52results about How to "With sustained release effect" patented technology

The invention belongs to the field of pharmaceutical preparations, and relates to activated neutrophil membrane coated neutrophil like nanoparticles and a preparation method. According to the activated neutrophil membrane coated like nanoparticles and the preparation method disclosed by the invention, a polymer, namely a poly(lactic-co-glycolic acid) copolymer PLGA, or a poly(lactic acid) copolymer PLA, or a polycaprolactone copolymer PCL is used as a material for preparing nanoparticles, the nanoparticles are used as kernels and are used for coating and loading model medicines, natural activated neutrophil membranes as a shell are used for coating the surfaces of the nanoparticles, and an activated neutrophil membrane coated biodegradable neutrophil like particle nanometer carrier system is prepared. Experiments in vivo and vitro indicate that the like particle nanometer carrier system can have the characteristics of being high in targetability and high in efficiency in accordance with a like treatment system for circulating tumor cells and micrometastases, provides new thought for individual and precision treatment and has higher clinical practice significance.

The invention provides a method for preparing a flower organic slow-release fertilizer by utilizing municipal sludge, comprising the following steps of: airing and dewatering raw sludge, crushing, adding microbes and dilatants, stack retting and fermenting, baking, crushing, sieving, adding inorganic fertilizers, pelleting, baking for the second time, cooling, sieving and metering packaging. The method for preparing the flower organic slow-release fertilizer by utilizing the municipal sludge has simple production process and low production cost and comprehensively utilizes municipal sewage to treat generated sludge, i.e. turns harm into good and changes waste into valuable, thereby realizing sludge reduction, harmlessness and reclamation. The invention provides an effective technical method and way.

The invention relates to a microbial fertilizer and a preparation method and application thereof, in particular to a rice hull carbon-based microbial fertilizer and a preparation method and application thereof, and aims at solving the problems that after an existing microbial fertilizer is applied, due to the low microbial content, the poor microbial activity and the weak microbial competitiveness, the yield of crops is low. The rice hull carbon-based microbial fertilizer is prepared from 50-70% of rice hull charcoal, 9-11% of beneficial microorganism complex microbial inoculant, 9-11% of binder and the balance nutrient elements. The preparation method includes the steps of 1, processing of the rice hull charcoal; 2, preprocessing of the nutritive elements; 3, fungicide compounding; 4, preparation of the rice hull carbon-based microbial fertilizer. According to the application, the rice hull carbon-based microbial fertilizer is added into chemical fertilizer according to the additive amount of 3%-5% by mass for being used. The rice hull carbon-based microbial fertilizer provides a perfect habitat for probiotics, crop growth can be stimulated, metabolism of the crops can be adjusted, the yield is increased obviously, the fertilizer efficiency is durable, and the per mu yield of the crops is increased by 8%-23%. The preparation method and application are suitable for the rice hull carbon-based microbial fertilizer.

The invention relates to dinotefuran granules and a preparation method thereof. The dinotefuran granules have effective components of dinotefuran and the balance of pesticide adjuvant and carriers, wherein the mass percent of the dinotefuran in the dinotefuran granules is 0.01-10%. The invention also discloses the preparation method of the dinotefuran granules. The dinotefuran granules provided by the invention are suitable for controlling pests of crops such as rice, wheat, vegetables, fruit trees, etc.

The invention relates to an organic fertilizer used for hillside planting. Hillsides are high in terrain, so that precautions should be taken for water retention and prevention of water and fertilizer loss. In addition, the bottom layer of a hillside planting field mainly comprises rock, and the like, and organic matters and mineral compounds may be poor, so that root extension is disadvantageous. Aiming at the abovementioned disadvantages, common crop waste straw are dipped, softened, pulped and mixed with microbial flora for the fertilizer, thus providing the soil with rich organic matters. Moss soil and the like have good modification functions for rock. The microbial flora comprises bacillus licheniformis, escherichia coli, azotobacter, and the like, improves soil quality and promotes absorption of inorganic mineral compounds and nutrients for roots and stems. The inside of the fertilizer comprises resin-covered NPK components. The whole fertilizer has a slow release function, reduces the using amount of the fertilizer and increases economic benefit.

