74 results about "Japanese encephalitis" patented technology

The invention discloses mosquito repellent. The mosquito repellent is made of raw materials including, by weight, 5-15 parts of flos caryophylli, 10-15 parts of folium artemisiae argyi, 8-20 parts of flos lonicerae, 5-7 parts of herba moslae, 10-12 parts of herba menthae, 6-9 parts of agastache rugosa and 10-30 parts of realgar. The mosquito repellent has the advantages that the mosquito repellent is prepared from purely natural Chinese herbal medicines and chemical products, mosquitoes mainly can be expelled according to mosquito biting and blood sucking and disease spreading common sense and principles, harmful germs, bacteria and the like in air can be killed by odor volatilized from the traditional Chinese medicines, accordingly, family members can be guaranteed against being disturbed by the mosquitoes and can be prevented from suffering from diversified diseases due to mosquito biting, effects of keeping the family members away from diseases such as malaria, filariasis, epidemic encephalitis and dengue fever can be realized, methods for manufacturing the mosquito repellent are simple, raw materials for the mosquito repellent are easily available, and the like.

The invention provides a porcine Japanese encephalitis live vaccine heat-resistant lyophilized protective agent. The protective agent comprises the following components in percentage by weight: 1.0-1.4% of gelatin, 9-11% of sucrose, 9-11% of trehalose, 0.15-0.35% of polyvinylpyrrolidone, 0 .3-0.8% of sorbitol, 0.3-0.8% of mannitol, 0.1-0.2% of PEG-6000, and 0.01-0.02% of tween-80, the pH value of the protective agent is 7.5, and the components are added with water to be dissolved and sterilized at high temperature to obtain the protective agent.The lyophilized protective agent disclosed by the invention is mixed with a porcine Japanese encephalitis live vaccine virus solution, and freeze-drying is carried out to obtain a lyophilized vaccine. The heat-resistant lyophilized protective agent disclosed by invention is simple in formulation, easy in preparation, suitable for large-scale production, has good protection efficacy for vaccines, and can ensure that the vaccines can be preserved for 10 days effectively at the normal temperature, even at the temperature of 37 DEG C, and preserved for 24 months at the temperature of 2-8 DEG C.

The invention discloses a cyclocompound of tetrahydropyrrole and dihydroimidazolone as well as preparation and pharmaceutical application thereof. The cyclocompound is a compound shown in a formula (I), an isomer or pharmaceutically acceptable salt thereof. The compound, isomer or pharmaceutically acceptable salt thereof can be applied to preparation of medicines used for preventing or treating related diseases (such as dengue fever, dengue hemorrhagic fever, dengue shock syndrome, Zika, Chikungunya, Japanese encephalitis, yellow fever, hepatitis C and West Nile disease) caused by a dengue fever virus and related viruses. (The formula (I) is described in the specification).

The invention discloses use of a dipeptide analogue, and particularly relates to use of compounds in formulas (I) and (II), a stereisomer or a pharmaceutically acceptable salt thereof in pharmaceutical aspects. The compounds shown in the formulas (I) and (II) can be utilized as drugs for treating and preventing a disease caused by a dengue fever virus, and simultaneously can become the drugs for treating and preventing the disease caused by other flaviviruses, such as a yellow fever disease, hepatitis c, Japanese encephalitis, forest encephalitis, a disease caused by west nile virus infection, or aids caused by a human immunodeficiency virus (HIV) and the like.

The invention provides a porcine Japanese encephalitis live vaccine heat-resistant lyophilized protective agent. The protective agent comprises the following components in percentage by weight: 1.0-1.4% of gelatin, 9-11% of sucrose, 9-11% of trehalose, 0.15-0.35% of polyvinylpyrrolidone, 0 .3-0.8% of sorbitol, 0.3-0.8% of mannitol, 0.1-0.2% of PEG-6000, and 0.01-0.02% of tween-80, the pH value of the protective agent is 7.5, and the components are added with water to be dissolved and sterilized at high temperature to obtain the protective agent.The lyophilized protective agent disclosed by the invention is mixed with a porcine Japanese encephalitis live vaccine virus solution, and freeze-drying is carried out to obtain a lyophilized vaccine. The heat-resistant lyophilized protective agent disclosed by invention is simple in formulation, easy in preparation, suitable for large-scale production, has good protection efficacy for vaccines, and can ensure that the vaccines can be preserved for 10 days effectively at the normal temperature, even at the temperature of 37 DEG C, and preserved for 24 months at the temperature of 2-8 DEG C.

A Chinese traditional medicine for curing epidemic type-B encephalitis belongs to a Chinese traditional medicine for curing type-B encephalitis. The ingredients of the medicine are 40g of plaster stone, 10g of rehmannia root, 6g of rhinoceros horn, 5g of coptis, 5g of liquorice, 5g of bamboo leaves, 8g of pittosporm roots and 8g of balloon flower roots; the auxiliary ingredients are 15g of scorpion and 15g of hooked uncaria under the situation of twich and lockjaw; 10g of tabasheer and 10g of articifical bezoar under the situation of much sputum; 12gof moutan bark under the situation of dark purple complexion or maculae on the skin. The medicines used in the prescription are all natural herbs and the Chinese traditional medicine is processed with traditional method; the fetching of material is convenient and the prescription and manufacture method are simple; the expense for manufacturing the medicine is low. The composition of the Chinese herbal medicine is simple and the medicines used in the prescription are all natural ones and the fetching and use are convenient; the manufacture method is simple and the effect is excellent; the price is low; in this way, the herbal medicine is especially fit for people living in remote villages far away from counties and towns; the curing expense for patients with the disease of epidemic type-B encephalitis is low which solves the problem that the household income is low and the life is poor and the medical conditions is deficient locally.

The invention discloses a Xingnaojing injection and a preparation method thereof. The Xingnaojing injection is prepared from raw materials in parts by weight as follows: 7.5 parts of musk, 30 parts of turmeric root tuber, 30 parts of cape jasmine fruits, 1 part of borneol, 8 parts of sodium chloride for injection, 0.1-0.5 parts of a stabilizer and 0.1-1 part of an antioxidant. According to the Xingnaojing injection and the preparation method thereof, the stabilizer and the antioxidant are added to the preparation process of the injection, the quality stability of the Xingnaojing injection is improved, the stabilizer further has a solubilization function and increases content of effective ingredients in the Xingnaojing injection, and the prepared Xingnaojing injection has functions of clearing away heat and fire, cooling blood, eliminating toxins and inducing resuscitation, and can be used for treating epidemic encephalitis, hepatic coma, the symptom of heat entering construction-blood, the symptom of invasion of pericardium by heat, high fever, dysphoria, coma and delirium, deep red tongue, rapid pulse and the like.

The invention discloses an encephalitis-related virus detection kit and application thereof. The kit is used on the basis of the principles of multiplex PCR (polymerase chain reaction) combined nucleic acid intrusive reaction and nano gold color development. The kit comprises a combination of five types of primers and probes, and can be used for simultaneously detecting eastern equine encephalitis virus, western equine encephalitis virus, epidemic encephalitis b virus, West Nile virus and Nipah virus. When being used for detecting the five viruses, the kit has the advantages of high specificity and high sensitivity, and does not need any expensive apparatus; the detection result can be observed by naked eyes; and thus, the kit can be applied to the basic level.