590 results about "Carcinogenesis" patented technology

A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumor cells in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells. We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis.

A method for screening cancer comprises the following steps: (1) providing a test specimen; (2) detecting the methylation state of the CpG sequence in at least one target gene within the genomic DNA of the test specimen, wherein the target genes is consisted of SOX1, PAX1, LMX1A, NKX6-1, WT1 and ONECUT1; and (3) determining whether there is cancer or cancerous pathological change in the specimen based on the presence or absence of the methylation state in the target gene; wherein method for detecting methylation state is methylation-specific PCR (MSP), quantitative methylation-specific PCR (QMSP), bisulfite sequencing (BS), microarrays, mass spectrometer, denaturing high-performance liquid chromatography (DHPLC), and pyrosequencing.

Methods and systems are provided for the noninvasive measurement of the subepithelial impedance of the breast and for assessing the risk that a substantially asymptomatic female patient will develop or be at substantially increased risk of developing proliferative or pre-cancerous changes in the breast, or may be at subsequent risk for the development of pre-cancerous or cancerous changes. A plurality of electrodes are used to measure subepithelial impedance of parenchymal breast tissue of a patient at one or more locations and at least one frequency, particularly moderately high frequencies. The risk of developing breast cancer is assessed according to measured and expected or estimated values of subepithelial impedance for the patient and according to one or more experienced-based algorithms. Devices for practicing the disclosed methods are also provided.

The invention discloses an image-guided lung interventional operation system which comprises an image acquiring module, a lung region reconstruction module, a lung respiratory movement model construction module, an operative instrument and operative region image space mapping module, a dynamic focus space-positioning and guide module and an another image acquiring module. The image acquiring module is connected with the lung region reconstruction module which is connected with the lung respiratory movement model construction module, the lung respiratory movement model construction module is connected with the dynamic focus space-positioning and guide module, and the another image acquiring module is connected with the operative instrument and operative region image space-mapping module which is connected with the dynamic focus space-positioning and guide module. Real-time space positioning of dynamic focuses is achieved, early diagnosis of carcinogenesis of lung nodule can be achieved, and error of space positioning precision is within 2mm.

In order to identify genes that can serve as indicators for predicting the effectiveness of drug treatments in cancers and provide novel methods for predicting the effectiveness of treatments with drugs targeting said genes, transcriptome sequencing was performed of diffuse-type gastric cancer. As a result, in-frame fusion transcripts between the CEP55 gene and the RET gene were identified. It was also found that said gene fusions induce activation of RET protein, thereby causing canceration of cells. Further, it was demonstrated that the RET protein activation and canceration caused by said gene fusion can be suppressed by using a RET tyrosine kinase inhibitor, and that treatments with a RET tyrosine kinase inhibitor are effective in patients with detection of said gene fusion.

A medical composition is provided which is advantageous as a sealant for wound openings as well as have a function promoting healing of intractable wound or incision wound, and which accelerate tissue regeneration but does not cause any side effect such as canceration. The present invention relates to a medical composition comprising a photo-crosslinkable chitosan derivative and a wound healing promoter. The photo-crosslinkable chitosan derivative is preferably a polymer obtainable by incorporating a carbohydrate chain containing a reducing terminal to at least one portion of amino groups of chitosan back bone and incorporating a photoreactive group to at least another part of the amino groups. The wound healing promoter is preferably a growth factor.

A method of prevention / treatment of pathological consequences of DNA damage triggered by incorporation of circulating apoptotic chromatin fragments into healthy cells of individuals / patients in need therefore, said method comprising ex vivo or extra corporeal treatment of blood / plasma for removal of circulating chromatin fragments released from apoptotic cells which apoptotic chromatin fragments are capable of triggering DNA damage leading to genomic instability, senescence, apoptosis and cancerous transformation of healthy cells on being integrated into their genomes

It has been demanded to improve the poor solubility of curcumin to develop an anti-tumor compound capable of inhibiting the growth of various cancer cells at a low concentration. Thus, disclosed is a novel synthetic compound, a bis(arylmethylidene)acetone, which has both of an excellent anti-tumor activity and a chemo-preventive activity. A bis(arylmethylidene)acetone (i.e., a derivative having a curcumin skeleton) which is an anti-tumor compound and has a chemo-preventive activity is synthesized and screened. A derivative having enhanced anti-tumor activity and chemo-preventive activity can be synthesized.

