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'Xingnaojing' dripping pills for treating cephalitis and hepatic coma and preparation process thereof

A technology for hepatic coma and awakening the brain and awakening the brain, which can be used in medical preparations containing active ingredients, pill delivery, pharmaceutical formulations, etc. Avoid gastrointestinal irritation symptoms, accelerate dissolution and absorption, and improve bioavailability

Inactive Publication Date: 2005-07-06
SHANDONG WOHUA PHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Traditional Chinese medicine injections are prone to cause allergies because their ingredients contain proteins, polysaccharides, polypeptides, etc.; the extraction purity is not enough; a variety of Chinese medicines are extracted, and the ingredients interact; they contain cosolvents, solubilizers, etc.
[0014] In addition, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking, which affect the quality of the drug. Efficacy, also directly affects the therapeutic effect Conventional oral dosage forms, such as tablets, capsules, etc.
In addition, due to the granulation process in the preparation process, large dust pollution will be generated, which will cause harm to the health of the staff to a certain extent, and will also cause certain pollution to the environment.
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0041] Now with several groups of specific examples, the preparation method of the Xingnao Jingdrop Pill of the present invention will be further described.

[0042] Group 1: Tests with a single matrix

[0043] 1. Weigh a certain amount of Chinese medicine raw materials according to the ratio given in [Preparation Method] 1, and then prepare pure Chinese medicine containing musk, turmeric, borneol, and gardenia according to the section [Appendix: a preparation method of a Chinese medicine extract] The extract extract of the active ingredient; or after low-temperature, reduced-pressure drying, and pulverization, the dry powder is obtained for later use;

[0044] 2. Substrate: polyethylene glycol (1000~20000) , polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac, etc. pharmaceutical carrier;

[0045] 3. Proportion—in g or kg, in parts by weight, drug extract: matrix = ...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating diseases including epidemic type B encephalitis and hepatic coma, which has the advantages of wherein the bolus has the advantages of high biological availability, quick-speed medicine release, quick-speed effect, less toxic and side effects, higher medicinal content, smaller amount of administration, accurate administration dosage, easy administration, low price, and facilitated carrying. The preparation is prepared through the conventional injection extracting processes.

Description

technical field [0001] The present invention relates to a medicine that has the functions of clearing away heat and purging fire, cooling blood and detoxification, and resuscitating the brain; it is used for treating epidemic type B encephalitis, hepatic coma, heat entering the blood, invagination of the pericardium, high fever, irritability, coma, delirium, tongue The pharmaceutical composition for the symptoms of crimson pulse, in particular relates to an oral drop pill preparation of the pharmaceutical composition based on the traditional Chinese medicine prescription Xinnaojing Injection, which has been reformed in dosage form and changed in administration route. Background technique [0002] According to the ministerial drug standard WS 3 -Xingnaojing Injection prepared according to the formula and extraction process given in B-3353-98 is a kind of liquid that has the functions of clearing heat and purging fire, cooling blood and detoxification, resuscitating and refres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K35/48A61K35/55A61P43/00
Inventor 曲韵智
Owner SHANDONG WOHUA PHARMACEUTICALS CO LTD
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