191results about How to "Improve drug loading capacity" patented technology

The invention provides a pharmaceutical composition that can be used for efficient administration of low-molecular weight drugs and polymeric compounds such as peptides and proteins by methods other than injection, as well as a method for producing the composition. The pharmaceutical composition is for transmucosal administration and comprises (a) a drug having a positive or negative charge at a predetermined pH, (b) a pharmaceutically acceptable small particle and (c) a pharmaceutically acceptable surface-coating polymer capable of being electrically charged at the pH, wherein the surface of the small particle is coated by the surface-coating polymer, the drug is immobilized on the surface of the small particle via the surface-coating polymer, and a complex is formed by a noncovalent interaction between the small particle and the surface-coating polymer and a concurrent electrostatic interaction between the surface-coating polymer and the drug.

The invention belongs to the field of pharmaceutical preparations, and relates to activated neutrophil membrane coated neutrophil like nanoparticles and a preparation method. According to the activated neutrophil membrane coated like nanoparticles and the preparation method disclosed by the invention, a polymer, namely a poly(lactic-co-glycolic acid) copolymer PLGA, or a poly(lactic acid) copolymer PLA, or a polycaprolactone copolymer PCL is used as a material for preparing nanoparticles, the nanoparticles are used as kernels and are used for coating and loading model medicines, natural activated neutrophil membranes as a shell are used for coating the surfaces of the nanoparticles, and an activated neutrophil membrane coated biodegradable neutrophil like particle nanometer carrier system is prepared. Experiments in vivo and vitro indicate that the like particle nanometer carrier system can have the characteristics of being high in targetability and high in efficiency in accordance with a like treatment system for circulating tumor cells and micrometastases, provides new thought for individual and precision treatment and has higher clinical practice significance.

The invention discloses pH-responsive comb-like copolymer and preparation and application thereof. The preparation includes obtaining pH-responsive group by ARGETATRP (activator regeneration by electron transfer and atomic transfer radical polymerization), obtaining hydrophobic group by ROP (ring opening polymerization), using the pH-responsive group and the hydrophobic group to form block copolymer, using the block copolymer as macroinitiator to initiate ARGETATRP of hydrophobic macromers, and obtaining the pH-responsive amphipathic comb-like copolymer by selective hydrolysis reaction. The proportion of functional groups in the polymer molecule is easy to regulate. The synthetic process is simple, and yield is high. The hydrophobic group and the pH-responsive group obtained by dialysis form polymeric micelles of a shell, drug slightly soluble in water can be entrapped in a core of the polymeric micelles, the drug is kept to release slowly in the presence of gastric juice, and the drug is quickly and controllably released in intestines.

The invention discloses a docetaxel-loading mixed micelle preparation and a preparation method thereof. The mixed micelle preparation is prepared by the following steps of: preparing docetaxel mixed micelle by using a thin-film dehydration method; and coating the docetaxel with hydrophobic nuclei by taking amphiphilic TPGS, MPEG-PLA and CSO-SA as carrier materials of the mixed micelle. The docetaxel-loading mixed micelle preparation is prepared by using the amphiohilic materials of TPGS, MPEG-PLA and CSO-SA, so that drug-loading rate is increased, solubility and oral bioavailability are improved, and the problems of poor water solubility, low medicine release speed, improper particle size and the like when hydrophilic medicines are prepared are solved.

The invention discloses a preparation method and application of a conductive hydrogel capable of slowly releasing drugs and factors. The preparation method comprises the following steps: step 1, a conductive macromolecular monomer solution is prepared, an oxidant is added, and after sufficient reaction, a conductive macromolecular polymer is obtained; step 2, a concentrated aqueous dopamine solution is prepared, the conductive macromolecular polymer obtained in step 1 is added, and after sufficient reaction, a polydopamine / conductive macromolecular polymer compound is obtained; step 3, a metalion salt solution and an organic ligand solution are prepared; step 4, the polydopamine / conductive macromolecular polymer compound is added into the metal ion salt solution, and after uniform mixing,the organic ligand solution is added; and reaction is sufficiently carried out; step 5, the metal-organic framework / polydopamine / conductive macromolecular polymer compound is added into a monomer ordouble-bond biomacromolecular solution; and after additive is added, the needed hydrogel is formed by polymerization. The conductive hydrogel has excellent conductivity and electrochemical activity, and can be used in the preparation of drug carriers and biological electrodes.