The present invention provides a new method and device for disease detection, more particularly cancer detection, from the analysis of diffuse reflectance spectra measured in vivo during endoscopic imaging. The measured diffuse reflectance spectra are analyzed using a specially developed light-transport model and numerical method to derive quantitative parameters related to tissue physiology and morphology. The method also corrects the effects of the specular reflection and the varying distance between endoscope tip and tissue surface on the clinical reflectance measurements. The model allows us to obtain the absorption coefficient ([mu]a) and further to derive the tissue micro-vascular blood volume fraction and the tissue blood oxygen saturation parameters. It also allows us to obtain the scattering coefficients ([mu]s and g) and further to derive the tissue micro-particles volume fraction and size distribution parameters.

Methods and apparatus are provided for determining the condition of selected regions of epithelial and stromal tissue. A plurality of electrodes are used to measure surface and transepithelial electropotential of tissue, especially breast tissue, as well as surface electropotential and impedance at one or more locations and at several defined frequencies, particularly low frequencies. An agent may be introduced into the region of tissue to enhance electrophysiological response characteristics. Measured and derived electrical properties facilitating diagnosis include DC potential, impedance, subepithelial resistance, epithelial resistance, capacitance, characteristic frequency, depression angle and transepithelial potential. Ambient and varying pressure measurements applied to epithelial tissue are also used for diagnosis. Improved diagnosis of tissue condition can be made based on the electrical properties and tissue electrophysiological response to altered ion transport and pressure. Devices for practicing the disclosed methods are also provided.

Disclosed is a system for placing an elongated permanent magnet into a volume of tissue within a human body that is suspected of being cancerous. The magnet's position is then detected by a magnet locating system that is used by a surgeon to find and remove the suspected tissue volume including a margin of tissue to assure that any and all cancer cells have been excised. The magnet locating system includes a wireless probe that sends a signal to a range indication device that indicates the range from the end of the probe to the magnet implanted in the human body. This indication of distance to the magnet is preferably accomplished by an audio signal or a visual display.

A method of treating a cancerous region in a breast of a patient comprising (i) imaging the breast in a three-dimensional coordinate system, (ii) stereotactically determining the location of the cancerous region in the breast, (iii) optionally determining the volume of the entire cancerous region to be treated, and (iv) while maintaining the breast in a three-dimensional coordinate system that is identical to or corresponds with the three-dimensional coordinate system used in (i), noninvasively exposing the cancerous region of the breast of the patient to a cancer-treatment effective dose of radiation; and equipment for use in such a method.

The invention provides an antineoplastic drug screening cell model utilizing STAT3 as target, belonging to the field of biomedicine. The model is created by a reporting system carrier containing an STAT3 specific binding sequence on the basis of active cells with constitutive STAT3, and the model is used for screening treatment medicine of carcinomatous changes and tumors caused by STAT3 constitutive activation. The active cells with the constitutive STAT3 are utilized, so the reporter gene in the model cell is situated at an overactive state, and no additional stimulant is necessary; besides, the obtained stable cell model can be directly used for screening the compounds, thereby not only greatly reducing the screening cost, but also simplifying the whole screening process from cell cultivation, STAT3 activation, compound feed and detection to cell cultivation, compound feed and detection, shortening the screening period, reducing the operation steps, and improving the stability, efficiency and usability of the system, so that the model is more suitable for high throughput medicine screening.

