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59 results about "Trypanosomiasis" patented technology
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Trypanosomiasis or trypanosomosis is the name of several diseases in vertebrates caused by parasitic protozoan trypanosomes of the genus Trypanosoma. In humans this includes African trypanosomiasis and Chagas disease. A number of other diseases occur in other animals.
Water-free dry washing agent for automobile
ActiveCN101024801ANo emissionsNo pollution in the processNon-surface-active detergent compositionsVehicle cleaningEmulsionSunscreen agents
The invention relates to a vehicle dry cleaner that is made up from 65-85% brazilian trypanosomiasis , 3-7% penetrant, 2-4% dispersable emulsifier OP-10, 5-20% regulator, 1-5% sunscreen agent, 1-3% quality maintain agent, and 0.01-0.03% essence. The manufacture method includes following steps: weighing raw material according to weight percent, heating Brazilian trypanosomiasis to fusion, putting into mixer to gain the first raw product; putting the raw material into emulsion machine to take second emulsification to gain the product. The invention has advantages of saving water resource and no environment pollution problem, low cost and lower customer vehicle cleaning cost.
Owner:朱正龙
Methods for enhancing immune response
InactiveUS20110256161A1Antibacterial agentsOrganic active ingredientsImmunosuppressionStomach cancer
This disclosure demonstrates a novel therapy immunological approach using polyamine-based therapy (PBT) for relieving tumor-induced suppression of the patient's immune system. The demonstration of the pharmacological release from the naturally occurring polyamine-mediated immune suppression offers profound impact on the immunotherapy of cancer together with a variety of diseases caused by the disease-causing vector's ability to evade an immune reaction. This therapeutic approach is equally applicable to disease states whereby immune system suppression by polyamines has been demonstrated including; bacterial infections, parasitic infections including malaria and typanosomiasis, viral infections, peptic ulcers and gastric cancer due to H. Pylori infection together with prevention of pregnancy. With a small molecule drug, used in combination with DFMO, the pharmacological manipulation of polyamine levels for therapeutic benefit in various disease states is possible.
Owner:AMINEX THERAPEUTICS
Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
ActiveUS20100055201A1Improve developmentShorten the counting processHeavy metal active ingredientsBiocideCoccidiosisTrypanosomiasis
The present invention includes methods and compositions for the treatment and prevention of protozoal parasitic infections utilizing Diindolylmethane-related indoles. Additive and synergistic interaction of Diindolylmethane-related indoles with other known anti-parasitic and pro-apoptotic agents is believed to permit more effective therapy and prevention of protozoal parasitic infections. The methods and compositions described provide new treatment of protozoal parasitic diseases of mammals and birds including malaria, leishmaniasis, trypanosomiasis, trichomoniasis, neosporosis and coccidiosis.
Owner:BIORESPONSE
Snornai-small nucleolar rna degradation by rna interference in trypanosomatids
ActiveUS20060079471A1Downregulating levelSugar derivativesGenetic material ingredientsDiseaseSmall nucleolar RNA
Polynucleotides and a method suitable for downregulation of small nuclear RNA which can be used to treat diseases associated with activity of small nuclear RNA are provided. Specifically, the present invention can be used to downregulate snoRNA molecules or box H / ACA-containing RNA molecules which are involved in diseases such as cancer.
Owner:BAR ILAN UNIV
Amomum planting method
InactiveCN104838866AImprove stress resistanceImprove disease resistanceVegetative propogationDiseaseFruit set
The invention provides an amomum planting method. The method includes: selecting seeds, preprocessing the seeds, coating the seeds, selecting a field, preparing the field, sowing, cultivating ribbon bees, planting in a division manner, controlling diseases and pests, strengthening flowers and fruits, performing field management and harvesting. The method has the advantages that the seed coating is performed to increase stress resistance and disease resistance, accelerate budding, promote seedling maturing and increase yield; amomum pollination is increased greatly by cultivating the ribbon bees in the planting field of the amomum, the disease resistance and stress resistance of the amomum are enhanced, and manpower cost is reduced; by spraying fruit and pedicel strengthening chemical on the amomum, fruit setting rate is increased effectively, fruit growth is promoted, fruit malformation is avoided, ghost is avoided, and false grain is avoided; the control methods aiming at the damping off, the leaf spot disease and the bolted trypanosomiasis which easily occur during amomum planting is provided, tests show that the effectiveness of the methods can reach above 90%, diseases during amomum planting are effectively prevented, and evident influence on amomum yield increasing is achieved.
Owner:宁明县红枫中药材种植专业合作社
Thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of their use
The present invention relates to thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of using such compounds to prevent and treat protozoan infections such as trypanosomiasis, malaria and leishmaniasis. The compounds also find use in inhibiting cysteine proteases associated with carcinogenesis, including cathepsins B and L.
