439 results about "Parasitic disease" patented technology

Methods of treating, preventing and / or managing various protozoan parasitic disease and disorders are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone, or in combination with a second active ingredient. The invention further relates to methods of reducing or avoiding adverse side effects associated with conventional anti-parasitic treatments which comprise the administration of an immunomodulatory compound. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

Disclosed herein are nucleotide analogs with one or more protecting groups, methods of synthesizing nucleotide analogs with one or more protecting groups and methods of treating diseases and / or conditions such as viral infections, cancer, and / or parasitic diseases with the nucleotide analogs with one or more protecting groups.

Disclosed herein are nucleotide analogs with protected phosphates, methods of synthesizing nucleotide analogs with protected phosphates and methods of treating diseases and / or conditions such as viral infections, cancer, and / or parasitic diseases with the nucleotide analogs with protected phosphates.

The invention provides a paraway plus which is prepared by the following materials in terms of parts by weight: 6-15 of cortex meliae, 6-15 of areca, 6-12 of fructus quisqualis, 6-12 of common carpesium fruit, 6-15 of cyrtomium fortunei, 6-15 of cushaw seed, 6-15 of dark plum fruit, 6-15 of omphalia, 6-15 of pomegranate peel, 6-15 of coptis root, 3-6 of pepper, 6-15 of costustoot and 6-15 of dried ginger. The paraway plus of the invention is mainly used for treating ascariasis and intestinal parasitic diseases such as enterobiasis, and also has effects on ancylostomiasis and taeniasis. After being taken, the paraway plus can cause parasites to be discharged from human bodies, simultaneously conduce to spleen and stomach nursing and help the patients to recover. The paraway plus adopts traditional Chinese medicines as raw materials and exerts no toxic side effects on the patients, thereby being suitable for children.

The invention relates to the technical field of aquaculture, and specifically relates to a feed for siniperca chuatsi. The feed is prepared by the following raw materials by weight: 55-60 parts of corn, 20-22 parts of rye bran, 10-12 parts of peanuts, 20-25 parts of rapeseed meal, 6-8 parts of chironomidae larvae powder, 8-10 parts of small carp meal, 8-10 parts of loach dry powder, 6-8 parts of herba houttuyniae, 10-12 parts of white fish meal, 6-8 parts of escargot powder, 8-10 parts of dry sphagna powder, 5-6 parts of meat and bone meal, 6-8 parts of radish leaves, 0.5-1 part of rheum officinale, 1-2 parts of saponin, 1-2 parts of felwort, a proper amount of salt and 4-5 parts of a phagostimulant. In consideration of the carnivorous characteristic of the siniperca chuatsi, an abundance of raw materials such as small carp meal, loach dry powder, white fish meal and escargot powder are added in the prepared feed for siniperca chuatsi, so that enough nutrients are provided for the growth and development of the siniperca chuatsi. Traditional Chinese medicine components such as herba houttuyniae, rheum officinale and saponin are added, so that disease-resistant capacity of the siniperca chuatsi can be enhanced. Particularly, parasitic diseases can be prevented; morbidity of the siniperca chuatsi is reduced; and loss of culture benefits can be prevented.

The invention discloses a disease-resistant growth promoter for aquatic animals and a preparation method thereof. The disease-resistant growth promoter is characterized in that a novel environmentally-friendly feed additive is prepared by combining the traditional Chinese medicine with a modern microbial transformation technology. The preparation method comprises the following steps: mixing dandelion, licorice root, lightyellow sophora root, barberry root and the like after crushing and screening; adding bran, soybean meal, corn flour and water as a fermentation culture medium, regulating thepH value, sterilizing, cooling, adding a strain, and fermenting; and drying after the fermentation is finished. The disease-resistant growth promoter for the aquatic animals is formed by virtue of beneficial combination of the traditional Chinese medicine and probiotics, can be used for replacing antibiotics and has the effects of resisting bacteria, preventing verminosis, resisting virus, improving the immunity, promoting the growth of the aquatic animals and the like; no toxicity, no side effects, no pollution, no residue and no drug resistance are produced during the long-term use of the disease-resistant growth promoter; and the effects are stable and reliable, and the requirements of people on safe production of aquatic products can be met. The disease-resistant growth promoter for the aquatic animals can also be applied as a veterinary drug by improving the using dose.

