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74 results about "Diindolylmethane" patented technology
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A phytonutrient and plant indole found in cruciferous vegetables including broccoli, brussels sprouts, cabbage, cauliflower and kale, with potential antiandrogenic and antineoplastic activities. As a dimer of indole-3-carbinol, diindolylmethane (DIM) promotes beneficial estrogen metabolism in both sexes by reducing the levels of 16-hydroxy estrogen metabolites and increasing the formation of 2-hydroxy estrogen metabolites, resulting in increased antioxidant activity. Although this agent induces apoptosis in tumor cells in vitro, the exact mechanism by which DIM exhibits its antineoplastic activity in vivo is unknown. Check for http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=462587&idtype=1 active clinical trials or http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=462587&idtype=1&closed=1 closed clinical trials using this agent. (http://nciterms.nci.nih.gov.libproxy1.nus.edu.sg/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C53434 NCI Thesaurus)
Phytochemicals for promoting weight loss
New dietary supplement compositions are disclosed that comprise the phytochemical Diindolylmethane (DIM), as well as its precursor, Indole-3-carbinol (I3C), and cogener, 2-(Indol-3-ylmethyl)-3,3' diindolylmethane (LTR-1), dietary supplement acceptable carriers and / or excipients. The use of these dietary supplement compositions facilitate weight loss as part of a nutritional system targeting release and metabolism of stored fat.
Owner:BIORESPONSE
Diindolylmethane-based compositions and methods of use thereof for promoting oral mucosal and bone health
InactiveUS20060264497A1Improve bioavailabilityEffective oral systemic useBiocideCosmetic preparationsDiseaseDental flossing
The present invention includes compositions and methods for the treatment and prevention of oral mucosal disorders and for promotion of bone health. In particular, the present invention describes new therapeutic and preventative uses for 3,3′-diindolylmethane (DIM), or a DIM-related indole, alone or in combination with anti-inflammatory agents and / or antibacterial agents, to treat oral mucosal disorders and promote bone health. The compositions of the invention are used to prevent and reverse oral mucosal disorders and bone loss (osteopenia and osteoporosis) associated with aging and chronic inflammation. Oral mucosal disorders include Periodontitis, gingivitis and related oral mucosal inflammation. Formulations of the compositions of the invention include capsules, tablets, toothpastes, oral gels, mouthwashes, mouth rinses, lozenges, chewing gum, dental floss, and dental topical formulations, and fortified foods.
Owner:BIORESPONSE
Compositions and methods for treating estrogen-dependent diseases and conditions
A pharmaceutical composition for the treatment of an estrogen-dependent disease or condition comprises: (1) at least one polysaccharide selected from the group consisting of an alginate and a fucoidan in a quantity effective to treat an estrogen-dependent disease or condition; and (2) a pharmaceutically acceptable carrier. The composition can include both an alginate and a fucoidan. The composition can include other ingredients such as at least one compound selected from the group consisting of diindolylmethane and indole-3-carbinol in a quantity sufficient to inhibit the activity of estrogen. Methods for use of the composition for the treatment of an estrogen-dependent disease or condition, especially endometriosis, are described.
Owner:CONCOURSE HEALTH SCI
Phytochemicals for treatment of mastalgia and endometriosis
InactiveUS6689387B1Reducing and preventing symptomPain reduction and preventionOrganic active ingredientsBiocidePhytochemicalMedicine
New compositions are disclosed that comprise the phytochemical Diindolylmethane (DIM), as well as its precursor, Indole-3-carbinol (I3C), and cogener, 2-(Indol-3-ylmethyl)-3,3'diindolylmethane (LTR-1), acceptable carriers and / or excipients. These compositions are administered to prevent or reduce symptoms associated with mastalgia and endometriosis.