Owner:RGT UNIV OF CALIFORNIA
Oxaborole esters and uses thereof
ActiveUS20170327519A1Boron compound active ingredientsGroup 3/13 element organic compoundsSouth American trypanosomiasisMedicine
The present invention provides oxaborole ester compounds and compositions thereof which are useful to treat diseases associated with parasites, such as Chagas Disease and African Animal Trypanosomosis.
Owner:ANACOR PHARMA INC
Multicomponent or monocomponent vaccine to be used against Chagas disease, pharmaceutical compositions containing them, procedure for the obtention of immunogen of said vaccines, and nucleic acid used in said procedure
InactiveUS8900598B2Stimulate immune responseEliminates itAntibacterial agentsPeptide/protein ingredientsChagas diseaseTrypanosomiasis
Owner:DE BAEREMAECKER BARROS CARLOS
Synthetic immunogen useful for generating long lasting immunity and protection against pathogens
InactiveUS20130183377A1Induced proliferationGenerating long lasting protective immunityAntibacterial agentsPowder deliverySynthetic ImmunogensTrypanosomiasis
The present invention relates to a synthetic immunogen represented by the general formula 1, useful for generating long lasting protective immunity against various intracellular pathogens which are the causative agents of tuberculosis, leishmaniasis, AIDS, trypanosomiasis, malaria and also allergy, cancer and a process for the preparation thereof. The developed immunogen is able to circumvent HLA restriction in humans and livestock. The invention further relates to a vaccine comprising the said immunogen for generating enduring protective immunity against various diseases. The said vaccine is targeted against intracellular pathogens, more particularly the pathogen M. tuberculosis in this case. In the present invention, promiscuous peptides of M. tuberculosis are conjugated to TLR ligands especially; Pam2Cys to target them mainly to dendritic cells and therefore elicit long-lasting protective immunity. (The formula (I) should be inserted here) General formula (I) wherein, X1=a promiscuous CD4 T helper epitope selected from SEQ ID No. 1 to 98 OR nil; X2=a promiscuous CD8 T cytotoxic epitope selected from SEQ ID No. 99 to 103 OR nil; when X1=nil; X2=SEQ ID No. 99 to 103 and when X2=nil; X1=SEQ ID No. 1 to 98; Y=Lysine; and S=Serine.
Owner:COUNCIL OF SCI & IND RES +1
Anti-trypanosomiasis vaccines and diagnostics
The present invention has as an object a novel genetic material coding for trans-sialidase-like proteins of African trypanosomes, and relates to the use of said genes and proteins in vaccines, therapeutics and diagnostics. The present invention also relates to the immunization of human and / or nonhuman animals against trypanosomosis.
Owner:UNIV BORDEAUX SEGALEN +1
Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
ActiveUS8586621B2Shorten the counting processHeavy metal active ingredientsBiocideCoccidiosisTrypanosomiasis
Owner:BIORESPONSE
Multicomponent or monocomponent vaccine to be used against chagas disease, pharmaceutical compositions containing them, procedure for the obtention of immunogen of said vaccines, and nucleic acid used in said procedure
InactiveUS20100297186A1Stimulate immune responseReduces clinical consequenceAntibacterial agentsProtozoa antigen ingredientsChagas diseaseTrypanosomiasis
A vaccine against the Chagas disease, capable of stimulating the immune response against the trans-sialidase virulence factor of the Trypanosoma Cruzi parasite, which is a multicomponent vaccine comprising: (a) an immunogenic portion formed by one or more recombinant or synthetic polypeptides or fractions of thereof and (b) one or more polynucleotides including the regions that codifying one or more immunogenic polypeptides, or a monocomponent comprising at least one component selected among an immunogenic portion formed by one or more recombinant or synthetic polypeptides or fractions of them and a group of polynucleotides including the regions codifying one or more immunogenic polypeptides derived from Trypanosoma Cruzi and pharmaceutical compositions containing said multicomponent and monocomponent vaccines, the procedures for obtaining the immunogen portion of said vaccines and the nucleic acid used in the procedure.
Owner:DE BAEREMAECKER BARROS CARLOS
Double hydrochloride vertebral gel spray for purifying nose and its use
InactiveCN101073552AEasy to useSmall local irritationAerosol deliveryAntiparasitic agentsNasal cavityVein
The invention is concerned with the Vertebral double net hydrochloride clean gelatin nebula pressurized spray for nose, which consists of Vertebral double net hydrochloride and gel substrate. It is uses for anti-trypanosomiasis. It is: stays in liquid form, in order to control to spray into nasal cavity easily and separates on the surface of Nasal evenly and forms gelatin by interdiffusing with nose grume. With its long lasting inside the nasal cavity, it can direct input the medicine to the brain that is 2-5 times over injection through vein.
