30results about How to "Excellent features" patented technology

The present invention relates to an FCN retina image blood vessel segmentation through combination of depth separable convolution and channel weighing. The method comprises the steps of: 1) performingCLAHE and Gamma correction to enhance a contrast ratio of a green channel of an eye bottom image; 2) in order to adapt network training, performing partitioning of the enhanced image to expand data;and 3) replacing a standard convolution mode with depth separable convolution to increase the width of the network, and introducing a channel weighing module to explicitly perform modeling of a dependency relation of a feature channel so as to improve the separability of the features. The depth separable convolution and the channel weighing are combined to be applied into the FCN network, an expert manual identification result is taken as supervision to perform experiment in a DRIVE database. The result shows that: the method can accurately perform segmentation of the retina image blood vessels and has high robustness.

The invention discloses a self-adaptive de-noising and characteristic enhancing method of an SAR (Synthetic Aperture Radar) image, which mainly aims at overcoming the defects that the traditional method has poor de-noising property and can not self-adaptively select parameters in the experiment. The method comprises the following steps: firstly, carrying out logaritmim and then ME-curvelet transformation on an original SAR image; secondly, self-adaptively selecting and optimizing parameters in improved gain functions by adopting an improved PSO (Particle Swarm Optimization) algorithm according to the provided evaluation criterion; and finally, carrying out the nonlinear transformation on ME-curvelet coefficients, ME-curvelet inverse transformation and exponential transformation by adopting the improved gain functions to obtain the final SAR image subjected to the de-noising and characteristic enhancement. By using the method, the noise can be removed while the characteristics are enhanced, the complexity for processing can be reduced and the better de-noising and characteristic enhancing effects of the SAR image can be achieved.

A method for test of human exhaled breath by using laser spectrums of optical frequency combs is characterized by: employing two groups of optical frequency combs with different pulse repetition frequencies to beat each other so that frequency spectrum signals are reduced to a microwave frequency range; employing a simple conventional microwave detection method to obtain frequency spectrum absorption and phase information of the exhaled breath in the entire optical frequencies, thereby to obtain gas components and traces; and determining a patient's possible condition by the analysis of components and corresponding absorption coefficients of each gas spectrum curve. The method for test of human exhaled breath by using laser spectrums of optical frequency combs of the invention can quickly measure the spectrum of human exhaled breath in a wide range once and for all, achieving a short measurement time and accurate measurement to real-time changing samples. The method has advantages of being non-invasive, quantitative, safe, simple, convenient, quick, repeatable, etc., with sensitivity and specificity better than conventional bronchoscopy.

The invention discloses an inverter-side control method and system based on an extra high voltage direct-current transmission project. The method comprises the steps of additionally adding an extinction angle modulation module at the inverter-side control system of a direct-current transmission system, increasing a reactive compensation capacity of an inverter station and setting an extinction angle given value when the direct-current transmission system is in a steady state; respectively obtaining second alternating current bus voltage values V0 and Vac at an inverter side when the system isin the steady state and goes wrong; judging whether the extinction angle given value is changed or not, and starting the extinction angle modulation module when a deviation between V0 and Vac is not in the range of + / -5%; and stopping modulation until the second bus voltage level restores to the given range, and restoring the original extinction angle set value. According to the method, the probability of commutation failures of a direct current can be reduced by additionally adding the extinction angle modulation module, the fluctuation range of the alternating current bus voltage is inhibited, the recovery speed of a direct current power is accelerated and the stability of the alternating current power grid voltage is improved.

The invention provides a near-infrared fluorescent heptamethine cyanine dye and application thereof in preparation of a tumor diagnosis agent and / or an imaging agent. The near-infrared fluorescent heptamethine cyanine dye is a compound DZ-1, wherein the side chain of the compound DZ-1 is (CH2)4SO3H, so that the compound DZ-1 can be directly dissolved in water; in addition, the near-infrared fluorescent heptamethine cyanine dye can be applied by intravenous injection during living imaging, thus achieving the same treatment and applying mode as clinic ICG (Indocyanine Green); the compound DZ-1 can be specifically absorbed by hepatoma carcinoma cell and is gathered at the tumor part to support no-intrusive NIRF imaging, so that the tumor growing part can be detected; the fluorescence intensity at the tumor part, the specificity and the targeting performance are prior to those of clinically-used ICG. Therefore, the tumor diagnosis agent and / or the imaging agent adopting the compound DZ-1 are high in tumor targeting performance and high in stability.