The invention relates to a folic acid coupled targeted ferriferrous oxide / mesoporous silica / copper sulfide nano-composite particle as well as a preparation method and an application thereof. The nano-composite particle consists of Fe3O4@mSiO2 core-shell structural nanoparticles, wherein the core-shell structural nanoparticles take Fe3O4 nanoparticles as cores and mSiO2 as shells, and copper sulfide nanoparticles and folic acid cover the surfaces of the shells; the folic acid is grated on one part of the mesoporous silica (mSiO2) and the copper sulfide particles are loaded on the other part of the mesoporous silica; and polyethylene glycol is grated on the surface of the copper sulfide nanoparticles. Compared with the prior art, the nano-composite particles disclosed by the invention has a broad application prospect in the aspects of nuclear magnetic resonance imaging, drug loading and photothermal therapy; anti-cancer drugs and photothermal reagents can be transmitted to tumor parts in a targeted mode; the nano-composite particle can reduce toxic and side effects on normal tissues and cells, and meanwhile, the nano-composite particle can effectively kill cells, so that a treatment effect is further improved; and moreover, the nano-composite particle is relatively low in preparation condition demand and cost.

The invention relates to microcapsules and a preparation method thereof. Each microcapsule has a structure of taking a polymeric hydrophilic colloid as a capsule core and a biodegradable polymer material as a capsule membrane; a water-soluble medicine is dispersed into the hydrophilic colloid capsule core; the microcapsules are prepared by the combination of multiple technologies such as a microemulsion technology, an ultra-low temperature quick-freezing technology and the like and a freeze-drying process; the particle sizes of the microcapsules can be controlled; the microcapsules are high in medicine loading capacity and medicine entrapment efficiency; and the microcapsules are uniform in particle size, microcapsule particles cannot be gathered, and the medicine release behavior is controllable. The microcapsules are applicable to the entrapment of water-soluble medicines, are particularly applicable to medicines with low thermal stability and macromolecular medicines such as protein, polypeptides, polysaccharides and the like, and can be applied to the injection and oral administration of multiple formulations for local or systemic treatment of mucous membranes, skins, wounds and orifices.

The invention relates to the field of Chinese medicine preparation, in particular to a method for preparing tripterine nano structure lipid carrier containing traditional Chinese medicine monomer and application of the tripterine nano structure lipid carrier in preparation of transdermal drugs used for treating psoriasis, rheumatoid arthritis, skin cancer and breast cancer. The tripterine nano structure lipid carrier is characterized by comprising the following components in parts by weight: 1 part of tripterine, 5-100 parts of mixed lipid, 0.5-10 parts of phospholipid, 0.1-15 parts of poloxamer-188 and 0.5-10 parts of vitamin E and tocopherol polyethylene glycol succinate, wherein the mixed lipid is composed of solid lipid monoglycerine and liquid lipid octylic acid / caprin according to the weight ratio of 1: 0.1-10: 1. Tripterine is prepared into the nano structure lipid carrier, the tripterine nano structure lipid carrier in a semi-solid or liquid preparation form is applied in a transdermal way, bioavailability of the tripterine can be improved, toxic response of tripterine can be reduced, and the nano structure lipid carrier provided by the invention has great clinical application value in the improvement of the treatment effect of tripterine.

