PLGA Gemcitabine sustained-release microsphere and its preparing method
A technology of gemcitabine and slow-release microspheres, which is applied in the field of pharmacy, can solve the problems of gemcitabine with short half-life, serious adverse reactions, and short maintenance time, and achieve good local curative effect, avoid first-pass effect, and long-lasting effect
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Embodiment 1
[0028] Embodiment 1: Preparation of PLGA gemcitabine sustained-release microspheres
[0029] Use an ultrafine grinder to make gemcitabine into a fine powder with a diameter of less than 20 μm; dissolve 4 g of PLGA [90:10 (molecular ratio of lactic acid to glycolic acid)] in 40 mL of acetone to make a PLGA acetone solution, add 0.4 g of fine powder of gemcitabine, and mix uniform, spray-dried under vacuum, collected microspheres, and sieved to obtain PLGA gemcitabine sustained-release microspheres (A) with a particle size of less than 100 μm.
Embodiment 2
[0030] Embodiment 2: Preparation of PLGA gemcitabine sustained-release microspheres
[0031] Dissolve 4 g of PLGA (80:20) in 40 mL of tetrahydrofuran to prepare a PLGA tetrahydrofuran solution, add 0.8 g of gemcitabine fine powder, mix well, spray dry under vacuum, collect microspheres, and sieve to obtain PLGA gemcitabine sustained-release microspheres with a particle size of less than 100 μm. ball (B).
Embodiment 3
[0032] Embodiment 3: Preparation of PLGA gemcitabine sustained-release microspheres
[0033] Dissolve 4 g of PLGA in 40 mL of dichloromethane to make PLGA dichloromethane solution, add 1.2 g of gemcitabine fine powder, mix well, spray dry under vacuum, collect microspheres, and sieve to obtain PLGA gemcitabine sustained-release microspheres with a particle size of less than 100 μm (C).
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