169 results about "Drug synergism" patented technology

The present invention relates to the methods of treating endocrine-regulated cancers, including hormone resistant cancers, for example. More specifically, the present invention relates to a method of increasing the sensitivity of hormone resistant cancers to hormonal therapeutic agents. In particular embodiments, the present invention concerns delivery of a histone deacetylase inhibitor and a hormone targeted drug to an individual with cancer. In specific embodiments, the histone deacetylase inhibitor and the hormone targeted drug act synergistically to treat the cancer, including by overcoming resistance to a cancer therapy.

The present invention is directed to the production of PKC isozyme epsi (PKCepsi)-deficient cells and non-human animals. The present invention is further directed to the identification of PKCepsi as a target for drugs that reduce anxiety. According to the present invention, PKCepsi-inhibiting compounds act in synergy with drugs acting at the GABAA receptor. The present invention is also directed to the use of modulators of PKCepsi to modulate alcohol consumption, self-administration of other drugs of abuse, and the effects of alcohol consumption as well as the use of inhibitors of PKCepsi, either alone or in conjunction with allosteric agonists of GABAA receptors, to treat conditions, such as addiction, withdrawal syndrome, skeletal muscle spasms, convulsive seizures, and epilepsy, that are amenable to treatment by allosteric agonists of GABAA receptors. Additional aspects of the present invention are diagnostic methods for identifying individuals at risk for becoming alcoholics or abusers of other drugs and kits for performing such diagnostic methods. The present invention relates to: cells and non-human animals deficient for the PKC isozyme epsi (PKCepsi); the use of PKCepsi as a target for drugs; the use of inhibitors of PKCepsi in methods of reducing anxiety and treating conditions associated with insufficient activity of the GABAA receptor; the use of modulators of PKCepsi in methods of modulating alcohol consumption, modulating self-administration of other drugs of abuse, and altering the effects of alcohol; pharmaceutical compositions comprising inhibitors of PKCepsi and allosteric agonists of GABAA receptors; and the identification of individuals with enhanced susceptibility to alcoholism or other forms of addiction.

The invention discloses a Chinese medicament for treating foot-and-mouth disease. The Chinese medicament is prepared from the following Chinese medicament raw materials by weight: 130g of subprostrate soplhor root, 65g of dyer woad leaf, 65g of radix isatidis, 65g of angelica, 65g of prepared rhizome of rehmannia, 65g of kudzu root, 65g of rhizome of rehmannia, 65g of platycodon root, 65g of plantain seed, 65g of cortex phellodendri, 65g of coptis root, 65g of baikal skullcap root, 65g of licorice, 65g of honeysuckle, 65g of honeysuckle stem, 65g of red sage root, 65g of rhubarb, 65g of radix bupleuri, 65g of starwort root, 65g of polygala root and 1000g of rock sugar. The Chinese medicament has a main effect of clearing away heat and toxic materials and is mild in the effect of medication, all the drugs have a synergistic action, and the Chinese medicament can achieve the aim of cure by reinforcing qi, reinforcing strength, removing blood stasis and eliminating swelling for recuperation.

The invention discloses a glutathione response-type dual-drug carrier as well as a preparation method and application thereof, and belongs to the field of biomedical engineering materials. The preparation method comprise the following steps: performing Michael addition reaction to obtain hyperbranched poly(amide amine)s; then connecting a hydrophobic drug onto an end group amino of a high polymer by amidation reaction, so as to form a prodrug micelle molecule; then loading another hydrophobic drug by subject-object assembly of the prodrug micelle molecule, thus effectively increasing drug loading capacity and promoting an synergistic effect of the drugs; preparing to obtain the glutathione response-type dual-drug carrier. The method is mile, the operation is convenient, byproducts are fewer, and a product is easy to separate and purify, thus facilitating the material biocompatibility. The glutathione response-type dual-drug carrier has the advantages of simple material components, easy-to-get raw materials and good biocompatibility, and is hopefully widely applied to the field of the biomedical engineering materials as a great amount of surface functional groups capable of being modified provide support for the application of the carrier in preparing the biomedical engineering materials.