Owner:BIORESPONSE
Diindolylmethane formulations for the treatment of leiomyomas
ActiveUS20050267193A1Good curative effectBiocideHydroxy compound active ingredientsMedicineNon invasive
The present invention relates to compositions and methods for treating or preventing leiomyomas by administration of diindolylmethane and diindolylmethane-related indole. The present invention also relates to compositions and methods for treating or preventing leiomyomas by administration of diindolylmethane in combination with an EGFR antagonist. The methods provide non-invasive treatments for leiomyomas.
Owner:BIORESPONSE
Chemoprevention and treatment of cervical or vaginal neoplasia
InactiveUS6399645B1Inhibit progressBiocideAnimal repellantsViral diseaseCervical intraepithelial neoplasia
The invention relates to non-surgical methods for treating cervical or vaginal neoplasia including cervical intraepithelial neoplasia, intraepithelial neoplasia, vulvar intraepithelial neoplasia and ano-genital warts. The treatment, which utilizes an effective amount of indole-3-carbinol and / or diindolylmethane, is effective whether or not the patient is also infected with human papillomavirus, the most common sexually transmitted viral disease in the United States and a known risk factor for both cervical intraepithelial neoplasia and cervical cancer.
Owner:BELL MARIA +1
Use of diindolylmethane-related indoles and growth factor receptor inhibitors for the treatment of human cytomegalovirus-associated disease
The present invention includes compositions and methods for the treatment and prevention of conditions associated with Human Cytomegalovirus (HCMV) infection. HCMV-associated conditions include infections (active and latent), benign cell-proliferative conditions, pre-cancerous cell-proliferative conditions, and cancerous conditions. In particular, the present invention describes new therapeutic and preventative uses for 3,3′-diindolylmethane (DIM), or a DIM-related indole, in combination with an inhibitor of a membrane bound Growth Factor Receptor (GFR), to treat conditions associated with exposure to HCMV. In certain embodiments, the compositions of the invention can be used in combination with radiation therapy.
Owner:BIORESPONSE
Combined use of cruciferous indoles and chelators for the treatment of papillomavirus-related conditions
Synergistic compositions and methods are disclosed for using cruciferous indoles with iron / zinc chelators in the treatment of papillomavirus-related conditions. These synergistic compositions of diindolylymethane (DIM), related trimeric derivatives, and related indole derivatives include combinations with deferoxamine, deferiprone, bipyridyl, Desferri-exochelin, picolinic acid, 3-hydroxypicolinic acid, and sodium butyrate as iron / zinc chelators. The methods described comprise more effective therapies for common cutaneous warts (verrucae) and related dysplasias of the oropharynx, genitalia, and uterine cervix.
Owner:BIORESPONSE
Analogs of Indole-3-Carbinol and Their Use as Agents Against Infection
ActiveUS20100069355A1Potent antibacterial agentLittle or no anti-bacterial activityAntibacterial agentsBiocideCarbazoleCombinatorial chemistry
Compounds useful as antibacterial agents are provided. The compounds are analogs of indole-3-carbinol and have a backbone selected from dihydroindolo[2,3-b]carbazole, 2,2′-diindolylmethane, 2′,3-diindolylmethane, and 3,3′-diindolylmethane. The compounds are useful therapeutic and prophylactic treatment of bacterial infections in mammals. Methods of synthesis of the compounds are provided, as are pharmaceutical compositions containing the compounds.
Owner:SRI INTERNATIONAL
Diindolylmethane for the treatment of HPV infection
New methods and compositions are disclosed that comprise the phytochemical Diindolylmethane, alone or in combination with immune potentiating steroids. These methods and compositions are utilized to treat subjects suffering from common cutaneous warts (verrucae) and Human Papilloma Virus (HPV) related conditions of the oropharynx, larynx, genitalia, and uterine cervix.
Owner:BIORESPONSE
3,3'-Diindolylmethane immune activating compositions
The invention provides immune response activating compositions and methods of use. The general methods deliver an immune response activator to a patient determined to be in need thereof, comprising the steps of: (a) administering to the patient a predetermined amount of an immune response activating, optionally substituted DIM; and (b) detecting in the patient a resultant immune response activation, such as an increase in T-cell proliferation, NO production, cytokine production, cytokine receptor expression, or cytokine signaling.