The invention discloses a novel efficient biochar-based water-retaining dedicated crop fertilizer, prepared from, by weight, 100-300 parts of urea, 350-500 parts of monoammonium phosphate, 100-300 parts of potassium chloride, 0-15 parts of calcium magnesium phosphate fertilizer, 40-100 parts of biochar, 0-30 parts of EDTA (ethylene diamine tetraacetic acid) chelated trace elements, 0-15 parts of polyglutamic acid, and 0-100 parts of additives. The preparation process of the fertilizer is simple, the fertilizer contains biochar, polyglutamic acid and various trace nutrients and can improve soil environmental conditions, land utilization and land maintenance are combined, crop yield is increased, and the fertilizer has high efficiency and zero pollution.

The invention discloses a hydroxycamptothecin slow-release microsphere and a preparation method thereof, relates to an anti-tumor pharmaceutical preparation and provides a hydroxycamptothecin slow-release microsphere and a preparation method thereof with long time of continuous drug release, stable drug release and high drug utilization; a carrier is polylactic acid, anti-cancer drug of hydroxycamptothecin is packed in the carrier and a modifying layer of water soluble derivative of chitosan is arranged on the surface of the carrier; the hydroxycamptothecin and the polylactic acid are dissolved in an organic solvent so as to obtain solution A; polyvinyl alcohol solution with the concentration of 0.5 percent to 5 percent is prepared and sodium dodecyl sulfate is added to prepare mixed solution B with the concentration of 0.5 percent to 1 percent; the solution A is transferred into a disperse phase container of a film emulsifier, the mixed solution B is added into a continuous phase container, a water suction pump is started to lead the continuous phase to be cycled, a mobile phase is collected, a certain pressure is maintained and a pressure indicating value which is operated to the film emulsifier is reduced to 0kPa. The collected mobile phase is centrifugated, precipitation is collected and freeze-dried to obtain the unmodified drug-carrying microsphere and then the surface modifying of the microsphere is carried out.

The invention relates to a drug compound playing the role of diminishing inflammation, alleviating pain and eliminating fever and being used for treating arthritis, odynolysis and pyrexia caused by upper respiratory tract infection, and particularly relates to a drug compound oral pharmaceutical formulation adopting nimesulide as the ingredient and being prepared jointly with the medicinal carrier used as the stroma. The drug compound aims to supplement the deficiency of the prior oral nimesulide pharmaceutical formulation and provide a drug compound oral formulation, sustained-release nimesulide dropping pill which has high bioavailability, controllable release time, long-acting effect, reduced frequency of drug taking for a patient, low cost and absence of contamination during the production. The sustained-release nimesulide dropping pill adopts nimesulide as the chemical ingredient and is prepared jointly with the medicinal carriers of hydrophilic frame ingredients and hydrophobic frame ingredients used as the stroma.

The invention relates to the field of organic-inorganic composite materials, and in particular relates to a slow-release double-effect pesticide and a preparation method thereof. The preparation method comprises the following steps: intercalating MCPA-(2-Methyl-4-chlorophenoxyacetic acid radical) into a hydrotalcite precursor, intercalating chlorpyrifos into the hydrotalcite precursor, and finallytreating the hydrotalcite precursor in a mixed solution containing hydrogen peroxide, n-propanol and water to obtain a slow-release double-effect pesticide; the chemical formula is: [(M<2 +>) 1-x (M<3 +>) x (OH) 2) x +( MCPA-)x (CPF) y.mH2O, wherein x = 0.25-0.33, y = 0.08-0.10, m = 3-6, m is the number of interlayer crystalline water molecules, M<2 +> is a divalent metal ion, M<3 +> is a trivalent metal ion, MCPA-is 2-Methyl-4-chlorophenoxyacetic acid radical, and CPF is chlorpyrifos. The slow-release double-effect pesticide of the invention has stable intercalation structure, can release the MCPA-and the chlorpyrifos l for a long time, and plays a slow-release effect.