The invention relates to a composite drug carried microsphere, a minocycline hydrochloride nano controlled-release composite drug carried microsphere system and a preparation method thereof. A drug carried system with a nuclear shell structure is formed by embedding minocycline hydrochloride inside a poly D,L-lactide-co-glycolic acid polymer microsphere and covering a cationic polymeric liposome prepared from O-QACMC modified by polyethylene glycol, O-QACMC and cholesterol outside the poly D, L-lactide-co-glycolic acid polymer microsphere; and the composite drug carried microsphere system covered and carried with the minocycline hydrochloride has the grain diameter ranging from 340 nm to 400 nm and positive surface Zeta electric potential. The composite drug carried microsphere system can be remained in a water solution for at least 2 months, has high entrapment rate reaching larger than 90 percent on drugs and strong drug carrying capacity reaching 9 percent. The minocycline hydrochloride nano controlled-release composite drug carried microsphere system has the characteristics of uniform and controllable grain diameter, good preparation stability, simple preparation process, high drug carrying rate, favorable controlled release function, and the like, and is suitable for batch production.

The invention provides the application of a polymer system based on beta-cyclodextrin in P-glycoprotein of suppressive tumour cells. The polymer consists of the beta-cyclodextrin and grafted amphipathy polymer. The star-shaped amphipathy polymer based on beta-CD and provided by the invention has remarkable effect of restraining P-gp protein, and the restraining effect thereof is obviously superior to the inhibitor CsA of the P-gp protein. The polymer of the invention has the characteristics of low cytotoxicity, good biocompatibility, biodegradability, long intracorporeal circulation time and the like, and provides an ideal dose carrier material for hydrophobic antineoplastic agents.

The invention provides a contrast medium used for glioma targeted magnetic resonance and fluorescence dual modality imaging, and a preparation method thereof. The contrast medium is composed of an acrylamide monomer, an allyl monmer containing sulfhydryl or carboxyl or amidogen, superparamagnetic iron oxide nanoparticles, a fluorochrome and lactoferrin. The preparation method comprises following steps: the acrylamide monomer and the allyl monmer containing sulfhydryl or carboxyl or amidogen are subjected to polymerization reaction so as to obtain a copolymer nanogel; the superparamagnetic iron oxide nanoparticles are added in polymerization reaction process so as to obtain a superparamagnetic copolymer nanogel; the fluorochrome and lactoferrin and combined via covalent bonds so as to obtain fluorochrome labeled lactoferrin; and the superparamagnetic copolymer nanogel and fluorochrome labeled lactoferrin are combined via covalent bonds so as to obtain the contrast medium used for glioma targeted magnetic resonance and fluorescence dual modality imaging. The contrast medium possesses characteristics such as high specificity, selectivity and contrast effect, and low toxic and side effect; and is capable of realizing dual modality imaging.

The invention relates to star amphipathic polyurethane and a preparation method thereof. According to the technical scheme, the preparation method, which is performed at 50-100 DEG C in the presence of nitrogen gas under a stirring condition, comprises the following steps: adding polyester diol and diisocyanate into a non-proton solvent, stirring for 1-10 hours, then, adding methoxy polyethylene glycol and further stirring for 1-10 hours to obtain linear polyurethane prepolymer; and then, adding polyalcohol into the linear polyurethane prepolymer and further stirring for 1-7 hours to obtain the star amphipathic polyurethane. According to the star amphipathic polyurethane and the preparation method thereof, the raw material source is rich and the preparation process is simple; the prepared star amphipathic polyurethane has the characteristics of good biocompatibility, excellent biodegradability, relatively small critical micelle concentration and relatively high medicine-carrying capacity, and can achieve efficient, low-toxic and sustained-release effects while being used as a medicine carrier.