The invention discloses an air intake duct lip deformation structure and an air intake duct lip deformation structure control method. The air intake duct lip deformation structure comprises a main bearing structure, a skin, a lip margin structure, temperature sensors, a plurality of strain sensors, a temperature adjustment device and a lip margin structure driving device. The main bearing structure is made of a memory alloy material, and is arranged in an enclosed cavity formed by the skin; the enclosed cavity is equipped with an air inlet and an air outlet; the temperature adjustment device is connected to the air inlet of the enclosed cavity; the temperature sensors are arranged on the main bearing structure; the strain sensors are arranged on the inner surface of the skin and the main bearing structure; and the lip margin structure driving device is arranged on the main bearing structure. The air intake duct lip deformation structure control method mainly utilizes the air intake duct lip deformation structure to realize control. According to the invention, the shape of the air intake duct lip can be changed repeatedly within certain range according to actual flying speed.

The invention relates to a cytoperm capable of being used as a hemolytic agent, which comprises the main components of saponin, sodium azide and paraformaldehyde. Proper amount of the components are mixed, and dissolved in phosphate buffer to prepare the cytoperm; and the cytoperm can be used as the hemolytic agent after dilution. Compared with the prior hemolytic agent and cytoperm, the cytoperm related to the invention can be directly used as the cytoperm, also can be used as the hemolytic agent after the dilution, and has double purposes. The hemolytic agent and cytoperm can be applied to a flow cytometer to detect various immunological indexes in human body blood, has obviously superior detection specificity, sensitivity and the like than imported reagents, and particularly has the advantages in pretreatment processes such as hemolysis, perm and the like on whole blood specimens of patients with leukemia, globalism and severe liver diseases.

The invention discloses a modular telescopic device with adjustable annular steel, and belongs to the technical field of bridge structure telescopic devices. The modular telescopic device comprises boundary beams, a center beam, bearing cross beams and boundary beam anchoring assemblies. According to the connecting relation of the boundary beams, the center beam, the bearing cross beams and the boundary beam anchoring assemblies, the boundary beam anchoring assemblies are arranged on the boundary beams, and the annular steel of the boundary beam anchoring assemblies can freely move along cross round steel; U-shaped anchoring steel bars are welded to the two sides of a bearing beam box or a displacement rod box, cross penetrating steel bars penetrate through embedded steel bars and the U-shaped anchoring steel bars, and connecting and anchoring of the displacement rod box and the embedded steel bars are achieved; the center beam is borne on the bearing beam box and connected with the bearing cross beams, an elastic displacement assembly is fixedly connected with the boundary beams or the center beam through the displacement rod box. The mounting efficiency of the modular telescopic device of a bridge can be improved.

The invention discloses a fundus image blood vessel segmentation method based on full convolutional neural network multi-scale features. The fundus image blood vessel segmentation method comprises thefollowing steps of 1) preprocessing a fundus retina image; 2) segmenting the preprocessed image into image blocks for data expansion; 3) constructing a convolutional neural network model, and performing network training by using the expanded data; and 4) testing the trained model to obtain a segmentation result. According to the invention, one encoding structure and two different decoding structures are connected; the method provided by the invention can overcome the defects of low segmentation precision and the like caused by a small number of blood vessel image data sets and low image quality by adopting multiple skipping connections, more fully fuses the characteristics of different depths, effectively alleviates the problem of gradient disappearance caused by network depth increase, and has higher accuracy and higher robustness.

The invention discloses a kit for detecting a novel coronavirus. According to the detection kit for the droplet type digital PCR technology, at least two amplification primers with sequences shown asSEQ ID No. 1 and SEQ ID No. 2 and a probe with a sequence shown as SEQ ID No. 3 are arranged in the kit. According to the invention, a specific primer and a probe are designed by utilizing an N genomein a COVID-19 gene sequence and are used for a droplet digital PCR technology (ddPCR), and related experiments verify the feasibility and specificity of the primers and the probe. The kit disclosed by the invention can be used as a supplement for detecting the new coronavirus, and has higher detection sensitivity and specificity.

The invention provides a Mini LED chip structure and a manufacturing method thereof. The Mini LED chip structure comprises a P-type current expansion injection metal layer and an N-type current expansion injection metal layer. The P-type current expansion injection metal layer and the N-type current expansion injection metal layer comprise anti-migration metal ruthenium. According to the Mini LEDchip structure and the manufacturing method thereof, the metal ruthenium is used as the anti-migration layer in the N / P type current expansion injection metal layer to replace traditional metal platinum, a higher anti-electromigration effect can be achieved, the process window of the metal ruthenium is stable, the price of the metal ruthenium is equivalent to that of platinum, and therefore cost cannot be increased, and it is guaranteed that the cost is proper.