The invention relates to the field of organic-inorganic composite materials, in particular to a sustained-release phoxim pesticide and a preparation method thereof. The method includes: low-release phoxim pesticide and a preparation method thereof. The preparation method comprises the following steps: intercalating a naphthylacetic acid group into a hydrotalcite precursor; and then intercalating phoxim into the hydrotalcite precursor to obtain phoxim / naphthylacetic acid intercalated hydrotalcite; and putting the hydrotalcite into a mixed solution containing hydrogen peroxide, ethanol and waterfor ultrasonic treatment, thus obtaining the sustained-release phoxim pesticide, the chemical formula of which is shown as [(M<2+>)1-x(M3<+>)x(OH)2]<x+>(NAA<->)x(Phoxim)y.mH2O, wherein x=0.25-0.33, y=0.04-0.05, m=3-6, m is the number of interlayer crystal water molecules, M<2+> is a divalent metal ion, M<3+> is a trivalent metal ion, and Phoxim is phoxim. The sustained-release phoxim pesticide provided by the invention has a stable intercalation structure, can release phoxim for a long time and reach a sustained-release effect, and the preparation method is easy to realize.

The invention discloses an antivirus drug compound and particularly relates to an oral pharmaceutical preparation adopting famciclovir as the ingredient and being prepared jointly with the medicinal carrier used as the stroma. The antivirus drug compound aims to supplement the deficiency of the prior antivirus oral pharmaceutical preparation and provide a sustained-release famciclovir dropping pill which has high bioavailability, fast effect, high drug content, low frequency of drug taking, full release, convenient drug taking, low cost and absence of contamination during the production. The sustained-release famciclovir dropping pill adopts famciclovir as the ingredient and is prepared jointly with the medicinal carriers of mixing hydrophilic frame ingredients and hydrophobic frame ingredients as the stroma.

The invention discloses a PLGA-PEG-ZOL drug-loaded nano-material specifically targeting bone tissues. The shell surface of PLGA is coupled with zoledronic acid, so the obtained PLGA has the in vivo targeting ability to actively target the bone tissues, and the PLGA has a treatment effect on osteoporosis and osteolysis, so the obtained PLGA can be used as a drug carrier shell to encapsulate a therapeutic drug in order to delay the initial burst release dose of the drug, prolong the half-life of the drug and increase the stability and the solubility of the drug, and enables nanoparticles to havea certain sustained release effect and a passive targeting property, that is, the PLGA-PEG-ZOL drug-loaded nano-material can be loaded with different drugs and target the drugs to the bone tissues according to different treatment demands in order to increase the drug concentration of the drugs in bone tissues, thereby the nano-material has the potential to be suitable for multiple skeletal systemdiseases. The invention also discloses a preparation method of the drug-loaded nanomaterial. The preparation method has the advantages of simple process, and easiness in operation.

The invention discloses a hydroxycamptothecin slow-release microsphere and a preparation method thereof, relates to an anti-tumor pharmaceutical preparation and provides a hydroxycamptothecin slow-release microsphere and a preparation method thereof with long time of continuous drug release, stable drug release and high drug utilization; a carrier is polylactic acid, anti-cancer drug of hydroxycamptothecin is packed in the carrier and a modifying layer of water soluble derivative of chitosan is arranged on the surface of the carrier; the hydroxycamptothecin and the polylactic acid are dissolved in an organic solvent so as to obtain solution A; polyvinyl alcohol solution with the concentration of 0.5 percent to 5 percent is prepared and sodium dodecyl sulfate is added to prepare mixed solution B with the concentration of 0.5 percent to 1 percent; the solution A is transferred into a disperse phase container of a film emulsifier, the mixed solution B is added into a continuous phase container, a water suction pump is started to lead the continuous phase to be cycled, a mobile phase is collected, a certain pressure is maintained and a pressure indicating value which is operated to the film emulsifier is reduced to 0kPa. The collected mobile phase is centrifugated, precipitation is collected and freeze-dried to obtain the unmodified drug-carrying microsphere and then the surface modifying of the microsphere is carried out.

The invention relates to a functional fertilizer for high-yield jujube trees. The fertilizer is suitable for jujube trees, and other perennial trees. Jujube trees blossom and yield fruits every year and need a large amount of nutrition elements and mineral compounds. In order to ensure fruits with high quality, fertilizing of NPK components is essential; and a plurality of mineral elements are needed to maintain fruit quality, enhance stress resistance and vitality of the trees. The fertilizer adopts waste chicken beds, waste edible mushroom culturing materials, sorghum vinasse, and other compound type organic matters, so that nutritions are various, pollution is prevented, and waste materials are utilized. A plurality of mineral elements except the NPK components are enveloped in the inside, so that the fertilizer has a slow release function, is long-term effective and is free of frequent fertilizing.