The invention discloses a preparation method of hydrogel. The preparation method has the advantages that the electrostatic interaction between TEMPO oxidized cellulose nano fibrils and water-soluble positive ion beta-CD polymer is used as the basis, the electrostatic interaction is further enhanced through the synergic effect of aminated nano-silver particles and the positive ion beta-CD polymer to double the content of the water-soluble positive ion beta-CD polymer, and the adsorption and drug loading performance of the water-soluble positive ion beta-CD polymer are increased greatly; meanwhile, the nano silver particles and the cellulose nano fibrils can also be used as the enhancement phase to increase the mechanical strength and viscoelasticity of the hydrogel; the use of toxic crosslinking agents during hydrogel assembling is avoided, the preparation conditions are mild, high crosslinking speed is achieved, the prepared hydrogel is good in biocompatibility and biodegradability andhas certain antibacterial performance, the identification and inclusion properties of cyclodextrin to hydrophobic molecules are kept, and the hydrogel has excellent hydrophobic drug loading capacityand excellent sustained release ability under different pH conditions.

The invention relates to a drug-loaded embolism microsphere with a developing function and a preparation method thereof, and belongs to the technical field of medical instruments. The preparation method of drug-loaded embolism microsphere with the developing function under X-rays comprises the following steps of step 1, preparing a reversed-phase suspension polymerization oil phase; step 2, preparing an aqueous phase of a reversed-phase suspension polymerization system; and 3, carrying out reverse suspension polymerization. The method has the advantages that iodide reacts with microsphere hostmolecules in the synthetic reaction process, a steric hindrance effect is avoided, the reaction is more sufficient, the iodine element is uniformly distributed in the microspheres, and a complete andclear development image is formed under X-ray fluoroscopy; the iodine-containing alcohol is used as an X-ray-impermeable substance, so that the safety risk caused by additional addition of an organicsolvent or addition of a toxic and difficult-to-remove organic solvent is avoided; the microspheres are high in hydrophilicity, good in expansion capacity and rapid in adsorption and drug loading capacity and high in drug loading capacity. The preparation method is simple and can be completed through one-time polymerization reaction, and grafting modification and then polymerization reaction arenot needed.

The invention relates to an amphiphilic block copolymer micelle containing a lepidopteron sex pheromone, wherein one of a plutella xylostella sex pheromone, a prodenia litura sex pheromone and a beet armyworm sex pheromone is adopted as the lepidopteron sex pheromone. A waterborne block of an amphiphilic block copolymer comprises at least a polyethylene glycol (MPEG) series polymer unit, and a lipophilic block comprises at least a polycaprolactone (PCL) series polymer unit. MPEG-PCL has the good biocompatibility and the good medicine passing ability for small-molecule medicine, is high in medicine loading capacity and good in stability and is a biodegradable and environment-friendly material; in addition, the usage amount of organic solvent is little in the preparation process, so that environment pollution in the usage process is avoided; the lepidopteron sex pheromone is slowly released through pores in the wall, so that the effect of lasting and stable releasing is achieved.

The invention discloses a preparation method of an asymmetric composite sponge. The method comprises preparing sodium carboxymethyl cellulose into a solution with a concentration of 1% with distilled water, and preparing chitosan with dilute acetic acid into a solution with a concentration of 1%. The gelatin is made into a solution with a concentration of 1% with warm water; sodium carboxymethyl cellulose, gelatin and chitosan are measured according to the ratio of 1:0.5~3:0.5~3 by volume, left standing for defoaming, poured into In the membrane device, the sponge product is obtained by vacuum freeze-drying; put the sponge product into a watch glass of carbodiimide solution, seal it with a plastic wrap, place it on a decolorizing shaker, vibrate for 24 hours, add distilled water, and seal the mouth with a plastic wrap , placed on a shaker, shaken for 1 h, and repeated this operation three times. The cross-linked sponge is pre-frozen twice and dried to obtain an asymmetric composite sponge. The product prepared by the invention has strong hemostatic effect, is convenient for clinical use, and has good water absorption and water retention properties and drug loading performance.