Anaphylactic diseases comprising urticaria, papilla, subacute dermatitis, eczema, and the like, are skin diseases which seriously puzzle the human beings. In the invention, antihistamine, zinc salt and weak acid are prepared into a topical compound preparation, which not only reduces the untoward effect of drugs, avoids the first pass effect of the liver when feeding the drugs by mouth, avoids the blood concentration peak valley phenomenon caused by oral feeding, but also can improve the curative effect and is convenient for clinic application. Simultaneously pharmacological tests show that the topical compound preparation obtains excellent drug synergism to the anaphylactic skin diseases and has excellent effects on curing the anaphylactic diseases.

The invention discloses a medicament composition for treating upper respiratory infections and a preparation method thereof and belongs to the technical scheme of traditional Chinese medicine preparations. The medicament composition comprises the following raw materials in parts by weight: 40-50 parts of ephedrine, 20-30 parts of liquorice, 20-40 parts of radix isatidis, 10-20 parts of radix bupleuri, 5-10 parts of pinellia ternate, 5-10 parts of scutellaria baicalensis, 10-20 parts of dandelion, 5-10 parts of dried orange peel, 3-5 parts of platycodon grandiflorum, 4-8 parts of menthol, 3-5 parts of saposhnidoviae radix, 6-12 parts of fructus forsythia, 10-15 parts of hindu datura flower, 10-15 parts of semen brassicae and 30-50 parts of dextrin. Through drug synergism, the medicament composition is capable of effectively treating upper respiratory infections and relieving uncomfortable syndromes; meanwhile, as pinellia ternate is separately extracted, the extraction yield of ephedrine is effectively improved; menthol is treated through an ultrafiltration membrane, impurities are removed, thus the stability of ephedrine in a finished product is remarkably improved.

The invention discloses a pharmaceutical composition, its preparing process and use, wherein the composition comprises epimedium extract, hooked uncaria extract and puerarin by the weight ratio of 20-500 : 3-80 : 40-1000. The composition can be prepared into clinically and pharmaceutically acceptable dosage forms including injections, tablets, capsules, soft capsules, dripping pills, oral liquids, and granules. The composition can be used for treating hypertension, cephalalgia, nervous prostration and cardiovascular and cerebrovascular diseases.

The invention discloses a medicament for treating coccidiosis, particularly a novel compound anti-coccidiosis medicament and a preparation method thereof. The novel compound anti-coccidiosis medicament is characterized by being prepared from the following components: decoquinate, toltrazuril, polymer carrier, solubilizing agent and anhydrous dextrose. Therefore, the medicament has the advantages that: the indissoluble decoquinate and toltrazuril are prepared into water-soluble substances by using solid dispersion technology and inclusion technology, and the decoquinate and toltrazuril are mixed to fulfill the aim of reducing dosage, improving curative effect and reducing drug resistance; moreover, the synergistic effect of the medicaments can be realized by combining the decoquinate and the toltrazuril, the killing effect is enhanced and the dosage of each medicament is reduced by half.

Disclosed is a medicinal preparation for treating ulcerative stomatitis which comprises (by weight ratio) borax 2.9659%-9.8863%, calamine 9.8863%-19.7726%, dried alum 9.8863%-29.6598%, borneol 0.2966%-0.9886%, pearl powder 2.9659%-9.8863%, amber 14.8294%-29.6589%, natural indigo 9.8863%-29.6589% and cinnabar 4.9431%-14.8295%.

The invention discloses a psoriasis rehabilitation liquid, which is an external-use medicine for treating psoriasis. The psoriasis rehabilitation liquid comprises the following components: a garter snake, Chinese azalea flowers, root of fangji, scandent schefflera stems and leaves, spatholobus suberctu, schizophragma integrifolium, asarum, musk, pearl grass, camphor, borneol and wine. The medicines have a synergistic effect, effects of expelling wind-damp, dredging meridians and collaterals, dispelling wind and eliminating dampness, promoting blood circulation to arrest pain and inducing dieresis to detoxify. The psoriasis rehabilitation liquid has a good curative effect and a rapid both symptoms and root causes, and can treat both symptoms and root causes, so that the psoriasis is not easily to reoccur after being treated.