The invention relates to a novel intelligent bra for early detection of breast cancer. The intelligent bra carries ultra-high sensitive computer micro-processing chips, which include temperature sensor, blood flow sensors, oxyhemoglobin quantity sensors and the like for all-round acquisition of breast tissue temperature, blood flow and the hemoglobin amount. The device saves periodically collected data in a computer through a wireless transmission system, and automatically analyzes and alarms whether carcinogenesis possibility exists in breasts.

A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell.We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumors in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells.We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis.

The invention relates to a cosmetic especially for a cream with 0. 65%-1. 8% turmeric extract and 8%-10% flax seed extract and making method, which is characterized by the following: extracting form natural plants; utilizing the extract of the turmeric and flax seed to be human body's forerunner substance effectively; improving autoregulation hormone secretion of human body; having much security in treating menopause symptom; avoiding the risk of inducing canceration to galactophore and endometrium through supplementing estrogen; improving appearance surface skin of human and adjusting and balancing internal secretion for women in menopausal period. The invention can improve chronic fatigue syndrome to improve metabolism and quality of life, which can treat acne and avoid liver primacy effect of oral medication with a simple making method.

The invention relates to a preparation method of a hair dye, especially to a preparation method for a botanical hair dye, and specifically relates to a preparation method for a hair dye based on a walnut green husk pigment. The preparation method comprises the following steps: striping walnut green husk, air drying in a shady place; crushing, sieving through a sieve of 70-90 meshes; adding green husk powder and acetone into a container with a solid-liquid mass ratio of 1:25-35 and an acetone concentration of 70-90%, oscillation processing the solution at a constant temperature of 40-50 DEG C for 10-14 h; centrifuging the solution for 2-4 times, filtering off impurities and collecting the supernatant; decompressing concentrating the solution at a temperature of 50-65 DEG C to obtain an ointment; and preparing the hair dye according to the following material ratios: 5-7% of the ointment, 85-87% of water, 0.5-1.5% of silicone oil, 0.5-1.5% of oil-solubility VE, 0.5-1.5% of VB, 3-5% of olive oil and 0.5-1.5% of white vaseline. The preparation method is simple, easy to operate and high in recovery rate. The prepared green husk pigment is granular, shows yellow under the developing effect of methyl red, has no escherichia coli, is suitable for exploitation of the hair dye, and helps to solve the problems that the conventional hair dye contains carcinogenesis substances and the natural hair dye is not exploited fully.

An oral cancer screening device 10 used for the detection of pre-cancerous and cancerous tissue has a power supply 100, an illumination source 200, a selector switch 300 that enables the activation of a specific wavelength of light from the illumination source 200, an electrical system 400 in communication with the selector switch 300 and the illumination source 200, a heat sink 500 in thermal communication with the illumination source, a filter or cover 600 to protect the illumination source, and a transparent sheath 700 for providing a sanitary shield for the device when it is brought into contact or close proximity with the patient oral cavity. The sheath may optionally have an angled mirror incorporated at a distal end of the sheath to provide the operator with a reflected image of the illuminated tissue 900. The operator will optionally utilize head mounted lenses 800 to assist the operator's visualization of the light from the illuminated oral cavity.

The present invention relates to the detection of malignant melanoma. In particular, the present invention relates to systems and methods for the early detection of cancerous lesions.

Carcinogenesis inhibitors containing as the active ingredient carotenoids extracted from the pure-line species of paradicsom paprika (species classified as Capsicum annuum L. var. grossum), etc., such as capsanthin, its fatty acid esters, capsorubin diesters, capsanthin 3,6-epoxide, capsorubin and cucurbitaxanthine A-3' ester. These carcinogenesis inhibitors and paradicsom paprika extracts originate in natural substances and, therefore, make it possible to provide excellent Epstein-Barr virus genome inactivating agents. Thus, they are expected as being useful in preventing carcinogenesis and, based on their effects, applicable in various fields including drugs, cosmetics and health foods.

