The invention provides a hand sanitizer containing chlorine dioxide, which is prepared by the following components according to a certain weight ratio: surfactant, chelant, humectant, thickener, water-soluble body lotion, fungicide precursor, pH regulator, essence and deionized water. The hand sanitizer provided by the invention has mild, safe and environment-friendly properties, thus cleaning, skin care and sterilization can be simultaneously finished; the chlorine dioxide is selected to serve as a component of fungicide, thereby having good sterilization effect, short action time and high sterilization ratio; the hand sanitizer can take effect as soon as being used because germs can not generate tolerance on the hand sanitizer; and in addition, during the using process of the hand sanitizer, carcinogen such as chloroform and the like can not be generated, the biodegradation rate of the surfactant is more than 90%, satisfies the national requirements, and has no toxicity and harm and environment protection, thereby people can use the product for long term trustingly.