A protein gel for encapsulation and controlled delivery of bioactive compounds is provided. These specific bioactive compounds may include but are not limited to vitamins, minerals, medications, probiotics and other bioactive supplements; and the amounts and / or dosages of the bioactive agents and ingredients may be adjusted to properly suit adults, children, or elderly dependent upon the end-use. This protein gel may act as both a pharmaceutical and nutraceutical, and may contain the active therapeutic compound, such as an antibiotic, chemotherapeutic, or pain medication in conjunction with specific nutrients that may act synergistically with the medication to enhance efficacy and overall health of the patient. The gel may be consumed alone or incorporated into food products such as cereal-type bars or mixed into biscuits, cookies, and the like.

This invention relates to compositions and methods utilizing a chemotherapeutic drug and 6-bromoindirubin3′-oxime (BIO) for the treatment of cancer, including glioblastoma multiforme. The present invention demonstrates that BIO works synergistically with chemotherapeutic drugs to increase the cytotoxic effects of these drugs in glioma cells.

The invention provides a traditional Chinese medicine composition for treating ulcerative colitis, and a preparation method thereof. The composition of the traditional Chinese medicine for treating ulcerative colitis is prepared by mixing the components in parts by weight as follows: 10-30 parts of chrysanthemum, 15-25 parts of pericarpium citri reticulatae, 10-30 parts of radix curcumae, 10-30 parts of hawthorn, 5-15 parts of liquorice, 15-25 parts of fructus amomi, 20-40 parts of endoconcha sepiae, 5-10 parts of coptis chinensis, 2-8 parts of gizzard pepsin, 15-25 parts of mangnolia officinalis, 30-50 parts of Chinese-date flesh, 10-20 parts of bletilla striata, 20-30 parts of rhizoma corydalis and 25-35 parts of propolis. The composition of the traditional Chinese medicine has the benefits that the composition is reasonable; a synergistic effect of every component is achieved; the composition of the traditional Chinese medicine has the functions of clearing away heat, drying dampness, tonifying spleen, nourishing stomach and the like, is good in curative effect, can take effect quickly and achieve the effect of treating both symptoms and root causes, and can be prepared easily; the components can be mixed more uniformly step by step; the composition of the pure traditional Chinese medicine is free from pollution, drug residues and drug resistance, low in cost, wide in material drawing range, high in availability and remarkable in curative effect; and superfine grinding is achieved.

The invention discloses a blood-glucose-lowering and pancreatic-islet-recovering plaster, and belongs to externally-used medicine for curing diabetes mellitus. The blood-glucose-lowering and pancreatic-islet-recovering plaster comprises radix scrophulariae, radix rehmanniae, liriope, trichosanthin, astragalus membranaceus, salvia miltiorrhiza, codonopsis pilosula, angelica sinensis, white muscardine silkworms, caulis spatholobi, cortex lycii radicis, quasi rhizoma dioscoreae, poria cocos, kudzu roots, schisandra chinensis, periostracum cicadae, coptis chinensis, salt-fried dodder, raw anemarrhena, raw gypsum powder, dark plums, bitter oranges, radix saposhnikoviae, rhizoma typhoon, pericarpium citri reticulatae viride, cistanche, cassia seeds, rhubarb, white peony roots, fenugreek, radix glycyrrhizae preparata, round-shaped rice, phenformin, glibenclamide and sesame oil, wherein each medicines acts synergistically. The blood-glucose-lowering and pancreatic-islet-recovering plaster performs the functions of yin nourishment, body strengthening, adverse Qi descending, stagnation elimination, liver clearing, vision improvement, yin-yang adjustment, kidney essence nourishment, blood nourishment and cooling, liquid engenderinging, thirst allaying, blood circulation promotion, stasis removal, meridian and collateral dredging, blood glucose lowering, pancreatic islet recovery, internal insulin secretion increase and recovery, global balance adjustment, metabolism enhancement, microcirculation improvement, prevention of the occurrence of cardiovascular and cerebrovascular diseases, nephropathy, nervous lesions and ophthalmopathy, and prevention of ketone toxicosis of elderly patients, and the like, achieves a good curative effect when being used for curing the diabetes mellitus, take effect quickly, achieve an effect of treating both principal and secondary aspects of diseases, and can reach a goal that the diseases have low probability of relapsing after being cured.