Owner:SHANGHAI INST OF PHARMA IND CO LTD
Thio semicarbazone and semicarbozone inhibitors of cysteine proteases and methods of their use
Owner:RGT UNIV OF CALIFORNIA
Oral bioavailable pentamidin prodrugs for treatment of diseases
InactiveUS20130085180A1Improve solubilityImprove oral bioavailabilityOrganic active ingredientsBiocideDiseaseLeishmaniasis
The present invention relates to prodrug derivatives of pentamidine, their use in the treatment and / or prophylaxis of diseases such as tumor diseases, as well as leishmaniasis, trypanosomiasis, pneumocystis carinii pneumonia (PcP), and malaria.
Owner:DRITTE PATENTPORTFOLIO BET GMBH & CO KG
Compound capable of killing trypanosoma brucei, and application thereof in treating trypanosoma brucei
ActiveCN107445953AEfficient killingHigh affinityOrganic active ingredientsOrganic chemistryTrypanosomiasisBinding domain
The invention relates to a compound capable of killing trypanosoma brucei, and application thereof in treating trypanosoma brucei. The compound is GSK2801, specifically targets a TbBDF2 acetylated lysine binding domain, has high affinity with the TbBDF2 acetylated lysine binding domain, and can be used for efficiently killing trypanosoma brucei.
Owner:UNIV OF SCI & TECH OF CHINA
Treatment of chagas disease
The invention provides compounds of the formula: wherein L1 and L2 are independently selected from O and S; R1 is C3-C6 straight or branched alkyl, C3-C7cycloalkyl, C5-C7cycloalkenyl, adamantly, phenyl or saturated heterocyclyl, any of which being optionally substituted; R2 is H, methyl or ethyl; R5 is NRxCORy, NRxRy, CH2COCH3, CH2C≡N, or a 5- or 6-membered heteroaryl group which is optionally substituted; X, Y and Z are independently N or CH; Rx is independently H or C1-C4alkyl; Ry is independently H, CrC4alkyl, phenyl or benzyl, either of which is optionally substituted; n is 0-3; salts, hydrates and N-oxides, wherein the optional substituents are further defined in the claims. The compounds have utility in the prophylaxis or treatment of trypanosomal diseases, such as T. cruzi (Chagas disease).
Owner:UNIVERSITY OF DUNDEE +3
Use of Inhibitors of the Activity or Function of PI3K
The invention relates to new uses of PI3K inhibitors, wherein said inhibitors have an inhibitory action on the PI3K isoform delta for the treatment of immunopathology in a subject suffering from a disease or disorder selected from malaria, leishmaniasis, trypanosomiasis, toxoplasmosis and / or neurocysticercosis, via functional inhibition of TLR9 of the infected subject.
Owner:NOVARTIS FARMA +1
Orally bioavailable pentamidine prodrugs for the treatment of diseases
ActiveUS20150111965A1Improve solubilityImprove oral bioavailabilityBiocideOrganic active ingredientsLeishmaniasisTrypanosomiasis
The present invention relates to prodrug derivatives of pentamidine, their use in the treatment and / or prophylaxis of diseases such as tumor diseases, as well as leishmaniasis, trypanosomiasis, pneumocystis carinii pneumonia (PcP), and malaria.
Owner:DRITTE PATENTPORTFOLIO BET GMBH & CO KG
Compounds useful against kinetoplastideae parasites
Dibenzylidene and heterobenzylideneacetone derivatives, related 4-piperidones, related 4-thiopyranones and the corresponding sulfinyl- and sulfonyl-analogues for their use for prophylaxis or treatment of trypanosomiasis and leishmaniasis.
Owner:CENT NAT DE LA RECHERCHE SCI
Treatment and prevention of diseases mediated by microorganisms via drug-mediated manipulation of the eicosanoid balance
Owner:UNITED STATES OF AMERICA
Trypanosoma cruzi antigen, gene encoding therefor and methods of detecting and treating chagas disease
InactiveUS6933110B1Improve presentationImprove stabilitySugar derivativesMicrobiological testing/measurementAntigenTrypanosoma antigen
The nucleotide sequence of Tc100, a gene encoding PTc100, a new Trypanosoma antigen, and the amino acid sequence of PTc100 are described. Tc100 and PTc100, or fragments thereof, modified or otherwise, can be used directly or indirectly for the detection of Trypanosoma cruzi, or for the monitoring of the infection generated by Trypanosoma cruzi, in man or in animals.