The invention relates to cationic polyhydroxylated polymer embolization microspheres and a preparation method thereof, and belongs to the technical field of biomedical polymer materials. The cationicpolyhydroxylated polymer embolization microspheres are formed by cross-linking and polymerizing functional macromolecules with biocompatibility through an amino compound, an alkyl acid derivative andan amino alkyl acid derivative or an ammonium salt thereof serving as a cross-linking agent; a main chain of each cationic polyhydroxylated polymer embolization microsphere is provided with a 1,2-glycol or 1,3-glycol structural functional group, and is also provided with an amino acetal or ester structure; a side chain is an amino alkyl olefine acid derivative. Compared with the existing polyvinylalcohol cationic microspheres, the microspheres greatly simplify the types of raw materials, reduce raw material purchase cost, and simplify a production process, and meanwhile, avoid environmental pollution caused by discharging a large number of dispersing agents and organic solvents.

The invention belongs to the field of biomedical materials, and specifically relates to a responsive drug-release microneedle patch and a preparation method thereof. The microneedle patch provided bythe invention comprises a needle tip and a base, wherein the base extends outwards in the direction of the needle tip to form a column base; the needle tip is located on the column base and comprisesresponsive cross-linked macromolecules, drugs and bioactive macromolecules; the responsive cross-linked macromolecules and the bioactive macromolecules are subjected to a cross-linking reaction to generate a response group and then wrap the drugs; and the response group can be decrosslinked under the triggering of active oxygen to release the drugs. According to the invention, the drug-carrying needle tip can be left in the skin through separation of the needle tip and the base, and programmed release of the drugs can be achieved through wrapping of the drugs with the responsive cross-linked macromolecules of the needle tip, so the purpose of continuous treatment is achieved, and the treatment effect is improved.

The invention relates to medicine-carried black phosphorus shell glycan composite nanospheres and a preparation method and application thereof. The medicine-carried black phosphorus shell glycan composite nanospheres are glycan nanospheres of which the surface modified with polyethylene glycol, and which are packed with black phosphorus quantum dots and medicines. The black phosphorus quantum dots, glycan and polyethylene glycol are creatively combined, the advantage of synergy is exerted, and the protective screen of a respiratory tract mucous layer and a pathogenic bacteria biomembrane can be efficiently broken through, so that the nanospheres have favorable capacity of carrying and delivering medicines, and the nanospheres are broad in application range. According to the nanospheres, various treatment medicines can be loaded, the treatment effect of the medicines can be increased, and the bad toxic and side effects can be reduced. Besides, the nanospheres have favorable biocompatibility. The medicine-carried black phosphorus shell glycan composite nanospheres provide a new strategy for treatment of respiratory diseases.

A chain of hollow nanoparticles made of polycrystal noble metal (Au, Pd, or Pt) is prepared through dissolving polyvinyl pyrrolidone in inertial gas and uniform magnetic field while stirring, adding hexahydrated cobalt chloride powder, dropping the aqueous solution of sodium bromohydride, adding the solution of AuCl3, PdCl6 or PtCl6 to obtain coarse product, and purifying.

The invention relates to a preparation method of a porous silicon hydrogel interpenetrating network (IPN) membrane, which comprises the following steps: (1) respectively dissolving polyethylene glycol in CaCl2 solution and Na2CO3 solution, adding sodium lauryl sulfate to one solution, and adding the sodium lauryl sulfate to the other solution; (2) adding CaCO3 microspheric powder to aluminum-zirconium coupling agent aqueous solution; (3) dissolving dimethyl polysiloxane, tetraethyl orthosilicate and stannous octoate in isopropanol, and adding CaCO3 template particles to obtain a PDMS first network membrane; (4) adding isopropanol to a mixed liquor of hydroxyethyl methacrylate (HEMA), azoisobutyronitrile and N,N'-dimethylene diacrylamide; and soaking the first network membrane in the mixed liquor to obtain PDMS / PHEMA IPN; and (5) soaking the first network membrane in dilute hydrochloric acid, and carrying out oscillating with ultrasonic wave to obtain the porous silicon hydrogel IPN membrane. The method is simple and suitable for industrial production; and the IPN membrane has an interpenetrating porous structure, and has the advantages of favorable water-retaining property and high drug loading capacity.