The invention discloses a medicinal composition which can clear heat, promote diuresis, remove heat from the blood and toxic substances, eliminate stagnation and relieve pains and is used for curing disease such as hemorrhage of cancer pain, in particular to a slow releasing oral preparation of the medicinal composition, which is prepared by using Chinese medicines of radices sophorae flavescentis and Rhizoma Hterosmilacis as raw materials and a pharmaceutical carrier as a substrate. The invention aims at supplementing the deficiencies of existing injection and oral pharmaceutical preparations and providing an oral compound radices sophorae flavescentis slow releasing drop pill which is suitable for family use and has the advantages of high biological availability, less medicine-taking times, long effective time, instant effect, small toxic and side-effect, low manufacturing and medical treatment cost and low price. The compound radices sophorae flavescentis slow releasing drop pill, which the invention relates to, is prepared by taking the Chinese medicines radices sophorae flavescentis and Rhizoma Hterosmilacis as the raw materials and taking the pharmaceutical carrier as the substrate.

The invention provides an insect-repelling waterborne wood coating. The insect-repelling waterborne wood coating is prepared from components in parts by weight as follows: 20-25 parts of a styrene-acrylic emulsion, 8-10 parts of an insect-repelling agent, 1-2 parts of a dispersant, 0.8-1.5 parts of a defoamer, 1-3 parts of a coalescing agent, 0.5-1.5 parts of benzophenone and 59-66 parts of water; the insect-repelling agent is chitosan with pyrethrin supported. A preparation method of the insect-repelling waterborne wood coating comprises steps as follows: pyrethrin is dissolved in ethanol, a pyrethrin-ethanol solution is prepared, chitosan is dissolved in a 3wt% acetic acid water solution, and a chitosan water solution is prepared, the pyrethrin-ethanol solution and the chitosan water solution are mixed uniformly, spray drying is performed, and the chitosan with pyrethrin supported is obtained. The provided insect-repelling waterborne wood coating adopts the chitosan with pyrethrin supported as the insect-repelling agent and has the characteristics of being low in toxicity, safe, efficient and high in stability, besides, pyrethrin has a slow release efficacy, and the insect-repelling time of the coating can be prolonged.

The invention relates to a preparation method of a coated type muscovado sugar modified nano-iron groundwater remediation agent and belongs to the field of groundwater remediation. According to the preparation method, firstly, a nano-iron material is modified with muscovado sugar, then the modified nano-iron surface is coated with a polymer film layer with an emulsion polymerization method, and the coated type muscovado sugar modified nano-iron groundwater remediation agent is prepared. According to the prepared groundwater remediation agent, nano-iron is taken as a functional core, the nano-iron surface is modified with the muscovado sugar, so that the dispersity of nano-iron is improved, and the problem that a traditional nano-iron material is prone to agglomeration is solved; modified nano-iron is coated with acrylic resin and is prevented from being directly contacted with air accordingly, the defects that nano-iron combusts spontaneously due to direct exposure to the air and is oxidized when contacted with the air, and surface activity is damaged because of generation of an iron oxide film on the surface are overcome, and the coated type muscovado sugar modified nano-iron groundwater remediation agent is a novel and efficient groundwater remediation agent and has broad application prospect.

The invention discloses a drug containing sustained-release ornidazole drug and used for treating infections of trichmonad, amoeba, giardia and anaerobic organism in gynecopathy as well as the preparation method thereof. The drug aims to provide a sustained-release ornidazole dropping pill formulation which has excellent curative effect, low toxic and side effects, broad-spectrum antibacterium, safer use, low frequency of drug taking and long effective hours and is prepared by adopting the solid dispersion technology, thereby thoroughly changing the defects existing in conventional oral formulations from the drug structure. The sustained-release ornidazole dropping pill adopts ornidazole as the ingredient and is prepared jointly with the medicinal carrier used as the stroma.