Owner:RGT UNIV OF CALIFORNIA
Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
ActiveUS20100055201A1Improve developmentShorten the counting processHeavy metal active ingredientsBiocideCoccidiosisTrypanosomiasis
The present invention includes methods and compositions for the treatment and prevention of protozoal parasitic infections utilizing Diindolylmethane-related indoles. Additive and synergistic interaction of Diindolylmethane-related indoles with other known anti-parasitic and pro-apoptotic agents is believed to permit more effective therapy and prevention of protozoal parasitic infections. The methods and compositions described provide new treatment of protozoal parasitic diseases of mammals and birds including malaria, leishmaniasis, trypanosomiasis, trichomoniasis, neosporosis and coccidiosis.
Owner:BIORESPONSE
Phytochemicals for the treatment of cervical dysplasia
InactiveUS7384971B2Preventing cervical dysplasiaPrevent and more symptomBiocideIn-vivo radioactive preparationsPhytochemicalMedicine
New compositions are disclosed that comprise the phytochemical Diindolylmethane (DIM), as well as its precursor, Indole-3-carbinol (I3C), and cogener, 2-(Indol-3-ylmethyl)-3,3′diindolylmethane (LTr-1), acceptable carriers and / or excipients. These compositions are administered to prevent or reduce symptoms associated with mastalgia, endometriosis and HPV-related conditions including cervical dysplasia.
Owner:BIORESPONSE
Anti-proliferative combinations
Combinations of a polyunsaturated fatty acid and diindolylmethane and pharmaceutical composition containing such combinations. Further provided are combinations including a polyunsaturated fatty acid, diindolylmethane, and folic acid. Also provided are combinations including diindolylmethane and folic acid. Also provided is a method for increasing the number of normal cells and decreasing the number of aberrant cells in a subject having the steps of administering to the subject a combination comprising a polyunsaturated fatty acid and diindolylmethane.
Owner:DRAGTEK CORP
Composition and Methods for Treating and Preventing Age-Related Macular Degeneration
InactiveUS20090035369A1Preventing and attenuating and inhibiting progressionInhibit and prevent progressionBiocideOrganic active ingredientsDiabetic retinopathyPhytochemical
The present invention relates to methods and compositions effective in preventing, attenuating, inhibiting the progression of, and treating eye diseases, e.g., age-related macular degeneration (AMD). The compositions comprise, as an active ingredient, an effective amount of 3,3′-diindolylmethane (DIM) and / or its precursor indole-3-carbinol (I3C). The compositions can further comprise additional agents such as carotenoids and other phytochemicals, which produce a synergistic effect in preventing, attenuating, inhibiting the progression of, and treating AMD and other eye diseases such as glaucoma, cataracts and diabetic retinopathy (DR). The compositions are particularly effective in treating and preventing wet AMD, and in preventing or inhibiting the progression of dry AMD (non-neovascular) to wet AMD (neovascular).
Owner:SELA YORAM
Application of indole-3-carbinol, diindolylmethane and derivatives thereof to preparation of medicine for preventing and controlling atherosclerosis
InactiveCN102389419APrevent atherosclerosisAchieve therapeutic effectOrganic active ingredientsMetabolism disorderMedicineBULK ACTIVE INGREDIENT
The invention provides new application of indole-3-carbinol, diindolylmethane and derivatives thereof to preparation of a medicine for preventing and controlling atherosclerosis (AS). The indole-3-carbinol, diindolylmethane and derivatives thereof have obvious effects of resisting oxidation and improving endothelial functions, can ensure that the expression and proportion of all vaso-active substances in a human body are normal and the endothelial functions can be recovered normally, and have the good effects of reducing blood fat, and resisting AS. Meanwhile, the active ingredients of the used small molecule medicines can be obtained easily, and the indole-3-carbinol, diindolylmethane and derivatives thereof are low in price, have stable performance and are convenient to store and transport, and have wide application prospect.