Methods are provided for improved immunization against coccidiosis and other bacterial, viral, or parasitic diseases in poultry. One method includes administering a solution of Propionibacterium acnes suspended in normal saline to a chick at age day one, following hatching. An anticoccidial vaccine and / or other vaccine is then administered to the chick such as by oral administration. Alternatively the method includes the steps of aseptically injecting Propionibacterium acnes in ovo at about day 18 in development, followed by post-hatching vaccination with an anticoccidial vaccine and / or other vaccine. Alternatively, either method can be utilized without the subsequent vaccination step for stimulating non-specific cell-mediated immune responses in poultry.

The invention relates to a Chinese herbal medicine feed additive for enhancing chicken immunity, a preparation method and a feed. The additive includes ingredients of, by weight, 30-90 parts of radix astragali, 30-90 parts of radix codonopsis, 30-90 parts of Chinese yam, 30-90 parts of poria cocos, 30-90 parts of coix seeds, 15-45 parts of fried lotus seed, 10-30 parts of bighead atractylodes rhizome, 10-30 parts of rhizoma atractylodis, 10-30 parts of dried orange peel, 15-45 parts of epimedium, 30-90 parts of stir-baked medicated leaven, 30-90 parts of stir-baked malt, 10-30 parts of betel nut, 10-30 parts of rhizome of cyrtomium and 10-30 parts of licorice. According to a compatibility principle of traditional Chinese medicine and a modern pharmacological research, the invention uses amedicament comprised of natural Chinese herbal medicines as an additive to feed chickens, so as to enhance chicken immunity, reduce infectious diseases, pathogenic microorganisms and parasitic diseases; besides, the additive has no antibiotic residuals, so as to enhance chicken and egg quality.

The invention relates to the technical field of biology, in particular to an antigen chip used for detecting human parasites antigens in serum and a preparation method thereof. The invention spots antigen array of parasites which are seriously harmful to human body, Schistosoma, Lung fluke, Clonorchis sinensis, Cysticercosis, Sparganum mansoni, Trichina, Angiostrongylus cantonensis, Toxoplasma gondii, and the like, on a solid phase membrane carrier, and specific gamma immunoglobulin (IgG) of human parasites in serum is detected by a specially made vertical flow chip detect device, and the detecting marker is colloid gold second antibody conjugate or colloid gold protein A conjugate of fresh color. IgG antibodies in serum specially bind with the antigens on the membrane in percolation process layer upon layer, and human IgG which specially binds with the antigens is detected by the colloid gold marker. Detecting of a plurality of parasites antigen indexes in serum sample can be finished within several minutes. The device and the method have the advantages of high throughput, simple operation, convenient use and being suitable for parasitic diseases clinical test and serum-epidemiological investigation.

A blood fluke infectious oncomelania detection kit and a detection method thereof belongs to the verminosis transmission medium detecting field. The invention provides a kit and a detection method for detecting blood fluke infectious oncomelania based on a loop-mediated isothermal DNA amplification technology (LAMP). According to the LAMP technology principle, six pairs of specific primers for amplifying a DNA fragment between the 20bp and 231bp of the schistosoma japonicum non-long terminal repeated inverse transcription transposon gene (AF412214) are designed. The LAMP method is constructed for detecting blood fluke gene in the body of the infectious oncomelania and the objective for distinguishing the blood fluke infectious oncomelania from the non-infectious oncomelania is reached. Comparing to the conventional blood fluke infectious oncomelania detection method the method of the invention has advantages of easy and fast operation, sensitive and specific without especial equipment and is suitable for bilharziasis controlling personnel use on site.

