12 hours can reach 900 ug.cm<-2>. Simultaneously, the characteristics of the direct administration and multi-component and large-dose administration of lesion sites can be achieved, and the compliance of the long-term administration of patients is improved; and the using effect of the levo-carnitine hydrogel patch is obviously superior to that of other conventional preparations of the levo-carnitine.

The invention relates to a medicinal oral preparation, i.e., a saussurea involucrata drop pill for treating rheumatic arthritis, chronic infectious arthritis and dysmenorrheal, which has the advantages of high biological availability, quick-speed medicine release, quick-speed effect, less toxic and side effects, higher medicinal content, smaller amount of administration, accurate administration dosage, easy administration, low price, and facilitated carrying. The medicine is prepared through the conventional drop pill preparing process.

A PLGA gemcitabine slow release microball is disclosed in the present invention belonging to pharmaceutical field. The PLGA gemcitabine slow release microball is prepared by supplementary polylactic acid-glycolic acid and raw material medicine gemcitabine with the weight ratio of 95 :5 to 35 :65. The present invention has the advantages that: preparing gemcitabine and polylactic acid-glycolic acid into slow release microball, directly sendint to tumor part by syringe to execute regional slow release chemotherapy, gemcitabine are released slowly, the tumor part has high medicine concentration, long duration, strong action intensity, big killing force to tumor cell, thereby can improve curative effect to tumor; medicine are centralized to act on local, whole body has little medicine amount, adverse response is minimal. After medicine are released, polylactic acid-glycolic acid start to degradate as lactic acid and glycolic acid, further degradate as carbon dioxide and water, no effect to human body.

The invention relates to a gastrodin gel administrating by nasal cavity, which is composed of main medicine gastrodin and proper watercraft gel matrix and other additive medicine. The inventive gel can be adhered on the mucous membrane surface and extend the resorting period in the nasal cavity after administration. The released medicine can not only be absorbed into the blood circulation from mucous membrane, but also into the brain from the olfactory system, bypassing the blood-brain barrier to better do a treatment as gastrodin. The invention provides a new gastrodin without mucous membrane cilia toxicity has a high bioavailability, a strong patent compliance, a good stability and a simple production process and can be used for the treatments such as headache, blackout, neurasthenia and etc.

An orally-disintegrating tablet of omeprazole and its derivative is prepared from omeprazole and its derivative, coating, filler, disintegrant, flavouring, flowing aid, lubricant and optional plasticizer. Its preparing process is also disclosed.

The invention relates to capparis spinosa fruit gel ointment, a production method thereof, and application thereof to antirheumatic medicaments. The capparis spinosa fruit gel ointment comprises a backing layer, a medicament-containing ointment body and a covering layer protective film, wherein the medicament-containing ointment body is prepared from the following raw materials: a medicinal part of the capparis spinosa and a medicinal excipient; a covering material of the covering layer protective film is one of release paper, a plastic film, a polyester, an aluminum foil-polyethylene composite film and hard gauze; and a backing material of the backing layer is one of cotton cloth, non-woven fabric and chemical fiber cloth. The apparis spinosa fruit gel ointment provided by the invention substitutes the apparis spinosa fruit serving as a medicament for the traditional root bark, so the contradiction between the resource utilization of the apparis spinosa medicinal plants and ecological protection is solved. More importantly, the apparis spinosa fruit gel ointment provided by the invention solves the problems of irritability and hypersensitivity caused by the clinical application of the traditional formulation and administration way of the apparis spinosa, and has the characteristics of long action time, high moisture retention, high air permeability, avoidance of the first pass effect of livers, using comfortableness and high compliance of patients.

The present invention relates to medicine technology, and is Granisetron cataplasm as 5-HT3 receptor agonist in new form. Granisetron is applied clinically in preventing and treating nausea, vomiting, etc caused by cytotoxicity treatment, and available Granisetron preparation forms have some demerits. The present invention prepares Granisetron into cataplasm with the hydrochloride or free alkali of Granisetron as main medicine component and some supplementary materials. The Granisetron cataplasm with transdermal administration has no first pass effect, reduced and constant systemic blood medicine concentration, less side effect, raised compliance and other advantages.

The invention discloses a preparation method of capsicine micro spheres, which comprises the following steps: (1) dissolving capsicine and carrier materials into an organic solvent to obtain an oil phase according to the mixing ratio of 100 to 250 mg / 27 to 100 mg / 2 to 5 mL; (2) dissolving emulsifying agents into water as a water phase, wherein the concentration of the emulsifying agents in the water phase is between 5 and 30 mg / mL; and (3) adding the oil phase into the water phase for forming oil-in-water latex emulsion according to the volume ratio of 1 / 20 to 1 / 40 under the conditions of the temperature between 20 and 30 DEG C and the stirring speed between 500 and 1200 rpm, continuously stirring the oil-in-water latex emulsion for volatilizing the organic solvent, carrying out centrifugation for collecting micro spheres, washing the micro spheres by distilled water, and preparing the capsicine micro spheres through freeze drying. The capsicine micro spheres prepared by the method of the invention can be made into various slow-release preparations, the stimulation of the capsicine can be reduced, and the medicine concentration can be maintained for a long time, so the medication times can be reduced, the toxic and side effect can be reduced, and the adaptability of patients can be improved.

