183 results about "Uterine cervix" patented technology

A system and method are disclosed for removing a uterus using a fluid enclosure inserted in the peritoneal cavity of a patient so as to enclose the uterus. The fluid enclosure includes a distal open end surrounded by an adjustable loop, that can be tightened, a first proximal opening for inserting an electrosurgical instrument into the fluid enclosure, and a second proximal opening for inserting an endoscope. The loop is either a resilient band extending around the edge of the distal open end or a drawstring type of arrangement that can be tightened and released. The fluid enclosure is partially inserted into the peritoneal cavity of a patient in a deflated condition and then manipulated within the peritoneal cavity over the body and fundus of the uterus to the level of the uterocervical junction. The loop is tightened around the uterocervical junction, after which the enclosure is inflated using a conductive fluid. The loop forms a pressure seal against the uterocervical junction to contain the conductive fluid used to fill the fluid enclosure. Endoscopically inserted into the fluid enclosure is an electrosurgical instrument that is manipulated to vaporize and morcellate the fundus and body of the uterus. The fundus and body tissue that is vaporized and morcellated is then removed from the fluid enclosure through the shaft of the instrument, which includes a hollow interior that is connected to a suction pump The fundus and body are removed after the uterus has been disconnected from the tissue surrounding uterus.

The invention relates to the use of a thermal reversible gel, such as a copolymer composition, as a biological filler or implant. The gel has a semi-solid form at body temperature, but upon cooling to a temperature below a threshold level, the gel is liquefied and can be re-shaped, re-sized, manipulated or removed from the body. The gel may be used as a subcutaneous implant, a biological filler, joint or tissue spacer, for wrinkle filling or other cosmetic implants, as a soft-tissue replacement for reconstructive surgery, or as a barrier within the lumen of a biological structure, such as a blood vessel. The implant may be used to provide reversible birth control by providing, for example, a reversible barrier to the cervix or a reversible blockage of the lumen of the vas deferens.

A system is provided for compressing one or both of the uterine arteries of a patient which is at least in part shaped to complement the shape of the exterior of the cervix, which allows the system to be self-positioning. One or more Doppler chips can be mounted or incorporated into the system which permit the practitioner to better identify the uterine artery and monitor blood flow therein. The system includes a pair of pivotally joined elements which can be moved toward and away from the cervix to compress a uterine artery.

A method and a pharmaceutical composition for inhibiting premature rapture of the fetal membranes, ripening of the uterine cervix and preterm labor of female mammals including human. The method includes the step of administering compounds for reversing at least two biochemical conditions being associated with the above processes. The pharmaceutical composition includes compounds for reversing at least two biochemical conditions being associated with the above processes.

The invention is directed to an intravaginal uterine artery occlusion device for treating uterine disorders such as fibroids, dysfunctional uterine bleeding, postpartum hemorrhage and the like. A occlusion device has a cervical receptacle or cap with an open distal end for receiving the patient's uterine cervix and an elongated shaft having a distal end secured to the closed proximal end of the cervical receptacle and an inner lumen extending to the distal end of the elongated shaft. The patient's uterine cervix is held within the interior of the receptacle by the application of a vacuum to the interior of the receptacle through the inner lumen of the shaft or otherwise, while the leading edge(s) of the cervical receptacle press against the patient's vaginal fornix to occlude an underlying or adjacent uterine artery. At least one blood flow sensor may be provided on the leading edge of the receptacle to aid in locating a uterine artery and to monitor blood flow through the located uterine artery.

Embodiments of the invention provide methods, assays, and kits for detecting HPV infection, including infection by various HPV genotypes, early and / or late HPV-associated or HPV-specific proteins or antibodies. Detection of HPV DNAs, genomes, and / or oncoproteins by protein chips immunological assays can be used in early clinical screening for HPV infection and general diagnosis for cervical cancer and can be advantageous performed in a multiplexed test. Comparative detection of altered levels of HPV proteins and host proteins can performed in one or more assays. The polypeptides, recombinant proteins, antibodies, nucleic acids, and various detection methods thereof are particularly useful for diagnosing carcinomas of the uterine cervix and those at risk of developing cervical cancer.

A method and device for delivering therapeutic agents to the cervix. The method utilizes a diaphragm with an electrically conductive surface that is placed atraumatically over the outer surface and inner os of the mammalian (animal or human) cervix. The agent is delivered to the diaphragm after which the conductive surface of the diaphragm may be charged by a power source to deliver a electrophoretic field to force the agent deep into cervical tissue and cells. The diaphragm may be used with or without the aid of external or internal leads. A unique intrauterine lead designed in this patent may also be used with the diaphragm to enhance delivery of therapeutic agents.