The invention relates to a biochemical feed and a preparation method thereof. The raw materials of the biochemical feed adopts the residues of crops such as straws, cornstalks, wheat straws and various soybean stalks and soybean pods, and the seeds, fruits, roots, stalks, leaves, flowers and husks of the following raw material crops: one or more of cassava, ryegrass, Rumex, comfrey and grassiness which are wild grass capable of being processed and chopped and forage grass capable of being planted; vine plants, namely the vines and leaves of potato, the vines and leaves of sweet potato and the leaves and stalks of Canna Edulis Ker; all kinds of green grass; aquatic plants, namely water hyacinth, mizuna and duckweed; all kinds of melons and fruits; and the processing wastes of agricultural and sideline products such as distiller grain, soybean residues, oil cake, rice brans and wheat brans. The preparation method of the biochemical feed comprises the following steps: performing physical machining to the raw materials, mixing and fermenting to obtain the biochemical feed. Animals fed by the biochemical feed of the invention hardly get ill and suffer from parasitic diseases, and the quality requirements of pollution-free products can be ensured.

The invention discloses a compound pesticide for fishing; the compound pesticide can be used for preventing aquatic livestock parasitic diseases caused by parasites such as trichodina, dactylogyrus, gyrodactylus, Chinese daphnia, lernaean, sporozoit and the like, belonging to the field of veterinary drugs. The ingredients of the compound pesticide for fishing are composed of radix sophorae flavescentis, betel palm, stone-like omphalia and cypermethrin; the preparation method of the compound pesticide is that: the radix sophorae flavescentis, betel palm and stone-like omphalia are weighted according to the proportion, refluxing and extraction are carried out, extracting solution is heated, evaporated and concentrated, and then cypermethrin, emulsifying agents, organic solvent and distilled water are added for preparation according to the proportion; the compound pesticide for fishing has the advantage of stable quality, convenient usage, low cost, having remarkable curative effect on the trichodina, dactylogyrus, gyrodactylus, Chinese daphnia, lernaean, sporozoit diseases of the aquatic livestock, rapid effect, thorough killing, small toxic and side effect and wide parasite expelling and killing spectra, and can effectively ensure health and safety of aquaculture animals.

The invention discloses an under-tree broiler chicken breeding method. The under-tree broiler chicken breeding method includes the following steps of selecting a high-quality-broiler-chicken under-tree stocking field; selecting a stocking house; selecting under-tree stocking high-quality broiler chicken varieties; managing high-quality-broiler-chicken under-tree breeding and feeding; selecting the formula of under-tree breeding feed; building a rotation grazing system of the forest land grazing field, and planting grazing; researching stocked chicken immune procedures, and selecting the brooding-stage immune procedure; controlling common parasitic diseases of high-quality-broiler-chicken under-tree stocking; conducting pollution-free treatment on chicken stocking waste.

The present invention includes methods and compositions for the treatment and prevention of protozoal parasitic infections utilizing Diindolylmethane-related indoles. Additive and synergistic interaction of Diindolylmethane-related indoles with other known anti-parasitic and pro-apoptotic agents is believed to permit more effective therapy and prevention of protozoal parasitic infections. The methods and compositions described provide new treatment of protozoal parasitic diseases of mammals and birds including malaria, leishmaniasis, trypanosomiasis, trichomoniasis, neosporosis and coccidiosis.

A therapeutic composition or a vaccine comprising tumor membrane-anchored cytokines or other immunostimulatory or costimulatory molecules are provided. The therapeutic composition or a tumor vaccine can be used for treating a tumor or other disease such as autoimmune disorder, viral diseases, bacterial diseases, parasitic diseases, and transplant rejection.

The invention belongs to the field of bioengineering and provides an Echinococcus granulosusglutathione transferase gene a base sequence of which is shown in SEQ ID NO: 1. The invention also provides a protein encoded by the Echinococcus granulosusglutathione transferase gene. The amino acid sequence of the protein encoded by the Echinococcus granulosusglutathione transferase gene is shown in SEQ ID NO: 2, or is the same as 1st-219th amino acid sequences as shown in SEQ ID NO: 3. The recombinant protein can be used for immunodiagnosis of cystic echinococcosis patients and can be used for coating a plate; and the serums of the patients having cystic echinococcosis, alveolitoid echinococcosis, cysticercosis and other parasite diseases and healthy people are detected by using an enzyme-linked immunosorbent assay (ELISA), and the obtained sensitivity and specificity are respectively 72.41% and 92.36%.