The invention provides a nanometer vaccine. The nanometer vaccine is a nanoparticle simultaneously loaded with tumor neoantigen and two adjuvants thereof. The invention also provides a composition used for preparing the nanometer vaccine. The composition comprises a micromolecular adjuvant R848, an amphiphilic diblock polymer containing a polyethylene glycol chain segment and with terminal modified with a maleamide bond, a nucleic acid adjuvant CpG, polyethylene glycol modified polypeptide and a tumor neoantigen. The nanometer vaccine disclosed by the invention has a significant immune activation effect and a good antigen-specific tumor inhibition effect in vivo and in vitro. The invention also provides a method for preparing the nanometer vaccine and an application of the nanometer vaccine in preparation of tumor vaccine drugs.

The invention relates to a preparation method for albumin nano-particles and the albumin nano-particles prepared by the method and a pharmaceutical use of the albumin nano-particles. The preparation method comprises the following steps: 1) dissolving the albumin in urea solution, uniformly mixing, adding sodium borohydride solution to obtain the urea solution of albuminate; and 2) adding absolute ethyl alcohol or other organic solvents to the urea solution of the albuminate, and adding purified water, namely forming the albumin nano-particles. In addition, the invention further relates to the albumin nano-particles prepared by the method and the pharmaceutical use of the albumin nano-particles.

Antineoplastic dendritic polymer conjugates which are useful drug delivery systems for carrying antineoplastic agents to malignant tumors are prepared. The antineoplastic agent is encapsulated within the dendritic polymer using an ionic charge shunt mechanism, whereby, the antineoplastic agent interacts with the anionic functional groups on the surface of the dendritic polymer allowing the antineoplastic agent to be uptaken by the dendritic polymer through an association with the functional groups of the interior of the dendritic polymer. The antineoplastic dendritic polymer conjugates may be administered intravenously, orally, parentally, subcutaneously, intraarterially or topically to an animal having a malignant tumor in an amount which is effective to inhibit growth of the malignant tumor. The antineoplastic dendritic polymer conjugates exhibit high drug efficiency, high drug carrying capacity, good water solubility, good stability on storage, and reduced toxicity.

The invention discloses a hollow SiO2 wrapped hollow Au cage nanometer bell and a preparing method and application thereof. The nanometer bell comprises a hollow SiO2 micro ball and a hollow Au cage movably arranged in an inner cavity of the hollow SiO2 micro ball. The preparing method of the nanometer bell comprises the steps that an Ag cuboid and the like are utilized as a template, the hollow Au cage is manufactured, Raman signal molecule modification and SiO2 shell layer wrapping are carried out on the surface of the Au cage, and an SiO2 wrapped hollow Au cage core-shell structure nanometer particle is formed; and in addition, the selective surface etching is carried out on the core-shell structure nanometer particle, and the nanometer bell is prepared. The nanometer bell has high stability and biocompatibility and can serve as a good medicine carrier, the absorption in a near-infrared area can be adjusted, the light energy of near-infrared lasers is converted into heat energy, meanwhile, the Raman signal can be enhanced, and huge application prospects are achieved in the medical fields such as medicine carrying, photo-thermal treatment and Raman imaging.

The invention belongs to the field of medicine preparations and relates to a formula of a lipid carrier of curcumin in a nano structure and a preparation method of the lipid carrier. The lipid carrier of curcumin in the nano structure extremely overcomes the deficiencies that curcumin is difficult to be dissolved in water, low in oral bioavailability, fast in metabolism and the like, provides a novel selectable transfer system for curcumin and has important meaning.

