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Medicament for treating encephalitis b and preparation method thereof

A Japanese encephalitis and medicine technology, which is applied in the field of medicine for treating Japanese encephalitis and its preparation, can solve the difficulty of inoculation of the whole people, the ineffective medicine for treating Japanese encephalitis, and the treatment of Japanese encephalitis human immune globulin which is not found. JE and other problems, to achieve the effects of good quality, high yield and purity, and high virus safety

Active Publication Date: 2009-01-28
SICHUAN YUANDASHUYANG PHARM CO LTD +1
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  • Summary
  • Abstract
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AI Technical Summary

Problems solved by technology

The preventive effect of live attenuated Japanese encephalitis vaccine is good, but it is difficult to vaccinate the whole population. Therefore, effective therapeutic drugs after the onset of Japanese encephalitis have become the focus of research in this field
[0003] At present, there is no relevant report on the drug that can effectively treat JE, let alone the relevant report on the use of JE human immunoglobulin in the treatment of JE

Method used

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  • Medicament for treating encephalitis b and preparation method thereof

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Comparison scheme
Effect test

Embodiment 1

[0056] The preparation of embodiment 1 Japanese encephalitis human immunoglobulin intravenous injection

[0057] 1. Before production, each bag of plasma should be re-examined for infectious pathogenic microbial markers such as hepatitis B surface antigen (HBsAg), HCV antibody, HIV (1+2) antibody, syphilis, and ALT with diagnostic reagents approved by the state. The results should be is negative. Eliminate unqualified plasma and strictly prevent cross-contamination between unqualified plasma bags and normal plasma during the melting operation

[0058] 2. Disinfect the surface of the plasma bag, break the bag, melt the plasma temperature to 0-4°C, and separate the components according to the low-temperature ethanol protein separation method:

[0059] Dilute the plasma protein content with 9g / L sodium chloride solution to 45-55g / L, adjust the pH value to 7.0±0.4, add 95% ethanol until the ethanol concentration of the reaction solution is 8%. The temperature of the reaction sol...

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Abstract

The invention relates to a drug used for treating Japanese encephalitis and a preparation method thereof, belonging to the field of blood products. The invention provides a drug which can effectively treat Japanese encephalitis, thus solving the technical problem. The drug for treating Japanese encephalitis of the invention is a preparation prepared by taking Japanese encephalitis human immunoglobulin as an active ingredient and adding medicinally acceptable accessories. The drug can effectively cure Japanese encephalitis and provides a novel drug choice for Japanese encephalitis patients. In addition, the Japanese encephalitis human immunoglobulin intravenous injection prepared by the method of the invention has the advantages of better quality, high yield and purification, high virus safety and great application prospect.

Description

technical field [0001] The invention relates to a medicine for treating Japanese encephalitis and a preparation method thereof, belonging to the field of blood products. Background technique [0002] Epidemic encephalitis B (Epidemic encephalitis B) is referred to as Japanese encephalitis, an acute insect-borne infectious disease with high mortality and disability rates. . Vector control is poor, and the disease is clinically characterized by high fever, disturbance of consciousness, convulsions, and meningeal irritation. In severe patients with central respiratory failure, the fatality rate is as high as 20-50%. After the disease, there may be disturbance of consciousness, dementia, aphasia, paralysis, epilepsy and other neuropsychiatric and mental disabilities, and the incidence rate is 45%. The preventive effect of live attenuated JE vaccine is good, but it is difficult to vaccinate the whole population. Therefore, effective therapeutic drugs after the onset of JE have ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/42A61K9/00A61K9/19A61P31/14C07K16/06
CPCY02A50/30
Inventor 魏宪义
Owner SICHUAN YUANDASHUYANG PHARM CO LTD
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