The present invention provides disposable illumination sheaths as a sterile barrier between an imaging device and a patient. An exemplary sheath can generally be usable with any imaging system known in the art, for example, an endoscopic imaging system, and can be designed to cover and / or enclose portions of the imaging device that may be exposed to patient tissue and / or bodily fluids. An exemplary sheath of the present invention can be designed to cover and protect the imaging shaft, optics housing, camera housing, handle, imaging output and / or other electrical and component cords, as well as any other portion of the imaging device that may be exposed to contamination. A used sheath can be disposed of after a first procedure and a new, sterile sheath can be used for a subsequent procedure. In this way, an imaging device can be utilized repeatedly without the need for a full sterilization between each procedure.