The invention relates to a decoction for treating silicosis and a preparation method thereof. The decoction is prepared from raw materials of low-cost traditional Chinese medicinal herbs, which mainly include red-rooted salvia root, red paeony root, Szechuan lovage rhizome, pinellia tuber, plantain herb, platycodon root, hairy asiabell root, manyflower solomonseal rhizome, root of straight ladybell, liquorice and the like, and the decoction is simple in preparation method and is obtained through decocting based on reasonable compatibility according to the basic principle of strengthening the body resistance to eliminate pathogenic factors. According to the invention, because the traditional Chinese medicinal herbs are adopted, the decoction has low cost and can be popularized and used in a large range; due to adoption of the pure natural Chinese medicinal herbs, not only is the curative effect enhanced based on the synergism of all medicinal herbs, but also the side effects of the medicinal herbs are reduced, and the decoction is easy to accept by patients; and the decoction can be used to alleviate onset pains of the patients, is suitable for being taken by patients of all age groups suffering from the silicosis of various stages, and has a short treat course and rapid response.

The present invention discloses animal remedy for treating cow mammitis, which is prepared with several kinds of Chinese medicinal materials in certain proportion. The animal remedy of the present invention has excellent medicinal cooperation, and has powerful effect of killing staphylococcus aureus and hemolytic coccus and effect of clearing away heat and relieving pain to congested inflammation.

The invention relates to a hot-natured Chinese traditional medicine insole. The effective component of heater in vacuum packed sole is activated by oxygen in the air, and generates heating action, the temperature is higher 5 minutes later and rises up to 40 -50 Deg. C 30 minutes later, the insole releases heat for 12 hours, and can improve blood circulation in plantar, prevent chilblain, deodorize, remove dampness, stimulate plantar reflection area, get rid of fatigue and moderate organ function through continuous heating action and medical effect. The product is the organic combination of modern biology with pharmacokinetics and provides new idea and method for insole development.

The invention provides a Chinese medicine composition capable of curing proctitis. The Chinese medicine composition capable of curing the proctitis is characterized by being prepared by the mixing of the following components by weight: 10 to 20 parts of liquorice, 15 to 25 parts of radix paeoniae alba, 10 to 20 of parts myrrh, 15 to 25 parts of plantain herb, 5 to 15 parts of kudzu vine roots, 10 to 20 parts of garden burnet, 5 to 15 parts of ophiopogon roots, 15 to 25 parts of honeysuckle, 5 to 15 parts of herba epimedii, 15 to 25 parts of smoked plum, 5 to 15 parts of salt, 10 to 20 parts of fried gorgon euryale seeds, 10 to 20 parts of rhizomacyperi, 15 to 25 parts of agrimonia pilosa, 20 to 30 parts of codonopsis pilosula and 5 to 15 parts of forged keel. The Chinese medicine composition capable of curing the proctitis has the advantages that the components are reasonable, medicine cooperate with each other and are complementary to each other, the absorbing effect is good, the curing effect is remarkable, and the effect of curing the proctitis is achieved. The Chinese medicine composition capable of properly curing the proctitis is a pure Chinese medicine composition, and is free from drug-fast, low in cost and wide in material.

The invention discloses a composition for treating bovine severe compound parasitic infection and a preparation method thereof, and aims to provide a composition with effect of killing most parasites and a preparation method thereof. The composition comprises the following components in percentage by weight: 1 to 10 percent of albendazole, 0.1 to 2 percent of ivermectin, 0.5 to 8 percent of praziquantel and the balance of talcpowder. Through synergy of three antiparasitic medicines, the composition pertinently kills parasites in vivo of livestock, and on body surface, muscles, brain and other parts, parasitic insects and various parasites; the three medicines complement one another, and the composition has powerful effect of killing most parasites at one time; culturists prepare the composition only and can solve the problem of parasitic disease; and the composition is convenient to use and is convenient to be carried and used by the culturists, particularly herders.