The invention relates to a drug compound which has the efficacies of dispelling wind, removing dampness, stimulating the circulation of blood, relaxing muscles and joints, subsiding swellings and relieving pain, and is used for treating rheumatic diseases. The drug compound aims to supplement the deficiencies of the prior oral pharmaceutical preparation used for treating the symptoms of rheumatoid arthritis (The symptoms are that joints are swollen, painful and hard to straighten, the limbs are chill tender and cold weather worsens the situation, and waist and legs lack strength or chill and fever jumble.) and provide a combined oral pharmaceutical preparation, thunder god vine total terpene slow-release dropping pill which has the advantages that the bioavailability is high, the effect is rapid, the release time is long, the taking frequency is low, toxic and side effects are small, the medicine content is high, the dose is small, the dose is precise, the medicine-taking is convenient, the price is low and the portability is available. The dropping pill is prepared according to a definite ingredient constitution by adopting the thunder god vine extractive as the ingredient and by adopting a hydrophilic framework material and a hydrophobic framework material as the stroma.

The invention relates to oxaziclomefone particles. The oxaziclomefone particles comprises oxaziclomefone as an active ingredient and the balance auxiliary agents. The oxaziclomefone particles comprise 0.01 to 5wt% of oxaziclomefone, are suitable for preventing and controlling annual weed in the paddy field and are safe and efficient herbicides convenient for use.

The invention relates to a fibrauretine sustained-release pill having the antibacterial and antiphlogistic action as well as a preparation method thereof. The invention aims at providing a medicine(the fibrauretine sustained-release pill) which takes fibrauretine as effective constituent and has the antibacterial and antiphlogistic action; compared with the existing oral preparation at the market, the pill has the advantages that: 1. the deficiency of the existing oral pharmaceutical preparation is made up and a pill preparation which has high bioavailability and rapid effect is provided; 2. after being made into the sustained-release pill, the medication content is high, the medicine release is controllable, the time of taking the medicine by the patient is few, the medicine taking is convenient, the price is low; 3. the production equipment is simple and no pollution is generated in the production. The fibrauretine sustained-release pill related by the invention takes the fibrauretine which is the effective constituent of calamus margaritae of traditional Chinese medicine as raw material and can be prepared together with medicated carrier that takes hydrophilic framework material and hydrophobic framework material as stroma.

The invention discloses an environment-friendly slow-release snow-melting agent, a preparation method thereof and application of the snow-melting agent in a micro-surfacing mixture, and aims to solve the technical problems that an existing snow-melting agent is large in side effect, and an existing micro-surfacing mixture is single in pavement performance and insufficient in wear resistance and high-temperature stability. The environment-friendly slow-release snow-melting agent is prepared from the graphene microchips, the white carbon black, the sodium carbonate, the sodium acetate, the calcium acetate, the surface treating agent and the like, is used for modifying the emulsified asphalt and is applied to a micro-surfacing mixture, has the effects of repairing an old pavement, preventing a new pavement from cracking and actively melting ice and snow, and is excellent in pavement performance; in the whole service period, the ice and snow removing effect, the high and low temperature performance and the abrasion resistance are good, and good economic benefits and social benefits are achieved.

The invention belongs to the technical field of organic-inorganic composite materials, and particularly relates to a slow-release bactericide suitable for a hospital environment and a preparation method of the slow-release bactericide. The slow-release bactericide suitable for the hospital environment includes apramycin, dodecylbenzene sulfonate and benzene sulfonate intercalated hydrotalcite. The preparation method comprises the following steps: firstly preparing a hydrotalcite precursor, then intercalating dodecylbenzene sulfonate and benzene sulfonate into the hydrotalcite precursor according to a certain proportion to obviously enlarge the interlayer spacing of hydrotalcite, then mixing the hydrotalcite with an apramycin aqueous solution, and diffusing apramycin into the interlayer of the hydrotalcite to obtain apramycin intercalated hydrotalcite, namely, the slow-release bactericide. According to the invention, the effect of adjusting the apramycin slow release rate can be achieved by adjusting the ratio of dodecylbenzene sulfonate radicals to benzene sulfonate radicals in layers.

