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Medicinal composition with synergic anti-tumor effect and application thereof

A technology of anti-tumor drugs and compositions, applied in the field of medicine, can solve problems such as abnormalities, achieve high scientific research value, good anti-tumor effect, and good application prospects

Inactive Publication Date: 2016-03-30
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But because sunitinib targets many different receptors, it also has many side effects, such as hand-foot syndrome, stomatitis, and other skin and subcutaneous tissue abnormalities
At present, there is no report on the combination of dihydroberberine and sunitinib for the treatment of tumors

Method used

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  • Medicinal composition with synergic anti-tumor effect and application thereof
  • Medicinal composition with synergic anti-tumor effect and application thereof
  • Medicinal composition with synergic anti-tumor effect and application thereof

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Experimental program
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Embodiment Construction

[0025] The present invention will be further described in detail below in conjunction with the specific experimental process and results of the present invention.

[0026] One, the cell viability experiment of the pharmaceutical composition provided by the present invention and the combined action index analysis

[0027] 1. Instruments and materials

[0028] SW-CJ-1F ultra-clean bench (Suzhou Antai Air Technology Co., Ltd.); Ti-U inverted microscope (Nikon); MAC15AC carbon dioxide constant temperature incubator (SANYO); 80-2 desktop electric centrifuge (Shanghai City Analytical Instrument Factory); GH water-proof constant temperature incubator (Beijing Kewei Yongxing Instrument Co., Ltd.); pipette (Eppendorf); UPT-IV-5T ultrapure water preparation machine (Chengdu Ultrapure Technology Co., Ltd. ); BP211D electronic balance (Shanghai Guangzheng Medical Instrument Co., Ltd.); cell counting plate (Shanghai Qiujing Biochemical Reagent Co., Ltd.); culture plate (Costar).

[0029]...

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Abstract

The invention provides a medicinal composition with a synergic anti-tumor effect and application thereof. The medicinal composition is prepared from, by mole, 1-3 parts of sunitinib and 10-20 parts of dihyrdroberberine; after the sunitinib and the dihyrdroberberine are mixed in proportion, auxiliary materials are added, and the mixed materials are prepared into capsules or tablets to be used. According to the medicinal composition with the synergic anti-tumor effect and the application thereof, it is found that the dihyrdroberberine and the sunitinib have the good anti-tumor effect after being jointly applied, the anti-tumor treatment effect can be maximized through the medicine synergism of the dihyrdroberberine and the sunitinib, and the composition can be used for treatment on tumors such as lung cancer, liver cancers and colon cancers and has the very high scientific research value and the good application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition with synergistic antitumor effect and application thereof. Background technique [0002] Tumor has become the second largest killer that seriously threatens human health, and its morbidity and mortality are increasing year by year all over the world. Especially with the change of human living environment, the morbidity and mortality of lung cancer are increasing the fastest, and it has become one of the most threatening malignant tumors to the health and life of the population. In China, the morbidity and mortality of lung cancer in males rank first among all malignant tumors, while the incidence and mortality in females rank second. The cause of lung cancer is still not completely clear. A large number of data show that long-term heavy smoking is closely related to the occurrence of lung cancer. At the same time, the incidence of lung c...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61P35/00A61P35/04A61K31/404
CPCA61K31/404A61K31/4375A61K2300/00
Inventor 张彦民代秉玲王文婕马玉娇展颖转张东东刘瑞祁军鹏
Owner XI AN JIAOTONG UNIV
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