The invention discloses a sublingual tablet for anaesthesia. The preparation method of the sublingual tablet comprises the following steps: taking dexmedetomidinehydrochloride and ketamine hydrochloride as raw materials, adding a certain amount of a filling agent, a disintegrating agent, a corrigent, an adhesive and a lubricant, and performing pretreatment, mixing, granulatinganddrying, total blending, aluminum plastic inner packaging, outer packaging and the likeseparately. The sublingual tablet does not require building a special administrationchannel, is directly dosed through sublingual veins, avoids the liver first pass effect, takes effect quickly and is good in effect; particle angles of the sublingual tablet are all smaller than 35 DEG C duringpreparation, so that the particle mobility of the sublingual tablet is good, finished products is rapid to disintegrate and can be completelydisintegrated within 3 minutes, the weight difference of finished products is small, the increment of impurities is small during storage, the stability is good, the shelf life reaches 24 months, the preparation technology is simple and practical, and the sublingual tablet is worthy of market promotion.

The invention relates to Chinese medicinal gel for treating gynecological inflammation and a preparation method thereof. The Chinese medicinal gel comprises the following raw material medicaments in part by weight: 270 to 330 parts of sophora flavescens, 250 to 275 parts of Chinese pulsatilla root, 45 to 55 parts of catecholamine, 225 to 275 parts of dandelion, 225 to 275 parts of cortex dictamni, 270 to 330 parts of fructus cnidii, 270 to 330 parts of belvedere fruit, 225 to 275 parts of phellodendron amurense and 225 to 275 parts of sessile stemona root. Each raw material medicament in the Chinese medicinal gel disclosed by the invention has the effects of clearing heat, removing toxicity, dispersing swelling, removing stasis and killing parasites to relieve itching; and the Chinese medicinal gel can be used for treating gynecological diseases such as the vaginitis, the pelvic inflammatory disease, the cervicitis, the cervical erosion and the like.

The invention relates to a Chinese medicinal fuming-steaming composition and a guiding medicament used in conjunction with the same. The fuming-steaming composition comprises angelica, corydalis tuber, unprocessed radix aconite, unprocessed kusnezoff monkshood roots, garden balsam stems, common threewingnut roots, atractylodes, Chinese alangium roots and other raw medicinal materials. The guidingmedicament of the Chinese medicinal fuming-steaming composition is an alcohol or high-alcohol-content white spirits extract of safflowers, asarum, white mustard seeds, atractylodes, common threewingnut roots, divaricate saposhnikovia roots, clematis roots, doubleteeth pubescent angelica roots, notopterygium roots, homalomena rhizoma and anisetree bark. The composition is reasonable in prescriptions, and uses two prescriptions together to play a good role in strengthening healthy energy, dispelling rheumatism and stopping arthralgia syndrome. The guiding medicament as a pioneer medicament has the effects of promoting blood circulation, opening pores, guiding medicinal properties, assisting in efficacy and promoting medicinal potential, leads a large number of Chinese medicinal effective components evaporated from the fuming-steaming composition to directly penetrate skin, apertures, meridian points and the like through permeation, absorption, diffusion and other ways, enter skin grain,internal organs and directly reach lesion sites so as to clear skin grain, warm channels, expel cold, clear meridians, promote blood circulation, remove blood stasis, activate collaterals, relieve pain, eliminate carbuncle swellings and kill pathogenic toxins, and has satisfactory therapeutic effects on arthralgia syndrome in Chinese medicament.

The invention provides a compound contraceptive composition, a contraceptive transdermal patch containing the composition and a preparation method. The compound contraceptive composition comprises effective contraceptive quantity of active components dispersed in a skeleton polymer substrate: etonogestrel and estrogen with a contraceptive cooperative function. Drugs are carried out bidirectional regulation by distribution and dispersal in two phases of the skeleton polymer substrate and a pressure sensitive adhesive substrate for drug transdermal release; and a crystallization inhibiting agent is added to a drug warehouse or the pressure sensitive adhesive substrate in order to effectively inhibit the drugs from crystallizing and maintain the long-time continuous transdermal high activity and power of the drugs in the substrates. The contraceptive transdermal patch prepared from the compound contraceptive composition maintains longer (1 to 7 days) stable drug release and blood drug concentration, has better effect, reduces administration frequency, adds user compliance and has obvious advantages in medical application.

The invention relates to a method for preparing temperature-sensitive aquagel hollow fiber, wherein it uses hollow fiber as carrier, whose chamber contains temperature-sensitive aquagel; the aquagel will change phase at human temperature to release the drug. And the preparation comprises a, holding the holes of hollow fiber; b, putting temperature-sensitive monomer solution into the chamber of hollow fiber; c, compositing temperature-sensitive aquagel in the chamber; d, using said aquagel to absorb drub. The invention has better temperature-sensitive property and slow-release property.