The invention provides a medicinal composition with a synergic anti-tumor effect and application thereof. The medicinal composition is prepared from, by mole, 1-3 parts of
sunitinib and 10-20 parts of dihyrdroberberine; after the
sunitinib and the dihyrdroberberine are mixed in proportion, auxiliary materials are added, and the
mixed materials are prepared into capsules or tablets to be used. According to the medicinal composition with the synergic anti-tumor effect and the application thereof, it is found that the dihyrdroberberine and the
sunitinib have the good anti-tumor effect after being jointly applied, the anti-tumor
treatment effect can be maximized through the
medicine synergism of the dihyrdroberberine and the sunitinib, and the composition can be used for treatment on tumors such as
lung cancer, liver cancers and colon cancers and has the very high scientific research value and the good application prospect.