The present invention relates to a method and apparatus which quantifies radiation safety in medical imaging through the creation and analysis of objective data for each individual imaging procedure with respect to acquisition parameters, calculated radiation dose, and clinical data related to imaging examination selection and performance. The present invention also calculates a cumulative radiation dose based upon an individual patient's entire medical record, along with occupational and environmental exposures, to calculate a dynamic cumulative radiation-induced carcinogenesis risk. The present invention provides reforms to improve patient safety, quality and accountability, by creating a technology which simultaneously records and tracks objective data referable to radiation safety, medical imaging quality, and accountability among the various stakeholders and technologies in use. This quantifiable data is referred to as the Radiation Dose Quality Index (RDQI), and creates an objective, data-driven measure of quality and safety as it relates to medical practice.

Inositol hexaphosphate (IP-6) is a polyphosphorylated carbohydrate with potent antioxidant activity to prevent active oxygen species-mediated mutagenesis, cell injury and carcinogenesis. IP-6 also activates DNA repair mechanisms. Sublethal radiation causes DNA damage through the formation of free radicals, reactive oxygen species, and pyrimidine crosslinks leading to cellular proliferation, cell cycle arrest and apoptosis. In the skin it results in the induction of skin cancer, premature skin aging, immuno-suppression, inflammation, and cell death. Likewise sublethal exposure to ionizing radiation as in nuclear blasts (war-time, accidental, terrorist-induced etc), cosmic radiation, etc. also causes the same spectrum of damage to the cells and the organisms with acute symptoms and eventual high risk of many cancers. IP-6 and / or inositol and their pharmaceutically acceptable salts and derivatives, including pyrophosphates and citrate derivatives, significantly counteract the harmful effects of radiation, affecting cell cycle progression in a protective manner (more cells in the protective GI phase) as well as decreasing apoptosis and caspase-3 activation. Various salts of IP-6 are used with comparable efficacy and the combination of IP-6+inositol affords the best protection against radiation-induced cell injury. Thus IP-6 and inositol are effective agents for protection against nuclear, solar and other radiation injuries.

The invention discloses a method for detecting and positioning of cancer regions with small samples or unbalanced samples. By combining the characteristics of the histopathological image containing cancer cells, the method enhances the data set by using a method of adding noise, rotating, increasing or reducing brightness, expands the data set, balances the specific gravity of the label type of the training set, and improves the training effect of the classifier. The method is characterized in that an Inception V2 network is used as a basis; aiming at the conditions of few samples and unbalanced samples, iterative training is carried out in combination with a small number of calibrated cancerous tissue image blocks and WSI pathological images; the method is advantaged in that WSI image-level pathological image cancer area detection and positioning can be accomplished with high accuracy; problems of over-fitting, local optimization and gradient disappearance of the over-deep neural network easily caused by too few labeled training samples are solved; and accuracy of the training result and usability of the network under the same level are improved.

The invention discloses a large-scale preparation method for foot-and-mouth disease totivirus marked vaccine with high yield, high purity and high safety and a product thereof. The method comprises the following steps: a)collecting a virus solution; b)performing deep filtration on a membrane, performing ultrafiltration and performing enzymolysis on nuclease; c)purifying through a strong anion exchange adsorption bed or an adsorption film; d)depositing by PEG, extracting by chloroform-isoamyl aleohl; e)inactivating; F)performing density gradient centrifugation on an inactivation liquid through cane sugar and purifying; g)performing ultrafiltration dialysis and aseptic filtration; and h)reserving a stock solution or emulsifying. The provided foot-and-mouth disease totivirus marked vaccine antigen is uniform and complete foot-and-mouth virus particle, The vaccine is injected into body, so animal infection and immunization can be completely distinguished, does not contain foot-and-mouth disease virus non-structural protein and other virus particle, and does not contain animal-based foreign protein, polypeptide and oligopeptides, animal latent anaphylactic reaction, carcinogenesis and latent risk such as mad cow disease for causing animal infectious diseases due to vaccine injection can be effectively reduced, and the vaccine has no influence on animal food safety and trade.