The invention relates to an anti-tumor dendric polypeptide macromolecule medicine vector system and application thereof in pharmacy. The dendric polypeptide macromolecule can be prepared by the solid phase, liquid phase or solid-liquid combination method of single or different natural amino acids, and can be used for preparing a vector release system which is loaded with malignant tumor resisting treatment medicines. The dendric polypeptide macromolecule medicine vector system is a covalent bond vector medicine system in which anti-tumor activity micromolecule medicines are sealed in dendric polypeptide macromolecule polymers, or the anti-tumor activity micromolecules are combined with functional groups on the surfaces of the anti-tumor dendric polypeptide macromolecules. The dendric polypeptide macromolecule medicine vector system can correspondingly inhibit growth of the malignant tumor and is applied to a patient suffered from the malignant tumor in the modes of venous, oral-taking, endermic and arterial administration or local administration. The anti-tumor dendric polypeptide macromolecule medicine vector system has the advantages of high targeting property, high medicine carrying capability, good waster solubility and stability and lower toxicity.

A preparation method of porous hollow calcium carbonate drug-loaded microspheres comprises the following steps of: (1) culturing of microbial cells: adding strains into a liquid culture medium, takingprecipitates, and putting the precipitates into a NaCl solution for resuspension for later use; (2) preparation of a strain surface layer-by-layer self-assembly coating: alternately adding the strains into a polydiene dimethyl ammonium chloride solution and a polystyrene sulfonic acid solution to obtain strain cells coated with polyelectrolyte on the surface; (3) calcium salt pretreatment: addingthe strain cells into a Ca<2+> solution, magnetically stirring and fully and uniformly mixing; (4) preparation of calcium carbonate shells: dropwise adding CO3<2-> solution with the same amount intothe solution, and magnetically stirring for 16 hours; and repeatedly cleaning with pure water, and then drying and grinding, thus obtaining nano calcium carbonate shells on the surfaces of the straincells. and (5) preparation of the porous hollow calcium carbonate microspheres: putting the nano calcium carbonate shell particles into a tubular furnace, and removing strain cells in the inner layerto obtain the hollow porous calcium carbonate microspheres. The method is low in cost and simple in preparation process.

The present invention relates to a metal implant having antibacterial and osteosynthesis-promoting functions and a preparation method thereof, and the method comprises (1) preparing a metal implant, (2) subjecting the metal implant to surface treatment by using a micro-arc oxidation method, and covering the surface of the metal implant with a micro-arc oxidation coating containing calcium and phosphorus elements; (3) immersing the metal implant treated in the step (2) into a dopamine hydrochloride solution with the concentration of 2 to 5 mg / mL, and shaking at constant temperature of 30 to 45DEG C for 20 to 24 hours; (4) using deionized water or distilled water as a solvent, adding heparin sodium to prepare a heparin sodium solution with the concentration of 1 to 5 mg / mL, using the heparin sodium solution as a solvent, and adding vancomycin hydrochloride for preparing a vancomycin hydrochloride solution with a concentration of 50-200 mug / mL; immersing the metal implant treated in thestep (3) in the vancomycin hydrochloride solution, and shaking at constant temperature of 30 to 45 DEG C for 3 to 12 hours to obtain the metal implant.

The invention relates to a thermosensitive liposome, which contains at least one phosphatidylcholine, at least one lysophospholipid, and at least one unsaturated phospholipid. The phase temperature of the liposome is 39.0DEG C-45.0DEG C. The liposome further contains a material having a long circulating characteristic and a fat-soluble active agent. Specifically, the phosphatidylcholine, the lysophospholipid, the unsaturated phospholipid, and the material having a long cycle characteristic are in a weight ratio of 69-94:1-6:1-10:4-15. And all the phospholipids and the fat-soluble active agent are in a weight ratio of 30-120:1-10. The invention also relates to a pharmaceutical composition containing the thermosensitive liposome. The invention additionally relates to application of the thermosensitive liposome and the pharmaceutical composition in preparing drugs treating tumors.