Double hydrochloride vertebral gel spray for purifying nose and its use
A spray and nasal technology, which is applied in the field of hydrochloric acid Shishuangjing nasal gel spray, can solve problems such as nasal mucosa and cilia toxicity, and achieve the effects of less local irritation, good therapeutic effect, and not easy to be lost.
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Embodiment 1~10
[0021] T-46(g): trypanazin hydrochloride; PEG: polyethylene glycol; the components of Examples 1-18 were made up to 1000 mL with water for injection. The commercial name of the junction angle of the present invention is Gelrite, which is purchased from Shanghai Zhongwei Biochemical Co., Ltd.
[0022] Examples 1-4, 18 preparation method: ① take the prescribed amount of isotonicity regulator, gelling agent and preservative in 850mL of water for injection, heat in a water bath at 90°C to dissolve completely. 2. hydrochloric acid dipyridine hydrochloride is used respectively [30ml 0.1mol / L (embodiment 1), 50mL 0.1mol / L (embodiment 2), 100mL 0.1mol / L (embodiment 3), 100mL 0.2mol / L (embodiment 4 ), 30ml 0.1mol / L (Example 18)] hydrochloric acid dissolved, added in the above solution under stirring, fully mixed. ③Examples 1 and 18 use 30% ethanolamine, and examples 2-4 use 30% trishydroxymethylaminomethane to adjust the pH to the required pH in Table 1, add water for injection...
Embodiment 17
[0024] Preparation method of Example 17: ① Take the prescribed amount of gelling agent in 680 mL of water for injection, and refrigerate overnight at 4°C to make the gelling agent fully swell and disperse evenly to obtain a clear solution. ②Tyrabiquinone hydrochloride was dissolved with water for injection, added into the above solution under stirring, and mixed well. 3. Add water for injection to a total amount of 1000mL, pack in white medical plastic bottles, and install a nasal cavity spray pump to obtain the nasal gel spray of Shishuangjing Hydrochloride of the present invention.
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