The invention relates to a traditional Chinese medicine pill for soothing the liver and regulating the flow of qi and a preparation method thereof. The traditional Chinese medicine pill comprises the following components in parts by weight: 10-20 parts of radix bupleuri, 1-20 parts of pericarpium citri reticulatae, 5-20 parts of radix paeoniae alba, 10-20 parts of radix curcumae and 10-30 parts of rhizoma cyperi. The traditional Chinese medicine pill disclosed by the invention is dainty in prescription, high in drug synergism and relatively good in effect of soothing the liver and regulating the flow of qi; by adopting a pill form, the medicine is high in effective utilization rate, slow in medicine release, lasting in effect, capable of delaying the absorption of irritant medicines, reducing toxic and side effects and eliminating and covering bad smells of the medicines, and convenient for medication of animals; and the production process and equipment are relatively simple, so convenience is provided for industrial production.

The invention discloses a bedsore granulation-promoting ointment and a preparation method thereof. The bedsore granulation-promoting ointment comprises components as follows: 5-15 parts of safflower, 3-15 parts of arnebia roots, 30-50 parts of Chinese angelica, 40-50 parts of dahurian angelica roots, 20-40 parts of liquorice roots, 20-30 parts of salvia miltiorrhiza, 10-20 parts of dragon's blood, 2-4 parts of calomel, 2-15 parts of borneol, 100-150 parts of beeswax, 400-600 parts of vegetable oil, 10-20 parts of Chinese gall and 5-10 parts of myrrh. The ointment is clear in overall therapeutic principle and reasonable in compatibility, all medicines have a synergistic effect, and the ointment has functions of clearing heat, performing detoxification, reducing swelling, eliminating stagnation, removing blood stasis, relieving pain, drawing out toxins and promoting granulation. Treatment is realized through application and smearing of the ointment, pain of patients is little, the bedsore treatment effect is good, the ointment takes effect quickly, the cure rate is high (the cure rate is up to 99%, and the total effective rate is up to 100%), and the ointment can realize effects of treating both symptoms and root causes and avoiding scaring after curing.

Disclosed is a medicine for treating rheumatic and rheumatoid arthritis, which is prepared from root of herbaceous peony, eucommia bark, peucedanum root, lotus leaf, frankincense, ledebouriella root, safflower, banksia rose, licorice root, adenophora root, wolferry fruit, achyranthes and cyathula root.

The present invention discloses a sealwort nourishing tea and a preparation method thereof. The sealwort nourishing tea comprises crude drugs by weight as follows: 4 to 8 parts of sealwort, 1 to 3 parts of siraitia grosvenorii, 4 to 8 parts of polygonatum odoratum and 2 to 6 parts of licorice. After washing, drying, crushing, preparing, bulking, packaging and other processes, the sealwort nourishing tea is obtained. The sealwort nourishing tea provided in the present invention has a reasonable composition ratio, and has an outstanding regulation function on organisms through drug synergistic effect. The sealwort nourishing tea has effects of invigorating vital energy as well as nourishing blood, and can fundamentally regulate a poor physique to achieve the objective of body building and physique enhancing.

The invention discloses a method for establishing a drug synergistic effect prediction model, a prediction method and a corresponding device, and relates to technologies such as deep learning and AI medical treatment in the technical field of artificial intelligence. The method comprises the following steps: obtaining a relation graph, wherein nodes in the relation graph comprise drug nodes and protein nodes, and indicating the interaction exists between the nodes; collecting medicine node pairs with definite synergistic effects from the relation graph, and taking the annotation indicating whether cooperative effect exist as the training samples; and taking the drug node pairs in the training samples as the input of a drug synergistic effect prediction model, taking the annotation indicating whether the drug node pairs have the synergistic effect as the target output, and training a drug synergistic effect prediction model, wherein the drug synergistic effect prediction model is obtained by learning the relation graph based on a graph convolutional network. On the basis, automatic prediction of the drug synergistic effect can be achieved, and more manpower and material resource cost is saved compared with a whole test mode.