The invention provides a simulator for training of personnel for immediate postpartum medical treatment, distinctive in that the simulator comprises a representation of an immediate postpartum stage uterus, a cervix, a vagina and a resilience member, the uterus is arranged at an angle to the vagina and the resilience member is arranged for allowing said angle to be straightened out by pressing horizontally forward on the uterus. The invention also provides a simulator for training of personnel for immediate postpartum medical treatment, distinctive in that the simulator comprises a representation of an immediate postpartum stage uterus, a cervix and a vagina, the uterus comprises a transparent top or intermediate layer allowing visual observation, and preferably a removable or foldable non-transparent top layer over the transparent layer.

A method and system of providing therapy to a patient's uterus. The method includes the steps of inserting an access tool through a cervix and a cervical canal into the uterus; actively cooling the cervical canal; delivering vapor through the access tool lumen into the uterus; and condensing the vapor on tissue within the uterus. The system has an access tool with a lumen, the access tool being adapted to be inserted through a human cervical canal to place an opening of the lumen within a uterus when the access tool is inserted through the cervical canal; an active cooling mechanism adapted to cool the cervical canal, the active cooling mechanism having a coolant source; and a vapor delivery mechanism adapted to deliver condensable vapor through the access tool to the uterus, the condensable vapor being adapted to condense within the uterus.

Uterine cervical cancer Computer-Aided-Diagnosis (CAD) according to this invention consists of a core processing system that automatically analyses data acquired from the uterine cervix and provides tissue and patient diagnosis, as well as adequacy of the examination. The data can include, but is not limited to, color still images or video, reflectance and fluorescence multi-spectral or hyper-spectral imagery, coherent optical tomography imagery, and impedance measurements, taken with and without the use of contrast agents like 3-5% acetic acid, Lugol's iodine, or 5-aminolevulinic acid. The core processing system is based on an open, modular, and feature-based architecture, designed for multi-data, multi-sensor, and multi-feature fusion. The core processing system can be embedded in different CAD system realizations. For example: A CAD system for cervical cancer screening could in a very simple version consist of a hand-held device that only acquires one digital RGB image of the uterine cervix after application of 3-5% acetic acid and provides automatically a patient diagnosis. A CAD system used as a colposcopy adjunct could provide all functions that are related to colposcopy and that can be provided by a computer, from automation of the clinical workflow to automated patient diagnosis and treatment recommendation.

A multi-gene-based assay for analysis of the following: (a) oncogene expression; (b) DNA methylation of tumor suppressor genes; (c) non-coding RNA expression (microRNA profiling); and (d) long non-coding RNA expression in cancer samples is disclosed. The assay method and device for conducting the assay are applicable to diagnosis, prognosis, and treatment of various cancers such as lung, breast, colorectal, prostate, liver, bladder; kidney, cervix, pancreatic, gastric, brain, oral, endometrium, and ovary. The assay methods allow avoidance of surgery to remove cancerous tissue.

A cup-like structure for engaging a cervix of a patient includes a rim, and includes a base defining an aperture through which one or more tubular members of a uterine manipulator may extend into the uterus. The cup-like structure is made from one or more of a polyphthalamide (PPA) material and a polyetheretherketone (PEEK) material. A uterine manipulator including a cup-like structure is also disclosed.

A cervical biopsy instrument that includes a central shaft defining a longitudinal axis and a stop extending laterally from the shaft. The stop typically is formed in substantially the shape of a circle in a plane disposed at substantially right angles to the central axis of the shaft. The instrument also includes an electrode extending from an endocervical portion of the shaft to the stop. The stop may be formed in the shape of a complete circle, or a partial circle. Any free ends are configured to be rounded and extend inwardly toward the shaft or away from the endocervical portion to prevent the presentation of sharp edges or the like which could be caught on irregularities of the uterine cervix. The stop may be affixed to the central shaft along a tangent, or ends of the stop may be affixed to the central shaft. In another embodiment, the stop encircles or partially encircles the shaft, with the shaft extending substantially through the center of the circle. In this embodiment, either one or two electrodes may be provided. Spokes support the stop with respect to the shaft. The spokes may be formed at an acute angle with respect to the shaft to extend away from the shaft toward the endocervical end thereof. These configurations allow the instrument to be rotated in either a clockwise or a counter-clockwise direction about the central axis of the shaft without fear of catching on the uterine cervix. In another aspect of the invention, a marker is provided on the stop to indicate the location of the electrode.