The invention relates to a primer group and detection system for detecting HPV common hypotypes through a LAMP method. The HPV common hypotypes include HPV6, HPV11, HPV16, HPV42, HPV43 and HPV44. The primer group is composed of a primer sequence having a nucleotide sequence of SEQ NO.1-24. The primer group is designed according to the six hypotypes of condyloma acuminate and HPV infected by common skin warts, and the LAMP primers are verified. Through the reaction system above, the specific HPV hypotype DNA in a template can be effectively amplified. Through verification of specificity and sensitivity of the system, compared with a method for clinical application in the prior art, the LAMP system has superior sensitivity. Therefore, the invention provides a HPV type detection method that is simple and fast and is convenient in detection and high in specificity and sensitivity.

The invention discloses a reagent kit for multi-channel fluorescent PCR detection of the polymorphism of IL28B gene loci. The reagent kit can specifically detect the polymorphism of the IL28B gene loci rs12979860 and rs8099917, the two loci are simultaneously detected in one PCR reaction pipe, and the specific genotype is made clear and definite. Besides, operation is easy, convenient and fast, the result is objective and high in controllability, efficiency is high, cost is low, contamination is avoided through closed-pipe operation, and the reagent kit is suitable for a multi-channel fluorescent PCR instrument and is a powerful product for clinically detecting the polymorphism of the IL28B gene loci.

The invention relates to a method for measuring trace triptorelin. The trace triptorelin in a sample is measured by using a liquid chromatography and mass spectrometry technology. The method is simple in operations and accurate in results, and has good specificity and high sensitivity. The invention also relates to applications of the measurement method for the qualitatively or quantitatively measuring the content of the triptorelin in a biological sample and for pharmacokinetic studies of triptorelin preparations.

The invention provides a braking and gear shifting control method and system for an electric vehicle. The method comprises the following steps that the total required braking force is calculated; determining a braking force distribution strategy according to a front and rear axle brake braking force distribution curve, and calculating regenerative braking force; optimizing the speed ratio; performing constant-acceleration gear shifting control; the required braking force obtained under the same braking strength z obtains a fixed regenerative braking torque according to a braking force distribution strategy, so that the acceleration at the current gear is obtained, then the speed does not suddenly change before and after gear shifting, the change of the transmission ratio can bring different reverse rotation speeds of the motor, and the speed change of the motor is changed. At the moment, new regenerative braking torque is generated, new acceleration is generated at the same time, the two accelerations are made to be equal, the relation between the front regenerative braking torque and the rear regenerative braking torque and distribution of the front regenerative braking torque and the rear regenerative braking torque on a motor efficiency curve graph are obtained, and therefore the economical requirement is met.

The invention relates to a key protein identification method based on protein clustering characteristics and activity co-expression. The method comprises the following specific steps: describing the clustering characteristics of a protein interaction network by utilizing an edge aggregation coefficient; setting gene activity expression by setting a threshold parameter, and describing by adopting aBoolean value; defining a calculation method based on the Boolean value of gene activity expression, and calculating the score of activity co-expression by utilizing a Jaccard coefficient; finally obtaining the key comprehensive scores based on the protein clustering characteristics and the activity co-expression, outputting a sorting result, and using the protein with the high key comprehensivescore after top sorting (top N is taken as a threshold value) as a key protein. According to the key protein identification method, the influence of gene expression data noise is eliminated, and the key protein identification method is superior to a centrality measurement method and a key protein prediction method with the same input data set in the aspects of identification accuracy, specificity,sensitivity and the like.

A gamma synuclein colloidal gold detection device comprises a strip base material. A sample pad, a colloidal gold conjugate pad, a reaction film and filter paper are sequentially arranged on the stripbase material. The colloidal gold conjugate pad is coated with colloidal gold marked rat anti-gamma synuclein monoclonal antibody alpha SNCG2; rat anti-gamma synuclein monoclonal antibody alpha SNCG1is sprayed to a testing area (T) of the reaction film; goat anti-mouse immune globulin IgG is sprayed to a quality control area (C). The colloidal gold detection device takes sodium casein as a stabilizing agent. The invention provides a preparation method and application of the gamma synuclein colloidal gold detection device. The gamma synuclein colloidal gold detection device has advantages that no other experimental equipment is needed in a detection process, low detection cost is realized, and a significant clinical value to diagnosis of carcinoma of urinary bladder, kidney cancer, prostatic cancer, endometrial cancer and breast cancer is achieved.