Owner:合肥博太医药生物技术发展有限公司
Diindol-3-ylmethanes as potent non-toxic antifouling compounds
ActiveUS20160037773A1Preventing and reducing settlementPreventing and reducing and foulingBiocideOrganic chemistryOrganic chemistryDiindolylmethane
The present invention provides high potency 3,3′-diindolylmethane (DIM) and analogue compounds as antifouling agents. The present invention further provides methods of preventing or reducing settlement and / or fouling of marine fouling organisms on surfaces of submerged objects by coating the surfaces with the 3,3′-diindolylmethane (DIM) and analogue compounds provided.
Owner:THE HONG KONG UNIV OF SCI & TECH +1
Self-emulsifying formulations of DIM-related indoles
Disclosed herein are self-emulsifying compositions and formulations of Diindolylmethane (“DIM”) and certain derivatives of DIM, their uses and methods of making. In particular, the disclosed compositions comprise a DIM-related indole as an active agent and a carrier, wherein the carrier comprises a solvent, one or more surfactants with an HLB of greater than 7, and one or more co-surfactants with an HLB equal to or less than 7. In certain aspects of the invention, the compositions disclosed herein show improved bioavailability.
Owner:BIORESPONSE
Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associated conditions
The present invention includes compositions and methods for the treatment and prevention of conditions associated with Respiratory Syncytial Virus (RSV) infection. RSV-associated conditions include acute infections in mammals, typically bronchiolitis and pneumonia, and post-infectious chronic respiratory conditions. In particular, the present invention describes new therapeutic and preventative uses for 3,3′-diindolylmethane (DIM), or a DIM-related indole, alone or in combination with an inhibitor of a membrane bound Epidermal Growth Factor Receptor (EGFR) inhibitors, to treat conditions associated with exposure to RSV.
Owner:BIORESPONSE
Diindolylmethane formulations for the treatment of leiomyomas
Owner:BIORESPONSE
Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associated conditions
InactiveUS20080103114A1Improve developmentBiocideHydroxy compound active ingredientsMedicineBronchitis
The present invention includes compositions and methods for the treatment and prevention of conditions associated with Respiratory Syncytial Virus (RSV) infection. RSV-associated conditions include acute infections in mammals, typically bronchiolitis and pneumonia, and post-infectious chronic respiratory conditions. In particular, the present invention describes new therapeutic and preventative uses for 3,3′-diindolylmethane (DIM), or a DIM-related indole, alone or in combination with an inhibitor of a membrane bound Epidermal Growth Factor Receptor (EGFR) inhibitors, to treat conditions associated with exposure to RSV.
Owner:BIORESPONSE
Diindolylmethane and C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers
Owner:TEXAS A&M UNIVERSITY
Phytochemicals for treatment of mastalgia and endometriosis
Owner:BIORESPONSE
Application of diindolylmethane compound in pesticide
ActiveCN105454237AEasy and cheap to synthesizeInhibit pathogenic bacteriaBiocideFungicidesBakanaeSheath blight
The invention discloses application of a diindolylmethane compound in pesticides, in particular relates to the application in the aspects such as resistance to sclerotinia sclerotiorum, gray mold, sheath blight, leaf spot, bakanae disease, rice blast and the like. The compound structure is represented in the following general formula (I). The diindolylmethane compound can effectively inhibit multiple phytopathogens, extend the application of diindolylmethane compounds, and has a better application prospect in plant disease control.