The present invention relates to a production device and a production method of a double slow release high dispersion medicinal fertilizer; the production device includes a urea solution pipeline, theurea solution pipeline is connected with a granulation system through a third valve, a fourth flow meter, a first inlet and an outlet of a pipeline mixer, the second inlet of the pipeline mixer is connected with a medicinal fertilizer emulsifying device; the medicinal fertilizer emulsifying device includes a pesticide tank which is connected with one side of the top of an emulsifying tank, a solvent tank is connected with the other side of the top of the emulsifying tank, an emulsifying tank motor is arranged at the middle of the top of the emulsifying tank, an emulsifying tank outlet is connected with the inner chamber of a nozzle through a solution pump, the nozzle is arranged on the lower middle part of a fluidized bed reactor, a middle powder inlet of the fluidized bed reactor is connected with a fertilizer carrier tank by a powder pump, a material outlet at the bottom of the fluidized bed reactor is connected with the second inlet of the pipeline mixer, a pesticide can be evenlydistributed inside a fertilizer without direct contact with the fertilizer, the compatibility effect of the pesticide and the fertilizer is overcome, and the purpose of unified double slow release ofthe pesticide and the fertilizer can be achieved.

The invention relates to an oxaziclozone granule, the active ingredient is oxaziclozone, and the balance is adjuvant. The mass percentage of oxaziclodione in the granules is 0.01%-5%. It is suitable for controlling annual weeds in paddy fields and is a safe, efficient and convenient herbicide.

The invention provides a mercaptamine premix. The mercaptamine premix is prepared from, by weight, 30-60 parts of mercaptamine slow-release particles, 3-5 parts of moisture absorbent, 8-15 parts of polyethylene glycol, 1-3 parts of sodium cyclamate and 40-55 parts of montmorillonite. A preparation method of the mercaptamine slow-release particles includes the following steps that chitosan and carboxymethyl cellulose sodium are dissolved in 3wt% aqueous acetic acid to prepare a solution A, mercaptamine is added into the solution A, and after the materials are stirred and mixed to be uniform, the mercaptamine slow-release particles are prepared through spray drying. The surface of mercaptamine is coated with chitosan and carboxymethyl cellulose sodium through a spray-drying method, a slow-release protective film is formed, the moisture absorption oxidation probability of mercaptamine is effectively reduced, the slow-release effect is achieved, and irritation of mercaptamine to the stomachs and intestines of animals is relieved.

The present invention relates to a preparation method of a targeted graphene nano-drug carrier. The present invention comprises the following steps: mixing a graphene nano-material, a hydrophobic anti-cancer drug, a tumour-targeting molecule and dopamine in an aqueous solution; ultrasonically and uniformly dispersing and adjusting pH to alkaline; magnetic stirring in the dark and stabilizing for some time, then centrifuging and isolating; uniformly dispersing the product in an aqueous solution; and obtaining a targeted nano-drug carrier based on the graphene nano-material. The characteristic of the present invention is as follows: polydopamine is formed by pH-induced self-polymerization of dopamine and during the polymerization, a graphene nano-material, a hydrophobic anti-cancer drug molecule and a tumour-targeting molecule are combined at the same time to achieve the rapid preparation of a targeted drug molecule. The advantages of the present invention are as follows: a targeted nano-drug carrier containing a hydrophobic anti-cancer drug molecule can be rapidly prepared in an aqueous solution at room temperature; the technology of the method is simple and convenient to operate; and has strong practicality and a broad application prospect.

The invention provides a composition with a function of skin repair. The composition is composed of, by weight, 4.5-16% of functional ingredients, 5-10% of additives and 74-90% of deionized water, wherein the sum of weight percentages of the materials is 100%. The functional ingredients include, by weight percentage of the composition, 1-3% of glycerol glycoside, 0.5-0.8% of phosphoinositide choline salt, 0.5-2% of ceramide, 1-5% of glucan, 0.5-1.5% of Radix Scutellariae extract, 0.5-1.5% of Radix Sophorae Flavescentis extract and 0.5-1.5% of Radix Glycyrrhizae extract. The composition is free of toxicity and irritation, excellent in moisturizing effect and capable of removing freckles, reliving redness and swelling and reducing winkles.

The invention relates to a granule of chlorfenapyr and cartap, the active ingredients of which are chlorfenapyr and cartap, and the rest are pesticide adjuvants. The mass ratio of chlorfenapyr to cartap is 1:1-1:50, and the mass percentage of chlorfenapyr and cartap in the composition is 0.01%-10%. The granules of the invention are suitable for controlling rice pests. The invention is safe and environment-friendly. The drug effect lasts for a long time.