The invention belongs to the technical field of simulation optimization of exhaust devices, and discloses a simulation optimization design method for a hot blowing snow removal exhaust device of a turbofan engine. Inlet and outlet boundary conditions of the exhaust device are determined based on the characteristics of the turbofan engine and a one-dimensional pipe flow theory; the current situation that a current hot blowing snow removal exhaust device is modified based the a turbojet engine is broken through, the inlet boundary condition of the exhaust device when an inner duct and an outer duct are mixed is accurately obtained, it is guaranteed that the exhaust device is in a critical or supercritical state, and the engine performance is fully utilized.

The invention discloses a handheld wireless ad hoc network communication device. A baseband processing module of the handheld wireless ad hoc network communication device comprises: a modulator / demodulator which is used for modulating / demodulating a signal frame; the modulator / demodulator adopts an OFDM (Orthogonal Frequency Division Multiplexing) / OQAM (Open Quadrature Amplitude Modulation) modulation / demodulation mode, various problems of handheld ad hoc network communication equipment in the prior art are solved, and real number symbols, real parts and imaginary parts which are subjected tooffset processing are modulated and sent instead of complex symbols; the handheld wireless ad hoc network communication device has excellent performance in the aspects of spectrum efficiency, ICI resistance, out-of-band radiation and the like, and solves the problems in the prior art.

The invention discloses a method of rapidly predicting smoking uniformity of a cigarette. Smoking uniformity of a cigarette is predicted according to a cigarette density distribution characteristic Y,if Y is within (1.2,3.0), the cigarette of the specification is qualified in smoking uniformity, and the smaller the Y, the better the smoking uniformity of the cigarette. The method is easy and rapid to operate, can measure online, and delivers an accurate, reliable result.

The invention discloses an application of a circRNA marker for diagnosing thalassemia, and belongs to the technical field of biology. The circRNA marker is hsa-circc-0129875 as shown in SEQ ID NO: 1,and the nucleotide sequence of the circRNA marker is shown in SEQ ID NO: 2. According to the circRNA marker provided by the invention, early diagnosis of thalassemia is realized; according to the invention, the circRNA marker and clinical examination indexes (HCT, MCV, MCH and MCHC) are combined to diagnose thalassemia. According to the invention, results show that the sensitivity of AUC diagnosedby combining hsa-circ-0129875 with clinical examination indexes is superior to that of AUC diagnosed by single circRNA, the area under an AUC curve is maximum, the sensitivity reaches 85% or above, and the specificity reaches 90% or above. The circRNA marker has the advantages of strong characteristics, strong sensitivity and stable result, provides a theoretical reference basis for the diagnosisof thalassemia, and has a wide clinical application prospect.

The invention discloses a goat pox virus Taqman-MGB (minor groove binder) probe real-time fluorescence quantitative PCR (polymerase chain reaction) detection primer, a kit and a detection method. According to the method, 2 pieces of the primers and a probe are designed according to one region of a target sequence, the kit includes 2 PremixExTaqTM buffer, a positive control, a negative control and sterilized deionized water. The method only needs two step amplification method and simple reaction conditions for fast, efficient, specific and highly-sensitive detection of an objective target sequence, is simple, does not need expensive equipment and reagents,has no technical requirement on operators, and is low in detection cost and short in testing time.

The invention provides a method for constructing tissue engineered cartilage by using bone-marrow mesenchymal stem cells, which comprises the steps of (1) preparing a chondrocyte aggregate, (2) centrifuging whole blood to prepare platelet-rich plasma, (3) placing the bone-marrow mesenchymal stem cells and the chondrocyte aggregates in the platelet-rich plasma, uniformly mixing, and adding a thrombin solution containing calcium chloride to the obtained mixture to form a cell complex; (4) injecting the cell complex into a subject for growth in vivo to obtain the tissue engineered cartilage, wherein the number ratio of the bone mesenchymal stem cell to chondrocyte contained in the chondrocyte aggregate in step (3) is 1:1. The method for constructing tissue engineered cartilage of the invention is simple in operation, can maintain optimal new cartilage morphology and cartilage differentiation characteristics, and effectively inhibits the occurrence of new cartilage edge ossification whileeffectively resisting central vacuolization.