The invention discloses an under-forest-based breeding method of laying hens. The under-forest-based breeding method comprises the following steps: preparing a high-quality laying hen under-forest stocking field; selecting an under-forest-based laying hen house; selecting an under-forest stocking high-quality laying hen variety; carrying out high-quality laying hen under-forest breeding and raising management; preparing an under-forest breeding laying hen feed formula; planting a rotation grazing system and forage grass on a forest land pasture; immunizing stocking laying hens and establishing an under-forest stocking laying hen immunizing procedure; preventing and treating common parasitic diseases of the under-forest breeding of the high-quality laying hens; carrying out harmless treatment on breeding wastes of the stocking laying hens. The under-forest-based breeding method of the laying hens, disclosed by the invention, combines the characteristics of the under-forest breeding, and the immunizing procedure of the laying hens is optimized, and furthermore, the health of chicken flocks is guaranteed; a stocking characteristic is combined so that the prevention and treatment of the common parasitic diseases of the stocking laying hens are completed; the harmless treatment of the breeding wastes of the stocking laying hens is researched, and an ecological environment and sustainable development are guaranteed.

The invention relates to the field of veterinary drugs, and particularly relates to prevention and cure of three main parasitic diseases, namely a tapeworm disease, a roundworm disease and a coccidium disease, or the tapeworm and coccidium mixed infection and the roundworm and coccidium mixed infection of free-ranging chickens. The invention particularly discloses a traditional Chinese medicine composite for resisting the parasites of the free-ranging chickens and a preparation method thereof. The traditional Chinese medicine composite is prepared into a traditional Chinese medicine formulation by taking rangooncreeper fruits, aloes, liquorice, hawthorns, fructus carpesii, medicated leaven, fructus hordei germinatus, azedarach, rhizoma atractylodis, codonopsis pilosula, betel nuts, radix dichroae, cyrtomium fortunei, radix astragali and pericarpium citri reticulatae as crude drugs. The traditional Chinese medicine disclosed by the invention is used for treating the three main parasitic diseases, namely the tapeworm disease, the roundworm disease and the coccidium disease, or the tapeworm and coccidium mixed infection and the roundworm and coccidium mixed infection of the free-ranging chickens, enhances the feed conversion rate, strengthens the organism resistance action and has the advantages of outstanding effect, safety in use, no residue, difficulty in drug resistance generation, low price, and the like.

The invention relates to a soluble powder for treating livestock and poultry bacterial infection and parasitosis, comprising nortloxacin lactate, trimethoprim and auxiliary materials, the medicament of the invention is taken as antibiotic medicament, is mainly used for treating various diseases and parasitosis caused by sensitive bacterias, has better curative effects for pig toxoplasmosis, pig hydropsy, poultry, rabbit coccidiosis, the nortloxacin lactate and the trimethoprim are compatible with each other for using and generating cooperating action, the medicament of the invention has excellent oral administration absorption effect and high safety.

The invention discloses a compound Chinese medicinal herbal preparation for the prevention and treatment of fish parasitic diseases, wherein the constituents include (by weight percent) pomegranate bark 15-25%, kuh-seng 15-25%, toosendan fruit 12-18%, cinnamon twig 8-12%, sweet wormwood 8-12%, garden burnet root 8-12% and baikal skullcap root 12-18%.

The present invention relates to the ester compound of thymol and / or carvacrol with the general expression as shown. The active medicine composition of the ester compound is new generation of farm animal medicine for treating parasitic disease and bacterial infection, including infection caused by drug resistant bacteria.

The invention relates to the field of aquaculture, and specifically relates to a grass carp culturing technology. According to the invention, water temperature and stocking time are controlled, such that fish fry survival rate can be improved. Different fishes are stocked at a same time, such that the pond and the water surface can be kept clean. Spotted silver carp helps in removing suspended matters, yellow-head catfish helps in reducing parasitic disease occurrence, and crucian helps in cleaning the river bottom. Therefore, grass carp quality safety is high, and farmer economic benefit is ensured.