Owner:BIOMERIEUX SA
Anti-trypanosomiasis vaccines and diagnostics
Owner:波尔多第二大学 +1
Method for inhibiting Trypanosoma cruzi
Owner:HOWARD UNIVERSITY
Anti-trypanosomiasis agent
ActiveCN101107246AHigh selective toxicityEasy to solveOrganic active ingredientsOrganic chemistryArylHydrogen
An anti-trypanosomiasis agent which has highly selective toxicity to trypanosomiasis and produces a high preventive or therapeutic effect thereon. The agent is characterized by containing a compound represented by the following general formula (1) as an active ingredient. (In the formula, R<1>, R<2>, R<6>, and R<7> each independently represents hydrogen, C1-5 alkyl, etc., provided that they may be bonded to each other; R<3>, R<4>, and R<5> each independently represents C1-5 alkyl or C5-8 aryl; Y and Z each independently represents atoms necessary for the formation of a 5- or 6-membered heterocycle; m and n each is 0 or 1; Q represents a physiologically acceptable anion; and k is an integer of 0-2 which is necessary for making the charge of the whole molecule zero.
Owner:FUJIFILM CORP +1
New pradimicin derivatives for the treatment of diseases caused by kinetoplastids
ActiveUS20160243140A1Reduce usageUseful in treatmentOrganic active ingredientsAntiparasitic agentsDiseaseChagas disease
The present invention relates to a class of novel pradimicins and analogues and derivatives thereof, including the compounds of formula A, I and 111, and / or a pharmaceutical acceptable addition salt thereof and / or a stereoisomer thereof and / or a solvate thereof and their use to treat or prevent kinetoplastid infections and their use to manufacture a medicine to treat or prevent kinetoplastid infections, particularly infections with trypanosoma and leishmania, such as Trypanosoma brucei, Trypanosoma cruzi and Leischmania donovani. wherein Ra, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the claim 1 or as described in detail in the description of the invention. The present invention also relates to pharmaceutical compositions of said compounds and the use of said pharmaceutical compositions to treat or prevent kinetoplastid infections. The present invention further relates active ingredients, more specifically as medicaments for the treatment of kinetoplastid infections and pathologic conditions such as, but not limited to Trypanosomiasis, such as African trypanosomiasis, sleeping sickness, Chagas disease and leishmaniasis.
Owner:KATHOLIEKE UNIV LEUVEN +1
Synthetic immunogen useful for generating long lasting immunity and protection against pathogens
InactiveUS9340622B2Generating long lasting protective immunityInduced proliferationAntibacterial agentsPowder deliverySynthetic ImmunogensDisease
Owner:COUNCIL OF SCI & IND RES +1
Detection kit for American trypanosomiasis and detection method thereof
InactiveCN108872605ASimple and fast operationEasy to detectBiological material analysisBiological testingSerum igeChromogenic Substrates
The invention provides a detection kit for American trypanosomiasis and a detection method thereof. The kit comprises 6 polypeptides with amino acid sequences of SEQ ID NO. 1 to SEQ ID NO. 6. The detection method comprises the following steps: (1) separating a sample to be detected by utilizing a separation solution and re-suspending separated cells in a serum free medium; (2) adding 6 polypeptides with the amino acid sequences of SEQ ID NO. 1 to SEQ ID NO. 6 into the re-suspended cells and carrying out common incubation; then adding a high-specificity mouse anti-human IgG antibody into a common incubation system and carrying out antigen and antibody reaction; (3) washing a system subjected to the antigen and antibody reaction; then adding a chromogenic substrate and carrying out chromogenic reaction; counting the quantity of spots generated by the reaction. The kit provided by the invention can be obtained by artificial complete sequence synthesis, is convenient and rapid to produce and has high stability and specificity; the kit is simple and convenient to operate and the cost is extremely reduced.
Owner:李梅秀
Oxaborole esters and uses thereof
ActiveUS10562921B2Boron compound active ingredientsGroup 3/13 element organic compoundsDiseaseChemical compound
The present invention provides oxaborole ester compounds and compositions thereof which are useful to treat diseases associated with parasites, such as Chagas Disease and African Animal Trypanosomosis.
Owner:ANACOR PHARMA INC
Treatment and prevention of diseases mediated by microorganisms via drug-mediated manipulation of the eicosanoid balance
The invention provides a method of enhancing the efficacy of antibiotic treatment of tuberculosis, trypanosomiasis, leprosy, and leishmaniasis involving co-administering to a mammal undergoing antibiotic treatment therapeutically effective amounts of a first compound that is an inhibitor of 5-lipoxygenase and optionally a second compound that is a product of the cyclooxygenase pathways. The invention also provides a pharmaceutical composition comprising an antibiotic, an inhibitor of 5-lipoxygenase, and a product of the cyclooxygenase pathways.
Owner:UNITED STATES OF AMERICA
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