A prognosis risk assessment system for gastric cancer patients is characterized by comprising a gastric cancer methylation data acquisition module, a differential methylation site acquisition module and a prognosis model construction module. The gastric cancer methylation data acquisition module is used for acquiring TCGA gastric cancer methylation spectrum and a gastric cancer methylation spectrum data set GSE30601, the differential methylation site acquisition module is used for obtaining a plurality of hyper-methylation sites and a plurality of hypo-methylation sites, and the prognosis model construction module is used for constructing a 11-DNA methylation site risk scoring formula of each patient.

The invention discloses a marker for colorectal cancer or precancerous lesions and application thereof, and relates to the technical field of tumor detection. The marker of colorectal cancer or precancerous lesion is a CpG site of the NTMT1 gene. Through the methylation level of the CpG site of the NTMT1 gene, early screening or auxiliary diagnosis of colorectal cancer or precancerous lesions can be realized. The NTMT1 gene has very high sensitivity and specificity on a colorectal cancer sample or a precancerous lesion sample in an excrement sample. Through verification, the detection sensitivity and the specificity of the methylation of the NTMT1 gene are far higher than those of SDC2, TFPI2, MAP3K14-AS1 and Septine 9 genes, and the sensitivity of the NTMT1 gene to I / II stage colorectal cancer and progression stage adenoma in a blood sample and the specificity of the NTMT1 gene to other intestinal diseases are also better.

The invention discloses application of mSEPT9 as a marker for predicting the postoperative recurrence risk of a colorectal cancer patient and in evaluating the effectiveness of a chemotherapy regimen. The mSEPT9 disclosed by the invention is remarkably superior to a traditional tumor marker (CEA, CA199 and CA242) in the aspects of sensitivity and specificity on the recurrence risk of a CRC patient, the recurrence prediction of the mSEPT9 is far earlier than that of imaging examination, and the median leading time is 5 months. Moreover, the most suitable patient groups of different chemotherapy regimens can be distinguished by detecting the mSEPT9, the postoperative recurrence of the patients is reduced, and the survival time is prolonged.

The invention relates to a method for preparing a pancreatic stone protein antibody and a method for detecting PSP (pancreatic stone protein), and belongs to the technical field of gene recombinationof bioengineering. The invention aims to provide the method for preparing the pancreatic stone protein antibody and the method for detecting PSP (pancreatic stone protein), so that a specific PSP immunogen is prepared, a PSP monoclonal antibody or polyclonal antibody is produced, the PSP detecting method is established, and a PSP in vitro diagnosis reagent kit is established. A tag-PSP recombinantprotein carrier is constructed through a gene recombination technique, a tag-PSP recombinant protein is expressed by bacteria, yeast, insect cells, animal cells or human cells, and the tag-PSP recombinant protein is purified to be used as a PSP recombinant protein immunogen. The method disclosed by the invention is used for detecting rise of the level of the PSP in blood, and can provide a reagent kit which can diagnose the generation of bacterial septicemia early, quickly and accurately, guide treatment of septicemia, monitor the progress of the septicemia and quickly detect the PSP by an immunology method.

The invention discloses application of a miRNA combined marker in preparation of a kit for diagnosing and detecting early liver cancer. The miRNA combined marker is a has-miR-1307-3p, a hsa-miR-221-3p, a hsa-miR-323b-3p and a hsa-miR-382-5p which are derived from a blood plasma exosome, and the miRNA combined marker is used for detecting the blood plasma exosome. The early liver cancer is primary HCC. The miRNA combined marker provided by the invention is not limited to whether a patient has hepatitis B HBV positive and liver cirrhosis LC symptoms, and is high in sensitivity and strong in specificity.

The invention discloses a preparation method of nano carbon spheres, and the method comprises the following steps: crop straw crushing, acidic lithium bromide hydrolysis, charcoal separation, drying and the like to obtain the nano carbon spheres. Compared with the prior art, the nano carbon spheres have the advantages that the reaction activity is higher, and the application potential is higher, particularly, the carbon nanospheres prepared by treating pennisetum purpureum are uniform and dispersed, the diameter is about 100 nm, and the application potential is wider.

The invention discloses an application of a miRNA combined marker to preparation of a kit for diagnosing or detecting HBV+ and LC-primary HCC. The miRNA combined marker is hsa-miR-146a-5p and hsa-miR-154-5p which are derived from a blood plasma exosome. According to the method, the LC-primary HCC of HBV+ is detected, the pertinence is higher, and the detection result is more convincing.