The invention relates to third-degree burn and scald repair ointment, which is external ointment for promoting the formation and dissociation of phloem islands, the union of third-degree surface of burns and scalds and growth of skin without skin grafting. The third-degree burn and scald repair ointment consists of Chinese arborvitae twig, garden burnet root, hairyvein agrimonia herb and bud, platanthera tuber, hedgehog hide, Chinese gall, Japanese ampelopsis root, astragalus, giant knotweed rhizome, cuttlebone, hard charcoal, dragon's bone, humus flava usta, phellodendron, purpleflower hollyleaf, thickleaf croton root, oyster shell, human placenta, pig skin, sesame oil, beeswax and borneol. The third-degree burn and scald repair ointment has the effects of astringing to arrest bleeding,removing putrefaction and promoting tissue regeneration, strengthening body resistance and cooling blood and the like under the synergistic action of each medicament, is used for promoting the formation and dissociation of the phloem islands and the union of the third-degree burn and scald wound surfaces, has a good curative effect, quick response, an effective rate of 100 percent and an effect of addressing both symptoms and root causes, and can fulfill the aim of relapse prevention after the skin heals. The third-degree burn and scald repair ointment also can be used for various ulcer woundsurfaces of the skin.

The invention provides a traditional Chinese medicine preparation for promoting wound healing. The traditional Chinese medicine preparation comprises bulk drugs of the traditional Chinese medicine in parts by weight: 48-54 parts of wind mugwort, 28-32 parts of camphor branches and 18-22 parts of kapur branches. The preparation method comprises the following steps of: taking materials; preparing salty water; preparing; decocting and the like. The traditional Chinese medicine preparation is rational in formula, has the effects of invigorating the circulation of blood and dissipating decoction, warming channel to remove coldness and relieving pain, relaxing the muscles and stimulating the blood circulation, festering and converging boils, removing the necrotic tissue and promoting granulation and the like through cooperative function of the drugs, treating wound infection, inflammation, swelling, water flow, suppuration and long treatment of the surface of the skin, and has the effects of treating both symptoms and root causes and realizing no relapse after healing; the preparation method is simple, and the production cost is low.

The invention relates to a burnt tissue regeneration promotion ointment which is an external ointment for treating various burns and scalds. The ointment is based on a Dang patrimonial medicine formula and verified by clinical practice of more than fifty years. The ointment comprises lithospermum, Chinese angelica, radix angelicae, olibanum, myrrh, gallnuts, garden burnet, rehmannia roots, coptisroots, rhubarb, amoorcorn tree bark, radix scutellariae, earthworms, pericarpium papaveris, elephant skin, tortoise plastron, gypsum, snow lotus herb, red halloysite, sesame oil, beeswax, bee glue, vaseline, calomel, borneol and sangusis draconis. The whole formula of the ointment is clear in treatment principle and reasonable in compatibility; all medicines exert a synergistic effect; the ointment has functions of clearing away heat and toxic materials, diminishing swelling, alleviating a pain, diminishing inflammation, dissipating blood stasis, removing necrotic tissues and promoting tissueregeneration, has a good treatment effect on various burns and scalds, takes effect quickly and can achieve significant effects of treatment of both symptoms and root causes of a disease, low recurrence possibility after curing, and no scar left; the clinical practice for many years proves that a cure rate reaches 100%; and the ointment receives unanimous praise from massive patients, and friendsand relatives of the patients.

The invention provides a traditional Chinese medicine extract with an antitumor effect as well as an extraction method and application thereof. In parts by mass, the traditional Chinese medicine extract comprises 3-9 parts of semen momordicae and 2-8 parts of semen strychni. The extraction method comprises the following steps: respectively extracting a semen momordicae extract and a semen strychni extract; and mixing the two extracts to obtain the traditional Chinese medicine extract, wherein the semen momordicae extract is obtained by extracting the semen momordicae by normal hexane, discarding the extracting solution and extracting the obtained extract by ethyl acetate, and the semen strychni extract is obtained by extracting the semen strychni by ethyl alcohol. The traditional Chinese medicine extract can be applied to the preparation of antitumor drugs, and can be used as a medicinal component to be prepared into capsules or tablets by adding auxiliary materials. By combining the semen momordicae and the semen strychni, the traditional Chinese medicine extract has a favorable antitumor effect; and through the medicine synergism of the semen momordicae and the semen strychni, the antitumor effect can be maximized; therefore, the traditional Chinese medicine extract has a high scientific research value and a favorable application prospect.