The invention relates to a Baofukang suppository with an expansion carrier, which is a vaginal suppository prepared by the following components in parts by weight: 60-100 parts of zedoary oil, 60-100 parts of borneol and matrix and 500-2,000 parts of expansion carrier; the surface of the expansion carrier is coated with a drug containing layer formed by at least a part of active ingredients and at least a part of matrix, and the expansion value of the expansion carrier is greater than 1.5. The Baofukang suppository has the benefits that the Baofukang suppository is convenient to use and long in effect time and takes effect fast; the pollution to clothes is avoided; an active drug can be uniformly distributed on a whole vaginal wall and uterine cervix, and permeated into a deep site of mucosa ruffles; surprisingly, the technological effects can still be realized under the conditions that even polyethylene glycol is not used and water is almost not used; the effective rate to mycotic vaginitis is 96.2%; and the effective rate to senile vaginitis is 96.6%.

The invention discloses a piece of cervical cancer precancerosis diagnostic equipment, comprising a cervical cancer inherent fluorescence detecting system, a uterine cervix acetic coloring detecting system, an image acquisition system and an external image processing system; wherein, the cervical cancer inherent fluorescence detecting system comprises a light source and a switch of the light source, and the light source includes an excitation light source for providing fluorescence and a cold light source for providing white light which are both installed in a reflection bowl with a specific focal distance; the uterine cervix acetic coloring detecting system comprises an acetic acid pool, a spray pipe connected to the acetic acid pool, a shift device of the spray pipe and a spray switch; the image acquisition system comprises a dim light CCD which is installed at the center of the reflection bowl; the image acquisition system is connected with an external image processing system whichcan process the images collected by the image acquisition system; the uterine cervix is sequentially irradiated by white light and excitation light and the images of the white light and the excitation light reflected by the uterine cervix are collected; the acetic acid is sprayed on the uterine cervix which is irradiated by the white light and the excitation light after waiting for a moment and the images of the white light and the excitation light reflected by the uterine cervix which is sprayed with the acetic acid are collected.

Stent devices comprising an inflatable inner balloon defined by an envelope and an outer balloon surrounding the inner balloon concentrically, the outer balloon serving as a therapeutic agent reservoir used for controlled therapeutic agent delivery. In some embodiments, the outer balloon has two separate walls which define its volume and is independently inflatable. In some embodiments, the two concentric balloons form a substantially cylindrical structure which has a proximal end and a distal end. A catheter carrying inflation and drainage lumens extends outward from the proximal end. In some embodiments, the distal end includes an embedded cervix accommodating tip or has a non-embedded cervix accommodating tip attached thereto. The stent devices can be used to maintain the integrity and placement of vaginally placed mesh or graft after reconstructive procedures, prevent vaginal hematoma formation and bleeding, provide pain control after surgery and deliver antibiotics or hormones to the vaginal epithelium.

Synergistic compositions and methods are disclosed for using cruciferous indoles with iron / zinc chelators in the treatment of papillomavirus-related conditions. These synergistic compositions of diindolylymethane (DIM), related trimeric derivatives, and related indole derivatives include combinations with deferoxamine, deferiprone, bipyridyl, Desferri-exochelin, picolinic acid, 3-hydroxypicolinic acid, and sodium butyrate as iron / zinc chelators. The methods described comprise more effective therapies for common cutaneous warts (verrucae) and related dysplasias of the oropharynx, genitalia, and uterine cervix.

An improvement on the extra-amniotic balloon and technique of placement is disclosed. It involves a large capacity balloon, modified to efficiently place pressure on the cervix, and markers for ease and of placement. The malleable introducing stylet allows for safe and easy insertion, either manually or visually, through a cervix that is 0.5 cm or more in dilation. The optional traction collar can aid in more efficiently placing pressure on the cervix. The automatic pump for instillation of the fluid has a forward and reverse mode to allow for deflation and repositioning of the balloon if placement is less than optimal. This process can be performed by a physician or a nurse, already certified in the placement of fetal scalp electrodes or intrauterine pressure catheters. Additionally, the procedure can be performed by one person.

A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or hetero 5 to 7 membered ring is effective as a propylactic or therapeutic agent for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, cancer of uterine cervix, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, polycystic ovary syndrome and acne vulgaris; is effective as a fertility controlling agent in both sexes (e.g. a pregnancy controlling agent and a menstrual cycle controlling agent); can be used as a contraceptive of male or female, as an ovulation-inducing agent of female; can be used as an infertility treating agent by using a rebound effect owing to a stoppage of administration thereof; is useful as modulating estrous cycles in animals in the field of animal husbandry, as an agent fro improving the quality of edible meat or promoting the growth of animals; is useful as an agent of spawning promotion in fish.