Owner:INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
Pharmaceutical formulations of acetyl-11-keto-b-boswellic acid, diindolylmethane, and curcumin for pharmaceutical applications
InactiveUS20140039031A1Good curative effectIncrease shear rateBiocideHydroxy compound active ingredientsSolubilityBeta-boswellic acid
The present disclosure is directed to compositions and methods for formulating a pharmaceutical dosage form by forming a composition comprising acetyl-11-keto-β-boswellic acid, diindolylmethane, or curcumin with one or more pharmaceutically acceptable excipients for enhanced solubility to increase bioavailability and improve therapeutic efficacy. The composition can be processed by thermo-kinetic compounding along with conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
Owner:DISPERSOL TECH +1
Compositions containing C-substituted diindolylmethane compounds
InactiveUS7232843B2Inhibit cell proliferationPotent activityBiocideOrganic chemistryMedicineWilms' tumor
Disclosed are methods and compositions for the treatment of a wide array of cancers and tumors. In illustrative embodiments, diindolylmethanes, C-substituted diindolylmethanes, and analogs thereof have been described, which when administered either alone, or in combination with other anti-cancer or anti-tumorigenic compounds, provide new therapies for the treatment of cancer.
Owner:TEXAS A&M UNIVERSITY
Method for synthesizing diindolylmethane derivative
The invention discloses a method for synthesizing a diindolylmethane derivative. The method comprises the following steps of: a, preparing an acid-modified H beta molecular sieve; b, putting the acid-modified H beta molecular sieve into a fixed bed reactor, mixing indol and benzaldehyde or benzaldehyde with a substituent group according to a molar ratio of (3.5-5):1, dissolving into lower alcohol, and introducing into the fixed bed reactor at the speed of between 0.5 and 2 mL / minute to react continuously; and c, adding water into liquid flowing out of the reactor, stirring, standing for precipitating, filtering, and drying a filter material. By the method, the synthesized product has high quality and yield and low cost, the process time is shortened greatly, and a synthetic process is simple and convenient and is easy to operate.
Owner:HEBEI UNIVERSITY
Medication on the basis of 3,3′-diindolylmethane (DIM) with high-bioavailability and its use in treatment of human hyperplastic and inflammatory diseases
The invention relates to medicine and chemico-pharmaceutical industry. A medication for treating human hyperplastic and inflammatory diseases containing 3,3′-diindolylmethane as an active agent and a carrier containing a mixture of cod-liver oil and at least one polysorbate at the following proportions of the components in mass %:3,3′-diindolylmethane 1-20cod-liver oil10-20polysorbatethe balance.
Owner:AKTSIONERNOE OBSCHESTVO ALGIREM
Compositions and methods for epigenetic modification of nucleic acid sequences
Provided herein are pharmaceutical compositions and methods for treating disorders characterized by reduced expression of anti-oxidative stress enzymes in a subject. In one aspect, the present invention provides a method for inducing expression of anti-oxidative stress enzymes in a subject in need thereof. The method includes administering to the subject a therapeutically effective amount of a demethylating agent. The demethylating agent includes a phytochemical that induces expression of Nrf2 and Nrf2-mediated genes expressing anti-oxidative stress. Such phytochemicals include indoles, such as 3,3′-diindolylmethane (DIM) and indole-3-carbinol (I3C), and isothiocyanates, such as phenethyl isothiocyanate (PEITC) and sulforaphane (SFN).
Owner:RUTGERS THE STATE UNIV
Pharmaceutical composition for peroral administration of diindolylmethane
InactiveUS20130065933A1Improve DIM deliveryReduce deliveryBiocideUrinary disorderOral medicationActive component
The invention relates to pharmacy. It comprises block copolymer pharmaceutical compositions containing 3,3′-diindolylmethane (DIM). The pharmaceutical composition for peroral administration comprises 3,3′-diindolylmethane as an active component and a target additive, the target additive being a block copolymer of oxyethylene and oxypropylene, in which the content of the hydrophobic block is less than 50 mass % and the molecular mass of the hydrophilic block is equal to 2,250 Da or more, at a ratio of the active component to the selected block copolymer varying between 10:1 and 2:1.The composition improves absorption of the active compound by the bloodstream upon peroral delivery.
Owner:AKTSIONERNOE OBSCHESTVO ALGIREM
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