The invention relates to an anti-parasitic ivermectin transdermal solution used for livestock and a preparation method thereof. The anti-parasitic ivermectin transdermal solution comprises the following components respectively according to parts by volume: 5 to 15 parts of ethyl acetate, 20 to 30 parts of dimethyl sulfoxide, 2 to 6 parts of azone, 1 to 3 parts of isopropanol and 50 to 70 parts of propanediol; and the content of ivermectin is 0.3g to 1g in a solution of 100ml, and the finished product is prepared by the processes of dissolving, mixing, filtering and filling. The azone related in the prescription of the invention is a novel skin penetration enhancer, can increase the transdermal absorption of the skin to various medicines of different types, effectively avoids the pass effect of hepar, avoids peak and valley phenomena in the absorption process of the medicine, reduces the toxic or side effect caused by the correlative dosage in the medicine, prolongs the effective effect time, changes the administration area, effectively regulates the administration dosage and reduces differences among individuals. The invention has the characteristic of simple, convenient and fast use, and is more suitable for the anti-parasitic prevention and treatment of a pasturing area compared with other preparation forms.

The invention provides neem oil microemulsion and a preparation method thereof which have the advantages of presenting high effect of killing vermin on the body surfaces of animals, overcoming the service durability of chemical drugs, reducing usage amount and drug cost and enhancing the insecticidal activity. The invention also has another purpose of providing the application of the neem oil microemulsion in controlling the verminosis which appears on the body surfaces of the animals. The invention adopts the following technical scheme to realize that seed oil prepared from the insecticidal plant, i.e. neem, is used as an insecticidal active component; and under the action of emulsifier and assistant emulsion, the neem seed oil is uniformly dispersed in deionized water to form the semitransparent or transparent nim oil microemulsion which is of oil-in-water type (O / W type).

The present invention relates to antibodies binding IL-15, in particular humanized antibodies. In particular, the anti-IL-15 antibodies according to the invention are able to neutralize IL-15 activity and are useful in the prevention and / or treatment of an autoimmune disease and / or inflammatory disorder, a malignancy, transplant rejection, metabolic condition and / or an infectious disease caused by parasitic, viral or bacterial pathogens.

The invention provides a feed additive capable of improving the pig lean meat percentage and resisting the parasitic disease, which consists of kelp powder, nistose trihydrate, D-biotin, pine needle meal and the like. After the kelp powder is pre-processed, the kelp powder is combined with the nistose trihydrate, the D-biotin, phytase, glycine betaine and the like to perform obvious lethal actionon the endoparasite of the live pig and good curative effect on the pig parasitic disease; and pine needle meal and substances, such as L-arginine and L-tryptophan in a formula can be used for supplementing nutrition ingredients in the feed, promoting live pig growth and improving the lean meat percentage. The feed additive capable of improving the pig lean meat percentage and resisting the parasitic disease has good effect on various pig parasitic diseases, especially has a good curative effect on the lungworm and has the advantages of high effect taking speed, and no toxic or side effect, the egg decrement rate and the egg negative conversion ratio are obviously improved, the live pig can be promoted to grow and develop, and the lean meat percentage is improved.

The present invention provides gene targets, constructs and methods for the genetic control of plant disease caused by multiple plant viruses. The present invention relates to achieving a plant protective effect through the identification of target coding sequences and the use of recombinant DNA technologies for post-transcriptionally repressing or inhibiting expression of the target coding sequences of plant-parasitic viruses. Protein-expression based approaches may also be utilized to augment phenotype resistance. Thus, transcription of a single transgenic event comprising one or more plant expression cassettes can allow for broad spectrum resistance of a plant to multiple plant viral strains and species among the geminiviruses, tospoviruses, and potexviruses.

The present invention describes a method of treating individuals suffering from microbial infections, including a parasitic disease such as malaria, by using an improved Artemisinin Combination Therapy, known as Tri-ACT. The improved ACT therapy includes administering a combination of three drugs. In one embodiment of the present invention, the method includes administering to an individual a first composition comprising a therapeutically effective amount of an artemether spray sublingually. The individual is then administered a second composition, a therapeutically effective amount of artesunate. A third composition, an effective amount of berberine, or its pharmaceutically acceptable derivatives or salts is administered to the individual.