The invention relates to the technical field of medical technology assistance, in particular to an artificial intelligence diagnosis method for gastric cancer under a narrow-band imaging amplificationgastroscope, which comprises the following steps: S1, constructing a mini-UNet neural network model; S2, constructing a UNet + + image segmentation neural network model, and obtaining an area ratio Rabnormal of an image feature difference region; S3, adopting a generative adversarial network (GAN) technology to obtain a microvascular morphological diagram and a microstructure morphological diagram of the feature abnormal region; S4, identifying the microvessel form dissimilarity degree and the microstructure form dissimilarity degree in the microvessel form diagram and the microstructure formdiagram by the neural network model ResNet50; and S5, carrying out identification and judgment by using the random forest model obtained by training to obtain final judgment of cancer or non-cancer,and identifying the canceration position range of the image, which is judged to be cancer, as the identified image feature difference region Pabnormal. The sensitivity and specificity of the kit to cancer and non-cancer recognition reach about 93.4% and 90.7% respectively, a clinician can be effectively assisted in discriminating and diagnosing cancer and non-cancer, and a canceration position range is given.

The invention relates to the technical field of medical image processing, in particular to a gastric early cancer auxiliary diagnosis method based on a deep learning multi-model fusion technology, which comprises the following steps: S1, constructing multiple models; s2, collecting gastroscope images, forming continuous serialized image frames, identifying the light source mode of the current image frame by utilizing the image classification model 1, entering the step S3 to mark the position of a focus by the target detection model 2 when the current image frame is identified as a white lightmode, and marking the high-risk focus by utilizing the image classification model 3; and when the image frame is identified as the dyeing amplification mode, entering the step S4 in which a segment model group can extract the boundary range, the microvessel form and the micro-tissue structure feature map in the image frame in real time, and outputting whether canceration occurs or not, the credibility and the differentiation type by the decision-making model 7. A plurality of deep learning models are constructed according to different tasks, a parallel cascade model fusion technology is adopted, and a full-process intelligent auxiliary diagnosis function is provided in the stomach early cancer screening process of endoscopists.

The invention belongs to the technical field of medicine and relates to purple perilla seed oil fat emulsion injecta being rich in omega-3 fatty acid and a preparation method thereof. The purple perilla seed oil fat emulsion injecta comprises 5 to 30 percent of refined purple perilla seed oil, 0.5 to 7.5 percent of an emulsifying agent, 1.4 to 3.6 percent of glycerin, 0 to 0.5 percent of EDTA-2Na, 0 to 0.5 percent of an antioxidant, 0.1 percent of hydrochloric acid or sodium hydroxide with the pH being 6.0 to 8.5 and the residual amount of water for injection. The purple perilla seed oil fat emulsion injecta has good stability and can avoid side effect caused by the metabolism of fat emulsion which is rich in omega-3 fatty acid. The injecta of the invention is the fat emulsion injecta with natural refined purple perilla seed oil, which can be sent for high-temperature sterilization and provide human bodies with energy to keep the factors needed by brain and nerve functions. The injecta has the functions of anti-thrombus and antiatheroscloresis, canceration prevention, inhabitation of tumour cells transfer and inhabitation of abnormalism symptoms.

Medicinal compositions for treating or preventing diabetes, rheumatoid, diseases wherein inflammation should be inhibited, diseases wherein alpha-glycosidase should be inhibited, diseases wherein the synthesis of prostaglandin should be inhibited, diseases wherein endotoxin shock should be inhibited, diseases wherein the production of interleukin should be inhibited, diseases wherein the production of heme oxygenase should be induced, and diseases wherein the production of tumor necrosis factor or carcinogenesis should be inhibited, which contain as the active ingredient at least one compound selected from the group consisting of 3,6-anhydrogalactopyranose represented by formula (I), its aldehyde, its hydrate and 2-O-methylated derivatives and 2-O-sulfated derivatives thereof.