The invention relates to a cervix brush, comprising a sheath tube, a core pole, a scraper, villus and a guiding head; wherein, the scraper, the guiding head and the sheath tube are formed by integrated injection molding, the guiding head is arranged at the foremost end of the sheath tube, the scraper comprises six plastic strips which can be detached to triangles, the front end of the scraper is connected with the guiding head, the back end of the scraper is connected with the sheath tube and a easy folded groove is arranged between the connection and the scraper, the core pole is axially sleeved in the sheath tube and is slideable, the head of the core pole is fixed in the guiding head, the villus is cultivated at the front ends of the guiding head, the scraper and the sheath tube, the stress on the surface of the cervix from the six scrapers which can be furled and spread is uniform, in particular that the cells at area with high incidence of the cervical cancer from the one third part outside of the cervical canal to the external cervical orifice can be gotten by the cervix brush. The cervix brush has the advantages of small radial direction size, convenient operation and low manufacturing cost.

A cervical biopsy system for improving the quality and efficiency of cervical biopsies. The cervical biopsy system includes an elongated housing with a handle attached to one end, a punch attached to an opposite end of the housing, a retrieval blade movably positioned within the punch for severing a biopsy tissue, and a trigger member mechanically connected to the retrieval blade for manipulating the retrieval blade within the punch. The punch is inserted into the inner wall of the uterine cervix for cutting around a uniform piece of biopsy tissue. The retrieval blade is manipulated to sever the biopsy tissue from the uterine cervix and the user is able to withdraw the biopsy tissue for medical testing.

New methods and compositions are disclosed that comprise the phytochemical Diindolylmethane, alone or in combination with immune potentiating steroids. These methods and compositions are utilized to treat subjects suffering from common cutaneous warts (verrucae) and Human Papilloma Virus (HPV) related conditions of the oropharynx, larynx, genitalia, and uterine cervix.

Embodiments of the invention provide methods, assays, and kits for detecting HPV infection and HPV associated epithelial cell abnormalities, most notably those associated with pre-malignant and malignant epithelial cell lesions. Detection of HPV DNAs, genomes, and / or oncoproteins by nucleic acid hybridization assays and immunological assays can be used in early clinical screening for HPV infection and diagnosis for cervical cancer. The polypeptides, recombinant proteins, antibodies, nucleic acids, and various detection methods thereof are particularly useful for diagnosing carcinomas of the uterine cervix and those at risk of developing cervical cancer.

The invention relates to the field of medicines, in particular to an angiogenesis inhibitor for inhibiting several matrix metal protein enzyme and inhibiting the transfer of the vascular endothelial cell, which can be applied to preparation and treatment of entity tumor and rheumatoid arthritis. The polypeptide comprises a polypeptide I, polypeptide II, polypeptide III and polypeptide IV (Seq NO.1, Seq NO.2, Seq NO.3, Seq NO.4); The polypeptide can be used for treating entity tumor and rheumatoid arthritis. The four angiogenesis inhibitors can be applied to preparation of medicine for treating tumor, and is characterized in that: the tumor is derived from primary of neck, brain, thyroid gland, esophagus, pancreas, lung, liver, stomach, mammary gland, kidney, colon or rectum, ovary, cervix, uterus, prostate, bladder and testis or secondary cancer, melanoma, hemangioma and sarcoma.

A vaginal drug delivery system includes a device formed of porous material that holds a flowable therapeutic formulation. The device, preferably in a soft, prewetted state, is inserted into the vagina to reside typically at or near the cervix where it continuously releases the flowable therapeutic formulation through its outer surface which is in contact with the vaginal surfaces. In operation, the flowable therapeutic formulation migrates via capillary forces from a reservoir that is centrally located in the device and through a covering that envelopes the reservoir.

The invention relates to the field of medicines, and in particular relates to an inhibitor of angiogenesis capable of inhibiting matrix metallo-proteinase and migration of vascular endothelial cells. The inhibitor can be used for preventing and treating solid tumor and rheumatoid arthritis. The polypeptide specifically means polypeptide I, polypeptide II, polypeptide III and polypeptide IV (with reference to SeqNO.1, SeqNO.2, SeqNO.3 and SeqNO.4). The polypeptide can be used for treating solid tumor and rheumatoid arthritis. The four inhibitors of angiogenesis can be applied to preparing medicines for treating tumor. The polypeptide is characterized in that tumor is originated from essential or subsequent cancers, melanoma, hemangioma and sarcoma of heat and neck, brain, thyroid, esophagus, pancreas, lung, liver, stomach, breast, kidney, gall bladder, colon or rectum, ovary, cervix uterus, uterus, prostate, bladder and testis.